Paulo Riceli

• PhD
• Analyst at Brazilian Agricultural Research Corporation (EMBRAPA)

Spondias tuberosa (umbu) has been studied from the perspective of natural product and pharmacology, revealing relevant biological activities. Therefore, from the point of view of chemical and biological studies, deepening knowledge about this species is of great importance. Additionally, the evaluation related to the metabolic variations of the sam...

Cashew nut testa shell (CNTS) is a plentiful by-product of cashew nut processing and is rich in bioactive compounds useful for the food, chemical, and pharmaceutical industries. The aim is to extract these compounds in an eco-friendly manner using GRAS (generally recognized as safe) solvents and energy-efficient processes to minimize the environmen...

The cashew agroindustry generates substantial by-products that are often improperly used. Cashew nut testa shell (CNTS) has attracted interest due to its elevated fatty acid contents and phenolic compounds, raising the relevance of environmentally friendly extraction techniques for its recovery. CNTS was submitted to high-pressure (supercritical fl...

Introduction Aedes mosquitoes are the main vectors of the dengue, chikungunya, and Zika viruses. Essential oils have been used in research as alternatives to the synthetic insecticides traditionally used in programs to control these diseases. Methods: leaves of plants from the Caatinga biome were used to obtain essential oils which were used for la...

Introduction The fungus Fusarium verticillioides significantly threatens maize crops in tropical soils. In light of this, biological control has emerged as a promising strategy to reduce fungicide costs and environmental risks. In this study, we aimed to test the antifungal activity of cell-free supernatant (CFS) from three Bacillus velezensis (CT0...

Lonchocarpus sericeus (Poir.) Kunth ex DC., Fabaceae, is traditionally used to treat stomach disorders and constipation. Previous studies examined its anti-inflammatory, antinociceptive, and hepatoprotective properties, but its potential as a gastroprotective agent remains unexplored. This study aimed to investigate the gastroprotective and gastric...

Cordiera myrciifolia is an abundant species in Northeast Brazil that presents metabolites of biological/therapeutic interest. From this perspective, the present study aimed to investigate the chemical constituents and evaluate the in vitro antimicrobial activity of hexane (HECM) and ethanolic (EECM) extracts of C. myrciifolia leaves. The extracts w...

The cashew agroindustry generates substantial by-products that are often improperly used. Cashew nut testa shell (CNTS) has attracted interest due to its elevated fatty acid contents and phenolic compounds, raising the relevance of environmentally friendly extraction techniques for its recovery. CNTS was submitted to high-pressure (Supercritical Fl...

Griffinia gardneriana Ravenna, Griffinia liboniana Morren and Griffinia nocturna Ravenna (Amarillydaceae) are bulbous plants found in tropical regions of Brazil. Our work aimed to determine the alkaloid profiles of Griffinia spp. and evaluate their anxiolytic potential through in vivo and in silico assays. The plants grown in greenhouses were dried...

Ethnopharmacological relevance Hancornia speciosa Gomes is a fruit and medicinal species used for treating infectious diseases of the genitourinary system. However, its mechanism of action against microbes is still not fully understood. Infections in the genitourinary system caused by Candida spp. are associated with its fungal resistance and path...

The potential of four commercial clones of unripe acerola fruit was investigated regarding a source of nutraceuticals and functional foods for industrial use. The chemical profiling of the BRS 235-Apodi, BRS 236-Cereja, BRS 237-Roxinha, and BRS 238-Frutacor clones was determined by the ultra-high performance liquid chromatography-quadrupole time-of...

Investigating specialized plant metabolites, traditionally referred to as ‘secondary metabolites’ present in leaf extracts of cashew trees (Anacardium occidentale) resistant and susceptible to anthracnose disease was carried out using metabolomics combined with chemometric tools. We used clones of dwarf-cashew with the following variations of chara...

Açai, a fruit typical of Amazonia in Brazil, is consumed due to beneficial health effects. Aqueous two‐phase systems (ATPS) based on ethanol (28% w/w) and ammonium sulfate (17.5% w/w) were employed in the partitioning of anthocyanins from açai. Experiments, applying 50 mL equilibrium cells and a 1‐L glass vessel reactor, evaluated anthocyanin parti...

