Pavel Drastich

Pavel Drastich
Institute for Clinical and Experimental Medicine (IKEM) | IKEM · Departement of Hepatogastroenterology

About

125
Publications
10,378
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2,570
Citations
Citations since 2016
48 Research Items
1430 Citations
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
Introduction
Skills and Expertise

Publications

Publications (125)
Article
Background: Inflammatory bowel disease (IBD) is mostly diagnosed in young women of fertile age, and a significant number of patients become pregnant while they have the disease. The remission of the illness, which is often achieved by intensive anti inflammatory treatment, has been found to be the most important factor of a successful pregnancy. Ve...
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Inflammatory bowel diseases (IBD) are chronic disorders of the gastrointestinal tract that have been linked to microbiome dysbiosis and immune system dysregulation. We investigated the longitudinal effect of anti-TNF therapy on gut microbiota composition and specific immune response to commensals in IBD patients. The study included 52 patients trac...
Article
Background: Vedolizumab demonstrated different placental pharmacokinetics than other immunoglobulin G1 antibodies, leading to lower drug levels in cord blood in contrast to maternal blood at the time of delivery. The placental transfer of ustekinumab seems to have a pattern similar to anti-tumour necrosis factor agents. Current evidence on the pla...
Article
Obesity is a serious global problem. Obesity is associated with a number of serious diseases that reduce the patient‘s quality of life and increase mortality (high blood pressure, dyslipidemia, type 2 diabetes mellitus, cancer and others). The treatment of obesity is a multidisciplinary and complex process that requires the cooperation of the patie...
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Background and aims: Ulcerative colitis (UC) is a chronic inflammatory disease. Fecal microbial transplantation (FMT) is a promising alternative treatment. Methods: This multicenter, open-label, noninferiority trial randomized patients with active left-sided UC (Mayo score 4-10) equally to FMT or 5-aminosalicylic acid (5-ASA) enemas. FMT enemas...
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Ulcerative colitis (UC) is an inflammatory bowel disease, and intestinal bacteria are implicated in the pathogenesis of this disorder. The administration of aminosalicylates (5-ASA) is a conventional treatment that targets the mucosa, while fecal microbial transplantation (FMT) is a novel treatment that directly targets the gut microbiota. The aim...
Article
Vedolizumab (VDZ) is a gut-selective anti-integrin monoclonal antibody indicated for the treatment of patients with moderate and severe Crohn's disease, who have failed conventional or anti-tumour necrosis factor a therapies. The main objectives in Crohn's disease are to avoid disease complications and preserve the patient's quality of life. Clinic...
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Backround: Capsule colonoscopy might present an alternative to colonoscopy for colorectal neoplasia screening. Aim: To assess the accuracy of second-generation capsule colonoscopy (CCE2) for colorectal neoplasia detection compared with conventional colonoscopy (CC). Methods: From 2011-2015, we performed a multicenter, prospective, cross-over s...
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Crohn’s disease (CD), ulcerative colitis (UC) and inflammatory bowel disease (IBD) associated with primary sclerosing cholangitis (PSC-IBD), share three major pathogenetic mechanisms of inflammatory bowel disease (IBD)-gut dysbiosis, gut barrier failure and immune system dysregulation. While clinical differences among them are well known, the under...
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Aim: To evaluate risk factors for primary sclerosing cholangitis (PSC) recurrence (rPSC) after orthotopic liver transplantation (OLT) in patients with well-preserved colons. Methods: We retrospectively evaluated the medical records of all patients transplanted for PSC in our center between July 1994 and May 2015 and selected 47 with follow-up of...
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Background: The role of budesonide-MMX (Cortiment®) in the induction of remission in mild to moderate active ulcerative colitis (UC) is already well established; however, data on maintenance treatment are limited. Aim: To assess the efficacy and safety of this medication as a long-term maintenance treatment. Methods: Forty patients, corresponding t...
