Pedro Vargas-Pinto

VetCor Colombia

The search for active phytopharmacological principles could contribute to findingmolecules as an alternative for themanagement of different pathologies. In this context, it is important to carry out a toxicological evaluation in order to know the safety of extracts derived from promising plant species. In Colombia, the use of medicinal plants is im...

Citation: Mancipe, J.C.; Vargas-Pinto, P.; Rodríguez, O.E.; Borrego-Muñoz, P.; Castellanos Londoño, I.; Ramírez, D.; Piñeros, L.G.; Mejía, M.C.; Pombo, L.M. Anti-Inflammatory Effect of Izalpinin Derived from Chromolaena leivensis: λ-Carrageenan-Induced Paw Edema and In Silico Model. Molecules 2023, 28, 3722. https://doi. Abstract: The flavonoid iza...

The flavonoid izalpinin was isolated from the aerial parts of Chromolaena leivensis. Its structural determination was carried out using MS and NMR spectroscopic techniques (1 H, 13 C). This compound was evaluated for its anti-inflammatory effect in a rat model on λ-carrageenan-induced plantar edema. Paw inflammation was measured at one-hour interva...

The flavonoid izalpinin was isolated from the aerial parts of Chromolaena leivensis. Its structural determination was carried out using MS and NMR spectroscopic techniques (1H, 13C). This compound was evaluated for its anti-inflammatory effect in a rat model on λ-carrageenan-induced plantar edema. Paw inflammation was measured at one-hour intervals...

El objetivo del presente estudio fue reconocer la relación de las variaciones en las concentraciones de lactato plasmático y de presión arterial en pacientes caninos con enfermedad cardíaca valvular crónica, sometidos a la prueba de marcha de 6 minutos en condiciones de gran altura (2650 msnm). Siete animales fueron seleccionados y se diagnosticaro...

p>La prueba de marcha de 6 minutos (PM6M) se realizó para medir la tolerancia al ejercicio submáximo en pacientes con ciertas condiciones de salud y en la que se evalúan parámetros fisiológicos y distancia recorrida. Como parte del examen clínico, se realizó un estudio experimental de tipo transversal incluyendo tres grupos de animales: Grupo 1: br...

La endocarditis infecciosa es un proceso patológico de baja incidencia en la clínica diaria; su principal etiología son los agentes bacterianos, los cuales colonizan con mayor prevalencia de válvula mitral y aortica. En este artículo se presenta el estudio de un perro con diagnóstico previo de síndrome vestibular periférico secundario a probable ot...

Reference intervals (RI) of physiological parameters related to the acid-baseequilibrium state were estimated from blood samples of 76 healthy mules at high altitude.The animals were at rest and subjected to the same diet. The data obtained were comparedwith those reported by various authors, finding closeness between the estimated RIsand those of...

El estudio busca establecer posibles diferencias entre la medición de la frecuencia cardiaca por tiempos inferiores a los 60 segundos (30 y 15 segundos) en caballos. Para esto, se evaluaron 37 caballos adultos sanos a los cuales se les realizó medición de frecuencia cardíaca, utilizando estetoscopio y cronómetro, de manera simultánea por tres perso...

Se da a conocer la presencia y duración de sonidos cardíacos en 24 equinos sanos habitantes de una zona ubicada a 2600 msnm. La toma de los datos se realizó mediante fonocardiografía directamente sobre la zona precordial. En todos los equinos se identificaron los sonidos 1 y 2. El sonido 4 estaba presente en el 87.5% de los equinos y el sonido 3 fu...

Insights on the canine mitral valve in the course of myxomatous mitral valve disease. Rev. CES Med. Artículo de revisión Insights on the canine mitral valve in the course of myxomatous mitral valve disease Información sobre la válvula mitral canina en el curso de la degeneración mixomatosa valvular mitral Percepções sobre a válvula mitral canina no...

La prueba de marcha de seis minutos es una herramienta diagnóstica y pronóstica ampliamente usada en medicina de humanos. Sin embargo, hasta la fecha no hay suficiente evidencia en medicina veterinaria para usar esta prueba de la misma manera. Este estudio fue realizado a 2600 metros sobre el nivel del mar e incluyó únicamente caninos jóvenes sanos...

This study aimed to determine possible significant variations in awake dogs in blood pressure between the four limbs, including the tail. The diastolic, systolic, and mean arterial pressures were taken using the SunTech Medical® equipment, using the oscillometry technique, in each of the limbs and the tail of 17 canine patients in a pet clinic in B...

The aim of this study was to investigate the effect of the practice of the sport discipline of Agility at high altitude (2600 meters above sea level) on some electrocardiographic variables in Border Collie dogs at rest. Fifteen dogs (athlete group), belonging to different «Agility» teams from the city of Bogota D.C., Colombia and 16 Border Collie d...

El objetivo del presente estudio fue determinar el efecto de la práctica de Agility en caninos en zonas de gran altura (2650 msnm) sobre la frecuencia cardiaca y su variabilidad. Diez caninos Border Collie practicantes de Agility (grupo Agility) y diez caninos sedentarios de iguales características (grupo sedentario) fueron evaluados mediante elect...

In recent decades, veterinary ultrasound has experienced a great technological and technical progress. Veterinary doctors not only use it for common evaluation of abdomen, or even heart, but techniques have been described for more special examinations, such as for the musculoskeletal, vascular, and ocular systems, among others. Literature on the su...

