Pedro Vieira Baptista

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Verified

Pedro verified their affiliation via an institutional email.

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• MD
• MD at Hospital Lusiadas

Objective To investigate the prevalence of vulvodynia in Portugal and factors associated with this condition. Methods In a cross-sectional study, an online survey was distributed by email and posted on a website and social networks. Women aged at least 18 years who were living in Portugal were eligible to complete the survey between June 1 and Nov...

Vulvovaginitis encompasses few conditions, which may be infectious or inflammatory. The common practice of symptomatic, empiric approach to management of vulvovaginitis is very limited. A significant number of women will not fit the “traditional” diagnosis of candidiasis, bacterial vaginosis, or trichomoniasis. These conditions are discussed, as we...

Objective: To validate the use of Seegene® AllplexTM Vaginitis assay in the diagnosis of candidiasis, bacterial vaginosis (BV) and trichomoniasis DESIGN: Cross-sectional, prospective study conducted in a single center SETTING: Outpatient clinic of a gynaecology department POPULATION: Consecutive symptomatic and asymptomatic women (18-60 years) MET...

Introduction The G-spot, a putative erogenous area in the anterior vaginal wall, is a widely accepted concept in the mainstream media, but controversial in medical literature. Aim Review of the scientific data concerning the existence, location, and size of the G-spot. Methods Search on Pubmed, Pubmed Central, Cochrane, clinicaltrials.gov and Goo...

Objectives: The aims of the study were to assess the available literature concerning the indications, performance, technique, and classification of wet mount microscopy (WMM) and to establish evidence-based recommendations. Methods: Literature review from the main scientific databases was performed by the ad hoc "Vaginitis and Microbiome Committ...

Human papillomavirus (HPV) is the most prevalent sexually transmitted infection globally, with significant implications for both individual and public health. While management protocols for HPV-positive women are well-defined, limited and controversial guidance exists for their male partners, creating challenges in clinical practice. This commentar...

Introduction This study aimed to investigate the efficacy of imiquimod in Anal High Grade Squamous Intraepithelial Lesion (HSIL). Methods Electronic databases (Pubmed, MEDLINE, EMBASE and Cochrane Library databases) were searched from inception until December 2024 for articles reporting imiquimod as a treatment for anal HSIL. Results Five studies...

Background: Vulvar squamous cell carcinoma incidence is increasing, especially among women under 60, largely attributed to human papillomavirus infections. Precursor pre-invasive vulvar lesions are frequently underdiagnosed. Routine vulvar inspection during cervical cancer screening could offer an opportunity for the detection of these lesions. O...

Two separate online surveys were presented to women who were confirmed to have purchased a boric acid vaginal suppository product in the previous year for themselves March 2020 (study 1) and July 2023 (study 2) to understand consumer expectations concerning the use of vaginal boric acid. Study 1 found that repeat purchasers are more likely to buy b...

This book is dedicated to everyone affected by vulvar lichen sclerosus (LS). Our aim is to provide comprehensive education and support to all who navigate this condition, emphasizing the importance of inclusive and respectful healthcare. Throughout the book we have referred to women and girls, reflecting that most people affected by vulvar LS ident...

Vulvar examination during procedures for cervical carcinoma screening (CCS) can be a valid chance for early diagnosis of vulvar diseases and precancerous lesions. With this aim an online questionnaire was sent to the members of the Italian Cervical Carcinoma Screening Group (GISCi) from either first level group (FLG, Pap/human papillomavirus test s...

Objectives This study was designed to evaluate the performance of a host gene methylation marker panel (ASTN1, DLX1, ITGA4, RXFP3, SOX17, and ZNF671) in the triage of human papillomavirus (HPV)-positive women, its possible impact in a cervical cancer screening program, and the possible influence of the variation of the rate of HPV16/18 in its perfo...

Objective Our aim was to evaluate the performance of different follow-up strategies after treatment for cervical intraepithelial neoplasia (CIN) 2 or 3, including human papillomavirus (HPV) detection, cytology, or colposcopy, as well as their combinations. Additionally, we compared the influence of the persistence of HPV 16/18 versus that of other...

