Pawel Krukow- PhD
- Head of Department at Medical University of Lublin
Pawel Krukow
- PhD
- Head of Department at Medical University of Lublin
Resting-state and task-dependent neural networks of young adults burdened with traumatic childhood experiences
About
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Introduction
I'm a neuropsychologist interested in cognitive dysfunctions present in neuropsychiatric diseases, especially schizophrenia, and bipolar disorder. My special interest concerns disorders of dynamic information processing, including cognitive speed, intra-individual variability of processing, initiation deficits, and cognitive effort. I study these disorders in relations to disconnection model of mental disorders, with the application of advanced qEEG and time-limited cognitive tasks developed in a computer version. I would like to establish cooperation with researchers having similar interests.
Current institution
Additional affiliations
February 2012 - present
Position
- The main objective of the project was to get acquainted with the original analysis method of brain oscillatory activity, involving the application of advanced evoked potentials and current dipoles measurement. The method allows the reconstruction of neural and psychological processes taking place in the ultra-narrow time intervals.
Description
- Applications of brain oscillation activity analysis with original method by Nina N. Danilova
Education
June 2012
Publications
Publications (92)
Background and Hypothesis
Given the available findings confirming accelerated brain aging in schizophrenia (SZ), we conducted a study aimed at verifying whether quantitative retinal morphological data enable age prediction and whether schizophrenia patients present with a positive retinal age gap (RAG).
Study Design
Two samples of patients and con...
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Schizophrenia is a serious mental disorder with a complex neurobiological background and a well-defined psychopathological picture. Despite many efforts, a definitive disease biomarker has still not been identified. One of the promising candidates for a disease-related biomarker could involve retinal morphology , given that the retina is a part of...
Facebook is a platform for social contacts, establishing relationships, and solving interpersonal
conflicts. Consequently, understanding online emotional and social behaviour in problematic and
nonproblematic Facebook use is important to explore how people function on social media. In
this context, the current study examined the differences between...
Our study aimed to verify the possibilities of effectively applying chronnectomics methods to reconstruct the dynamic processes of network transition between three types of brain states, namely, eyes-closed rest, eyes-open rest, and a task state. The study involved dense EEG recordings and reconstruction of the source-level time-courses of the sign...
Schizophrenia is a serious mental disorder with a complex neurobiological background and a well-defined psychopathological picture. Despite many efforts, a definitive disease biomarker has still not been identified. One of the promising candidate for such biomarker might be the retinal morphology. In this study Optical Coherence Tomography (OCT) da...
Introduction: Language and speech serve as significant biomarkers for psychiatric disorders, including schizophrenia. The linguistic features associated with schizophasia have been a focal point since the early descriptions of schizophrenia. Over the past twenty-five years, scientific reflection on language in mental illnesses has dynamically provi...
Introduction: In recent years, one of the most interesting areas of research is the change in hemodynamic response of the prefrontal cortex as a predictor of response to electroconvulsive treatments (ECT). Near-infrared spectroscopy (fNIRS) is non -invasive functional neuroimaging technique that allows the assessment of neuronal activity in frontot...
Background
Anorexia nervosa (AN) is a life-threatening disease with a low effectiveness of treatment. The high relapse and mortality rate indicate new treatment approaches are needed. Here, we represent the protocol for randomized clinical trial (RCT) of transcranial direct current stimulation (tDCS) efficiency in the AN treatment. The main purpose...
Our study aimed to verify the possibilities of effectively applying chronnectomics methods to reconstruct the dynamic processes of network transition between three types of brain states, namely, eyes-closed rest, eyes-open rest, and a task state. The study involved dense EEG recordings and reconstruction of the source-level time-courses of the sign...
There is growing evidence of disproportionate retinal thinning in schizophrenia, but doubts are still raised regarding its signifcance in the context of the neurobiology of the disease. Therefore, we examined whether these abnormalities are
signifcantly associated with neurological soft signs (NSS) which are closely related to the risk of schizophr...
Objectives
Retinal layers thinning is already well-known feature of the visual system abnormalities in schizophrenia. We wanted to verify whether retinal morphology in schizophrenia present different age trajectories compared to healthy controls, and whether these morphological characteristics in the patients group show relationships with specific...
