Pawan Maurya

Pawan Maurya
Central University of Haryana · Biochemistry

Doctor of Philosophy

About

127
Publications
39,484
Reads
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2,771
Citations
Citations since 2016
89 Research Items
2298 Citations
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
Introduction
I am a passionate researcher, working on biochemical diagnostics, neuropsychiatric disorders, oxidative stress, and aging. Done PhD from University of Allahabad (A Central University) & Post-Doc from National Taiwan University (NTU), Taipei Medical University (TMU), Taiwan and Universidade Federal de Sao Paulo - UNIFESP, Brazil . Involved in teaching courses of Advanced Biochemistry and Metabolic Regulations.
Additional affiliations
October 2016 - October 2016
Amity University
Position
  • Professor (Assistant)
October 2016 - October 2016
Amity University
Position
  • Professor (Assistant)
May 2011 - March 2012
Taipei Medical University
Position
  • PostDoc Position

Publications

Publications (127)
Article
The disparity in the free radical generation and the production of antioxidants to counteract its effect is known as oxidative stress. Oxidative stress causes damage to the macromolecules such as lipids, carbohydrates, proteins, and DNA and RNA. The oxidative damage to the cellular components leads to a process of aging and various age-associated d...
Chapter
Common metabolic functions in the human body are interrupted by metabolic disorders, which can be hereditary or acquired. The prevalence of metabolic disorders has reached epidemic proportions. Too far, a variety of approaches for preventing and treating metabolic illnesses have been used, including systemic medication therapy and surgery. Current...
Book
The book starts with a brief introduction on cancer and cardiovascular diseases in cancer patients, as well as the changes observed in the cardiovascular system; which serves to provide a deeper understanding of therapeutic approaches targeting cardio-oncology. It then looks into the pathways and inhibitors involved in cancer immunology, as well as...
Article
Full-text available
Polyphenols are the known group of phytochemicals that essentially consists of phenolic rings. These are the plant product present in varied fruits and vegetables. These secondary metabolites perform a protective function in plants from environmental and biological stress. When consumed as a human diet these are also known to prevent various age-as...
Book
Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detect...
Article
The telomere length (TL) has increasingly been used as a biomarker of human aging because it has been shown to predict the chances of survival and longevity. Oxidative stress is presumed to be a major cause of telomere shortening but the importance of oxidative stress as a determinant of telomere shortening remains less clear and has recently been...
Article
The interaction of nanoparticles with the biological system has increased with the increasing popularity of nanomedicines. Red blood cells (RBCs) are very sensitive, and abundant cells in the blood. They are highly prone to oxidative damage due to constant interaction with oxygen itself, foreign particles in the blood, and the lack of repair mechan...
Chapter
Neurodegeneration, the slow and progressive dysfunction and loss of neurons and axons in the central nervous system, is the primary pathological feature of acute and chronic neurodegenerative conditions such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Neurodegenerative diseases affect not only the life quality of the aging population...
Chapter
This chapter has provided an overview of the types, synthesis approaches, functionalization of synthesized nanoparticles (NPs), and their targeted biochemical applications. Nanomaterials are classified on the basis of size (zero, one, two, three dimensional), shapes (NPs, quantum dots, nanosheets, nanoribbons, nanowires, nanorods, fullerenes), and...
Chapter
According to cdc.gov, 655,000 Americans die from heart disease every year, i.e., 1 in every 4 deaths in the United States. Heart disease is one of the leading causes of death around the world. In fact, the heart was considered one of the most important organs for the proper functioning of the human body according to ancient Greeks. Since the ancien...
Chapter
Clinical and preclinical studies in the last dacade have implicated the role of gut microbiome as one of the possible factors for neurological disorders, including neurodegenerative, neuropsychiatric, and brain autoimmune disease. The field is still new and a lot of data has come from preliminary studies conducted on animals. Therefore, more studie...
Article
Increasing interest has recently focused on determining whether quercetin may exert anti-aging properties or not? The objective of this study was determination of Na+, K+ -ATPase activity in quercetin-treated red blood cells during human aging. The study was carried out on human blood samples. The subjects were divided into different age groups, yo...
Article
Metal oxide nanoparticles are known to exhibit unique properties such as catalyzing the neutralization of superoxide anions, hydroxyl radicals, hydrogen peroxides and behave as antioxidant enzymes. Oxidative stress, damage and chronic inflammation are major causes and consequences of aging and age-associated disorders. With the increasing popularit...
