Pavlo Hrab

Pavlo Hrab
Ivan Franko National University of Lviv | ivan franko · Department of Genetics and Biotechnology

Master of Science

About

12
Publications
1,106
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
2
Citations
Additional affiliations
May 2020 - present
Ivan Franko National University of Lviv
Position
  • Technician
Education
September 2019 - December 2020
September 2015 - June 2019

Publications

Publications (12)
Article
Streptomyces cyanogenus S136 is the only known producer of landomycin A (LaA), one of the founding members of angucycline family of aromatic polyketides. LaA displays potent anticancer activities which has made this natural product a target of numerous chemical and cell biological studies. Little is known about the potential of S136 strain to produ...
Conference Paper
Full-text available
Background: 16S rRNA remains the most widely used method for fast classification of Bacteria. However, bacterial genomes often carry several non-identical rRNA operons. The extent to which this variability persists in the chosen group and approaches to assess the former remain largely unaddressed. We created rRNADif, which computes ML phylogenetic...
Conference Paper
Full-text available
Introduction. Health care-associated infections (HAIs), it`s one of global health care system problem. According to WHO, approximately 15.0% of all hospitalized patients have HAIs. HAIs control and study of causative pathogens are the main tools against HAIs. Genus Raoultella was separated from Klebsiella in 2001. Bacteria from genus Raoultella...
Poster
Full-text available
Antismash is the most popular tool for biosynthetic gene cluster (BGC) annotation. However, the other tools exist offering alternative means for BGC mining. These tools are not integrated with the Antismash, still providing a space for novel BGC discovery. Here we present BGCViz app which summarizes and visualizes BGC coordinates retrieved by DeepB...
Preprint
Full-text available
The age-related mortality and morbidity risk of COVID-19 has been considered speculative without enough scientific evidence.This study aimed to collect more evidence on the association between patient age and risk of severe disease state and/or mortality from SARS-CoV-2 infection.Genomic dataset along with metadata (3608 samples) retrieved from GIS...
Poster
Full-text available
Intro: Genus Streptomyces is notable for the production of antimicrobial substances. A large part of their genomes is allocated to different secondary metabolism biosynthetic gene clusters (BGCs). The discovery of new BGCs relies on the comparison to the already known ones, often with a reference to a species tree. To build the latter the 16S rRNA...
Conference Paper
Full-text available
This research aimed to study the antimicrobial activity of 22 gel hand sanitizers, which are available in Ukraine and European Union chain stores, against multi-drug resistant clinical strains of infective agents (Gram-positive, Gram-negative, and fungi). The results have shown that only 5 of them (22.7 %) are truly active, 12 (54.5 %) are showing...
Conference Paper
Full-text available
We have analyzed the pleiotropic regulator adpAin context of paralogy in order to perform optimal visual representation of evolution of this group of genes. Starting from model species, S.coelicolorM145, we defined adpAparalogous groups in a number of streptomycetes, calculated several relevant codon indices and attempted to visualize evolutionary...
Conference Paper
Full-text available
Streptomyces cyanogenus S136 attracts attention due to rich secondary metabolism and aberrant morphogenesis. LC-MS analysis of S136 showed the production of novel compounds. Sets of genes for small morphogenetic proteins, chaplins and rodlins, are reduced in S136. We revealed rather diverse pattern of their location and abundance in Streptomyces cl...
Conference Paper
Full-text available
AdpA is a regulatory protein of the AraC/XylS type which was first identified in 1993 as an activator of streptomycin production by Streptomyces griseus. Today streptomycete genomes are known to invariably harbor gene adpA, which is important for processes as diverse as replication and transcriptional control of genes for morphogenesis, antibiotic...

Network

Cited By