Pedro Martins

Pedro Martins
  • MD, PhD
  • Assistant Professor with Habilitation at Universidade NOVA de Lisboa

About

141
Publications
44,092
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Introduction
Pedro Martins currently works at the Chronic Diseases Research Centre (CEDOC), New University of Lisbon. Pedro does research in Allergology and Pathology.
Current institution
Universidade NOVA de Lisboa
Current position
  • Assistant Professor with Habilitation
Additional affiliations
January 2009 - present

Publications

Publications (141)
Article
Full-text available
Background/Objectives: The interest in processing human speech and other human-generated audio signals as a diagnostic tool has increased due to the COVID-19 pandemic. The project OSCAR (vOice Screening of CoronA viRus) aimed to develop an algorithm to screen for COVID-19 using a dataset of Portuguese participants with voice recordings and clinical...
Article
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Olea europaea L. pollen is one of the main causes of pollinosis and respiratory diseases in the Iberian Peninsula (IP). The aim of this study was to provide a pollen calendar in different regions of the IP, which could help allergists and allergic patients in the management of Olea europaea allergic diseases, and to update/complement what has alrea...
Article
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Background: Concept maps (CMs) visually represent hierarchical connections among related ideas. They foster logical organization and clarify idea relationships, potentially aiding medical students in critical thinking (to think clearly and rationally about what to do or what to believe). However, there are inconsistent claims about the use of CMs...
Article
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This study aims to analyze how visual tools, labeled as maps, are built, and used in medical education. Based on the educational model of concept maps (CMs), proposed by Novak and Cañas (2008), and adapted to medicine by Daley and Torre (2010), we are currently analyzing the results of a scoping review following the PRISMA extension methodology, sp...
Article
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Objective: To quantify the impact of different air pollutants on respiratory health based on robust estimates based on international data and to summarise the evidence of associations between indoor exposure to those pollutants and respiratory morbidity in the Portuguese population. Results: Several systematic reviews and meta-analyses (MA) at t...
Article
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Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over 20 years ago, is a simplistic approach of the links between upper‐ and lower‐airway allergic diseases. With new data, it is time to reassess the concept. This article re...
Article
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MASK‐air®, a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK‐air® is a Good Practice of DG Santé on digitally‐enabled, patient‐centred care. It is...
Article
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Nos últimos anos, o pólen produzido pelas plantas da família Amaranthaceae tem ganho uma maior relevância como causa de alergia dado que as plantas desta família têm a capacidade de colonizar rapidamente zonas sob condições adversas que têm vindo a aumentar nalgumas regiões do mundo devido às alterações climáticas. Objetivos: 1) Analisar a prevalên...
Article
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Introduction Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK‐air®, these data have only been analyzed cross‐sectionally, without considering the changes of symptoms over time. We analyzed data from MASK‐air® longitudinally, clustering weeks according to reported rhinitis symptoms....
Book
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The aim of GERIA project is to carry out a risk assessment, often difficult for older people, involving the identification of multiple factors potentially affecting health and quality of life, the quantification of human exposure to pollutants, and the evaluation of the individual’s response to these stimuli. The results of this project contribute...
Article
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Antti Lauerma 76 | Susanne Lau 77 | Daniel Laune 78 | Michael Levin 79 | Desiree E Larenas-Linnemann 80 | Karin C Lodrup Carlsen 81,191 | Carlo Lombardi 82 | Olga M Lourenço 83 | Bassam Mahboub 84 | Hans-Jørgen Malling 85 | Patrick Manning 86 | Gailen D Marshall 87 | Erik Melén 88,188 | Eli O Meltzer 89 | Neven Miculinic 90 | Branislava Milenkovic...
Article
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Background Different treatments exist for allergic rhinitis (AR), including pharmacotherapy and allergen immunotherapy (AIT), but they have not been compared using direct patient data (i.e., “real‐world data”). We aimed to compare AR pharmacological treatments on (i) daily symptoms, (ii) frequency of use in co‐medication, (iii) visual analogue scal...