1. OBJECTIVES Electroconvulsive therapy (ECT) is one of the therapeutic options for treatment-resistant schizophrenia (SZ). We wanted to verify whether ECT changes the scope and regional patterns of hemodynamic response of the frontal cortex during performance of verbal and figural fluency tasks, with special reference to initial interval of tests...
Introduction and objective:
Various types of social media (SM) have recently played a huge role in shaping the world and one's self-esteem. Previous research on this issue has shown that frequent use of MS leads to the creation of unrealistic body image ideals. Time spent on SM is sometimes associated with increased body dissatisfaction, which cou...
Data represents raw, uncorrected measures of retinal morphology and additional clinical and demographic information.
Previous studies evaluating the morphology of the selected retinal layers in schizophrenia showed abnormalities regarding macular thickness, retinal nerve fiber layer (RNLF), and ganglion cell complex (GCC). Concurrently, accumulating neuroimaging results suggest that structural alterations of the brain in this disease might be an effect of acceler...
Citation: Jonak, K.; Marchewka, M.; Podkowiński, A.; Siejka, A.; Plechawska-Wójcik, M.; Karpiński, R.; Krukow, P. How Functional Connectivity Measures Affect the Outcomes of Global Neuronal Network Characteristics in Patients with Schizophrenia Compared to Healthy Controls. Brain Sci. 2023, 13, 138. https://doi. Abstract: Modern computational solut...
When performing cognitively demanding tasks, people tend to experience momentary distractions or personal associations that intercept their stream of consciousness. This phenomenon is known as Mind Wandering (MW) and it has become a subject of neuroscientific investigations. Off-task thoughts can be analyzed during task performance, but currently,...
Introduction: Psychotic disorders are heterogeneous in terms of pathophysiology.
Therefore, the validity of searching for a single biomarker of the disease is questioned, pointing to the need to stratify patients based on a common biological basis. The membrane hypothesis assumes that changes in fatty acid metabolism can lead to abnormal structure...
Introduction: According to Horrobin’s theory, abnormal fatty acid metabolism is a predisposing factor to the development of schizophrenia (SCHI), bipolar disorder (BD) or schizoaffective disorder (SCHA). The niacin test is a reproducible and non-invasive method of assessing the skin reaction to the application of nicotinic acid, which indicates dis...
Introduction: The aim of the current study was to present the results of the first step of the Mind Wandering Questionnaire (MWQ) adaptation to the Polish sample. The adaptation involved performing translation of the scale, verification of the translated items’ accessibility and the analysis of the internal consistency.
Material and methods: MWQ in...
When performing cognitively demanding tasks, we all sometimes experience a momentary distractions or our stream of consciousness is intercepted by personal associations. This phenomenon is called Mind Wandering (MW) and it became a subject of neuroscientific investigations. Off-task thoughts can be analyzed during task performance, but currently MW...
The study is focused on applying ex-Gaussian parameters of eye-tracking and cognitive measures in the classification process of cognitive workload level. A computerised version of the digit symbol substitution test has been developed in order to perform the case study. The dataset applied in the study is a collection of variables related to eye-tra...
Introduction: Although the typical symptoms of SARS-CoV-2 infection are respiratory symptoms, it has been shown that the virus can also attack the central nervous system (CNS) causing neurological and psychiatric symptoms.
Aim: The aim of the study was to present a case of a 52-year-old woman, previously untreated for psychiatric diseases, who deve...
In this study, we focused on the verification of suitable aggregation operators enabling accurate differentiation of selected neurophysiological features extracted from resting-state electroencephalographic recordings of patients who were diagnosed with schizophrenia (SZ) or healthy controls (HC). We built the Choquet integral-based operators using...
Background: Schizophrenia is a chronic mental illness that affects 20 million people worldwide. Patients diagnosed with paranoid schizophrenia are characterized by cognitive deficits and the so-called negative symptoms, which significantly lower their quality of life and have implications for their independence and ability to fulfill various social...
