Pavel Chernyshov

• MD, PhD
• Professor (Associate) at Bogomolets National Medical University

In this paper, the European Academy of Dermatology and Venereology (EADV) Task Force on Quality of Life (QoL) and Patient‐Oriented Outcomes presents its position statements on health‐related (HR) QoL assessment in epidermolysis bullosa (EB). The EADV TF on QoL and Patient‐Oriented Outcomes recommends the use of the EB‐specific instrument QOLEB in p...

Backgorund: This study aimed to explore the relationship between different types of skin cancer and factors such as sun exposure and photoprotection measures in a Greek cohort on the island of Crete. Methods: This cross-sectional observational study was conducted in the Dermatology Department of the University Hospital in Heraklion, Crete, between...

Introduction: The goal of the present study was to develop a short version (SV) of the Quality of Life Relevance-Acne (QOLRELEVANCE-ACNE) based on the identified most relevant items for acne patients. Methods: Members of the international internet group for acne patients were asked to fill in the short prototype version of the QOLRELEVANCE-ACNE....

Background Dermatological research has traditionally concentrated on evaluating mental comorbidities, neglecting positive concepts like happiness. Initial studies indicate that psoriasis and atopic dermatitis (AD) impair the happiness of those affected. Considering global happiness variations, this study aimed to explore the disease‐ and country‐sp...

For assessing health‐related quality of life in patients with chronic wounds, the Wound‐QoL questionnaire has been developed. Two different versions exist: the Wound‐QoL‐17 and the Wound‐QoL‐14. For international and cross‐cultural comparisons, it is necessary to demonstrate psychometric properties in an international study. Therefore, the aim of t...

In this study, the European Academy of Dermatology and Venereology (EADV) Task Forces on Quality of Life and Patient-Oriented Outcomes and Urticaria and Angioedema has examined the Health-Related Quality of Life (HRQoL) measurement in the treatment of urticaria. The Dermatology Life Quality Index was the most frequently used HRQoL instrument in cli...

The European Academy of Dermatology and Venereology (EADV) Task Forces on quality of life (QoL) and patient-oriented outcomes and on urticaria and angioedema recommendations for the assessment of Health-related (HR) QoL in all patients with urticaria in research and practice are as follows: to use the DLQI for adults and the CDLQI for children as d...

Background The complexity, high prevalence, and substantial personal and socioeconomic burden collectively render atopic dermatitis (AD) a major public health concern. Using crowdsourced Internet data has the potential to provide unique insights into this concern, as demonstrated by several previous studies. However, a comprehensive comparison acro...

Background Participating members of the European Academy of Dermatology and Venereology Task Forces on quality of life (QoL) and Patient Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa initiated data collection in 9 European countries and formed the list of the most relevant topics for acne patients. Objective The aim of this stud...

Background There are few studies on bullying in skin diseases. Persons with skin diseases are especially prone to bullying. Objectives This component of the project ‘Bullying among Dermatologic Patients’ aimed to study the prevalence and nature of bullying in patients with skin diseases from different countries and age groups. Methods Data were c...

The Wound‐QoL assesses the impact of chronic wounds on patients' health‐related quality of life (HRQoL). A 17‐item and a shortened 14‐item version are available. The Wound‐QoL‐17 has been validated for multiple languages. For the Wound‐QoL‐14, psychometric properties beyond internal consistency were lacking. We aimed to validate both Wound‐QoL vers...

Many events, including the COVID‐19 pandemic, have accelerated the implementation of teledermatology pathways within dermatology departments and across healthcare organizations. Quality of Life (QoL) assessment in dermatology is also a rapidly developing field with a gradual shift from theory to practice. The purpose of this paper organized jointly...

The Infants and Toddlers Dermatology Quality of Life (InToDermQoL) is the dermatology-specific proxy health-related quality of life (HRQoL) instrument for children from birth to 4 years. The aim of the present study was to confirm the responsiveness and establish minimal clinically important difference (MCID) for the InToDermQoL. Parents of childre...

