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137
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Citations since 2017
Publications
Publications (13)
Complex internal dynamics of conformational transformations in single enzyme molecules is essential for their catalytic function
[1, 2]. Such experimental methods as time-resolved X-ray spectroscopy of protein crystals or single-molecule fluorescence microscopy
[3–6] allow observation of individual enzymic turnover cycles [7, 8]. Enzymic reactions...
The diffusive mixing and delivery times of regulatory molecules in micrometer and submicrometer reaction volumes can be shorter
than the characteristic times of conformational transformations in single enzyme molecules. Under these conditions, mutual
synchronization of individual molecular turnover cycles takes place when strong allosteric activati...
Living cells are highly organized systems. The question has been posed [1], whether the principles of self-organization in small biological cells are the same as in macroscopic chemical reactions like, e.g. the Belusov-Zhabotinsky reaction [2]. In this chemical reaction-diffusion system complex wave patterns and spirals can be formed with a macrosc...
In small micrometer volumes typical of living cells, regulatory molecules of enzymic reactions can diffuse so fast from one enzyme molecule to another that the diffusion time is much shorter than the turnover time of an enzyme. Under these conditions, a special kinetic regime of a molecular network is realized. We consider molecular networks formed...
The diffusive transport and mixing times of regulatory molecules in micrometer and submicrometer reaction volumes can be shorter than characteristic times of conformational transformations in single enzyme molecules. Under these conditions, synchronization of individual molecular turnover cycles takes place when a fraction of the reaction products...
Diffusion of regulatory molecules during an enzymic reaction in micrometer and submicrometer reaction volumes can lead to mixing and transport times much shorter than the turnover time of enzymes. Our theoretical investigations of a stochastic model of an allosterically product-inhibited enzymic reaction show that under these conditions the turnove...
Strong diffusional mixing and short delivery times typical for micrometer and sub-micrometer reaction volumes lead to a special situation where the turnover times of individual enzyme molecules become the largest characteristic time scale of the chemical kinetics. Under these conditions, populations of cross-regulating allosteric enzymes form molec...
The diffusive transport and mixing times of regulatory molecules in micrometer and sub-micrometer reaction volumes can be
shorter than characteristic times of conformational transformations in single enzyme molecules. Under these conditions, mutual
synchronization of individual molecular turnover cycles takes place when strong allosteric activation...
The diffusive transport and mixing times of regulatory molecules in micrometer and submicrometer_ reaction volumes can be shorter than characteristic times of conformational transformations in single enzyme molecules. Under these conditions, mutual synchronization of individual molecular turnover cycles takes place when strong allosteric activation...
This work contains theoretical investigations of the kinetics of enzymic reactions under the conditions of small spatial volumes, and taking into account the internal dynamics of single molecular enzymatic cycles. In such confined micro reactors typical for compartments of living cells the characteristic diffusive transport and mixing times of subs...
Projects
Project (1)
The goal of this project is to develop a better understanding of the relationship between signals (time dependent field strengths) and biological effects. In the first step this is solely based on already published investigation results, during the last decades. The aim of this understanding is, to identify appropriate signals for specific applications and to develop better insights of the mechanisms of PEMF in biological systems.