Aggrandized fluctuations in the series of reaction times (RTs) are a very sensitive marker of neurocognitive disorders present in neuropsychiatric populations, pathological ageing and in patients with acquired brain injury. Even though it was documented that processing inconsistency founds a background of higher-order cognitive functions disturbanc...
High-grade gliomas are infrequent in the pediatric population compared to adults, nevertheless, mortality and morbidity caused by malignant gliomas in this group of patients remain significant. PD-L1 and PD-1 Immune checkpoints (IC) molecules maintain immunological balance between activation and suppression. Eighteen patients with a histopathologic...
Introduction:
Lumbar disc herniation (LDH) is a common cause of back pain and leg pain. For more than 60 years, standard discectomy by fenestration has been used to treat LDH. In his study, three commonly used scales were used to assess the outcome after microdiscectomy, such as the Low Back Pain Rating Scale (LBPRS), Oswestry Disability Index (ODI...
Examining individuals with Leber’s hereditary optic neuropathy (LHON) provides a rare opportunity to understand how changes in mitochondrial DNA and loss of vision can be related to changes in organization of the whole-brain structural network architecture. In comparison with the previous neuroimaging studies with LHON participants, which were focu...
Leber's hereditary optic neuropathy (LHON) is a maternally inherited genetic disorder leading to severe and bilateral loss of central vision, with a young male predilection. In recent years, multiple studies examined structural abnormalities in visual white matter tracts such as the optic tract and optic radiation. However, it is still unclear if t...
Introduction: Deep Brain Stimulation can directly alter brain activity in a controlled manner and the effect is reversible. The
mechanism is that the electrode acts locally on neural activity, which is transferred to monosynchronous and multisynaptic
network connections.
Methods: We present studies conducted on a group of patients that show an impr...
Introduction: Dyskinesia is a symptom complex in the form of involuntary, repetitive movements of lips, lower jaw, tongue, less
often the trunk and limbs. Despite the use of newer drugs in treatment neuroleptics, dyskinesia has not ceased to be a clinical
problem.
Method: The work is based on a research review for which the Google Scholar database...
Background. An electroencephalogram (EEG) is a simple and widely used assessment tool that allows one to analyze the bioelectric activity of the brain. As a result, one can observe brain waves with different frequencies and amplitudes that correspond to the temporary synchronization of different parts of the brain. Synchronization patterns may be c...
Schizophrenia has been considered a disorder linked with faulty lipid homeostasis, and the proposed tool for assessment of these disruptions is the niacin skin flush test. The aims of the study were: 1. Create a new tool to analyze results of the niacin skin flush test more precisely and objectively. 2. Verify the utility of a self-created tool for...
Leber’s hereditary optic neuropathy (LHON) is one of the mitochondrial diseases that causes loss of central vision, progressive impairment and subsequent degeneration of retinal ganglion cells (RGCs). In recent years, diffusion tensor imaging (DTI) studies have revealed structural abnormalities in visual white matter tracts, such as the optic tract...
Among multiple cognitive impairments present in schizophrenia, a decline in fast information processing is one of the most severe neuropsychological deficit. Reduced ability to efficiently launch a coherent cognitive activity might be a significant factor contributing to poor results in time-limited tasks obtained by schizophrenia patients. The aim...
Magnetic Resonance Imaging (MRI) of the Optic Nerve is difficult due to the fine extended nature of the structure, strong local magnetic field distortions induced by anatomy, and large motion artefacts associated with eye movement. To address these problems we used a Zero Echo Time (ZTE) MRI sequence with an Adiabatic SPectral Inversion Recovery (A...
Background:
Current treatment of major depressive disorder (MDD) often does not achieve full remission of symptoms. Therefore, new forms of treatment and/or adjunct therapy are needed. Evidence has confirmed the modulation of the gut-brain-microbiota axis as a promising approach in MDD patients. The overall purpose of the SANGUT study-a 12-week, r...
Introducing the Minimum Spanning Tree (MST) algorithms to neural networks science eliminated the problem of arbitrary setting of the threshold for connectivity strength. Despite these advantages, MST has been rarely used to study network abnormalities in schizophrenia. An MST graph mapping a network structure is its simplification, therefore, it is...
