Pedro Oliveira

Pedro Oliveira
Cooperativa de Ensino Superior Egas Moniz · Anatomy

PhD

About

58
Publications
7,029
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415
Citations
Citations since 2016
23 Research Items
258 Citations
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201620172018201920202021202201020304050
201620172018201920202021202201020304050

Publications

Publications (58)
Preprint
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Introduction: The concentrations of some chemical elements may differ between healthy and diseased tissues. The knowledge of these differences is pivotal to understand the metabolic processes involved in both physiological and diseased states. The aim of this study was to evaluate the elemental composition of calcium (Ca) and phosphorus (P) in the...
Article
Full-text available
Introduction The influence of burnout, academic engagement, and their interaction in dropout intention among medical students should be further studied. Current research shows its consequences are relevant, however, there is little understanding on burnout and academic engagement moderation in dropout intention. The current study tested a model tha...
Article
Full-text available
Introduction: Urban noise pollution has been associated with an increased risk of developing metabolic syndrome. Nevertheless, existing observational studies relating to noise exposure and metabolic syndrome are based on non-generalizable cohorts. Lisbon remains a noisy city where this association has not been evaluated, and for this reason, we stu...
Article
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Recent focus has been given on the effects of high-intensity infrasound (HII) exposure, and whether it induces changes in pancreatic morphology and glucose metabolism is still unknown. As such, we have studied the impact of HII exposure on glucose tolerance, insulin sensitivity, pancreatic islet morphology, muscle GLUT4 and plasma insulin and corti...
Article
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This systematic review and meta-analysis aimed to assess the literature about the incidence of oral mucositis and its degrees (mild, moderate, and severe), in patients undergoing head and neck cancer treatment (radiotherapy, chemotherapy, and surgery). Addressing this issue is important since oral mucositis has a negative impact on oral health and...
Article
Full-text available
Introduction Elements such as Ca and P are involved in important physiological processes and their concentrations may differ significantly between healthy and diseased individuals [1 Brito J, Sena V, Zagalo C, et al. Investigation of type 1 diabetes mellitus as risk factor for secondary osteoporosis. Translational research and Innovation in human a...
Article
Full-text available
Introduction It has been shown that the concentrations of some elements, for example K, Ca, Cu, Fe, and Zn, may differ significantly between the healthy area and the tumour area in the same human tissue [1 Carla A, Fonseca J, Brito JAA, et al. Serum Zn levels in dysphagic patients who underwent endoscopic gastrostomy for long term enteral nutrition...
Article
Full-text available
Introduction Histology knowledge is important to medical sciences as well as an important support to understand the pathology. However, teachers and students feel the need for innovative methods for teaching normal histology [1 Drake RL. A retrospective and prospective look at medical education in the United States: trends shaping anatomical scienc...
Article
Full-text available
Introduction Recent data has shown a significant association between noise exposure and atrial fibrillation (AF) in a large cohort [1] but the pathophysiology remains unclear. The acoustic spectrum of industrial environments is particularly rich in high-intensity infrasound (IFS), which we have previously found to induce coronary perivascular fibro...
Article
Full-text available
Previous experimental studies show that exposure to noise with high and audible frequencies causes multiple metabolic alterations, such as increased liver glycogen and triglycerides. However, the effect of exposure to sound with lower frequencies, such as high-intensity infrasound (frequency <20 Hz and sound pressure level >90 dB), on the liver lip...
Article
Background Noise is an important environmental risk factor. Industrial environments are rich in high-intensity infrasound (hi-IFS), which we have found to induce myocardial and coronary perivascular fibrosis in rats. Recently, a significant association between noise exposure and the incidence of atrial fibrillation (AF) was found in large cohort st...
Article
Background: Noise is an important environmental risk factor. Industrial environments are rich in high-intensity infrasound (hi-IFS), which we have found to induce myocardial and coronary perivascular fibrosis in rats. The effects of exposure to IFS on the ventricles have been studied, but not on the atria. We hypothesized that rats exposed to hi-I...
Article
Full-text available