DST-J bras Doenças Sex Transm 2024;36:e24361396 The genital tract microbiome: bridging the gap between hype and clinical reality O microbioma do tracto genital: colmatando o fosso entre a moda e realidade clínica Abstract In the last years there has been a huge interest in the study of the human microbiome, and the genital tract one has been no exc...

Introduction Vulvodynia is defined as vulvar pain of at least 3 months' duration, without clear identifiable cause, which may have potential associated factors. It can have a significant impact on women's quality of life due to a combination of physical pain, emotional distress, and limited treatment options. Despite affecting a considerable number...

Objectives The objective of this study is to investigate vulvovaginal disease (VVD) awareness in Italian obstetrics and gynecology (Ob/Gyn) residents. Materials and Methods A 25-question survey on VVD basic knowledge (17 questions) and willingness to improve it (8 questions) was distributed through Ob/Gyn resident online group chats, from differen...

Sexually transmitted infections (STIs) constitute one of the leading causes of disease burden worldwide, leading to considerable morbidity, mortality, health expenditures, and stigma. Of note are the most common bacterial STIs, chlamydial and gonococcal infections, whose etiological agents are Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (N...

In most papers and textbooks, it is still considered that “vaginitis” are limited to candidiasis or candidosis, bacterial vaginosis (BV), and trichomoniasis. Not surprisingly, some studies report a rate of “unspecific vaginitis” that can be as high as 30%.1 This high rate derives from both insufficient diagnostic workup, but also from the non-ackno...

Esta publicação foi inspirada pelos objetivos e missão da Sociedade Internacional para o Estudo de Doenças Vulvovaginais (ISSVD, International Society for the Study of Vulvovaginal Disease), nomeadamente: • promover a comunicação internacional entre ginecologistas, patologistas, dermatologis- tas e outros profissionais de saúde; • estabelecer um co...

Unlabelled: Vulvar lichen sclerosus is a chronic inflammatory disease involving vulvar skin. The risk of developing invasive vulvar cancer for women with LS is reported in the literature, but the risk of extra-vulvar tumors has been under-investigated. This multicentric study aims to estimate the risk of developing cancers in a cohort of women wit...

This review analyzes the clinical associations between specific low genitourinary tract clinical circumstances in perimenopausal and postmenopausal women living with human immunodeficiency virus (WLHIV). Modern antiretroviral therapy (ART) improves survival and reduces opportunistic infections and HIV transmission. Despite appropriate ART, WLHIV ma...

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) developed consensus statements on pre-invasive vulvar lesions in order to improve the quality of care for pati...

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) developed consensus statements on pre-invasive vulvar lesions in order to improve the quality of care for pati...

Members and non-members of the International Society for the Study of Vulvovaginal Dis- ease (ISSVD), acknowledged as experts in the field of vulvovaginitis, from different countries and backgrounds, were invited to participate in this mission. Participants were involved in one or more working groups, according to their expertise and interest. Each...

Objective: This study aimed to analyze which clinical characteristics are associated with recurrence and progression of vulvar high-grade squamous intraepithelial lesion (vHSIL). Materials and methods: This was a retrospective cohort study, including all women with vHSIL followed in 1 center between 2009 and 2021. Women with a concomitant diagno...

Background Cytolytic vaginosis (CV) is a little-known, controversial condition that is typically not considered for women presenting with vulvovaginitis symptoms. Objective: The objective of this scoping review was to identify and compile the global evidence on CV. Methods A medical librarian searched Prospero, Wiley Cochrane Library, Ovid Embase,...

Hypertrophic herpes is a rare and often missed diagnosis that significantly compromises quality of life.

Objective To evaluate the efficacy of the hormonal and nonhormonal approaches to symptoms of sexual dysfunction and vaginal atrophy in postmenopausal women. Data Sources We conducted a search on the PubMed, Embase, Scopus, Web of Science, SciELO, the Cochrane Central Register of Controlled Trials (CENTRAL), and Cumulative Index to Nursing and Allie...