Background: Asthma is a chronic inflammatory disorder of the airways and one of the most important non-communicable diseases worldwide. Analyzing crowdsourced data can help understand public interest and unmet needs as well as potential factors influencing search behavior. Objective: The study aimed to investigate asthma-related web search data...

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Pruritus (or itch) is an unpleasant sensation leading to a desire to scratch. In the epidermis, are selective C or Aδ epidermal nerve endings which are pruriceptors. At their other ends, peripheral neurons form synapses with spinal neurons and interneurons. Many areas in the central nervous system are involved in itch processing. Although itch does...

The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient-Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa (ARHS) do not recommend the use of any generic instrument as a single method of Health Related (HR) QoL assessment in rosacea, except when comparing quimp (quality of life...

Background: Health-related quality of life (HRQoL) assessment in patients with acne is recommended by several national guidelines. There are several acne-specific HRQoL instruments. Objectives: Participants of the European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on QoL and Patient Oriented Outcomes (PO) and Acne, Rosacea,...

The US Food and Drug Administration approved a supplemental application for HPV 9-valent vaccine for 27-45-year-old women and men. The Advisory Committee on Immunization Practices did not recommend catch-up vaccination of adults aged 27-45 years, but recognized that some adults who were not previously vaccinated may be at risk for new HPV infection...

Background The Infants and Toddlers Dermatology Quality of Life (InToDermQoL) is the first dermatology-specific proxy health related quality of life (HRQoL) instrument for children from birth to 4 years. Score meaning bands and the sensitivity to successful therapeutic intervention are important to interpret the clinical meaning of an instrument....

Members of the European Academy of Dermatology and Venereology (EADV) Task Force on Quality of Life (QoL) and Patient Oriented Outcomes reviewed the instruments available for health-related (HR) QoL assessment in vitiligo and together with external vitiligo experts (including representatives of the EADV Vitiligo Task Force) have made practical reco...

Background Atopic dermatitis (AD) is a chronic inflammatory skin condition that has a major impact on the quality of life of patients and their families. Therapeutic patient education (TPE) is recommended for all patients with this condition to improve disease management, adherence to therapy, and quality of life. Nurse‐led consultation, when perfo...

Background: Eczema is a common skin condition. Although topical corticosteroids have been a first-line treatment for eczema for decades, there are uncertainties over their optimal use. Objectives: To establish the effectiveness and safety of different ways of using topical corticosteroids for treating eczema. Search methods: We searched databa...

Core outcome sets (COSs) are an agreed standardized collection of outcomes that should be measured and reported in all clinical trials for a specific clinical condition. Tsekhe aim of our position paper by the European Academy of Dermatology and Venereology (EADV) Task Force on Quality of Life and Patient Oriented Outcomes was to identify the chall...

Introduction: Different aspects of quality of life (QoL) of infants and children with atopic dermatitis (AD) are well studied but there is a lack of studies on seborrhoeic dermatitis (SD) and allergic contact dermatitis (ACD). The aim of this study was to compare the impact of SD, ACD and AD on young children. Parts of questionnaires were filled i...

In chronic skin diseases such as atopic dermatitis (AD), therapeutic failure due to poor patient adherence to treatment is commonly reported. Therapeutic patient education (TPE) is an approach to improve self-management and adherence. Several studies demonstrated that TPE programmes have positive effects on disease management resulting in decreased...

Linked article: C. Kursawe Larsen et al. J Eur Acad Dermatol Venereol 2021; 35: 1577–1581. https://doi.org/10.1111/jdv.17148.

Knowledge on hidradenitis suppurativa/acne inversa (HS) is rapidly increasing. HS has a profound impact on patients and their family life. Several factors, such as comorbidities, unemployment and HS severity, make this impact even more severe. The most widely used instrument to measure this impact is the dermatology-specific DLQI. We also identifie...