Article
No estudo geriátrico dos efeitos na saúde da qualidade do ar interior em lares da 3.ª idade de Portugal (GERIA) foi estabelecido como objetivo principal de estudar os efeitos da qualidade do ar interior (IAQ) de equipamentos residenciais para pessoas idosos (ERPI) na saúde respiratória de idosos institucionalizados. Um total de 269 idosos responder...
Article
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Background Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real‐life studies. Objective To compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK‐air® app: those receiving sublingual AIT...
Article
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Background Co‐medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This is particularly relevant since AR is understood differently across European countries, as reflected by rhinitis‐related search patterns in Google Trends. This study aims to assess AR co‐medication and its regional patterns...
Article
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As long as the COVID-19 pandemic is still active in most countries worldwide, rapid diagnostic continues to be crucial to mitigate the impact of seasonal infection waves. Commercialized rapid antigen self-tests proved they cannot handle the most demanding periods, lacking availability and leading to cost rises. Thus, developing a non-invasive, cost...
Article
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Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID‐19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID‐19 vaccines due to high risk of death. In very rare instances, the COVID‐19 vaccines can induce anaphylaxis, and th...
Conference Paper
Pathophysiology at NOVA Medical School adopted the concept mapping methodology to promote the visual display of pathophysiological reasoning and learning, based on clinical vignettes. The objective of this project is to identify and label the linking words, in order to study their role in the structure and organization of the concept maps construct...
Article
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Allergen immunotherapy (AIT), the gradually increasing repeated administration of high doses of allergens to allergic patients, offers the potential for immune tolerance against reactions to the natural exposures to specific allergens. AIT may lead to the long-lasting remission of allergic symptoms and is the only disease-modifying intervention in...
Article
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Though the approach used to classify chronic respiratory diseases is changing to a treatable-traits (TT) approach, data regarding very elderly patients is lacking. The objectives of this study were to assess TT frequency in very elderly patients and to study the link between extrapulmonary TT and ventilatory defects. Individuals (≥75 years) residin...
Article
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Introduction and objectives: Severe asthma management during the coronavirus disease 2019 (COVID-19) pandemic is a challenge and will continue to be, at least in the next few months, as herd immunity is still a mirage. A lot has to be learned about how COVID-19 affects underlying diseases, and severe asthma is no exception. Methods: Narrative re...
Article
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Background The coronavirus disease 2019 (COVID‐19) has evolved into a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS‐CoV‐2). Allergists and other healthcare providers (HCPs) in the field of allergies and associated airway diseases are on the front line, taking care of patients potentially infected...
Poster
BACKGROUND The genus Olea is widely represented in the Mediterranean region by the species Olea europaea L., which has two varieties, var. sylvestris (wild olive) which is part of the natural vegetation and the var. europaea, cultivated olive tree primarily for olive oil production. In Portugal, olive growing is an activity of significative import...
Article
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Aims: To identify distinct asthma control clusters based on Control of Allergic Rhinitis and Asthma Test (CARAT) and to compare patients’ characteristics among these clusters. Methods: Adults and adolescents (≥13 years) with persistent asthma were recruited at 29 Portuguese hospital outpatient clinics, in the context of two observational studies of...
Article
The Allergic Rhinitis and Its Impact on Asthma (ARIA) initiative started more than 20 years ago and has developed and disseminated evidence-based guidelines and projects in the field of allergic rhinitis. This initiative is currently focused on providing patient-centred guidelines that contribute to an integrated care pathway between the various le...
Article
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There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) an...
Article
Introduction. The Test for Respiratory and Asthma Control in Kids (TRACK) is a tool to assess asthma control in preschool children. This study aims to validate the Portuguese from Portugal version of the TRACK questionnaire. Methods. A prospective cohort study was carried out to assess their psychometric characteristics. Caregivers of 141 children...
Article
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Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and mana...
