Pedro Salvador Escribano

Pedro Salvador Escribano
University of Valencia | UV · Department of Pharmacology

Bachelor of Biology

About

22
Publications
1,643
Reads
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213
Citations
Additional affiliations
April 2017 - April 2017
University of Valencia
Position
  • Professor
Description
  • 30 ECTS of the Course of Pharmacology in the Degree in Pharmacy
April 2016 - June 2016
University of Valencia
Position
  • Professor
Description
  • 30 ECTS of the Course of Pharmacology in the Degree in Pharmacy
May 2013 - December 2013
University of Valencia
Position
  • Superior Technical Support to Research
Education
September 2012 - September 2013
September 2007 - July 2012

Publications

Publications (22)
Article
The synonymous single nucleotide polymorphism (SNP) rs731236, located in the vitamin D receptor (VDR) gene (Taq I) has been associated with both decreased levels of the protein in peripheral blood mononuclear cells and a fibrosis-related complication in Crohn´s disease (CD). Interactions between VDR and a protein-disulfide isomerase-associated 3 (P...
Article
Full-text available
Vitamin D (VD) deficiency has been associated to Crohn’s disease (CD) pathogenesis, and the exogenous administration of VD improves the course of the disease, but the mechanistic basis of these observations remains unknown. Vitamin D receptor (VDR) mediates most of the biological functions of this hormone, and we aim to analyze here the expression...
Article
Full-text available
Background and Aims Epithelial-mesenchymal transition (EMT) has been related to fibrosis and fistula formation, common complications associated to Crohn´s disease (CD). The WNT signaling pathway mediates EMT and specific WNT/FZD interactions have been related with the activation of this process in several diseases. We aim to analyze the relevance o...
Article
Full-text available
Background : Intestinal fibrosis represents a serious complication of inflammatory bowel diseases (IBD), often necessitating surgical resections. Myofibroblasts are primarily responsible for interstitial matrix accumulation in fibrotic diseases. However intestinal myofibroblasts (IMF) remain inadequately characterized. The aim was to examine fibrob...
Article
Background Macrophages contribute to fibrosis through the release of different mediators and the pattern of secretion may vary according to their phenotype. The expression of WNT ligands has been related with the macrophage phenotype and strong evidence identifies the WNT signalling pathway as an emerging modulator of fibrosis. Methods The aim of...
Article
Background Vitamin D deficiency and a defective signalling has been reported in Crohn’s disease (CD) patients. Vitamin D signals through the vitamin D receptor (VDR) which is a member of the nuclear receptor family of transcription factors that play an immunoregulatory role in the gut. We have previously demonstrated that a single-nucleotide polymo...
Article
Background Fibrosis and fistula development constitute the main complications associated to Crohn’s disease. Notch signalling has been implicated in lung, kidney, liver, and cardiac fibrosis and in various disease conditions such as scleroderma. We aim to analyse here the pattern of NOTCH ligands, receptors, and effectors expression in surgical res...
Article
Full-text available
Succinate, an intermediate of the tricarboxylic acid cycle, is accumulated in inflamed areas and its signaling through succinate receptor (SUCNR1) regulates immune function. We analyze SUCNR1 expression in the intestine of Crohn's disease patients and its role in murine intestinal inflammation and fibrosis. We show that both serum and intestinal su...
Article
Full-text available
Background Vitamin D signaling modulates inflammation through the vitamin D receptor (VDR). The synonymous single nucleotide polymorphism (SNP) rs731236, located in the VDR gene, has been associated with a higher risk of Crohn’s disease (CD). We analyzed differences in VDR expression levels among CD patients who were homozygous for allelic variants...
Article
Full-text available
Background Intestinal fibrosis is a common complication associated with Crohn’s Disease (CD) which cannot be reverted with any drug and forces repeated surgery. It has been reported that succinate, a metabolite accumulated in inflammatory pathologies, plays an important role in the activation of synovial fibroblasts and hepatic stellate cells throu...
Article
Full-text available