New treatment options may lead to an increased interest in using reliable and sensitive instruments to assess health‐related quality of life in people with alopecia areata (AA). The purpose of this paper is to present current knowledge about quality of life assessment in AA. The dermatology‐specific Dermatology Life Quality Index (DLQI) was the mos...

Since the introduction of active vaccination against SARS‐CoV‐2 infection, there has been a debate about the risk of developing severe allergic or anaphylactic reactions among individuals with a history of allergy. Indeed, rare cases of severe allergic reactions have been reported in the United Kingdom and North America. By february 2021 a rate of...

The coronavirus disease 2019 (COVID-19) pandemic is caused by rapid spread of different strains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severity of infection ranges from mild, or even asymptomatic, to very severe. Signs and symptoms include fatigue, fever, exanthemas, upper respiratory illness, loss of smell and tas...

Abstract Frequency of hand disinfection and adverse skin reactions among health care workers dramatically increased since the COVID-19 outbreak and consensus recommendations on hand hygiene were presented. The aim of the present study was to check the efficacy of the European Academy of Dermatology and Venereology (EADV) Task Force (TF) on Contact...

Atopic dermatitis (AD) is a disease that can have a high impact on quality of life, especially due to itch and skin pain. This paper utilizes expertise from members of the International Society of Atopic Dermatitis (ISAD)/Oriented Patient‐Education Network in Dermatology (OPENED) task force to review the epidemiology, pathophysiology and exacerbati...

The pharmaceutical approach to skin disease has been hugely successful, but despite effective drugs being available and used, there are still vast numbers of people who continue to have some level of persisting skin disease and continue to experience quality of life (QoL) impairment. So the question that needs to be answered, while we await further...

Children with epidermolysis bullosa (EB) experienced the highest quality of life impact among several skin conditions and have problems which had not been reported by parents of children with other skin diseases. The EB‐specific module of the Infants and Toddlers Dermatology Quality of Life (InToDermQoL) questionnaire was recently developed to meas...

We were interested to read the paper by Gabes et al.1 about the results of the group discussions during the meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative. We are happy that content validity of the most widely used and comprehensive atopic dermatitis (AD) specific proxy quality of life (QoL) questionnaire the IDQoL and der...

Background Although most European countries experienced a decrease in cervical cancer mortality, Ukraine, Latvia and Belarus have experienced an increase in mortality. There is no national vaccination programme against human papilloma virus (HPV) in Ukraine and vaccination rates are low. Objectives To study the knowledge of HPV‐related cancers and...

The European Academy of Dermatology and Venereology (EADV) has started the ‘Healthy Skin @ Work’ campaign aimed to raise awareness among the public and EU authorities on the frequency and impact of occupational skin diseases (OSDs). The EADV Task Forces (TFs) on Quality of Life and Patient Oriented Outcomes (QoL/PO) and on OSD present their mutual...

Risky behavior in students is not infrequent. The prevalence of HIV in Ukraine is one of the highest in Europe. The aim of this study was to investigate risk factors of HIV transmission and prevalence of HIV testing in medical students from Ukraine. Medical students were invited to answer questions concerning individual risk factors of HIV transmis...

Letters to the Editor should not have an abstract nor acknowledgements, should be formatted in one continuous section (no subheadings) and should not exceed 600 words, 10 references and a total of 2 figures; or 2 tables; or 1 figure and 1 table. No supplementary material (figure, table or text) is allowed when submitting a Letter to the Editor. All...

The pandemic of COVID‐19 is a global challenge for health care and dermatologists are not standing apart from trying to meet this challenge. The European Academy of Dermatology and Venereology (EADV) has collected recommendations from its Task Forces (TFs) related to COVID‐19. The Journal of the EADV has established a COVID‐19 Special Forum giving...

Atopic dermatitis (AD) is a complex disease with elevated risk of respiratory comorbidities.1,2 Severely affected patients are often treated with immune‐modulating systemic drugs.3,4 On March 11th 2020, the World Health Organization declared the 2019 novel coronavirus severe acute respiratory syndrome (SARS‐Cov‐2) epidemic to be a pandemic. The num...