Time-of-flight angiography (ToF) was presented for the first time by Suryan and used by Hinshaw et al. This protocol allows to visualize blood flow within the vessels in vivo without the contrast administration, which is possible due to the large magnitude of magnetization, received from the moving spins and small magnitude of magnetization receive...
Trace elements play a crucial role in many biochemical processes, mainly as components of vitamins and enzymes. Although small amounts of metal ions have protective properties, excess metal levels result in oxidative injury, which is why metal ion homeostasis is crucial for the proper functioning of the brain. The changes of their level in the brai...
The study aimed at identifying the cognitive and clinical determinants of impaired design fluency in bipolar patients, with special reference to processing speed and performance strategy. A sample of bipolar disorder patients (BD, n = 45) and matched healthy controls (HC, n = 42) underwent the assessment of figural fluency, cognitive and manual spe...
The aim of this study was to compare neural network topology of 30 patients with first episode schizophrenia (FES) and 30 multiepisode schizophrenia (mean number of psychotic relapses =4 years, duration of illness >5 years) patients, who were assessed with graph theory methods. This comparison was designed to identify network differences, which mig...
Central neurocytoma (CN), first described in 1982 by Hassoun and colleagues, is a rare tumor accounting for 0.25% to 0.5% of all tumors of the central nervous system. The tumor is a neoplasm of neuroepithelial origin, with intermediate malignancy (WHO grade II), detectable with both computed tomography and magnetic resonance imaging. Complete excis...
There is an increasing amount of evidence which links the pathogenesis of irritable bowel syndrome (IBS) with food IgG hyperreactivity. Some authors have suggested that food IgG hyperreactivity could be also involved in the pathophysiology of major depressive disorder (MDD). The aim of this study was to compare levels of serum IgG against 39 select...
This study aimed at identifying abnormal cortico-cortical functional connectivity patterns that could predict cognitive slowing in patients with schizophrenia. A group of thirty-two patients with the first-episode schizophrenia and comparable healthy controls underwent resting-state qEEG and cognitive assessment. Phase Lag Index (PLI) was applied a...
This study aimed at identifying abnormal cortico-cortical functional connectivity patterns that could predict cognitive slowing in patients with schizophrenia. A group of thirty-two patients with the first-episode schizophrenia and comparable healthy controls underwent resting-state qEEG and cognitive assessment. The Phase Lag Index (PLI) was appli...
Cognitive assessment in neurological diseases represents a relevant topic due to its diagnostic significance in detecting disease, but also in assessing progress of the treatment. Computer-based tests provide objective and accurate cognitive skills and capacity measures. The Ruff Figural Fluency Test (RFFT) provides information about non-verbal cap...
Aktualne metaanalizy wykazują, że spowolnienie poznawcze jest czynnikiem determinującym wystąpienie innych zaburzeń neuropsychologicznych w różnych grupach zaburzeń neuropsychiatrycznych. Przeprowadzone badania wskazują, że omawiany deficyt może być wynikiem podwyższonego poziomu niestabilności w przetwarzaniu informacji zachodzącej w czasie wykony...
Wprowadzenie. Projekt Connectome jest międzynarodowym przedsięwzięciem naukowym mającym na celu zmapowanie wszystkich strukturalnych i funkcjonalnych połączeń w ludzkim mózgu. Jednocześnie ukierunkował wiele współczesnych badań neuronaukowych, skupionych na poszukiwaniu nieprawidłowości w obrębie struktury tych połączeń, w tym zaburzeniach neuropsy...
ABSTRACT
Aims: Patients with schizophrenia (SCH) show impaired verbal and non-verbal fluency. However, these individuals’ fluctuations in words or designs generation efficiency over time, a phenomenon that may significantly affect fluency, have never been studied. Thus, the aim of this research was to investigate if individuals with SCH may present...
Contemporary research on the neurobiological determinants of schizophrenia is focused on the role of white matter abnormalities, studied mainly at the cellular level using Diffusion Tensor Imaging. At the same time, there are few reports on the effects of white matter damage that can be visualized in a typical MRI scan, on the brain function of sch...