Article
Concept mapping methodology is a way of representing knowledge described as a useful tool in medical education. It was introduced in the pathophysiology curricular unit at NOVA Medical School in 2002, within an ongoing experience of problem-based learning. Our goal is to present a comparison between the students’ opinions and performances in two ac...
Article
Background and objective: There are controversial data about risk factors for uncontrolled asthma in preschool children. Objective: This study aims to explore the association between clinical and functional parameters and the lack of asthma control in preschool children. Methods: Children 3-5 years-old with asthma and healthy controls were recru...
Article
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Separation techniques hyphenated to high-resolution mass spectrometry are essential in untargeted metabolomic analyses. Due to the complexity and size of the resulting data, analysts rely on computer-assisted tools to mine for features that may represent a chromatographic signal. However, this step remains problematic, and a high number of false po...
Conference Paper
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The main objective of pathophysiology teaching is to facilitate the learning of mechanisms of diseases and the understanding of their expressions in patients (symptoms, signs and tests). This objective requires the application of basic biomedical science to explain the abnormalities expressed by the patients. The capacity to integrate this new orga...
Preprint
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Background: This study aimed to characterize the clinical, functional, inflammatory and immunological features of the main obstructive lung diseases (OLD) in elderly. Methods: We included subjects aged ≥ 65 years. In Phase I, participants answered standardized questionnaires, performed spirometry, fractional exhaled nitric oxide, an atopy assessme...
Article
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Introduction: Cupressaceae pollen type is considered a cause of pollen allergy in winter, throughout the world, mainly in the Mediterranean countries. Objective: To analyze the prevalence and aerobiological behavior of Cupressaceae pollen (Cupressaceae pollen type) in Portugal. Material and methods: This study used Cupressaceae pollen data of the P...
Article
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This article was migrated. The article was marked as recommended. Background: The use of concept maps (CMs) in health and medical education is increasing, particularly in the last decade. The research developed in this area has not yet clarified the role played by CMs in meaningful learning. Approach: Our group developed a methodology, in a pathoph...
Article
In the last years, disease classification of chronic respiratory diseases (CRD) has been vivaciously discussed and new concepts have been introduced, namely asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO). Controversially the GOLD consensus document of 2020 considered that we should no longer refer to ACO, as they constitute two d...
Article
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Background: Spirometry is the single most important test for the evaluation of respiratory function. The results are interpreted by comparing measured data with predicted values previously obtained from a reference population. Reference equations for spirometry have been discussed previously. The aim of this study was to compare reference values ba...
Article
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Aims Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurre...
Article
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Objective We aimed to compare patient's and physician's ratings of inhaled medication adherence and to identify predictors of patient-physician discordance. Design Baseline data from two prospective multicentre observational studies. setting 29 allergy, pulmonology and paediatric secondary care outpatient clinics in Portugal. Participants 395 patie...
Article
The selection of pharmacotherapy for patients with allergic rhinitis aims to control the disease and depends on many factors. Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines have considerably improved the treatment of allergic rhinitis. However, there is an increasing trend toward use of real-world evidence to i...
Article
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Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example...
Article
In the Portuguese Geriatric Study of the Health Effects of Indoor Air Quality in Senior Nursing Homes, we aimed to evaluate the impact of indoor air contaminants on the respiratory symptoms and biomarkers in a sample of elderly living in nursing homes. A total of 269 elderly answered a health questionnaire, performed a spirometry and 150 out of the...
Article
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Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis pat...
Article
Full-text available
Background: Spirometry is the single most important test for the evaluation of respiratory function. The results are interpreted by comparing measured data with predicted values previously obtained from a reference population. Reference equations for spirometry have been discussed previously. The aim of this study was to compare reference values b...
Article
Full-text available
The Portuguese Severe Asthma Registry ( Registo de Asma Grave Portugal, RAG) was developed by an open collaborative network of asthma specialists. RAG collects data from adults and pediatric severe asthma patients that despite treatment optimization and adequate management of comorbidities require step 4/5 treatment according to GINA recommendation...