Die Entwicklung des Dermatology Life Quality Index (DLQI) Fragebogens erleichterte die Durchführung zahlreicher Studien zu den Auswirkungen von Hautkrankheiten auf die Lebensqualität (quality of life, QoL) der Patienten. Viele nationale und internationale Leitlinien empfehlen die Erfassung der Lebensqualität in der Dermatologie und einige enthalten...

The Infants and Toddlers Dermatology Quality of Life (InToDermQoL) – the first dermatology‐specific proxy health‐related quality of life (HRQoL) instrument for 0–4 years old children – showed that children with epidermolysis bullosa (EB) have the highest impact and disease specific problems that were not mentioned by parents of children with other...

Atopic dermatitis (AD) is a common inflammatory skin disease that affects both children and adults, including a large number of adults of reproductive age. Several guidelines for the treatment of AD exist, yet specific recommendations for the treatment of pregnant or lactating women and for adults planning to have a child are often lacking. This po...

p>This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To establish the effectiveness and safety of different ways of using topical corticosteroids in people with eczema.</p

Introduction: The human papillomavirus (HPV) vaccination has not yet been integrated into the national immunization program in Ukraine, and the vaccination rate is low. The objectives of our study were to investigate HPV vaccination prevalence and knowledge, risk of HPV transmission, and HPV-related cervical cancer awareness in female medical stud...

Acne patients may have significant quality-of-life (QoL) impairment, therefore assessment of health-related QoL (HRQoL) in acne patients is recommended by several national and international guidelines as an integral part of acne management. The inclusion of QoL assessment in core outcome sets is now a popular idea. Several acne-specific QoL questio...

The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient Oriented Outcomes, Melanoma and Non‐Melanoma Skin Cancer (NMSC) present a review of the literature and position statement on health‐related (HR) QoL assessment in skin cancer patients. A literature search was carried out to identify pub...

This paper is organized jointly by the European Academy of Dermatology and Venereology (EADV) Task Force (TF) on Quality of Life (QoL) and Patient‐Oriented Outcomes and the EADV TF on acne, rosacea and hidradenitis suppurativa (ARHS). The purpose of this paper was to present current knowledge about QoL assessment in HS, including data on HS‐specifi...

The creation of the Dermatology Life Quality Index (DLQI) questionnaire facilitated many studies on the impact of skin diseases on patients' quality of life (QoL). Many national and international guidelines recommend QoL assessment in dermatology, and some of them contain detailed recommendations on treatment goals and changes of treatment approach...

Background The first dermatology‐specific proxy health related quality of life (HRQoL) instrument for children 0‐4 years old with skin diseases, the Infants and Toddlers Dermatology Quality of Life (InToDermQoL), was recently developed. In order to avoid the problem of cross‐cultural inequivalence focus groups work and pilot tests were organized si...

Background Epidermolysis bullosa (EB) may have severe impact on different aspects of patients’ life. Until now there was no EB‐specific quality of life (QoL) instrument for young children. Objective To create EB‐specific proxy module of the Infants and Toddlers Dermatology Quality of Life (InToDermQoL) questionnaire. Methods Focus groups with par...

Background Until now there was no validated dermatology‐specific health‐related quality of life (HRQoL) instrument to be used in youngest patients. Objective To create dermatology‐specific proxy instrument for HRQoL assessment in children from birth to 4 years. Methods International focus groups, item selection and pilot tests were utilized. In o...

Treatment of chronic relapsing skin diseases, where presence of disfiguring lesions may be a major problem, is not an easy task even in the era of “biologics”. Are the patients really satisfied with treatment if lesions still persist? In assessment of psoriasis signs, both the dermatologist and the patient are based on their own experience. However...