Varronia curassavica Jacq. is a medicinal plant found in Brazil used as anti-inflammatory. Here, we investigated the in vitro antioxidant activity of 70 % ethanol extract of V. curassavica leaves on synthetic radicals (ABTS•+/DPPH•) and reactive oxygen species (O2•-, ROO•, HOCl/OCl-, H2O2), besides its in vitro cytotoxicity. The extract was charact...

Kalanchoe brasiliensis Cambess is a native Brazilian plant that is traditionally used to threat skin, pain, inflammation and gastrointestinal disorders. Here, we evaluated the in vivo orofacial nociception and possible mechanisms of action of the aqueous extract from the leaves of Kalanchoe brasiliensis (ELKB) using adult zebrafish models. The agon...

Oral preparations of Casearia sylvestris (guacatonga) are used as antacid, analgesic, anti-inflammatory and antiulcerogenic activities. The clerodane diterpenes casearin B (cas B) and caseargrewiin F (casg F) are major active compounds in vitro and in vivo. The oral bioavailability and metabolism of cas B and casg F were not previously investigated...

This study aimed to evaluate, in vitro, the use of leaf extracts of Azadirachta indica (A. indica) and Melia azedarach (M. azedarach) as antivirals against caprine lentivirus (CLV) in colostrum and milk of goat nannies. These were collected from eight individuals and infected with the standard strain of CLV. Samples were then subdivided into aliquo...

Ethnopharmacological relevance Egletes viscosa (L.) (macela) is a native wild herb that can be found in different states of northeastern Brazil. The infusions of its flower buds are traditionally used for the treatment of gastrointestinal disorders. E. viscosa possesses two chemotypes (named A and B), distinguishable by the composition of the essen...

This study evaluated the changes caused by cooking presoaked aged carioca beans in the autoclave steam, focusing on its bioactive components, antioxidant activity, and nutritional compounds. Additionally, to identify which carioca bean cultivar could preserve the most quantity of bioactive compounds in cooked flour. The cooked flours from Imperador...

Silva, A.d.A.; da Silva, V.B.; dos Santos, A.T.L.; Juno Alencar Fonseca, V.; de Macêdo, D.G.; da Cruz, R.P.; Almeida-Bezerra, J.W.; et al. LC-MS Analysis and Antifungal Activity of Turnera subulata Sm. Plants 2023, 12, 0. https://doi.org/ Academic Editors: Abstract: Fungi of the Candida genus are responsible for invasive candidiasis, which affects...

Endophytic fungi are important sources of anticancer compounds. An endophytic fungus was isolated from the medicinal plant Achyrocline satureioides, and molecularly identified as Biscogniauxia sp. (family Xylariaceae) based on partial nucleotide sequences of the internal transcribed spacer genomic region (GenBank Accession No. ON257911). The chemic...

Fungi of the Candida genus are responsible for invasive candidiasis, which affects people all over the world and has high mortality rates. This is due to their virulence factors, which give them great resistance and pathogenicity. In addition, the emergence of multidrug-resistant strains makes it difficult to treat these infections. In this way, na...

This study aimed to identify the chemical composition of the Spondias tuberosa aqueous leaf and root extracts (EALST and EARST) and to evaluate their effect, comparatively, against opportunis-tic pathogenic fungi. Ultra-Performance Liquid Chromatography Coupled to a Quadrupole/Time of Flight System (UPLC-MS-ESI-QTOF) was employed for chemical analy...

[This corrects the article DOI: 10.1016/j.fochms.2022.100149.].

Lantana camara L. (Verbenaceae), commonly called lead cambar�a, has often been used in folk medicine as antiseptic, antispasmodic, against hemorrhages, flu, colds, and diarrheic. This plant is considered a weed and an ornamental and medicinal plant and is an essential source of natural organic compounds, mainly flavonoids. This work aims to investi...

The aim of this study was to produce powders from the phenolic extract of the cashew by-product using maltodextrin and gum arabic as encapsulating agents to preserve these bioactive compounds and their antioxidative activity. Extraction was assisted by an ultrasound bath to increase the release of the bioactive compounds, resulting in the hydroalco...

COVID-19, caused by SARS-CoV-2, is a viral infection that has generated one of the most significant health problems in the world. Spike glycoprotein is a crucial enzyme in viral replication and transcription mediation. There are reports in the literature on using bile acid in the fight against this virus through in vitro tests. This work presents t...

The present study aims to demonstrate the chemical composition of the ethanolic extract of Sarcomphalus joazeiro bark and to evaluate its antibacterial and antibiofilm activity. For that, the ethanolic extract of the stem bark was prepared, and chemical characterization was carried out in UPLC-ESI-QToF-MSE. Minimum inhibitory concentration and anti...