Introduction: The cardiovascular effects of the exposure to low frequency noise (LFN) (<500 Hz) are not fully understood. Previous experimental work confirmed an increase in collagens I and III and ultrastructural changes in the intercalated discs of cardiomyocytes from rats exposed to LFN. Our work aims at characterizing the alterations in gene ex...
Article
Full-text available
Introduction: Oral disorders are highly prevalent worldwide and remain a major public health challenge [1 Kassebaum N, Smith A, Bernabé E, et al. Global, Regional, and National Prevalence, Incidence, and Disability-Adjusted Life Years for Oral Conditions for 195 Countries, 1990–2015: A Systematic Analysis for the Global Burden of Diseases, Injuries...
Article
Background Chronic exposure to industrial noise is known to affect biological systems, namely, by inducing fibrosis in the absence of inflammatory cells. In rat hearts exposed to this environmental hazard, we have previously found myocardial and perivascular fibrosis. The acoustic spectrum of industrial environments is particularly rich in high-int...
Article
Introduction: Low-frequency noise (LFN) is a ubiquitous physical stressor known to cause degenerative cellular changes and organ alterations with functional repercussions both in humans and animals. Materials and methods: After acceptance of the study protocol by a local ethics committee, 20 Wistar rats were randomly divided into two equal group...
Article
Full-text available
Objectives Currently, there is lack of human in vitro full tooth models that hold the odontoblast layer with pulp tissue in their native environment. The appearance of new in vitro and in vivo models has provided new understanding of the potential of tissue engineering in dental pulp regeneration. However, the development of new in vitro full tooth...
Article
Purpose: To identify the possible risk factors for implant failure and peri-implant pathology in a population of systemically compromised patients. Materials and methods: This retrospective clinical study included a total of 721 systemically compromised patients (422 women, 299 men), with an average age of 51 years (range: 20 to 87) rehabilitate...
Article
Unlabelled: Background Potentially inappropriate medications (PIMs) are often found in high proportion among the elderly population. The STOPP criteria have been suggested to detect more PIMs in European elderly than the Beers criteria. Objective This study aimed to determine the prevalence of PIMs and potential prescribing omissions (PPOs) in a s...
Article
Full-text available
Background Currently, people live longer but often with poor quality of life. The decrease in healthy life-years is partly attributable to the institution of polypharmacy to treat various comorbidities. Objectives The objectives of the study were to determine the prevalence and nature of drug-related problems (DRPs) in polypharmacy elderly patients...
Poster
Full-text available
This poster focuses on the secondary analysis of a database of drug-related problems (DRP). Primary analysis was undertaken by community pharmacists engaged in elderly patients monitoring, focusing on potentially inappropriate medicines (PIM) and DRPs. Secondary analysis was undertaken by the research team, focusing on PIM and interactions. The res...
Poster
Full-text available
This poster describes the overall results of the ”SOS Pharma Idoso” project, which focused on medication review in the elderly. The component here presented refers to nursing homes results but combines the work developed focusing on drug-related problems (DRPs) and the work focusing on potentially inappropriate medicines (PIMs) and prescribing omis...
Article
Full-text available
Background: Menopause is associated with important systemic and oral changes. Many researchers have tried to evaluate the influence of hormonal changes associated with menopause in the periodontium, however results are contradictory. Objective: Evaluate the possible effects of menopause on the severity of periodontal disease and tooth loss, by c...
Article
Full-text available
Long-term low-frequency noise (LFN) (≤500Hz, infrasound included) exposure is known to cause extracellular matrix proliferation with fibrosis, in the absence of inflammatory signs. The aim of this work was to study the morphological alterations to the periodontium of Wistar rats exposed to LFN. 10 rats were exposed to LFN for 2184 consecutive hours...
Article
Vibroacoustic disease (VAD) is a systemic disease that results from long-term exposure to low-frequency noise (LFN). VAD can cause lesions in several organs. Noise-exposed individuals frequently present digestive symptoms, but only a few studies have attempted to evaluate gastrointestinal lesions. The aim of this study was to investigate the duoden...
Article
Full-text available
Tooth wear is a complex multifactorial process that involves the loss of hard dental tissue. Parafunctional habits have been mentioned as a self-destructive process caused by stress, which results in hyperactivity of masticatory muscles. Stress manifests itself through teeth grinding, leading to progressive teeth wear. The effects of continuous exp...