Article
Schizophrenia is a severe and multifactorial disorder with an unknown causative pathophysiology. Abnormalities in neurodevelopmental and aging processes have been reported. Relative telomere length (RTL) and DNA methylation age (DMA), well-known biomarkers for estimating biological age, are both commonly altered in patients with schizophrenia compa...
Chapter
Research for novel drug delivery carriers is being explored competitively so that maximum therapeutic impact while minimizing the detrimental effects can be obtained. Despite numerous pharmaceutical advancements in drug formulations, one of the fundamental challenges nevertheless persisting is controlled drug release. Microparticle (MP)-based carri...
Chapter
With the success of recent developments in cancer technologies to optimize the therapeutic properties of new drugs, biologics, and delivery devices, a slow trend in the reduction of their clinical failures has been observed. Since the late 1900s, many drugs have been approved by the European Medicines Association (EMA) and the US Food and Drug Admi...
Article
No one questions the existence of presumptive knowledge of invisible organisms causing disease, decay and destruction mentioned before the discovery of the microbial world by Antonie Van Leeuwenhoek, who was the first to describe the invisible world as per literature available today. However, the knowledge about microbial world by Indian Rishis pre...
Chapter
Mycobacterium tuberculosis (Mtb), the causitive agent of Tuberculosis (TB) is the leading cause of infection. The infection is caused by aerosols and infects the alveolar macrophage. The lungs counteract against the infection by the antioxidant system in response to the oxidative stress (OS) caused. Mycobacterium stimulates the lung macrophage to p...
Chapter
As research in medicine flourishes, so does the life expectancy. The average life expectancy is consistently growing and has come to be 70 years for most adults in the developed and developing countries. However, even as the life expectancy is growing, the lifespan, i.e. the age for healthy living, isn’t growing as much. In diseases such as dementi...
Chapter
Mucoadhesive based pulmonary drug delivery is an advanced novel intervention against several pulmonary diseases including asthma, chronic obstructive pulmonary disease, cystic fibrosis, etc. Mucoadhesive polymers are required to prolong the residence time of the drug to promote drug absorption via mucosa at a controlled rate in order to enhance the...
Article
Regardless of advances in detection and treatment, breast cancer is a major cause of women death and affecting about 1.5 million women all over the world. Since the last decade, genome wide association studies (GWAS) have been extensively conducted for breast cancer to define the role of miRNA as a tool for diagnosis, prognosis and therapeutics. Mi...
Book
This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of th...
Chapter
The human population is aging at an unprecedented rate. Researchers working on aging are trying not only to extend the life span but also to maintain good health. The selection and use of animals in translational research is vital and use of plants and its product is increasing to fight aging.
Chapter
The pulmonary system is a unique drug delivery system as it offers large surface area, thin layer of epithelia, and higher blood supply ensuring quick absorption of therapeutics. The delivery of pulmonary drugs is relatively complex because the respiratory tract has developed defense mechanisms to keep the inhaled drug particles out of the lungs an...
Article
Background Candida species are the important etiologic agents for candidiasis, the most prevalent cause of opportunistic fungal infections. Candida invasion results in mucosal to systemic infections via immune dysfunction and helps in further invasion and proliferation at several sites in the host. The host defence system utilizes a wide array of c...
Article
Full-text available
This study aimed to investigate the effect of gonadotropin-releasing hormone agonist (GnRHa) treatment on the expression of neuritin 1 (NRN1) in women with ovarian endometriosis. We collected tissues and serum from women with endometriosis treated with (n = 45) or without (n = 37) GnRHa. NRN1 mRNA and protein levels were measured using qPCR and Wes...
Chapter
Nanoparticle-based drug system is a powerful technique, which can be customized for targeting and causing a therapeutic effect. Numerous nanoparticle-based drug system has experimented, which includes different types of nanoparticles such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposome (Singh and Lillar...
Book
Nanotechnology in Modern Animal Biotechnology: Concepts and Applications discusses the advancement of nanotechnologies in almost every field, ranging from materials science, to food, forensic, agriculture and life sciences, including biotechnology and medicine. Nanotechnology is already being harnessed to address many of the key problems in animal...
Article
Blood and the linings of blood vessels may be regarded as a fifth tissue type. The human body contains 5 × 10⁹ red blood cells (RBCs) per ml, a total of 2.5 × 10¹³ cells in the 5 l of blood present in the body. With an average lifetime of 125 days, human RBCs are destroyed by leukocytes in the spleen and liver. Nowadays red blood cells are extensiv...