A method based on liquid-liquid microextraction assisted by ultrasound energy (UALLME) and UPLC-ESI/QDa detection was developed for SeMet analysis in cashew nut samples. The UALLME conditions were optimized through an experimental design of three factors in two levels with central point, which was observed the highest yield of SeMet extraction from...

The untargeted metabolomics approach was used to compare the chemical profiles of acerola (Malpighia emarginata DC.) pomace extracts. The effect of drying the raw material before subcritical water extraction (SWE) at different temperatures on the yield, phenolic content, and in vitro antioxidant activity was evaluated. The results were compared wit...

To understand the influence of environmental factors on the metabolic diversity of phytochemical compounds from extracts of leaves and bark of Anacardium occidentale, collected in two different geographic areas, ultraperformance liquid chromatography and mass spectrometry were used, as well as the composition of physicochemical properties of both s...

(1) Background: Candida is a genus of yeasts with notable pathogenicity and significant ability to develop antimicrobial resistance. Gossypium hirsutum L., a medicinal plant that is traditionally used due to its antimicrobial properties, has demonstrated significant antifungal activity. Therefore, this study investigated the chemical composition an...

Mesosphaerum suaveolens is a herbaceous plant native to the Caatinga, and has the ability to change the plant composition of surrounding areas, possibly through to the action of allelochemicals. In this study, the effect of M. suaveolens leaf decomposition on the germination and initial growth of two columnar cacti endemic to Brazil, Cereus jamacar...

In the present study, we suggest that the Myrciaria floribunda (West ex Willd.) O. Berg fruit (cambuí) is a natural source of potential molecules against COVID-19. Extracts from orange and purple cambuí were obtained by using pressurized hot water extraction (PHWE). Extraction overall yield was 39.66 ± 1.62% and 33.00 ± 8.44% for the extracts of pu...

The aim of this study was to evaluate whether volatile compounds released by melon genotypes interfere in the attractiveness and repellency of Liriomyza sativae Blanchard (Diptera: Agromyzidae), and to characterise the phenolic compounds of melon genotypes, as well as the antibiotic action of these compounds on L. sativae . Through experiments, it...

Touriga Nacional is a well-adapted Portuguese grape variety in São Francisco River Valley (northeastern Brazil). Nevertheless, it has only been indicated to short-term consumption because of the lack of chemical stability, which is attributed to low grape acidity and incomplete phenolic maturity. Therefore, we used Ultra-Performance Liquid Chromato...

Sida L. is one of the most diverse genera within Malvaceae, with species popularly used in different countries for the treatment of diseases. Scientific support for the ethnopharmacological potential of some of these species has been provided by bio-assays. In this work, leaf extracts of S. galheirensis, one of the least chemically and pharmacologi...

The chemical composition of the Cynophalla flexuosa hydroethanolic extract (CFHEE) was identified and its antioxidant, antifungal and antipleomorphic activities against C. albicans and C. tropicalis strains were evaluated. Phytochemical prospecting evidenced polyphenolic and triterpenoid compounds while UPLC-MS analysis revealed the presence of Iso...

Chagas Disease and Leishmaniasis are neglected parasitic diseases that constitute a major public health problem. In the search for new therapeutic alternatives for such pathologies, the essential oil of the leaves of Psidium brownianum Mart ex DC was investigated regarding its chemical composition, antiparasitic, and cytotoxic effects. The chemical...

Stryphnodendron rotundifolium Mart., popularly known as “barbatimão”, is a plant species traditionally used by topical and oral routes for the treatment of infectious and inflammatory diseases. Considering the well-described antioxidant properties of this species, this study investigated the protective effects of its keto-aqueous extract using an i...

Azadirachta indica have allelopathic potential, attributed to the presence of allelochemicals capable of altering plant diversity in surrounding areas. This work aimed to evaluate if the decomposed leaves of A. indica can affect the germination and growth of Myracrodruon urundeuva. A. indica leaves were collected at the end of senescence and mixed...

The methanolic extract of the fungus Lentinus crinitus was submitted to biological assays, identification of the chemical composition by LC-MS, and in silico study by molecular docking with all identified compounds. The test against Artemis salina reached LD 50 > 1000 μg/mL within 24h, and total mortality within 48 hours; the antioxidant test 62.4%...