Conference Paper
Full-text available
Background The elderly population is frequently polymedicated, including with potentially inappropriate medications (PIM). The use of explicit criteria can play an important role in the identification of areas for pharmaceutical interventions. Purpose This study aimed to characterize and to quantify the occurrence of PIM detected during medication...
Conference Paper
Full-text available
Background The numerous comorbidities associated with ageing often lead to treatment with multiple drugs. Pharmacist-led medication review of polymedicated patients may play an important role in the detection of Drug Related Problems (DRP), thus contributing to their prevention or solution. Purpose To determine the prevalence of real and potential...
Conference Paper
Full-text available
Background Adherence in the polymedicated elderly is recognised to be suboptimal. The use of dose administration aid (DAA) systems has been proposed as an effective tool to reduce unintentional non-adherence, especially effective when combined with other enhanced services. Purpose To test the ability of students to be actively involved in the imple...
Poster
Full-text available
This poster describes the results of the project SOS Pharma idoso focusing on the detection of potentially inappropriate medicines in elderly polypharmacy residing in nursing homes. Only results obtained from the application of the Beers criteria (AGS, 2012) are presented.
Poster
Full-text available
This poster focuses on the component of the project ”SOS Pharma idoso” resorting to the Granada Consensus of Drug Related Problems to judge the necessity, effectiveness and safety of medicines prescribed to elderly polypharmacy patients residing in nursing homes.
Poster
Full-text available
This poster focuses on the component of the project of ”SOS Pharma Idoso” directed at autonomous elderly. The intervention developed by community pharmacists included medication review and the delivery of multicompartiment aids as a strategy of adherence improvement.
Article
Full-text available
Introduction: Elderly population is frequently polymedicated, including with potentially inappropriate medications (PIM), sometimes instead of preventive medication, designated as potentially prescribing omissions (POM). Objectives: This study aims to characterize and to quantify the occurrence of PIM and POM in a sample of institutionalized elderl...
Article
Full-text available
Introduction: Exposure to noise rich in low frequency components induces abnormal proliferation of extracellular matrix and collagens. The previous studies have shown alterations in the periodontium of both humans and animals. Our objective was the evaluation of collagens I, IV and V of the periodontium of Wistar rats exposed to noise rich in low...
Article
Peri-implant soft tissues are essential for osseointegration. The peri-implant mucosa may lack vascular supply, and histological observation, even without plaque, shows the presence of inflammatory cells. The objectives of this study were to assess the histopathological changes of the epithelium and connective tissue around the implant. Twenty pati...
Article
Full-text available
Chronic exposure to Industrial Noise (IN), rich in Low Frequency Noise (LFN), causes systemic fibrotic transformation and sustained stress. Dental wear, significantly increased with exposure to LFN, affects the teeth particularly through the circumpulpar dentin. Our goal is to understand the consequences of IN exposure on the circumpulpar dentin of...
Article
Low-frequency noise (LFN) leads to the development of tissue fibrosis. We previously reported the development of myocardial and perivascular fibrosis and a reduction of cardiac connexin43 in rats, but data is lacking concerning the affected type of collagen as well as the ultrastructural myocardial modifications. The aim of this study was to quanti...
Article
Low-frequency noise (LFN) leads to an abnormal proliferation of collagen and development of tissue fibrosis. It has been shown that myocardial fibrosis in association with gap junction remodeling occurs in several cardiac diseases and can be implicated in the development of ventricular tachyarrhythmias. We previously reported a strong development o...
Article
Full-text available
Introduction: Excessively traumatic surgery can adversely affect the maturation of bone tissue and consequently diminish the predictability of osseointegration so the mechanical and thermal damage should be minimized during surgical procedure. The purpose of this study is to evaluate immediate histological alterations in rabbit tibias, produced by...
Article
Full-text available
Introduction: In tissues and organs exposed to large pressure amplitude low frequency noise fibrosis occurs in the absence of inflammatory signs, which is thought to be a protective response. In the parotid gland the perivasculo-ductal connective tissue surrounds arteries, veins and the ductal tree. Perivasculo-ductal connective tissue is believed...