Chapter
Chronic obstructive pulmonary disease (COPD) and asthma are the most common inflammatory respiratory diseases related to an increase in mortality and morbidity. Generally, bronchodilators, ß- agonists, anticholinergics and theophylline used for treatment in these conditions and administered by inhalation for delivery, have localized and systematic...
Article
The design and development of modern biosensors for sensitive and selective detection of various biomarkers is important in diversified arenas including healthcare, environment, and food industries etc. The requirement of more robust and reliant biosensors lead to the development of various sensing modules. The nanomaterials having specific optical...
Chapter
Nanomaterial has been employed as an alternative to antibiotics, diagnostic tools and delivery of therapeutics. In particular, nanomaterial has grabbed the attention of researchers due to their antimicrobial properties due to the emergence of multi-drug resistance of several micro-organisms. The present chapter highlights the antimicrobial nanomate...
Book
The book introduces the basic concepts of nanotechnology and the various technologies to characterize nanomaterials. It also covers the nanostructural features of mammalian cells/tissues and related nanomechanical properties. In addition, the book comprehensively describes the current state-of-the-art and future perspectives of nanotechnology in bi...
Article
Macrophages are considered as the most flexible cells of the hematopoietic system that are distributed in the tissues to act against pathogens and foreign particles. Macrophages are essential in maintaining homeostatic tissue processes, repair and immunity. Also, play important role in cytokine secretion and signal transduction of the infection so...
Article
Chronic obstructive pulmonary disease accounts as the leading cause of mortality worldwide prominently affected by genetic and environmental factors. The disease is characterized by persistent coughing, breathlessness airways inflammation followed by a decrease in forced expiratory volume1 and exacerbations, which affect the quality of life. Determ...
Article
Gold nanoparticles (AuNPs) have found a wide range of biomedical and environmental monitoring applications (viz. drug delivery, diagnostics, biosensing, bio-imaging, theranostics, and hazardous chemical sensing) due to their excellent optoelectronic and enhanced physico-chemical properties. The modulation of these properties is done by functionaliz...
Chapter
A convergent body of evidence suggests an overlap between neural, molecular, and functional findings in patients with severe mental illnesses and normative ageing. Patients in late stages of mood disorders and psychosis present brain changes and cognitive decline consistent with a pattern of accelerated ageing. In addition, replicated but heterogen...
Article
Background: Neurodegenerative diseases are becoming more and more common in today's world. As people are continuously being exposed to exogenous factors like UV radiations, gamma rays, X-Rays, environmental pollutants and heavy metals, the cases of increased oxidative damage are increasing. Even though some amount of oxidative damage occurs in all...
Article
Silver nanoparticles (AgNPs) are amongst the most fascinating nanomaterials which have been extensively synthesized by chemical reduction and biological method using enzymes, microorganisms and plant extracts. In our study, an aqueous extract of green tea was used as a stabilizing and reducing agent for AgNPs synthesis. The synthesized AgNPs were c...
Article
Study objectives: We aimed to determine the association between short telomere length, sleep parameters, and sleep disorders in an adult general population sample. Methods: As part of the EPISONO cohort (São Paulo, Brazil), 925 individuals answered questionnaires, underwent a full-night polysomnography and clinical assessment, and had peripheral...
Article
Oxidative stress is intensely involved in enhancing the severity of various chronic respiratory diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD), infections and lung cancer. Even though there are various existing anti-inflammatory therapies, which are not enough to control the inflammation caused due to various contrib...
Article
The present study was carried out to detect intracellular quercetin uptake by RBCs during human aging. The study was carried out on 95 normal healthy subjects of both the sexes. Intracellular quercetin uptake was estimated by performing ethyl acetate extraction. A significant (p < 0.001) decline in intracellular quercetin uptake by human RBCs was o...
Article
Introduction: Many cell-migration-related molecules are associated with endometriosis. Tensin 1 (TNS1), which has been implicated in cell migration, may play a role in endometriosis. The study goal was to evaluate the TNS1 expression in endometrial tissue and serum from women with endometriosis treated with gonadotropin-releasing hormone agonist (...
Article
Full-text available
Peroxisomes are dynamic organelles essential for optimum functioning of a eukaryotic cell. Biogenesis of these organelles and the diverse functions performed by them have been extensively studied in the past decade. Their ability to perform functions depending on the cell type and growth conditions is unique and remarkable. Oxidation of fatty acids...