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Human gut microbiota, complex ecosystem of microbes associated with human gut, is essential for the development of the host's immune system and many other physiological functions. Recently, numerous diseases and syndromes were associated with disruption of this ecosystem thus stressing its importance in maintaining the host's health. Growing eviden...
Article
Primary sclerosing cholangitis (PSC) is a progressive disease of the biliary tree which represents one of the most frequent indications for orthotopic liver transplantation (OLTx) in developed countries. LTx is currently the only curative procedure for PSC. Concomitant inflammatory bowel disease (IBD) is present in approximately 70 % of patients wi...
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Introduction: Endoscopic full-thickness resection (FTR) is a novel endoscopic technique that allows transmural resection of the colonic wall. Limited data suggest that FTR is efficacious and safe for the management of local residual neoplasia (LRN). Standard endoscopic treatment of LRN is usually complicated by scarring and non-lifting sign caused...
Article
Introduction: The global increase in obesity incidence results in an increase of type 2 diabetes mellitus (T2DM). Surgical treatment has proven to be effective, however it carries a high risk of complications. The duodenal-jejunal bypass liner (EndoBarrier®, GI Dynamics, EB) is an endoscopic implant that mimics the intestinal bypass portion of the...
Article
Background Treatment of active ulcerative colitis (UC) after orthotopic liver transplantation (OLTx) for primary sclerosing cholangitis (PSC) remains to be challenging. Anti-tumour necrosis factor alfa agents (anti-TNF) and vedolizumab are mainly used for treatment of refractory patients. Available data are limited and adverse events, mainly infect...
Article
Background: Endosonography (EUS)-guided drainage is a commonly used method for the treatment of symptomatic pancreatic fluid collections, such as pancreatic pseudocyst (PC) and walled-off pancreatic necrosis (WOPN). Data on efficiency and complication rates are heterogenous. Patients and Methods: We conducted a retrospective study of all patients w...
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We report a case of a 66-year-old female without substantial internal comorbidities. In September, 2010, she was treated for 3 weeks with amoxicillin at a dose of 1,000 mg daily for suspected Lyme disease (erythema migrans). Before the end of antibiotic treatment, the patient presented with jaundice and was diagnosed with advanced liver cirrhosis,...
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AIM To characterize the gut bacterial microbiota of patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). METHODS Stool samples were collected and relevant clinical data obtained from 106 study participants, 43 PSC patients with (n = 32) or without (n = 11) concomitant inflammatory bowel disease, 32 UC patients, and 31 he...
Article
Background: Most patients with Crohn's disease (CD) require one or more operations during their lifetime. Repeated resections and surgical complications may result in short gut in a subset of patients, typically those with extensive small bowel disease or a penetrating CD phenotype. The effects of short bowel syndrome (SBS) can range in seriousnes...
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Background: Primary sclerosing cholangitis (PSC) is a chronic liver disorder of unknown etiology, characterized by inflammation, fibrosis and stenoses of both extra- and intrahepatic bile ducts. For those who develop end – stage liver disease, orthotopic liver transplantation (OLT) remains the only effective treatment currently available. PSC is ac...
Article
Methods: prior to launch of the clinical program, preparation started in 2006 initially with extensive experimentation carried out on pigs. The clinical phase involved a specialized, multidisciplinary team who examined 23 patients being considered for transplantation. Seven patients were put on a waiting list and one female, due to the improvement...
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Background: Budesonide MMX (Cortiment® 9 mg) is a novel local-acting glucocorticoid for the treatment of mild-to-moderate active ulcerative colitis (UC). Aim: To assess the efficacy and safety of this treatment in UC patients. Methods: In 81 patients (ten centers in the Czech Republic were involved) with mild-to-moderate UC, treatment with Cortimen...
Article
Background: The global increase in the incidence of obesity results in an increase in the incidence of type 2 diabetes mellitus (T2DM). Surgical treatment has proven to be effective; however, it carries a high risk of complications. The duodenal-jejunal bypass liner (DJBL) EndoBarrier® (GI Dynamics). is an endoscopic implant that mimics the intesti...
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Full-text available