Sexually transmitted infections (STIs), such as Chlamydia trachomatis (Ct) infection, have serious consequences for sexual and reproductive health worldwide. Ct is one of the most common sexually transmitted bacterial infections in the world, with approximately 129 million new cases per year. C. trachomatis is an obligate intracellular Gram-negativ...

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Leptothrix are long bacteria of rare occurrence; although these bacteria have been implicated in causing vaginal symptoms identical to candidiasis, studies on prevalence and effect on overall vaginal health are lacking. In this study, we evaluated data of women referred to a private clinic for treating vulvovaginal symptoms (n = 1847) and reassesse...

Objective: The etiology of localized provoked vulvodynia (LPV) remains unknown, but observations suggest the involvement of the vaginal microbiota. We examined the vaginal microbiota of women with LPV and healthy controls, upon after a low-oxalate diet (LOD). Materials and methods: A total of 9 women diagnosed with secondary LPV and 21 healthy c...

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) developed consensus statements on pre-invasive vulvar lesions in order to improve the quality of care for pati...

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) developed consensus statements on pre-invasive vulvar lesions in order to improve the quality of care for pati...

Background Vulvar Paget's disease (VPD) is a rare neoplasm with high recurrence rates even after surgical treatment. Imiquimod topical cream is a promising therapy; however, experience with it is limited to small series or case reports. This study aims to analyze the effectiveness and safety of topical imiquimod in a large cohort of patients with V...

The spectrum of vulvar lesions ranges from infective and benign dermatologic conditions to vulvar precancer and invasive cancer. Distinction based on the characteristics of vulvar lesions is often not indicative of histology. Vulvoscopy is a useful tool in the examination of vulvar pathology. It is more complex than just colposcopic examination and...

Objective: The aim of the stud was to evaluate risk factors for positive margins on surgical specimens of patients submitted to transformation zone excision (TZE). Materials and methods: We conducted a retrospective study evaluating women submitted to TZE in our center, between 2012 and 2020. Our study population included only women with the dia...

Objective: Vulvar lichen sclerosus (VLS) and possibly vulvar lichen planus (VLP) are associated with an increased vulvar cancer (VC) risk. We analyzed the risk of VC and its precursors after a diagnosis of VLS or VLP. Materials and methods: A search was performed to identify articles describing the development of vulvar neoplasia in women with V...

ABSTRACT Acute vulvar ulcer (Lipschütz’s ulcer) is a rare lesion with local hyperimmunoreactivity triggered by infection, which is characterized by acute, painful, and necrotic ulcerations. This condition is usually found in non-sexually active adolescents, and it resolves spontaneously. We report a case of a 35-year-old woman who was diagnosed wit...

Objective: The aim of the study was to evaluate whether vaginal dysbiosis (bacterial vaginosis [BV] or moderate/severe aerobic vaginitis [AV]/desquamative inflammatory vaginitis) in women subjected to intrauterine insemination (IUI) or in vitro fertilization/intracytoplasmic sperm injection influences the rates of pregnancy. Materials and methods...

Objective This series of articles, titled The Vaginal Microbiome (VMB), written on behalf of the International Society for the Study of Vulvovaginal Disease, aims to summarize the recent findings and understanding of the vaginal bacterial microbiota, mainly regarding areas relevant to clinicians specializing in vulvovaginal disorders. Materials a...

Objective: This series of articles, titled The Vaginal Microbiome (VMB), written on behalf of the International Society for the Study of Vulvovaginal Disease, aims to summarize the recent findings and understanding of the vaginal bacterial microbiota, mainly regarding areas relevant to clinicians specializing in vulvovaginal disorders. Materials...

Objective: This series of articles, titled The Vaginal Microbiome, written on behalf of the International Society for the Study of Vulvovaginal Disease, aims to summarize the current findings and understanding of the vaginal bacterial microbiota, mainly regarding areas relevant to clinicians specializing in vulvovaginal disorders. Materials and m...

Objective: This series of articles, titled The Vaginal Microbiome (VMB), written on behalf of the International Society for the Study of Vulvovaginal Disease, aims to summarize the recent findings and understanding of the vaginal bacterial microbiota, mainly regarding areas relevant to clinicians specializing in vulvovaginal disorders. Materials...

