Paweł Świt

• PhD. Eng.
• Professor (Assistant) at University of Silesia in Katowice

The typical phenolic profile in grapes is characterized by its complexity both in terms of number of diverse chemical structures and their variation during ripening. Besides, the specific phenolic composition of grapes directly influences the presence of those components in the resulting wine. In this contribution, a new method based on the applica...

Acetylcholine (ACh) is one of the most crucial neurotransmitters of the cholinergic system found in vertebrates and invertebrates and is responsible for many processes in living organisms. Disturbances in ACh transmission are closely related to dementia in Alzheimer’s and Parkinson’s disease. ACh in biological samples is most often determined using...

Recently, a growing number of reports have indicated a positive effect of hallucinogenic-based therapies in different neuropsychiatric disorders. However, hallucinogens belonging to the group of new psychoactive substances (NPS) may produce high toxicity. NPS, due to their multi-receptors affinity, are extremely dangerous for the human body and men...

The basic variant of the integrated calibration method (ICM), based on a combination of external calibration (EC) and standard addition method (SAM), was applied to multi-component (MC) analysis to obtain a new methodological approach to improve the quality of analytical results. The analytical performance of the proposed method was evaluated on in...

Cancer has been one of the most prevalent diseases around the world for many years. Its biomarkers are biological molecules found in the blood or other body fluids of people with cancer diseases. These biomarkers play a crucial role not only in the diagnosis of cancer diseases, but also in risk assessment, selection of treatment methods, and tracki...

Modifications of integrated calibration method (ICM) in its basic variant and complementary dilution method version (CDM) were adapted to multi-component (MC) analysis to obtain novel calibration approaches improving the accuracy of analytical results. Methods were developed conceptually and their performance was assessed on the basis of polycyclic...

The design of a sandwich-type SERS immunoassay (surface-enhanced Raman spectroscopy) is demonstrated operating in dual surface enhancement and dual-tag paradigm. The capture and detection antibodies are linked to two SERS-active substrates and form together the three-dimensional (3D) structure after specific binding to interleukin 6. A variety of m...

Analytical methods using the fluorescence properties of bisphenols (BPA, BPF and BPS) and their complexes with β-cyclodextrin and methyl-β-cyclodextrin were developed. The methods were applied for the analysis of thermal paper and canned food. Their performance was compared with a standard HPLC approach with a diode array and fluorescence detection...

Microfading testing allows to evaluate the sensitivity to light of a specific artwork. Characterization of the illumination spot is important to determine its shape, dimensions, light distribution, and intensity in order to limit and account for possible damage. In this research the advantages and disadvantages of several methods used to determine...

A new point of view on ensuring the best quality of analytical results has been presented. We proposed the strategy called Good Methodology Practice leading to the improvement of the quality of analytical results and assessment of interference effects. Four calibration methods: External Calibration, Standard Addition Method, Integrated Calibration...

Microfading testers have become widely accepted by the conservation science community for establishing and recommending appropriate lighting conditions that minimize damage to collections. These devices offer the opportunity of measuring the photostability of cultural heritage objects due to their optical setup, which allows to conduct and quantify...

The combination of noble metals and semiconductors opens new routes for surface enhancement of Raman signal. Gold nanostructures were here photocatalytically grown from solutions of gold(III) chloride trihydrate under UV illumination on sol-gel derived TiO2 coatings deposited on silicon wafers. Resulting nanoplatforms were designed to serve as supe...

PurposeN-Methoxybenzyls, a group of toxic phenylethylamine derivatives of the 2C family compounds, are a new class of potent serotonin 5-HT2A receptor agonist hallucinogens with potential harmful effects. This study summarizes current state of knowledge of one of the most dangerous representative of this group—N-(2-methoxybenzyl)-2,5-dimethoxy-4-ch...

NBOMes are N-benzylmethoxy derivatives of the 2C family compounds with N-2-methoxy-benzyl moiety substituted by the methoxy group at the 2- and 5- position and the halogen group at the 4- position of the phenyl ring. These substances are a new class of potent serotonin 5-HT2A receptor agonist hallucinogens with potential harmful effects. The substi...

Recently the novel psychoactive substances (NPS) have become popular as recreational drugs of abuse. Each year the number of NPS discovered on the illicit drug market is maintaining a high level. In 2018, European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) emerged 55 new drugs from different classes of substances, including new halluci...