In this paper the results of Matching Pursuit (MP) Octave algorithm applied to noise, vibration and harness (NVH) diagnosis of rolling bearings are presented. For this purpose two bearings in different condition state were examined. The object of the analysis was to calculate and present which energy error values of MP algorithm give the most accur...
Background:
Bipolar patients show high intra-individual variability during cognitive processing. However, it is not known whether there are a specific fluctuations of variability contributing to the overall high cognitive inconsistency. The objective was to compare dynamic profiles of patients and healthy controls to identify hypothetical differen...
Objectives:
The aim of the study was to find factors associated with higher severity of anxiety and depressive symptoms in female patients experiencing intimate partner violence (IPV).
Methods:
The study was conducted in six randomly selected primary healthcare centers in Lublin province. The HADS (Hospital Anxiety and Depression Scale) and a st...
Background: According to current knowledge, gamma frequency is closely related to the functioning of neural networks underlying the basic activity of the brain and mind. Disorders in mechanisms synchronizing brain activity observed in patients diagnosed with schizophrenia are at the roots of neurocognitive disorders and psychopathological symptoms...
Kynurenic acid (KYNA) is a neuroactive metabolite of tryptophan formed in the brain and in the periphery, known to block ionotropic glutamate receptors and α7 nicotinic receptors, and to act as a ligand of G protein-coupled GPR35 receptors and human aryl hydrocarbon (AHR) receptors. KYNA seems to modulate a number of mechanisms involved in the path...
Background: Processing speed turns out to be the central area of research on cognition in schizophrenia.
So far the relationship between this dimension and the IQ level of patients and their healthy
siblings has not been investigated.
Aim: To investigate the differences in cognitive speed in patients with schizophrenia and their healthy
siblings, a...
Wstęp. Szybkość przetwarzania informacji mierzona testami neuropsychologicznymi, w których osoba badana ma w ciągu określonego czasu przepracować jak największą liczbę bodźców okazała się istotnie różnić pacjentów z rozpoznaniem schizofrenii od osób zdrowych, co więcej wpływać na różnice w zakresie innych wymiarów poznawczych. Aspekt szybkości pozn...
Wstęp. Spowolnienie przetwarzania informacji jest jednym z najszerzej
opisanych deficytów poznawczych w schizofrenii, co
więcej, przeprowadzone badania (Ojeda i in., 2012) wykazały, że
spowolnienie jest ściśle powiązane z całym spektrum tych procesów
poznawczych, które odróżniają in minus pacjentów ze
schizofrenią od osób zdrowych. Pomimo tych usta...
Introduction: Fluency tasks, e.g. verbal, design fluency test etc. are often used in the evaluation of cognitive function in patients with schizophrenia. In the standard approach the test result is the sum of stimuli generated in a given time period. However, this approach does not allow to determinate of what strategies are usedby subjects to regu...
Introduction
Fluency tasks, e.g. verbal, design fluency test, etc. are often used in the evaluation of cognitive function in patients with schizophrenia. In the standard approach, the test result is the sum of stimuli generated in a given time period. However, this approach does not allow to determinate of what strategies are used by subjects to re...
Introduction
There is an evidence indicating that women experiencing intimate partner violence (IPV) quite common suffer from anxiety and depression, but predictors and protective factors are not well known in this group of patients.
Aim
The aim of the study was to try to find factor that are connected with higher rates of anxiety and depressive s...
Objectives
Intellectual functioning in schizophrenia has been associated with genetic vulnerability and obstetric complications.
Aims
The aim of this study was to assess:
– the incidence of complications during pregnancy, labor and delivery;
– the association of OCs with general intellectual ability in two groups: patients with schizophrenia and t...
Aim:
The aim of the study was to examine the prevalence of intimate partner violence (IPV) among patients seeing a general practitioner as well as to determine relationships between IPV and somatic complaints other than direct somatic consequences (such as injuries), including somatic diseases and healthcare services use.
Materials and methods:...