Article
A large body of evidence indicates that chronic obstructive pulmonary disorder (COPD) is accompanied by oxidative stress and inflammatory and genetic pathways. Epidemiological studies indicate that COPD is a major cause of mortality and morbidity in the world. Recent research development in COPD focuses on accelerated aging and various oxidative st...
Article
A large body of evidence indicates that chronic obstructive pulmonary disorder (COPD) is accompanied by oxidative stress and inflammatory and genetic pathways.Epidemiological studies indicate that COPD is a major cause of mortality and morbidity in the world. Recent research development in COPD focuses on accelerated aging and various oxidative str...
Article
Peroxisomes are dynamic organelles essential for optimum functioning of a eukaryotic cell. Biogenesis of these organelles and the diverse functions performed by them have been extensively studied in the past decade. Their ability to perform functions depending on the cell type and growth conditions is unique and remarkable. Oxidation of fatty acids...
Article
Introduction Telomeres are specialized sequences at the end of chromosomes that shorten with aging, and whose length is negatively modulated by genotoxic stressors. Considering the importance of sleep in the homeostasis regulation, we aimed to determine the association between mean leukocyte telomere length (LTL) and sleep parameters as well sleep...
Article
Full-text available
Nanostructured materials (NSMs) have increasingly been used as a substitute for antibiotics and additives in various products to impart microbicidal effect. In particular, use of silver nanoparticles (AgNPs) has garnered huge researchers' attention as potent bactericidal agent due to the inherent antimicrobial property of the silver metal. Moreover...
Article
Among various problems faced by mankind, health-related concerns are prevailing since long which are commonly found in the form of infectious diseases and different metabolic disorders. The clinical cure and management of such abnormalities are greatly dependent on the availability of their diagnoses. The conventional diagnostics used for such purp...
Article
Full-text available
Gold nanoparticle (AuNP)-based optical assays are of significant interest since the molecular phenomenon can be examined easily with change in the color of AuNPs. Herein, we report the development of a dipstick using a AuNP-labeled single-chain fragment variable (scFv) antibody for the detection of morphine. The scFv antibodies for morphine were de...
Article
Introduction Oxidative stress has been documented in chronic schizophrenia and in the first episode of psychosis, but there are very little data on oxidative stress prior to the disease onset. Objective This work aimed to compare serum levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in young individuals at ultra-high risk (UH...
Article
Full-text available
Vitamin D is the only secosteroid, a prohormone produced endogenously in dermis under the influence of ultraviolet-B irradiation (UVB 280-315 nm) on bare skin from 7- dehydrocholesterol which is converted into pre-vitamin D3 and then to vitamin D3 (cholecalciferol). The present study has been carried out to investigate the relationship between 25-h...
Book
This book discusses the importance of oxidative stress, related biomarkers, and its diagnostic methods including bio-analytical and advanced detection systems. Oxidative stress is associated with diminished capacity of a biological system to overcome the overproduction of reactive oxygen species. Since oxidative stress has been suggested as a causa...
Article
Full-text available
Content: The increased oxidative stress in chronic obstructive pulmonary disease (COPD) patients is the result of increased inhaled oxidants, generated by various cells of the airways. Objective: The investigation included measurements of malondiadehyde (MDA), uric acid, ascorbic acid, and matrix metalloproteinase-12 (MMP-12) in COPD patient. We al...
Article
Recent research has demonstrated that telomere maintenance might be a key integrating point for the cumulative effect of genetic and environmental factors in patients with first-episode psychosis (FEP) and schizophrenia (SCZ). Eighty-one participants with antipsychotic-naïve FEP, 173 with SCZ and 438 HC were enrolled in this study. Psychiatric diag...
Article
Cancer is one of leading causes of death in the world and occurs in more than two hundred types according to the National Cancer Institute. Its early diagnosis has been remained a prime focus amongst scientists and clinicians since long, not only to understand the complications but also to mitigate its chance of further proliferation. Nowadays, tre...
Article
Full-text available
Objectives The study aims to generate an immunological age (IA) trait on the basis of immune cell differentiation parameters, and to test whether the IA is related to age and disease characteristics. Methods Forty‐four euthymic type I bipolar disorder patients were included in this study. Five immunosenescence‐related parameters were assessed: pro...
