Pegah Akbari

The Children’s Hospital of Eastern Ontario | CHEO · Department of Anesthesiology and Pain Medicine

Pregnant women are recommended to engage in 150 min of moderate-intensity physical activity per week to reduce pregnancy complications. Many women struggle to remain physically active throughout pregnancy, and there is no consensus about whether women adopt a less efficient movement pattern as they progress through pregnancy and experience gestatio...

We assessed the role of purinergic P2 receptors in the regulation of cutaneous vasodilation in young adults at rest and during intermittent moderate-intensity exercise in the heat (35°C). P2 receptor blockade augmented resting cutaneous vasodilation but had no influence during and following exercise. This increase was partly diminished by nitric ox...

Aging and chronic disease such as type 2 diabetes (T2D) are associated with impairments in the body's ability to dissipate heat. To reduce the risk of heat-related injuries in these heat vulnerable individuals, it is necessary to identify interventions that can attenuate this impairment. We evaluated the hypothesis that intradermal administration o...

Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilation during exercise in younger adults. We hypothesized that endothelial NOS (eNOS) and neuronal NOS (nNOS) mediate NOS-dependent sweating, whereas eNOS induces NOS-dependent cutaneous vasodilation in younger adults exercising in the heat. Further, aging may upregulate induci...

Angiotensin II (Ang II) has been implicated in the pathophysiology of cardiovascular disease through several mechanisms, including evoking elevations in oxidative stress. We tested the hypothesis that increases in oxidative stress induced by Ang II impair the local heat loss responses of cutaneous vasodilation and sweating. Eleven young (24 ± 4 yea...

Our recent work showed that nitric oxide (NO)‐dependent sweating and cutaneous vasodilation are diminished in young males during intermittent exercise at high (700 W) relative to moderate (400 W) rates of metabolic heat production. We tested the hypothesis that this impairment results from increased oxidative stress during high intensity exercise....

Recent studies demonstrate that nitric oxide synthase (NOS) is involved in sweating during intermittent exercise in the heat in young adults (Stapleton, Exp Physiol 99:921, 2014; Fujii, J Physiol 2014, in press). However, it remains unknown which NOS isoform mediates NOS‐dependent sweating. We tested the hypothesis that endothelial NOS (eNOS), but...

It is unclear if angiotensin II, which can increase the production of reactive oxygen species (oxidative stress), modulates heat loss responses of cutaneous blood flow and sweating. We tested the hypothesis that angiotensin II-induced increases in oxidative stress impair cutaneous perfusion and sweating during rest and exercise in the heat. Eleven...

This study evaluated the separate and combined roles of nitric oxide synthase (NOS) and cyclooxygenase (COX) in forearm sweating and cutaneous vasodilation in older adults during intermittent exercise in the heat. Twelve healthy older (62 ± 7years) males peformed two 30-min cycling bouts at a fixed rate of metabolic heat production (400 W) in the h...