Problemy diagnozy różnicowej u pacjentki z uszkodzeniem istoty białej i rozpoznaniem schizofrenii - aspekty neuropsychologiczne i neurofizjologiczne
Problemy diagnozy różnicowej u pacjentki z uszkodzeniem istoty białej i rozpoznaniem schizofrenii - aspekty neuropsychologiczne i neurofizjologiczne
Problemy diagnozy różnicowej u pacjentki z uszkodzeniem istoty białej i rozpoznaniem schizofrenii - aspekty neuropsychologiczne i neurofizjologiczne
Advanced methods of electrophysiological signals
This paper presents the possibility of using advanced IT tools for the identification and analysis of biological signals on the example of electroencephalographic tests. Identification and numerical analysis of EEG signals from a person suffering from epilepsy during and between seizures is presented.
This paper's aim is to illustratethe relationship between self-awareness and social cognition in clinical groups, with varying brain health status and locationof its damage. Ongoing discussions both within the social neuroscience and clinical neuro-psychology represents different theoretical models to explain the relationship between understanding...
Depressive episodes are associated not only with changes in neurotransmission in the central nervous system, but also may lead to structural changes in the brain through neuroendocrine, inflammatory, and immunological mechanisms. The aim of this article is to present a new hypothesis connecting the inflammatory theory of depression with IgG food hy...
Although considerable research has been devoted to cognitive functions deteriorating due to diseases of
cardiovascular system, rather less attention has been paid to their theoretical background. Progressive vascular disorders as hypertension, atherosclerosis and carotid artery stenosis generate most of all pathological changes in the white matter...
Cel
Pomimo burzliwego rozwoju badań nad zaburzeniami poznania społecznego w schizofrenii nadal trwają poszukiwania szerszych modeli konceptualnych, w tym uwzględniających teorie sieciowe, wyjaśniających obserwowane zaburzenia. Celem naszej pracy była ocena struktury procesów poznania społecznego w schizofrenii na tle grupy porównawczej osób zdrowyc...
This article considers different aspects of the new neuropsychological theory of the social brain and its relationship to Luria's and Vygotsky's understanding of a human as a social and biological unity. The main functions of social cognition are described. Five aspects of these functions and five groups of evidence are analyzed: the negative conse...
Despite rapid development of research on social cognition (SC) impairments in schizophrenia, efforts are still made to generate new, broader theoretical models which include the neural network approach to those dysfunctions. The aim of this study was the evaluation of the structure of SC in patients with schizophrenia in comparison to healthy subje...
The paper considers the history of development and different aspects of the new neuropsychological theory of social brain, its relations with Luria’s and Vygotsky’s understanding of humans as a social and biological unity. Different theoretical models of analyzed. Experimental studies of influence of brain damages
on social cognition and social beh...
Metoda analizy mikrostruktury oscylacyjnej aktywności mózgu N. Daniłowej jako �próba operacjonalizacji współczesnych teorii sieci neuronowych
Paper is devoted to the medical neuropsychology of cardiovascular diseases. Discussed diseases were: cardiac arrest, coronary artery bypass grafting, especially developed was a nature of cognitive problems and their neuroanatomical correlates resulting from hypertension and atherosclerosis. Author described mentioned diseases in terms of mechanism...
In recent times the social dimension of patients with acquired brain dysfunctions functioning has become an important area of interest for neuroscientists and clinical neuropsychologists. Empirical analyses using different methods reveal the role of the right hemisphere in many processes responsible for interpersonal behavior.
The study was design...
At the beginning of presented material author discusses the definition of attachment
and describes the most important assumptions of John Bowlby’s theory, then – he describes
the animal models, next human research and clinical analysis of several forms
of attachment disorders. The aim of the article is to show a modern knowledge about
brain basis o...
Postępy Psychiatrii i Neurologii 2006; 15 (3): 185191 Praca pogl¹dowa Review Zabójstwo jest zachowaniem skrajnie agresywnym. Czyn taki jak zabicie innego cz³owieka jest wydarzeniem wywo³uj¹cym w spo³eczeñstwie silnie negatywne oceny i wyrane poruszenie. Z tych wzglêdów zabójstwo od lat jest zachowaniem poddawanym analizie w ramach wielu dyscyplin...
Questions
Questions (8)
I have preliminary results from a specific subclinical group indicating that predictive coding, general prediction, and implicit learning are disrupted due to the absence of neuronal activity suppression. These are rather theoretical suggestions regarding the results of a study that did not directly address implicit learning, but now I would like to conduct some studies, as it were, "dissecting" some neurophysiological phenomena related to predictive coding in this group. I'll be grateful.
