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Publications (18)
Dear Editor,
Dysfunction of the circadian timing system is a distinguishing feature of many neurodegenerative diseases [1]. We report here on an apparent phase advance in the self-selected bedtimes of patients with Alzheimer’s disease (AD) observed during baseline of a clinical trial.
This analysis used baseline data from two randomized controlled...
Background
We used baseline polysomnography (PSG) data obtained during the clinical program development for suvorexant to compare the PSG profiles of people with Alzheimer's disease and insomnia (ADI) versus age-matched elderly individuals with insomnia (EI).
Methods
Sleep laboratory Baseline PSG data from participants age 55–80 years from 2 trial...
We evaluated a single‐item Patient Global Impression‐Severity (PGI‐S) scale for assessing insomnia severity during the clinical development programme for suvorexant. The analyses used data from two randomised, double‐blind, placebo‐controlled, 3‐month, Phase III clinical trials of suvorexant in patients with Diagnostic and Statistical Manual of Men...
Objective:
The determinants of sleep quality (sQUAL) are poorly understood. We evaluated how well a large number of objective polysomnography (PSG) parameters can predict sQUAL in insomnia patients participating in trials of sleep medications or placebo.
Methods:
PSG recordings over multiple nights from two clinical drug development programs inv...
Objectives:
To examine the duration and frequency of wake bouts underlying the wakefulness-after-sleep-onset (WASO) reduction with suvorexant.
Methods:
We analyzed polysomnogram recordings from clinical trials involving 1518 insomnia patients receiving suvorexant (40/30mg, 20/15mg) or placebo to determine: 1) the number of, and time spent in, lo...
Introduction
Different from our previously reported studies examining the bivariate correlation between each of the sleep parameters assessed objectively by polysomnography (PSG) and patient-reported sleep quality (SQ), we investigated how accurately a large number of PSG parameters can jointly predict (explain) SQ.
Methods
PSG recordings from two...
Previous studies of the differences between patients with insomnia and good sleepers with regard to quantitative electroencephalographic measures have mostly utilized small samples and consequently had limited ability to account for potentially important confounding factors of age, sex and part of the night. We conducted a power spectral analysis u...
Introduction
Spectral analysis has been used to quantify differences in the sleep EEG between primary insomniacs (PI) and good sleeper controls (GSC). Previous studies have been based on relatively small samples with varying inclusion criteria, and have not typically examined the effects of important factors such as age, gender, and sleep period of...
To study the characteristics of unintentional muscle activities in clinical EEG, and to develop a high-throughput method to reduce them for better revealing drug or biological effects on EEG.
Two clinical EEG datasets are involved. Pure muscle signals are extracted from EEG using Independent Component Analysis (ICA) for studying their characteristi...
After a review of the ocular artifact reduction literature, a high-throughput method designed to reduce the ocular artifacts in multichannel continuous EEG recordings acquired at clinical EEG laboratories worldwide is proposed. The proposed method belongs to the category of component-based methods, and does not rely on any electrooculography (EOG)...
A robust image watermarking scheme in curvelet domain is proposed. The curvelet transform directly takes edges as the basic representation element; it provides optimally sparse representations of objects along edges. The image is partitioned into blocks and curvelet transform is applied to those blocks with strong edges. The watermark consists of a...
In this paper, a robust block-based watermarking scheme operating in curvelet domain is proposed. Curvelet transform directly take the edge as the basic representation element; it provides optimally sparse representations of objects along a general curve with bounded curvature. The image is partitioned into small blocks; an edge map is computed to...
In this paper, a robust watermarking scheme operating in curvelet domain is proposed. Curvelet transform directly take the edge as the basic representation element; it provides optimally sparse representations of objects along a general curve with bounded curvature. The image is partitioned into small blocks, Unequally-Spaced Fast Fourier Transform...
Objective video quality measurement is a challenging problem in a variety of video processing application ranging from lossy compression to printing. An ideal video quality measure should be able to mimic the human observer. We present a new video quality measure, M-SVD, to evaluate distorted video sequences based on singular value decomposition. A...
Because of the transition from analog to digital technologies, content owners are seeking technologies for the protection of copyrighted multimedia content. Encryption and watermarking are two major tools that can be used to prevent unauthorized consumption and duplication. In this paper, we generalize an idea in a recent paper that embeds a binary...