Objective: This series of articles, titled The Vaginal Microbiome (VMB), written on behalf of the International Society for the Study of Vulvovaginal Disease, aims to summarize the recent findings and understanding of the vaginal bacterial microbiota, mainly regarding areas relevant to clinicians specializing in vulvovaginal disorders. Materials...

The estrogen decrease in postmenopausal women results in functional and anatomical changes in the genitourinary tract. The most prevalent and bothersome symptoms are vaginal dryness, dyspareunia, and reduced lubrication, which can significantly affect the quality of life of these women, principally those who are sexually active. Hormonal therapy wi...

Menopause is a physiological and progressive phenomenon secondary to decreased ovarian follicular reserve that significantly affects the genital tract. Although postmenopausal vulvovaginal atrophy primarily affects postmenopausal women, it is also seen in premenopausal women. The hypoestrogenic condition results in hormonal and anatomical changes,...

Genitourinary syndrome of menopause (GSM) is a term used to define a compilation of signs and symptoms arising from decreased estrogenic stimulation of the vulvovaginal and lower urinary tract. Among 27–84% of women in postmenopausal are affected for symptoms of GSM, and these can unquestionably impair health, sexual function, consequently the qual...

Objectives: Anal squamous cell carcinoma (ASCC) has a higher incidence described in certain groups, namely, in women with vulvar high-grade squamous intraepithelial lesions (vHSILs) and/or human papillomavirus squamous cell carcinoma (VSCC). This review describes terminology, vHSIL, and VSCC in their association with ASCC and the published recommen...

The treatment of vulvodynia remains challenging. Surgery (vestibulectomy) is an option for localized vulvodynia, but it is often considered only after failure of conservative approaches. The authors reviewed the available literature to establish the role, indications, complications, and success rates of surgical procedures. We conducted a literatur...

Superficially, invasive vulvar squamous cell carcinoma (SISCCA) (FIGO stage IA) is a rare subset of vulvar cancer defined as a single lesion measuring ≤2 cm with a depth of invasion of ≤1.0 mm. This is a retrospective study performed on 48 patients with SISCCA, surgically treated between 1981 and 2018 at the S. Anna Hospital, University of Turin, t...

Objective To compare the performance of the Amsel criteria, culture of Gardnerella spp., and wet mount microscopy (WMM) in the diagnosis of bacterial vaginosis. Methods A cross‐sectional cohort study was conducted, consisting of evaluating 749 consecutive women, regardless of symptoms. The Amsel criteria were evaluated, WMM microscopy and Gram sta...

A vulvodinia, de acordo com a International Society for the Study of Vulvovaginal Disease (ISSVD), é uma dor (ou ardor) vulvar, dependente ou não de um estímulo, com duração de pelo menos 3 meses, e para os quais não se encontra uma explicação. Trata-se, portanto, de um diagnóstico de exclusão. (1) A sua etiologia é desconhecida, acreditando-se que...

Objective To develop a best practice document for the management of postmenopausal vulvovaginal atrophy (VVA). Method Literature review carried out using clinical terms, treatments or interventions and comorbidity related to VVA. Results There is a wide variety of interventions that may produce temporal benefits for VVA. However, there are signif...

Introduction It is estimated that 50% of women will suffer a severe form of vulvovaginal atrophy (VVA) related to menopause. Equally, young women may temporarily present this clinical problem while receiving various pharmacological or endocrine treatments or radiotherapy. Aim To determine clinical and diagnostic exams required to confirm the prese...

Objective: The aim of the study was to investigate the knowledge of vulvar anatomy and vulvar self-examination (VSE) in a sample of Italian women attending a gynecology clinic. Methods: For this original research from May to July 2019, 512 women attending the Lower Genital Tract Clinic at the Department of Surgical Sciences of the University of...

Brazilian Journal of Sexually Transmitted Diseases

PurposeTo analyze the prognostic factors of recurrence and overall survival in rare histotypes of vulvar cancer.Methods An international multicenter retrospective study including patients diagnosed with vulvar cancer was performed. One hundred centers participated in the study and 2453 vulvar cancer cases were enrolled from January 2001 until Decem...