A new calibration approach based on the adaptation of Integrated Calibration Method (ICM) to consecutive two components analysis in separation science is presented. Consecutive ICM method (C-ICM) was conceptually developed and applied to determination of two excitatory amino acids - glutamate and aspartate in cerebrospinal fluids collected by the u...

A new calibration approach based on the adaptation of Integrated Calibration Method (ICM) to consecutive two components analysis in separation science is presented. Consecutive ICM method (C-ICM) was conceptually developed and applied to determination of two excitatory amino acids - glutamate and aspartate in cerebrospinal fluids collected by the u...

NBOMes are N-benzylmethoxy derivatives of the 2C family hallucinogens. 4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe) is one of the commonly used illicit drugs. It exhibits high binding affinity for 5-HT2A/C and 5-HT1A serotonin receptors. Activation of 5-HT2A receptor induces head-twitch response (HTR) in rodents, a behavioral...

Novel psychoactive substances (NPS), also known as „legal highs” have become popular as recreational drugs of abuse in the recent years. Hallucinogens, a class of NPS potently alter mood and perception but do not produce addiction and dependence. NBOMe compounds are substituted phenethylamine hallucinogens and derivatives of 2C-X drugs, acting thro...

Recently the novel psychoactive substances (NPS) have become popular as recreational drugs of abuse. Hallucinogens, a class of NPS, powerfully alter perception and mood but do not produce dependence and addiction. Indoloamine and phenylethylamine hallucinogens are potent agonists of serotonin receptors. 4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phene...

Lysergic acid diethylamide (LSD) is a semisynthetic, indolamine hallucinogen stimulating central serotonin receptors: 5-HT1A/1B/1D, 5-HT2A/2C/5A, 5-HT6, 5-HT7, dopamine D1, D2 and adrenergic α1 and α2 receptors. The consumption of LSD in Europe is small but stable in the long run. LSD has strong psychoactive properties but does not induce addiction...

The possibility of adapting the Standard Addition Method (SAM) to calibration in very difficult analytical conditions, namely when there is a need to determine an analyte with the use of nonlinear calibration graph and in the presence of matrix components causing additive interference effect, is investigated. To this aim the SAM in the common versi...

Paper‐based heritage objects on exhibition are typically framed using a transparent glazing material such as glass or acrylic. This often makes the task of measuring their light fastness a difficult one since cultural institutions may have unframing restrictions, especially for large‐format objects. However, a testing programme recently conducted a...

A new gradient ratio approach to Chemical H-point Standard Addition Method (C-HPSAM) was developed in flow injection analysis with spectrophotometric detection. C-HPSAM is based on an idea to use SAM for calibration in several different chemical conditions in order to correct unspecific (additive) interferences in samples with unknown matrix. The a...

A new calibration methodology based on the combination of the Integrated Calibration Method (ICM) and the H-point Standard Addition Method (HPSAM) is presented. It allows the diagnosis and correction of errors caused in an analytical system by different kinds of interference effects. Six calibration solutions consisting of mixtures of sample, dilue...

A novel method for correction of unknown unspecific (additive) interferences was developed in sequential injection analysis (SIA) using a Lab on Valve module (LOV) with spectrophotometric detection. The method implements a novel idea to calibrate by the standard addition method in several different chemical conditions created in such a way to measu...

The aim of this study was to investigate the influence of selected organic compounds such as acetic acid and formaldehyde on the historical glass objects of corrosion processes. This is a very important problem for the field of conservation and restoration of glass of art. Glass objects exhibited in museum display cases can be suffered by evaporati...

The generalized calibration strategy (GCS), developed and previously applied to chemical analysis, has been adapted to two-component (2C) analysis. According to the 2C-GCS procedure, a set of ten calibration solutions containing a sample and standards of two analytes in well-defined composition were diluted. The measurements performed at a given di...

X-ray fluorescence (XRF) analysis has become a standard method in archaeological science due to its non-invasive and non-destructive nature. This technique has extensively been used for the study of numismatic collections since the data derived from it can be correlated with manufacturing processes, provenance of raw materials, and geographical dis...

Integrated calibration method (ICM) is one of novel approaches in the field of analytical calibration. ICM enables to obtain several (e.g. six) estimations of an analytical result in a single calibration procedure. These values are differently resistant to errors caused by interference and non-linearity effects, thus giving a possibility to: a) ver...

Generalized calibration strategy (GCS) is one of the innovative approaches aimed at verification and improvement of accuracy of analytical determinations. It combines in a single procedure the interpolative and the extrapolative calibration approaches along with stepwise dilution of a sample with the use of a dedicated flow system. In the paper a s...