I am interested in studying the mechanisms of inhibition at the neuronal level and, above all, its disorders in psychiatric diseases. Unfortunately, I do not have access to MRI spectroscopy. I will be grateful for specific information regarding glutamate or GABA, based on which the effectiveness of inhibition processes at the neuronal level can be estimated. I will be grateful for your help.
Ich möchte Sie recht herzlich zur Forschungszusammenarbeit im Bereich der Psychiatrie, Neurowissenschaft und Psychologie einladen. Ich bin Leiter der Abteilung für Klinische Neuropsychiatrie an der Medizinischen Universität in Lublin, Polen. Unsere Abteilung spezialisiert sich in der Analyse der Störungen von Erkenungsfunktionen und Organisation der neuronalen Netzen bei den Patienten mit Diagnose der Schizophrenie und affektiven Störungen. Zur Zeit arbeiten wir an den Projekten, die den Einfluss der intensiven biologischen Behandlung (z.B. Elektrokonvulsion-Therapie) auf kognitive Prozesse und Gehirnfunktionieren betreffen. Wir führen auch neurowissenschaftliche Anorexieversuche. Weiterhin wollen wir unsere Forschungsaktivität mit der Nutzung der neurobildlichen Methoden, wie z.B. EEG und fNIRS, Experiment-Erkennungsaufgaben und psychologische Versuche der klinischen Gruppen mit Verwendung der Methodologie von „experience sampling methods” auf Mobiltelefonen kontinuieren. Wir haben den ständigen Kontakt mit den hospitalisierten Patienten in der Universitätsklinik. Wir meinen, dass die Zusammenarbeit mit den Wissenschaftlern und Kliniker aus Deutschland und Osterreich, die Verwirklichung der gemeinsamen Forschungen, deren Richtungen wir gemeinsam festlegen würden, möglich machen könnte. Persönlich glaube ich, dass unsere Zusammenarbeit positive Verhältnisse und den Austausch der Erfahrungen ermöglichen würde. Mein Team spricht gut Englisch und ich lerne Deutsch. Als Liebhaber der deutschen Kultur und Wissenschaft wäre es mir sehr nett, mit den Vertretern der Länder, die den ausgezeichneten Eintrag zur Entwicklung sowohl Psychiatrie als auch Neurowissenschaften haben, zusammenzuarbeiten.
Mit freundlichen Grüßen,
Priv.-Doz. Pawel Krukow
Dear All, We would like to establish a scientific cooperation with someone or a team having experience and computational background enabling calculation of EEG data (64 electrodes) with application of the Wavelet Coherence or other continuous connectivity measure. We have already collected EEG recordings from an experimental group (students), and our research paradigm requires the development of such data processing that will allow to estimate the change in the organization of functional connecity taking place over time.
The EEG recordins are already initially pre-processed with removed artifacts according to well-known reccomendations. We would like to offer a cooperation with participation in publications and conference presentations, we plan to expand such research also with clinical group of psychiatric patients to whom we have constand access.
My team has already several IF publications containing analyses of EEG data, and we have substantial experience with EEG outcomes.
We will be grateful for your response.
I am working on the issue of relationships between brain activity disruptions, measured on the basis of eLoreta, and a specific cognitive deficit in a group of patients with schizophrenia. I know that the correlation analysis between these two sets of data (neurophysiological: currrent source density, lagged connectivity, behavioral: cognitive deficiency indicators) can be done in the eLoreta statistical package, referring to nonparametric randomization and r and t values thresholding, but I don't know how to do it, what are the exact steps of such analysis. I will be very grateful for response.
I am to compare four groups (two clinical and two controls) in the field of nominal variables in the form 0/1. Is there one test or does the only way to use the Chi-square test for separate pairs of groups? Does anyone have an idea to conduct such an analysis in Statistica software?
This is very important in evaluating the dynamics of the information processing using multiple reaction time results.
We intend to conduct research related to the inflammatory theory of the genesis of mental disorders.