Objective: The aim of the study was to describe the course of IgG/IgA immune response in women immunized with bivalent vaccine and in women non-vaccinated with HPV infection, as well as evaluating the cross-protection against non-vaccine HPV types. Methods: Serum and cervical mucus samples were collected from infected and vaccinated women for HPV d...

Objective: The aim of the study was to compare the rate of high-risk human papillomavirus (HR-HPV) genotypes in vaccinated (Gardasil [quadrivalent]) and unvaccinated cohorts of young women. Materials and methods: This is a retrospective, cross-sectional study, consisting of the comparison of the prevalence of HPV 16, 18, and other HR genotypes i...

LASERs are frequently marketed as a complication‐free treatment for vaginal atrophy (genital syndrome of menopause [GSM]) and urinary incontinence (UI). At the same time, the disadvantages and risks of the standard options are overemphasized (i.e. topical oestrogens and risk of breast cancer; mid‐urethral slings and risk of erosion, etc.). Less oft...

Tidy et al showed that 1/3 of all referrals for colposcopy, in settings where primary high-risk HPV (HR-HPV) test is used for screening, are due to persistently positive tests with a negative triage cytology (BJOG 2020 xxxx). These represent a significant burden for colposcopists but yielding a relatively low number of cases of CIN2+ (7%), thus tra...

Objective The aim of the study was to assess the risk of vulvar cancer and precursors in a cohort of women with vulvar lichen planus (LP) and the clinical and therapeutic features of these patients. Materials and Methods A retrospective cohort study, including all the women with the diagnosis of vulvar LP, followed in one institution during a peri...

Objective: The objective of this study was to test the severity rating of the signs and architectural changes for interrater reliability among world experts via analysis of lichen sclerosus (LS) photographs. Methods: A recent Delphi consensus exercise established a list of symptoms, signs, and architectural changes, which experts feel are import...

Objective: The aim of the study was to compare the International Classification of Diseases, 11th revision, (ICD-11) with current terminology of vulvodynia, approved by a broad-based consensus of the International Society for the Study of Vulvovaginal Disease (ISSVD), the International Society for the Study of Women Sexual Health (ISSWSH), and the...

Objective: To quantify the effects of available treatments of vestibulodynia. Methods: Systematic review of randomised controlled trials (RCTs) in six search engines until December 2018, comparing any intervention vs. placebo or sham in women with vestibulodynia. Primary outcome was dyspareunia assessed with visual analogue (VAS) or numeric rating...

Human papillomavirus (HPV) infection is a necessary cause of cervical cancer. Contrarily to most preinvasive cervical lesions, the majority of cancers occur in the perimenopause or early after the menopause. Nevertheless, around 15% of cervical cancers occur after 65 years old. There are data suggesting that screening beyond this age can decrease c...

Vulvar dermat may have added an increased risk of missing oses are prevalent inflammatory conditions, frequently associated with itching and burning. The diagnosis is usually clinical but sometimes challenging due to superimposed or associated conditions. This challenge can be harder in postmenopausal women, as the signs and symptoms of vulvovagina...

Objectives: Wet mount microscopy (WMM) is an ancillary test in the diagnosis of vulvovaginitis. However, there are little data about the impact of the sampling site. Our main objective was to determine the agreement between samples collected from different vaginal sites. Materials and methods: Five vaginal samples (one from each of the fornices...

Background: The clinical role of LASER for vulvar and vaginal treatments in gynecology and female urology is controversial. Aims: In this best practice document, we propose recommendations for the use of LASER for gynecologic and urologic conditions such as vulvovaginal atrophy, urinary incontinence, vulvodynia, and lichen sclerosus based on a t...

Objectives Three scientific societies, the International Society for the Study of Vulvovaginal Disease (ISSVD), the International Society for the Study of Women Sexual Health (ISSWSH), and the International Pelvic Pain Society (IPPS) developed the “2015 ISSVD, ISSWSH, and IPPS Consensus Terminology and Classification of Persistent Vulvar Pain and V...