Article
Low frequency noise (LFN) characterized by large pressure amplitude (> or =90 dB SPL) and low frequency bands (< or =500 Hz) can lead to structural and ultrastructural modifications in the extracellular matrix of several tissues, with an abnormal proliferation of collagen and development of fibrosis. It is not known whether LFN induces similar stru...
Article
Industrial noise (IN) is characterized by high intensity and a wide spectrum of wavelengths that induce physical vibration on the body structures. This effect, resulting from the low-frequency sound waves, can lead to pathological alterations in the extracellular matrix with an abnormal proliferation of collagen and development of tissue fibrosis,...
Article
Low frequency noise (LFN) characterized by large pressure amplitude (≥ 90 dB SPL) and low frequency bands (≤ 500 Hz) can lead to structural and ultrastructural modifi cations in the extracellular matrix of several tissues, with an abnormal proliferation of collagen and development of fi brosis. It is not known whether LFN induces similar structural...
Article
Introduction Industrial noise (IN) is characterized by high intensity and a wide spectrum of wavelengths that induce physical vibration on the body structures. This eff ect, resulting from the low-frequency sound waves, can lead to pathological alterations in the extracellular matrix with an abnormal proliferation of collagen and development of tis...
Article
Full-text available
Only a few studies evaluated the digestive alterations caused by low frequency noise (LFN) and most focused only on mucosal alterations. To investigate the morphological injury of LFN-exposed gastric wall, beyond the epithelial layer. Wistar rats were exposed to low frequency noise (LFN), during increasing periods, 1 to 13 weeks. A control group wa...
Article
Full-text available
Low frequency noise (LFN) (>_ 90 dB SPL, <_ 500 Hz) is an agent of disease that regularly goes unchecked during standard noise assessment procedures. Vibroacoustic disease (VAD) is an extra-aural noise-induced systemic pathology, caused by long-term exposure to LFN and characterised by a proliferation of extra-cellular matrices. The present study a...
Article
Non-auditory effects of noise, including digestive disorders have long being reported. Low frequency noise (LFN) is considered to be responsible to most of non-auditory effects of noise and is widely spread in modern societies. Only a few studies were designed to evaluate these noise-induced digestive alterations. The pathogenesis of duodenal ulcer...
Conference Paper
Full-text available
In 2007, at the 2nd International Conference on Wind Turbine (WT) Noise, held in Lyon, France, low frequency noise (<500 Hz, LFN)-induced pathology, consistent with vibroacoustic disease (VAD), was shown to be emerging in the R. Family, exposed to residential LFN generated by 4 WT installed in close proximity (300-700 m) to their home. Herein, a fo...
Article
Long-term low-frequency noise (LFN) (<or=500 Hz) exposure is known to cause extracellular matrix proliferation by fibrosis in the absence of inflammatory signs. We have examined the morphofunctional alterations of the parotid glands of Wistar rats exposed to LFN. The hypothesis is that the parotid glands are a target for LFN-induced lesions. Ten ra...
Article
Full-text available
Exposure to low frequency noise (LFN) can lead to vibroacoustic disease (VAD), recognized as a systemic disease with lesions in a broad spectrum of organs. Although gastrointestinal complaints are common among individuals exposed to noise, only few studies tried to evaluate the digestive lesions. The authors performed this study in order to investi...
Conference Paper
Full-text available
The goal of this study is to evaluate the morphological abnormalities of the parotid gland of the Wistar rat exposed to low frequency noise (LFN) (=500Hz, infrasound included). Long-term exposure to LFN, may lead to the development of vibroacoustic disease, a multisystemic disease, characterized, among other abnormalities, by a excessive proliferat...
Conference Paper
Full-text available
INTRODUTION: The clinical stages of vibroacoustic disease (VAD), as advanced in 1998 for aircraft technicians, show that gastrointestinal (GI) complaints appear within the first 3 years of occupational exposure to low frequency noise (LFN, <500 Hz, including infrasound). Within 12 years of LFN exposure, gastritis can develop, and further exposure c...
Article
Introduction. Long-term (years) exposure to low frequency noise (LFN) (≤ 500 Hz, including infrasound) can lead to the development of vibroacoustic disease (VAD). In animal models, oedema is an immediate and sustained response to LFN exposure. Goal. To investigate possible a) alterations of lymphatic morphology, and b) lesions of the lymphatic netw...

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Projects (6)
Project
The aims of this project is to study whether and how noise exposure affects glucose homeostasis as an initial step toward type 2 diabetes development.
Archived project