Pavel Žvátora

Pavel Žvátora
Zentiva · Formulation Department

PhD

About

24
Publications
4,620
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329
Citations
Citations since 2016
7 Research Items
245 Citations
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040

Publications

Publications (24)
Article
The present study investigates the physicochemical properties and stability of a novel lipid-based formulation—surfactant-enriched oil marbles containing abiraterone acetate. While the biopharmaceutical performance of this formulation has been reported recently, this study aims to fill the gap between a promising in vivo performance and industrial...
Article
Abiraterone acetate has limited bioavailability in the fasted state and exhibits a strong positive food effect. We present a novel formulation concept based on the so-called oil marbles (OMs) and show by in vitro and in vivo experiments that the food effect can be suppressed. OMs are spherical particles with a core-shell structure, formed by coatin...
Article
Abiraterone acetate is a potent drug used for the treatment of metastatic castration resistant prostate cancer. However, currently marketed product containing crystalline abiraterone acetate exhibits strong positive food effect which results in strict dosing regimen. In the present work, a rational approach towards design of novel abiraterone aceta...
Article
Full-text available
In this paper, we present a comprehensive crystallographic study of Ibrutinib polymorphs and their behavior. Three neat polymorphs (A, B and C) and a methanol solvate (F) were obtained and characterized. The structures of forms A, C and F were solved from single-crystal diffraction data. Form B has only ever been prepared as powder and its structur...
Article
A search for new solid forms of an active pharmaceutical ingredient (API) is an integral part of the drug product development process. The studied compound, Ibrutinib, is a recently approved anticancer drug. The main aim of this study was to search for new solvates of Ibrutinib and to perform their structural characterization. To do so, we performe...
Article
Full-text available
Introduction Magnetic nanoparticles (NPs) represent a tool for use in magnetic resonance imaging (MRI)-guided thermoablation of tumors using an external high-frequency (HF) magnetic field. To avoid local overheating, perovskite NPs with a lower Curie temperature (Tc) were proposed for use in thermotherapy. However, deposited power decreases when ap...
Article
Nanomaterials are currently the subject of intense research due to their wide variety of potential applications in the biomedical, optical and electronic fields. We prepared and tested cobalt zinc ferrite nanoparticles (Co0.5Zn0.5Fe2O4+γ [CZF-NPs]) encapsulated by amorphous silica in order to find a safe contrast agent and magnetic label for tracki...
Article
Full-text available
Single phase La1-xSrxMnO3 nanoparticles (x = 0.18 - 0.37) are prepared by a novel way in molten NaNO2 at 500 °C. Their rhombohedral perovskite structure is confirmed by XRD patterns and exact chemical composition is determined by XRF (X-ray fluorescence) spectroscopy. The mean size of the as-prepared crystallites is of about 50 nm, the grains are r...
Article
We propose a concept for the analytical application of gold nanoparticles modified by mercaptophenylboronic acid as a receptor of saccharides in a potentiometric sensor based on a conducting polymer.
Article
Herein we present a supramolecular non-covalent approach for the modification of gold nanoparticles (GNPs) and silver nanoparticles (SNPs) with porphyrin derivatives. The immobilization of porphyrin derivatives was carried out by two different procedures of ionic interaction. The first one was direct immobilization of the conjugate on nanoparticles...
Article
Full-text available
In this work, a simple method for alcohol synthesis with high enantiomeric purity was proposed. For this, colloidal gold and silver surface modifications with 3-mercaptopropanoic acid and cysteamine were used to generate carboxyl and amine functionalized gold and silver nanoparticles of 15 and 45 nm, respectively. Alcohol dehydrogenase from Thermoa...
Data
Title: Characterization of silver and gold nanoparticles. Description: UV–vis and TEM images of Ag-citr and Au-citr-stabilized nanoparticles [50].
Data
Full-text available
RP- and chiral HPLC analyses. Description: RP- and chiral HPLC conditions for the separation of 7-hydroxy-2-tetralone and7-hydroxy-2-tetralol.
Article
Porphyrins represent an interesting family of compounds with a broad field of applications. From all of them, we have focused on those based on their strong interaction with light. High molar absorptivity and high quantum yield of fluorescence due to their unique electronic structure based on a cyclic array of adjacent π orbitals are precursors for...
Article
In this study, bare gold nanoparticles (GNPs) immobilized in the sol-gel-pretreated fused-silica (FS) capillary as a stationary phase for open-tubular capillary electrochromatography (OT-CEC) are for the first time shown to be able to separate both hydrophobic polyaromatic hydrocarbons (PAHs) as well as hydrophilic cationic antimicrobial peptides....
Article
Full-text available
In this study, spherical gold nanoparticles (GNPs) of 14.7 nm diameter, prepared by citrate reduction of a gold(III) salt and characterized by UV–Vis absorption spectrometry and transmission electron microscopy, were modified by a covalent attachment of 6I-O-(3-mercaptopropyl)β-cyclodextrin (β-CD-SH) or per-6-deoxy-per-6-mercapto-β-cyclodextrin (β-...
Article
Full-text available
This study deals with preparation of substrates suitable for surface-enhanced Raman spectroscopy (SERS) applications by sputtering deposition of gold layer on the polytetrafluorethylene (PTFE) foil. Time of sputtering was investigated with respect to the surface properties. The ability of PTFE-Au substrates to enhance Raman signals was investigated...
Article
Better detection limits for some analytes can be obtained by using an appropriate detection method combined with surface immobilization of the receptor. To immobilize analytically important receptors on the nanoparticle surface is often impossible because the receptors do not contain suitable functional groups. In this case various multifunctional...

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