Мета роботи — порівняти якість життя хворих на акне, в яких виявлені кліщі Demodex folliculorum та Demodex brevis у ділянках ураження шкіри, з пацієнтами, у яких кліщів демодецид не було.Матеріали та методи. Під нашим спостереженням перебували 105 хворих на акне. Усіх їх обстежено на наявність кліщів Demodex folliculorum та Demodex brevis. Крім цьо...

Background: Acne is a common dermatologic disease that can have a profound negative impact on a patient's health-related quality of life (HRQoL). HRQoL correlates with acne severity in some, but not all, studies. In other words, patients with the same level of acne severity might experience different levels of impact on their HRQoL. Objective: We a...

Acne may have severe negative impact on different aspects of patient health-related quality of life (HRQoL). Prevalence of acne in university and school students is high, and the HRQoL of students with acne from different countries was studied. There is a lack of studies on direct comparison of HRQoL impairment of university and school students wit...

According to results of a recent literature search performed by the European Academy of Dermatology and Venereology (EADV) Task Forces (TF) on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS) most of publications where health‐related (HR) QoL of acne patients was studied were clinical...

There has been a constant growth in the number of publications each year concerning “quality of life (QoL)” and “dermatology,” since the publication of the Dermatology Life Quality Index in 1994. Numerous dermatology and disease-specific QoL instruments have since been created. Quality of life is frequently assessed in clinical trials, educational...

Acne causes profound negative psychological and social effects on the quality of life (QoL) of patients. The European Dermatology Forum S3-Guideline for the Treatment of Acne recommended adopting a QoL measure as an integral part of acne management. Because of constantly growing interest in health-related QoL assessment in acne and because of the h...

Background: Adherence to topical corticosteroids (TCS) is essential for the effective treatment of atopic dermatitis but can be limited by concerns about their use. This study examined the feasibility of applying the validated TOPICOP score for assessing TCS phobia across different countries. Methods: This was a prospective multicenter feasibili...

The patient is the centre of a web of relationships and the impact of his/her disease on family members and caregivers must be taken into account. The aim of this study was to identify the specific instruments that measure the impact of a dermatological disease on the quality of life (QoL) of family members, by performing a systematic search of the...

Abstract is missing (In this Issue...)

There is a need for researchers to have easy reference to the wide spectrum of different types of quality of life (QoL) instruments that can be used in atopic dermatitis (AD). Previous reviews on QoL in AD do not cover the full spectrum of QoL measures used in studies on AD. This paper, on behalf of the European Academy of Dermatology and Venereolo...

The aim of this study was to describe the many ways in which quality of life (QoL) measurement may potentially be advantageous in routine clinical dermatology practice. Thirteen members of the EADV Task Force on Quality of Life, eight dermatologists, three health psychologists, one epidemiologist and one pharmacoepidemiologist, independently listed...

Background: Atopic dermatitis has a significant impact on quality of life of children and families. Objective: It is important to assess gender differences in health-related quality of life in children with atopic dermatitis in order to effectively use health-related quality of life results. Methods: Children 5- to 16-years of age with atopic...

Atopic dermatitis (AD) is one of the most common skin diseases. Prevalence of AD is highest in childhood. Because of chronicity and often visible lesions, AD may lead to stigmatization and problems with self-perception. However, problems of self-perception and stigmatization in AD children are poorly studied. Literature data on general tendencies o...

The impact of skin conditions in children can profoundly affect a variety of lifestyle parameters that may have important personal consequences. Several national guidelines for children with different skin conditions recommend health-related quality of life (HRQoL) measurement as part of the assessment process. HRQoL also plays an important role in...

Atopic dermatitis (AD) is a common childhood chronic inflammatory skin conditin that greatly affects the quality of life (QoL) of affected children and their families. The aim of our study was to assess QoL and family QoL of children with AD from 4 different countries and then compare the data, evaluating the effects of AD severity and age of child...