Article
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Introduction: Asthma is one of the most frequent chronic non-communicable diseases. Nowadays it affects about 700,000 Portuguese. Screenings provide an opportunity to clarify the disease to the population, to alert the population to the importance of asthma control and recognition of their symptoms. Objectives, material and methods: Socio-demograph...
Article
Full-text available
Introduction: Asthma is one of the most frequent chronic non-communicable diseases. Nowadays it affects about 700,000 Portuguese. Screenings provide an opportunity to clarify the disease to the population, to alert the population to the importance of asthma control and recognition of their symptoms. Objectives, material and methods: Socio-demograph...
Article
Background: Large observational implementation studies are needed to triangulate the findings from randomized control trials (RCTs) as they reflect "real world" everyday practice. In a pilot study, we attempted to provide additional and complementary insights on the real life treatment of allergic rhinitis using mobile technology. Methods: A mob...
Article
Piperacillin is a beta-lactam antibiotic of penicillin family. Some penicillins were report-ed as occupational diseases cause, but piperacillin anaphylaxis with occupational sensi-tization is rare. We describe the case of a female nurse with recurrent anaphylaxis in last few months without apparent cause, only in work environment. Latex allergy was...
Article
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This study aimed to examine the differences between mothers of children with and without respiratory problems in variables related to psychological, parental, and marital functioning and to determine which contributed more to parenting stress, because there is a lack of information in this field. Participants were 459 mothers of children attending...
Poster
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Introdução A análise de amostras de expetoração induzida é um método utilizado para a fenotipagem de doentes asmáticos baseando-se na contagem diferencial de leucócitos na expetoração.1 Existem diversos protocolos para processamento das amostras com eficácias variáveis.2 Objetivos Foi nosso objetivo otimizar o protocolo para processamento de amostr...
Article
Thermal comfort (TC) parameters were measured in 130 rooms from nursing homes (NH), following ISO 7730:2005 in order to evaluate the influence of winter season TC indices on quality of life (QoL) in older individuals. Mean radiant temperature (mrT), predicted mean vote (PMV) and predicted percent of dissatisfied people (PPD) indices, and the respec...
Article
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Allergic rhinitis often impairs social life and performance. The aim of this cross-sectional study was to assess the impact of uncontrolled rhinitis assessed by visual analogue score VAS on work productivity using cell phone data collection. A mobile phone app Allergy Diary, Android and Apple stores collects daily visual analogue scales VAS data fo...
Article
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Background: The use of Apps running on smartphones and tablets profoundly affects medicine. The MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) assesses allergic rhinitis symptoms, disease control and impact on patients' lives. It is freely available in 20 countries (iOS and Android platforms). Aims: To ass...
Article
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The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used glob...
Article
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Table of contents WORKSHOP 4: Challenging clinical scenarios (CS01–CS06) CS01 Bullous lesions in two children: solitary mastocytoma S. Tolga Yavuz, Ozan Koc, Ali Gungor, Faysal Gok CS02 Multi-System Allergy (MSA) of cystic fibrosis: our institutional experience Jessica Hawley, Christopher O’Brien, Matthew Thomas, Malcolm Brodlie, Louise Michaelis C...
Article
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Introduction: Most well validated techniques to study eosinophilic inflammation in asthma are Fractional exhaled nitric oxide (FENO) and sputum cellularity assessment. FENO is a simple and noninvasive method but may be elevated even in the absence of eosinophilic inflammation; Sputum eosinophil count is a more difficult to implement technique, part...
Article
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Few studies have assessed the quality of life (QOL) related to chronic respiratory diseases in the elderly. In the framework of the geriatric study on the health effects of air quality in elderly care centers (GERIA) study, a questionnaire was completed by elderly subjects from 53 selected nursing homes. It included various sections in order to ass...