Ulcerative colitis is primarily treated conservatively. Surgical treatment consists of the removal of the large bowel with or without restoration of intestinal continuity. The third part of the recommendations for surgical treatment of patients with inflammatory bowel diseases addresses the indications for acute and elective surgery. The recommenda...
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Objective: The infliximab biosimilar CT-P13 (Remsima®, Inflectra®) was approved in Europe for the treatment of inflammatory bowel disease (IBD) based on extrapolation of data from patients with rheumatic disease. Because there are limited published reports on clinical outcomes for IBD patients treated with CT-P13, we monitored responses to inductio...
Article
The etiopathogenesis of inflammatory bowel disease (IBD) is not yet fully understood. One theory proposes that IBD onset is an overreaction of the gut immune system to some parts of the gut microbiome. Thus, one therapeutic approach is to employ a faecal microbiota transplant (FMT) to change the composition of the gut microbiome. FMT involves trans...
Article
Authors describe a case report of 70 years old female patient with autoimmune disease affecting skin, gastrointestinal, and musculoskeletal systems and present here a variable organ involvement that may occur in patients with spondyloarthropathies. Initially, our patient presented only with mild psoriatic skin lesions. Afterwards, arthritis of wris...
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Surgical treatment of Crohn's disease is a part of care of patients primary treated by gastroenterologist. Understanding of surgical principles and indications to surgery improves the quality of care. Therefore, members of IBD Working group of Czech Society of Gastroenterology and Section of IBD Surgery of Czech Surgical Society created guidelines...
Article
Inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD) can be understood as a unique phenotype of IBD due to its specific characteristics. The highest prevalence can be found in north European and American countries which also have the highest prevalence of PSC. Both IBD and PSC are multifactorial diseases, in the devel...
Article
Small intestinal dysplastic lesions are rare and difficult to detect before they progress to cancer. New investigative modalities, such as capsule endoscopy and doubleballoon enteroscopy, are very promising in search for premalignant lesions. Screening patients at high-risk for small bowel neoplasia is the only sensible approach. Duodenal adenoma r...
Article
Malignant gastric outlet obstruction is often treated by stent placement. To investigate the outcomes of stent placement in the palliative treatment of malignant neoplasms. Prospective, observational, multicenter registry. Six tertiary care centers in 5 countries. A total of 108 adult patients with malignant gastric outlet obstruction. Placement of...
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The national colorectal cancer screening program has been running in the Czech Republic (CR) since 2000. It is based on an examination by faecal occult blood test (FOBT) and colonoscopy. In 2012 the target population coverage reached the level of 25.8%. The European guidelines set the acceptable participation rate to at least 45%, and the recommend...
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Aim: To evaluate the expression of epithelial markers of colorectal carcinogenesis in patients with long-term ulcerative colitis (UC) and primary sclerosing cholangitis (PSC) before and after transplantation. Methods: Eight patients with UC and PSC prior to liver transplantation (PSC-UC), 22 patients with UC after liver transplantation for PSC (...
Article
Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic liver disease of unknown origin. PSC is closely associated with inflammatory bowel disease, mainly ulcerative colitis (UC). PSC presents a significantly increased risk of hepatobiliary and colorectal neoplastic changes. PSC gradually leads to cirrhosis with a significant por...
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Full-text available
One thousand orthotopic liver transplantations (LTx) were performed in the Transplant Centre of the Institute of Clinical and Experimental Medicine in Prague in 950 transplant recipients, 559 men and 391 females, aged 0.4-74 years during the period between April 2, 1995 and August 13, 2013. At the beginning of the programme, the average age of the...
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To study the coincidence of celiac disease, we tested its serological markers in patients with various liver diseases. Large-scale screening of serum antibodies against tissue transglutaminase (tTG), and deamidated gliadin using enzyme-linked immunosorbent assay and serum antibodies against endomysium using immunohistochemistry, in patients with va...