Background: Atopic dermatitis (AD) and psoriasis have significant negative impact on patients' lives. Objective: To compare the impact of psoriasis and AD in adult patients matched by disease severity and to perform further validation of the Ukrainian versions of the DLQI and Skindex-16 in these skin conditions. Methods: 63 adult AD and 63 pso...

Background Quality of life (QoL) of family members of patients with chronic skin diseases is often impaired. Disease-specific family QoL instruments for most of the skin conditions are not available. Family Dermatology Life Quality Index (FDLQI) is a dermatology-specific family QoL instrument that has been used in few studies to assess the impact o...

The interest to the health related quality of life (HRQoL) in children with dermatologic conditions is growing and it was studied in children with different dermatologic diseases. Generic, dermatology-specific and disease-specific instruments can be used to measure HRQoL in pediatric dermatology. In most cases HRQoL questionnaires to be used in adu...

Background: Atopic dermatitis (AD) has severe impact on the quality of life (QoL) of children suffering from the disease and their families. The infant's dermatitis quality of life index (IDQoL) and the dermatitis family impact questionnaire (DFI) were designed to study this impact. Aims: To compare the impact of AD on children and their familie...

Original version of the Cardiff Acne Disability Index was translated into Ukrainian by two independent forward translators and then back-translated into English by two other independent translators. The probe technique for pre-testing was used. Retest reliability, discriminant and convergent validity and over time sensitivity were checked. The resu...

Original version of the Cardiff Acne Disability Index was translated into Ukrainian by two independent forward translators and then back-translated into English by two other independent translators. The probe technique for pre-testing was used. Retest reliability, discriminant and convergent validity and over time sensitivity were checked. The resu...

Atopic dermatitis (AD) has an established impact on health-related quality of life (HRQoL) and family QoL. This study was designed to investigate gender differences in health-related and family QoL in children with AD. Cohorts of 25 girls and 25 boys with AD aged <4years were selected from 102 children with AD. Children in the girls' and boys' grou...

Lithuania and Ukraine have different models of national health care. We decided to determine whether difference in health care systems influence quality of life (QoL) of psoriasis patients from Lithuania and Ukraine. Lithuanian and Ukrainian versions of the Dermatology Life Quality Index (DLQI) and Skindex-16 were used. 157 Lithuanian and 136 Ukrai...

Abstract Background and aim: A beneficial role of probiotics, especially Lactobacillus rhamnosus, in children with atopic dermatitis (AD) has been reported. Their effects are primarily mediated through immune pathways, which need further investigation. This study aimed to investigate clinical and immunologic effects of probiotics in the treatment o...

Background and aim : A benefi cial role of probiotics, especially Lactobacillus rhamnosus , in children with atopic dermatitis (AD) has been reported. Their effects are primarily mediated through immune pathways, which need further investigation. This study aimed to investigate clinical and immunologic effects of probiotics in the treatment of chil...

The best defined costimulators for activation of T lymphocytes are B7-1 and B7-2 on antigen presenting cells (APC) that bind to CD28 on T cells. Several studies showed that CD28 is critical for type 2 T helper cells (Th2) inflammation and depends mainly on the interaction of CD28 with B7-2. Some authors suggested a role for B7-2 B cells in immunogl...

Despite it is well known that atopic dermatitis has severe negative impact on child's and family life there is little information concerning gender influence on health-related quality of life assessment. We did not find any statistically significant gender differences in assessment of the Infant's Dermatitis Quality of Life Index and the Dermatitis...

Original versions of SKINDEX-29, SKINDEX-16 and Psoriasis Disability Index questionnaires were translated into Ukrainian by two independent forward translators and then back-translated into English by two other independent translators. The probe technique for pre-testing was used. Retest of reliability, discriminant validity, over time sensitivity...

Origional versions of the Dermatitis Family Impact, Infant's Dermatitis Quality of Life Index and Children's Dermatology Life Quality Index questionnaires have been translated into Ukrainian independently by two translators and then back- translation was done by other translators. Total number of forward or back-translation was 6. A final back-tran...