This study aims to establish the effect of sildenafil on the distance covered during the six-minute-walk-test (6MWT) in dogs with pulmonary hypertension (PH) and in healthy ones on heart rate (HR) and respiratory rate (RR) in a high altitude geographic zone (2650 m above sea level). A group of nine dogs diagnosed with PH and other of 10 healthy dog...

Introduction: Over the last 40 years omega-3 polyunsaturated fatty acids (PUFAs) have been shown to be anti-arrhythmic or pro-arrhythmic depending on the method and duration of administration and model studied. We previously reported that omega-3 PUFAs do not confer anti-arrhythmic properties and are pro-arrhythmic in canine model of sudden cardiac...

Objective. To stablish the electrocardiographic parameters of individuals of the species Amazona ochrocephala, from the Unidad de Rescate y Rehabilitacion de Animales Silvestres at the Universidad Nacional de Colombia. Materials and methods. The electrocardiographic examination was performed under inhaled anesthesia with isoflurane. Leads I, II, II...

Degenerative valvular disease or endocardiosis is the most common cardiovascular pathology in dogs. It is characterized by regurgitation of blood into the atria with decreased cardiac output, leading to volume overload with eccentric hypertrophy and congestive heart failure. This report describes the clinical and autopsy findings of a dog, suggesti...

Objective: To determine the effects of rapid small-volume fluid administration on arterial blood pressure measurements and associated hemodynamic variables in isoflurane-anesthetized euvolemic dogs with or without experimentally induced hypotension. Design: Prospective, randomized, controlled study. Animals: 13 healthy dogs. Procedures: Isof...

The role of IKCa in cardiac repolarization remains controversial and varies across species. The relevance of the current as a therapeutic target is therefore undefined. We examined the cellular electrophysiologic effects of IKCa blockade in controls, chronic heart failure (HF) and HF with sustained atrial fibrillation. We used perforated patch acti...

En caninos, la enfermedad valvular degenerativa o endocardiosis es la patología cardiovascular con mayor prevalencia. Se caracteriza por regurgitación de la sangre hacia las aurículas, con disminución del gasto cardiaco, lo que lleva a sobrecarga de volumen con hipertrofia excéntrica e insuficiencia cardiaca congestiva. Este reporte tiene como obje...

Heart failure (HF) is a chronic disease that develops over months to years. In HF, ventricular repolarization is prolonged. We tested the hypothesis that I KCa modulates repolarization only when ventricular repolarization reserve is reduced as occurs in chronic HF, but not short term HF. Methods: A tachypacing - induced HF canine model was used, an...

Bisphosphonates, including ibandronate, are used in the prevention and treatment of osteoporosis. We report a case of suspected ibandronate-associated arrhythmia, following a single dose of ibandronate in a 55-year-old female. ECG at presentation revealed frequent ectopy and QT/QTc interval prolongation; at follow-up 9 months later the QT/QTc inter...

-Reentrant arrhythmias involving the sinoatrial node (SAN), namely, SAN reentry, remain one of the most intriguing enigmas of cardiac electrophysiology. The goal of the present study was to elucidate the mechanism of SAN micro-reentry in canine hearts with post myocardial infarction (MI) structural remodeling. -In vivo, Holter monitoring revealed v...

Contractile dysfunction of atria and atrial arrhythmias are common comorbidities in heart failure (HF). Although abnormal Ca handling has been recognized to underlie both reduced contractility and increased propensity to arrhythmias in failing left ventricle, its role in HF-related atrial pathogenesis is not well established. We studied Ca handling...

For years researchers have looked for the perfect model to study heart failure (HF), and thereby understand its mechanistic causes and consequences. Among those models, there is one, rapid pacing, that has been used for decades because it recreates the process in weeks to months, as happens in human beings. Rapid pacing has answered several questio...

Heart failure (HF) is a common antecedent to atrial fibrillation (AF). Concomitant HF and AF increases morbidity and mortality over that of either disease alone. AF- and HF-induced atrial electrophysiologic remodeling is known to favor the progression of AF. AF results in accelerated repolarization and reductions in multiple ion currents, including...

Background: In patients with sinoatrial nodal (SAN) dysfunction, atrial pauses lasting several seconds may follow rapid atrial pacing or paroxysmal tachycardia (tachy-brady arrhythmias). Clinical studies suggest that adenosine may play an important role in SAN dysfunction, but the mechanism remains unclear. Objective: To define the mechanism of...

Electrical and structural remodeling during the progression of cardiovascular disease is associated with adverse outcomes subjecting affected patients to overt heart failure (HF) and/or sudden death. Dysfunction in integral membrane protein trafficking has long been linked with maladaptive electrical remodeling. However, little is known regarding t...

Introduction: In patients with sino-atrial nodal (SAN) dysfunction, long pauses lasting several seconds are often observed after rapid atrial pacing or paroxysmal tachycardia. Clinical studies suggest that adenosine may play an important role in the SAN dysfunction observed during metabolically compromised myocardial states, but the mechanism is un...

his study was conducted to characterize, more completely, the hypoxic canine model of pulmonary hypertension, with the intent of using the model for evaluating pathophysiology, diagnosis, and treatment. Methods: Nine healthy dogs were anesthetized with acepromazine/butorphanol/propofol, and instrumented to record electrocardiograms, pressures from...