In this best practice document, we propose recommendations for the use of LASER for gynecologic and urologic conditions such as vulvovaginal atrophy, urinary incontinence, vulvodynia, and lichen sclerosus based on a thorough literature review. Most of the available studies are limited by their design; for example, they lack a control group, patient...

Aims Energy‐based devices using radiofrequency and laser technologies have gained popularity as therapies for vaginal atrophy, urinary incontinence, and vaginal prolapse. They have been promoted by cosmetic and aesthetic industries for vaginal “laxity” and vaginal “rejuvenation,” both of which are undefined conditions and terms. This article aims t...

Highlights • Vulvodynia affects at least 6% of women, and can be found at any age and in all ethnic groups. • The diagnosis is one of exclusion but is very often missed. • Women with vulvodynia are frequently misdiagnosed as having vaginismus. • Failure to make the diagnosis often leads to irrelevant or deleterious examinations and treatments.

In recent years, new, controversial, and elusive syndromes, such as genitourinary syndrome of menopause (GSM) and vaginal laxity syndrome have fostered the market for new treatments, namely using laser and radiofrequency. The boundaries between GSM treatment and vaginal ‘‘rejuvenation’’ are dangerously difficult to discern. We undoubtedly agree wit...

Female genital cosmetic surgeries (FGCSs) and procedures are increasingly being advertised as common, simple, and complication-free, capable of not only improving aesthetic appearance but also increasing self-esteem and sexual pleasure. Guidelines for physicians and clear, scientifically correct information for patients must be made available, to m...

Vulvodynia, defined as vulvar pain or burning sensation for more than 3 months, without an identifiable cause, can occur at any age. In this paper, the authors address the classification, epidemiology, etiology, diagnosis, and treatment of this condition, focusing on postmenopausal women. In postmenopausal women, vulvar pain and dyspareunia can oft...

Objective To characterize the vaginal microbiome and the rate of sexually transmitted infections (STIs) in the women of Príncipe (São Tomé and Príncipe). Methods Cross-sectional study of 100 consecutive women, invited for a free appointment and cervical cancer screening. A vaginal slide (wet mount microscopy) and a cervical sample (ThinPrep®) (Pap...

Background: Lichen sclerosus most commonly affects the genital area. Contrarily to lichen planus, the involve- ment of the oral or vaginal mucosa is rare. Only four cases of vaginal lichen sclerosus have been described in the literature. Case report: The authors report two cases of postmenopausal women with a history of vulvar pruritus and burn- in...

Female lichen sclerosus is a chronic inflammatory dermatitis, with a predilection for the anogenital area, which in some cases can become seriously distorted (atrophy of the labia minora, phimosis, introital stenosis, etc.). Most cases are diagnosed in postmenopausal women, but it can affect women of any age. Lichen sclerosus is usually a prurigino...

Objective To assess the medical doctors and medical students' opinion regarding the evidence and ethical background of the performance of vulvovaginal aesthetic procedures (VVAPs). Methods Cross-sectional online survey among 664 Portuguese medical doctors and students. Results Most participants considered that there is never or there rarely is a me...

«Vulvovaginitis» are one of the main reasons that lead women to visit their gynecologist. Most physicians in this area tend to base their diagnostic evaluation on the signs, symptoms and physical examination of the patient, overlooking the microscopic evaluation of the vaginal discharge. This practice leads to a high percentage of underdiagnosed «v...

Background: Vulvodynia is a frequently missed pathology, often confused with vaginismus. The Q-tip test (QTT) is fundamental for the diagnosis; however, there is lack of data about its performance in asymptomatic women. Objective: This study intended to evaluate the QTT for painful vestibular spots in asymptomatic women. Methods: Q-tips were gently...

Aerobic vaginitis (AV) is the name given in 2002 to a vaginal infectious entity which was not recognized as such before. It is characterized by abnormal (dysbiotic) vaginal microflora containing aerobic, enteric bacteria, variable levels of vaginal inflammation and deficient epithelial maturation. Although AV and bacterial vaginosis (BV) share some...