Chapter
Translational research facilitates the application of basic scientific discoveries in clinical and community settings to prevent and treat human diseases. The translation of knowledge and innovations from basic laboratory experiments to point-of-care patient applications; production of new drugs, devices, and healthcare products; and promising trea...
Article
Telomere length attrition has been demonstrated in schizophrenia but not in individuals in ultra high risk (UHR) for psychosis. The present study aimed to compare the leukocyte telomere length (TL) between patients at UHR for psychosis and healthy controls (HC). Twenty-two participants with UHR and 88 HC were enrolled in this study. Telomere length...
Article
Full-text available
Major depressive disorder (MDD) and bipolar disorder (BD) are among the leading causes of burden and disability worldwide. Despite intensified research efforts to improve the treatment options and remission rates in mood disorders, no disease modifying treatment exists for these disorders. Accumulating evidence implicates the involvement of the gut...
Conference Paper
The timeline of human civilizations has been demarcated after the name of materials that have been used in abundance in that era such as; iron age, bronze age etc. In addition to the classical materials, there are few other interesting materials which are known for its environmental intelligence and responsiveness, also called as “smart materials”....
Article
Marine sponges, ubiquitously occurring invertebrates, are sources of diverse variety and unique metabolites that indicate their potential in therapeutics and biomedical science. They are the richest sources of pharmacologically active compounds from marine organisms. These bioactive compounds have the potential to become future drugs against import...
Article
Metallic nanoparticles (MNPs) have seen myriad applications in various fields of science and technology. Green chemistry based NP synthesis offers several advantages over conventional approaches. In addition to being inexpensive, the biological approach is a facile, rapid, and environmentally benign method to synthesize NPs. Characterization of NPs...
Article
Full-text available
Homeostasis is a key characteristic of cellular lifespan. Its maintenance influences the rate of aging and age related disorders. Only certain flavonoids have been shown to alter homeostasis of red blood cells in the course of aging. It has been demonstrated that myricetin possesses both antioxidant and pro-oxidant properties. The objective of this...
Article
Full-text available
Aging is associated with an increase in the prevalence of obstructive sleep apnea syndrome (OSAS) as well as the shortening of telomeres. It is known that OSAS-related factors are stimuli that can contribute to the acceleration of cellular senescence. Thus, the present study aimed to compare the leukocyte telomere length (LTL) between OSAS patients...
Chapter
Oxidative stress (OS) is the imbalance between oxidant producing system and antioxidant defense mechanism resulting in an excessive production of reactive oxygen species (ROS) [1]. Under normal physiological conditions aerobic cells use oxygen as terminal electron acceptor in electron transport chain (ETC) in mitochondria. Mitochondria are the grea...
Article
Full-text available
Background Socioeconomic disadvantage (SED) has been consistently associated with early life mental health problems. SED has been shown to impact multiple biological systems, including the regulation of neurotrophic proteins, immune-inflammatory and oxidative stress markers, which, conversely, have been reported to be relevant to physiological and...
Article
Evolution-optimized specimens from nature with inimitable properties, and unique structure– function relationships have long served as a source of inspiration for researchers all over the world. For instance, the micro/nanostructured patterns of lotus-leaf and gecko feet helps in self-cleaning, and adhesion, respectively. Such unique properties sho...
Article
Background: Early life stress (ELS) and addiction are related to age-related diseases and telomere shortening. However, the role of telomere length (TL) in crack cocaine addiction remains unknown. The purpose of this study was to investigate the TL in a sample of crack cocaine dependent-women who reported an ELS history and in a community-based sa...
Article
Quercetin and myricetin are important dietary flavonoids with potential health benefits and interfere with reactive oxygen species metabolism. The objective of this study was multi-target spectroscopic analysis of oxidative stress biomarkers (malondialdehyde (MDA), glutathione (GSH) and sulfhydryl (-SH) groups) in quercetin and myricetin treated re...
Article
Context: Oxidative stress plays a key role in the patho-physiology of hypertension. (-)- epicatechin have many important biological properties. Objective: The present study was undertaken to evaluate effect of (-) - epicatechin on protein carbonyl content in gender based hypertensive patients and normal subjects. Methods: The study was carried...
Article
Content: Quercetin uptake by erythrocytes is rapid. The sodium hydrogen exchanger (NHE) is a secondary active transporter, regulating intracellular pH, Na(+) concentration, and cell volume. Objective: The aim of present study was to investigate NHE as a function of human age and effect of quercetin on its activity. The NHE activity was correlate...