Conference Paper
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Table of contents Poster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101) P92 16 years of experience with proton pump inhibitors (PPIs) Javier Dionicio Elera, Cosmin Boteanu, Maria Aranzazu Jimenez Blanco, Rosario Gonzalez-Mendiola, Irene Carrasco García, Antonio Alvarez, Jose Julio Laguna Martinez P93 Allergy evaluation of quinol...
Article
Introduction: There are rather few publications about hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAID) in the paediatric age. In this study, we aimed to assess the frequency of confirmed NSAID hypersensitivity in children with a previous reported reaction to NSAID in order to investigate the role of the drug provocation...
Conference Paper
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Background: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive multifactorial disease with limited treatment options.
Article
Background: Scarce information is available about the relationships between indoor air quality (IAQ) at day care centers (DCC), the estimated predisposition for asthma and the actual wheezing susceptibility. Methods: In the Phase II of ENVIRH study, 19 DCC were recruited after cluster analysis. Children were evaluated firstly using the ISAAC questi...
Article
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Background: persons who are 65 years or older often spend an important part of their lives indoors thus adverse indoor climate might influence their health status. Objective: to evaluate the influence of indoor air quality and contaminants on older people's respiratory health. Design: cross-sectional study. Setting: 21 long-term care residen...
Article
BACKGROUND AND OBJECTIVE: Data on chronic respiratory diseases (CRD) are scarce or unavailable in most African countries. We aimed to determine the prevalence of CRD and associated risk factors in Cape Verde, at the primary healthcare level. METHODS: In the frame of the Global Alliance Against Chronic Respiratory Diseases, a cross-sectional study w...
Article
Background: There is no gold standard for the assessment of asthma control, although GINA guidelines are commonly used. The TRACK (Test for Respiratory and Asthma Control in Kids) is the only asthma and wheezing questionnaire for use in preschool children. Aim: To study the agreement between different respiratory control levels obtained by distinct...
Article
Background: The Global Lung Function Initiative (GLI 2012) proposed the use of unifying reference equations, based on the lower limit of normal (LLN). Aim: To compare the theoretical values obtained through the GLI's equations (Equation 1) and those obtained with Stanojevic all-ages reference equations (Equation 2) and determine the interpretative...
Article
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Antecedentes A qualidade do ar interior (IAQ) é considerada um determinante importante da saúde humana. A associação entre a exposição a compostos orgânicos voláteis, partículas, ácaros, bolores e bactérias em creches (DCC) não é perfeitamente clara. O objectivo deste estudo foi estudar esses efeitos. Metodologia – desenho do estudo Este estudo de...
Article
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strong>Introduction: Data about drug allergy prevalence in the general population, particularly in children, are lacking. This study aimed to estimate the prevalence of parent-reported drug allergy, in children attending day care centers in Lisbon and Oporto. Material and Methods: In Phase II of the “ENVIRH study – Environment and Health in Childre...
Article
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Children attending day care centers (CDCC) have been reported to be more prone to infectious diseases when compared with those cared for at home, and are exposed to conditions that may increase the risk of allergies and asthma. Several studies revealed that consequences of poor ventilation conditions include high levels of carbon dioxide (CO2) and...
Article
Industrial development from the second half of the 20th century coupled with population growth and concentration in urban areas has accentuated the concern for potential effects and impacts from air pollutant emissions on environmental and human health. This study examined the Estarreja region, an urban area that has one of the largest chemical com...
Article
Full-text available
Introduction: Data about drug allergy prevalence in the general population, particularly in children, are lacking. This study aimed to estimate the prevalence of parent-reported drug allergy, in children attending day care centers in Lisbon and Oporto. Material and Methods: In Phase II of the "ENVIRH study - Environment and Health in Children Day C...
Article
Indoor air quality (IAQ) is considered an important determinant of human health. The association between exposure to volatile organic compounds, particulate matter, house dust mite, molds and bacteria in day care centers (DCC) is not completely clear. The aim of this project was to study these effects. This study comprised two phases. Phase I inclu...

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