Background Fibrosis and fistula development constitute the main complications associated to Crohn′s disease. The Wnt signalling pathway induces fibroblast activation and EMT which are involved in these complications. We aim to analyse here the pattern of Wnt ligands expression in surgical resections from stenotic and fistulising CD patients and to...
Article
Full-text available
Background Vitamin D signals through the vitamin D receptor (VDR) which is a member of the nuclear receptor family of transcription factors that play an immunoregulatory role in the gut. Defective signalling due to vitamin D deficiency or decreased mucosal VDR levels has been related to Crohn’s disease (CD). We aim to analyse the acute effects of V...
Article
Full-text available
Background and aims: Fibrosis is a common complication of Crohn's disease, and is related with dysregulated tissular repair following inflammation, in which macrophages play a central role. We have previously observed that STAT6-/- mice present delayed mucosal recovery after TNBS-induced colitis due to a deficiency in reparatory IL4/STAT6-dependen...
Article
Full-text available
Background and pourpose: A defective autophagy is involved in the pathogenesis of inflammatory disorders such as IBD. Cross talk interactions between autophagy and inflammation have been reported and we analyse the effects of autophagy stimulators on murine colitis. Experimental approach: Mice were treated with intrarectal administration of TNBS...
Article
Full-text available
Background: A defective autophagy is involved in the pathogenesis of inflammatory disorders such as IBD. Cross talk interactions between autophagy and inflammation have been reported and we analyse the effects of autophagy stimulators on murine colitis. Methods: Mice were treated with intrarectal administration of TNBS (3.5 mg/20 mg mice) and body...
Article
Full-text available
Background Vitamin D signaling modulates inflammation through the vitamin D receptor (VDR) which is a member of the nuclear receptor family of transcription factors. The presence of C instead of T in the single-nucleotide polymorphism (SNP) rs731236 in the VDR gene has been associated with a higher risk for Crohn's disease (CD). We analysed the rel...
Article
Full-text available
Background: STAT6 plays a crucial role in M2a macrophage polarization in vitro and these cells mediate mucosal healing in an acute model of TNBS-colitis through the expression of Wnt ligands [1]. We have recently reported that STAT6 deficiency favours fibrosis in a murine model of TNBS colitis [2] and we aim to characterize here the functional rele...
Article
Full-text available
Background: Intestinal fibrosis is a common complication of IBD. We have recently reported in STAT6 knockout mice treated with TNBS that intestinal fibrosis is associated with up-regulation of M2c macrophages which express high levels of Wnt10b. The aim of the present study is to analyze the direct effects of Wnt10b in fibrosis development in a mur...
Poster
Background:IntestinalfibrosisisacommoncomplicationofIBD.Fibrosisisaconsequenceoflocalchronicinflammationandischaracterizedbyanexcessiveextracellularmatrixdepositionandlossofnormalfunction.Residentmacrophagesplayakeyroleinmaintainingintestinalhomeostasisaswellasininjuryrepair,andtheirphenotypeevolvesduringthephasesofinflammation,remissionandwoundhea...
Poster
Intestinal fibrosis, which is caused by excessive extracellular matrix deposition, is a common complication of inflammatory bowel disease. Macrophages assume a wide spectrum of different functional phenotypes (M1, M2a, M2b, and M2c) that differ in the expression of surface proteins, transcription factors, and cytokine production. It is believed tha...
Article
Full-text available
Background & aims: IBD is a chronic disorder of the gastrointestinal tract characterized by mucosal inflammation and epithelial damage. Biologic therapy has significantly improved the course of the disease but there are still a high percentage of patients that do not respond to current therapies. We aim to determine the effects of the flesh ethano...
Article
Toll-like receptors (TLRs) are expressed by hematopoietic stem and progenitor cells (HSPCs), and may play a role in hematopoiesis in response to pathogens during infection. We have previously demonstrated that (i) inactivated yeasts of Candida albicans induce in vitro differentiation of HSPCs toward the myeloid lineage, and (ii) soluble TLR agonist...

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