Payal Mukherjee

Payal Mukherjee
Royal Prince Alfred Hospital | RPA · otology

FRACS MBBS MS PhD
3D printing, Bioprinting, Medical devices, Cochlear Implantation, Meniere's Disease, Artificial Intelligence

About

53
Publications
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359
Citations

Publications

Publications (53)
Article
Full-text available
Long-term health-related quality of life (HRQOL) and functional outcomes following mandibular and maxillary reconstruction are lacking. To determine these outcomes, a cross-sectional study of patients with a history of cancer who underwent jaw reconstruction was undertaken. Participants were identified from a database of jaw reconstruction procedur...
Article
Meniere's disease (MD) is a progressive inner ear disorder involving recurrent and prolonged episodes or attacks of vertigo with associated symptoms, resulting in significantly reduced quality of life for sufferers. In most cases, MD starts in one ear; however, in one-third of patients, the disorder progresses to the other ear. Unfortunately, the e...
Article
The sensory end-organs responsible for hearing and balance in the mammalian inner ear are connected via a small membranous duct known as the ductus reuniens (also known as the reuniting duct (DR)). The DR serves as a vital nexus linking the hearing and balance systems by providing the only endolymphatic connection between the cochlea and vestibular...
Article
New solutions are emerging that address specific facial regions in facial nerve palsy (FNP). However the most dreaded consequence of FNP is paralytic lagophthalmos threatening the eye. A way to prioritize these regions is thus required. A review of the literature is conduced to capture the current concepts in evaluating FNP. Overall, patients are a...
Article
Full-text available
This study demonstrates a cost-effective portable fabrication system for 3D printing complex structures from polydimethylsiloxane (PDMS). Material development and characterisation allowed for the design and production of a 3D printer that is capable of fabricating PDMS structures using a photo-initiator and a LED curing process. A 3D model of a par...
Article
The organs of balance, the semicircular canals (SCCs) and otolith organs (utricle and saccule) of the inner ear labyrinth, are essential to basic human movement and function. While the SCCs (both external and internal structure) are well visualized and understood, the seemingly vague bony structure of the utricle and saccule remains largely unexplo...
Article
Background There is a wide range of commercial and custom-made devices available for the treatment of trismus (restricted jaw opening). They are used often in conjunction with a prescribed exercise program with the aim of improving maximal inter-incisal opening (MIO). This study compared the efficacy (MIO and patient reported outcome results), adve...
Article
Full-text available
Advances in 3D bioprinting allows not only controlled deposition of cells or cell-laden hydrogels but also flexibility in creating constructs that match the anatomical features of the patient. This is especially the case for reconstructing the pinna (ear), which is a large feature of the face and made from elastic cartilage that primarily relies on...
Article
Objectives: Surgical resection of the maxilla impairs aesthetics, speech, swallowing, and mastication. Maxillary reconstruction is increasingly performed with virtual surgical planning (VSP) to enhance functional dental rehabilitation with a conventional denture or osseointegrated implants. The aim of this study was to determine whether dental stat...
Article
Full-text available
Background Vascularised periosteum can used for reconstructing bony defects due to its intrinsic osteogenic properties. This osteogenic potential can be harnessed as a vascularised flap to induce bone growth of complex constructs in-vivo. The authors aimed to use a novel pedicled periosteal flap from the scapula to induce bone growth in a critical...
Article
Background There is a growing effort to develop implantable bionics for restoring eye closure in paralytic lagophthalmos. Knowledge of the natural eyelid attachments is important for active implants that mobilise these attachments or replace them with a sling. Whitnall's tubercle (WT) is traditionally used to identify lateral canthal attachments, h...
Article
Hypothesis/background: Bast's valve is a poorly understood inner ear structure located at the junction between pars superior and inferior in the membranous labyrinth. Anatomically precise three-dimensional reconstructions (3D-reconstructions) of Bast's valve can help illuminate the morphology of the valve, and point toward its role in normal physi...
Article
Full-text available
The inner ear contains the end organs for balance (vestibular labyrinth) and hearing (cochlea). The vestibular labyrinth is comprised of the semicircular canals (detecting angular acceleration) and otolith organs (utricle and saccule, which detect linear acceleration and head tilt relative to gravity). Lying just inferior to the utricle is the memb...
Article
Full-text available
The membrana limitans (ML) is a membranous vestibular structure found within the bony labyrinth, housed in the petrous temporal bone. It is located inferior to the semicircular canals (which detect changes in angular acceleration of the head) and adjacent to both otolith organs, the utricle and saccule (responsible for detecting linear acceleration...
Article
Full-text available
Background: Superior Canal Dehiscence is classically diagnosed with typical abnormalities on Vestibular Evoked Myogenic Potentials (VEMPs) and Computed Tomography (CT) scans. Aim: This paper discusses the utility of the video Head Impulse Test (vHIT) in SCD. Methods: Data from 11 ears (8 patients) with SCD were retrospectively reviewed. Result...
Article
Full-text available
Introduction: Long term results of ossiculoplasty surgery are considered poor with displacement and extrusion amongst the common reasons for failure. Application of 3Dimensional (3D) printing may help overcome some of these barriers, however digital methods to attain accurate 3D morphological studies of ossicular anatomy are lacking, exacerbated b...
Article
Full-text available
Abstract Background: Bioprinting has shown promise in the area of microtia reconstruction. However clinical translation has been challenged by the lack of robust techniques to control delivery of stem cells. Hybrid printing allowing multiple materials, both cell and support, to be printed together may overcome these challenges. Objective: This stu...
Article
Full-text available
Introduction: Three-dimensional (3D) tools have played a significant role in advancing anatomical knowledge, in simulation and clinical practice in Otology. Technology is evolving at a rapid rate with new applications being reported at an overwhelming pace. It is important to continuously review new applications, assess emerging trends, and identi...
Article
Objectives: Virtual surgical planning (VSP) uses patient-specific modelling of the facial skeleton to provide a tailored surgical plan which may increase accuracy and reduce operating time. The aim of this study was to perform a time and cost-analysis comparing patients treated with and without VSP-technology. Material and methods: A retrospecti...
Article
As scaffolds approach dimensions that are of clinical relevance, mechanical integrity and distribution becomes an important factor to the overall success of the implant. Hydrogels often lack the structural integrity and mechanical properties for use in vivo or handling. The inclusion of a structural support during the printing process, referred to...
Article
Full-text available
Background The anatomy of the membranous labyrinth within the vestibule has direct implications for surgical intervention. The anatomy of the otoliths has been studied, but there is limited information regarding their supporting connective tissue structures such as the membrana limitans in humans. Methods One guinea pig and 17 cadaveric human temp...
Article
The need to search for biomaterials that can promote tissue regeneration and easy to replicate and manufacture is a major driving force for research and development in the area of reconstructive surgery and regenerative medicine. It is of great importance to otolaryngologists to find alternate solutions that require harvesting large amounts of auto...
Article
Full-text available
Virtual surgical planning (VSP) is an applied use of 3D printing showing improvement in patient outcome and health costs though its use in ear surgery has not been reported. VSP was applied to Bonebridge (BB) surgery. A 3D printed temporal bone of a patient requiring revision Modified Radical Mastoidectomy (MRM) was used. MRM was performed on the p...
Article
Full-text available
Background: Mandibular and maxillary reconstruction using fibula free transfer is common in many tertiary referral centres. Virtual surgical planning (VSP) is a relatively recent adjunct that allows surgeons to plan resection and reconstruction prior to theatre. This has been shown to reduce operative times and decrease surgeon stress intraoperati...
Article
Full-text available
With the advent of single-sided hearing loss increasingly being treated with cochlear implantation, bone conduction implants are reserved for cases of conductive and mixed hearing loss with greater complexity. The BoneBridge (BB, MED-EL, Innsbruck, Austria) is an active fully implantable device with no attenuation of sound energy through soft tissu...
Article
Full-text available
Temporal bone and skull base anatomy is complex and can pose difficulties in patient’s perception of disease and anatomy, perceived risks, and complications of surgery. We wish to demonstrate the development and use of augmented reality (AR) technology and three-dimensional (3D) printing to assist in preoperative patient consultation in the case of...
Article
Full-text available
This paper reports a patient with a large recidivist cholesteatoma who underwent audio-vestibular tests and used customized 3D technologies (3D printing, augmented reality, virtual reality) to understand risks of the surgery. The patient was extremely concerned with her clinical findings and it found difficult to understand them. Customized 3D mode...
Article
Objective: To investigate outcomes of cochlear implantation (CI) in patients with Ménière's disease (MD) with and without surgical labyrinthectomy. Study design: Retrospective study. Setting: Multiple tertiary referral centers. Subjects: Thirty one ears from 27 patients (17 men, 10 women, aged 42-84) with CI in ipsilateral MD ear. Intervent...
Article
Objective: Three cases of internal carotid artery aneurysm affecting the distal cervical segment were retrospectively reviewed. Methods: Two patients underwent open surgical repair requiring petrous segment exposure for bypass of the affected segment using a Fisch type A lateral skull base approach. The third patient underwent endovascular stent...
Article
Single-sided deafness patients are now being considered candidates to receive a cochlear implant. With this, many people who have undergone a unilateral vestibular labyrinthectomy for the treatment of chronic vertigo are now being considered for cochlear implantation. There is still some concern regarding the potential efficacy of cochlear implants...
Article
Rehabilitation of hearing is complicated in patients with profound bilateral hearing loss in the presence of sporadic vestibular schwannoma (VS) or neurofibromatosis 2 (NF2), especially if the tumor does not need to be removed. We present the outcome of patients who have had a cochlear implant in the tumor affected ear without removal of the primar...
Article
To assess the degree of intracochlear trauma using the Cochlear™ Straight Research Array (SRA). This electrode has recently been released by Cochlear™ on the CI422 implant. Electroacoustic stimulation (EAS) enables recipients to benefit from cochlear implantation while retaining their natural low-frequency hearing. A disadvantage of short EAS elect...
Article
Measurements of the proximity of the membranous labyrinth to the stapes footplate show considerable variation. Largely, such measurements have been from histologic sections of fixed temporal bones, which may be affected by shrinkage artifact and perspective distortion in the 2-dimensional plane. To overcome these problems, the present study underto...
Article
To assess the long-term outcome of lipomas affecting the cerebellopontine angle (CPA) and internal auditory canal (IAC). This is a retrospective, single-center study of 10 CPA and IAC lipomas that have presented for the last 6 years. There were 8 male and 2 female patients whose age ranged from 22 to 71 years. These lesions were distributed equally...
Article
The pathogenesis of Ménière's disease is associated with a disorder of ionic homeostasis, with the pathologic correlate being endolymphatic hydrops. Despite uncertainty as to its particular mode of action, it is accepted wisdom that intra-tympanic gentamicin has a definite therapeutic role in the control of symptoms in patients who fail to respond...
Article
The primary aim of treatment of cholesteatoma is to attain a dry, safe, stable ear, free of disease. Maintaining or improving hearing is important but the pursuit of a hearing result should not compromise this primary aim. This study reviews the long-term outcome of 133 patients, suffering from advanced disease, who underwent modified radical masto...

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