The barks of Anacardium occidentale (cashew tree) been used for centuries in the popular pharma-copoeia of South America and West Africa for the treatment of infections and neurodegenerative diseases. Thus, this work aimed to evaluate the biological effect of the ethanolic extract of the barks against strains of Candida spp. and cancer cell lines,...

Croton heliotropiifolius Kunth (Euphorbiaceae), whose occurrence has already been registered in the most varied Brazilian biomes, is commonly found in the Chapada do Araripe, Ceará. The species is traditionally used to treat fungal, parasitic, and degenerative diseases. This study investigated the chemical composition and pharmacological potential...

Croton heliotropiifolius Kunth (Euphorbiaceae), whose occurrence has already been registered in the most varied Brazilian biomes, is commonly found in the Chapada do Araripe, Ceará. The species is traditionally used to treat fungal, parasitic, and degenerative diseases. This study investigated the chemical composition and pharmacological potential...

This study investigated the anti‐inflammatory and antioxidant effects of hydroalcoholic extracts of mango peel and pulp on oxidative damage in a naproxen‐induced gastric injury rat model. The extracts were assessed for antioxidant activity (ABTS and FRAP methods), and the phenolic profile was investigated with UPLC‐QToF‐MSE. Gastric damage was eval...

Hippeastrum elegans is a Brazilian Amaryllidaceae plant producing galantamine (GAL), an anticholinesterase drug for Alzheimer's disease, besides other alkaloids such as pseudolycorine (PSE), narciclasine (NAR) and sanguinine (SAN). Therefore, we used a metabolomic approach to investigate the influence of the harvest time on its chemical composition...

Phytochemicals from tropical fruits and their by-products have shown the potential to use as antimicrobial natural. This study aimed to optimize the recovery of phenolic compounds (total polyphenols and flavonoids) from cashew apple using ultrasound-assisted extraction to promote the functional attributes to its coproducts and to evaluate their ant...

Vigna unguiculata is an important source of proteins and energy for humans and animals. However, postharvest losses caused by Callosobruchus maculatus can reach from 20 to 100% of stored seeds. In this study, the insecticide potential of compounds extracted from Himatanthus drasticus latex was assessed. The latex was extracted with ethanol (70%) an...

This study aimed to determine how the cooking methods change the phenolics and saponins profiles, oligosaccharides, antinutrients and antioxidant properties of flours from colorful beans. The autoclave cooking consisted of: 6h soaking and 5 min cooking (C5); and 20 min cooking without soaking (C20). Both cooking methods significantly promote change...

This study was aimed at investigating the phytochemical constituents, antifungal properties and antibiotic-modifying activity of the aqueous crude extract and fractions of Amburana cearensis seeds (CEFAC). The CEFAC were chemically characterized by LC–MS/MS–QTOF. In addition, the antifungal activity was assayed by the microdilution method against s...

The objective of this study was to evaluate the behavior of slow and fast-darkening carioca beans during storage, and the profile of phenolics and saponins, aiming to identify which compounds may be involved in the browning process of the integument of these grains. Cultivars Madreperola and Dama presented the lowest total color difference (ΔE) and...

Anacardium occidentale (Anacardiaceae), popularly known as cashews, is a vegetable native to South America, consumed worldwide in the food sector. Its leaves and bark are used in the preparation of teas for health maintenance, being indicated in ethnobotanical studies for the treatment of cancer, which is considered a serious public health problem...

The essential oil of Cymbopogon nardus, citronella, has been extensively studied. However, the chemical and biological properties of the ethanolic extract (EE) of C. nardus have not been evaluated. The aim of this study was to characterize the chemical composition of the EE of C. nardus and its active fraction (FrD). Moreover, the cytotoxic and ant...

Background/Purpose The fractions were tested to investigate their chemical composition and antifungal potential in vitro. Methods/Results The results obtained through the chromatographic analysis allowed the identification of 28 compounds. Microbiological assays were carried out in order to determine the IC50, cell viability curve and inhibitory e...

Since Myrtaceae is considered a complex family concerning the taxonomic classification due to the elevated number of components, difficult morphologic differentiation, and relatively low amount of studies in area, this article describes the potentiality of classification using chemometrics applied to UPLC-qToF/MS-MS dataset for chemotaxonomy invest...

Pulsed light, as a postharvest technology, is an alternative to traditional fungicides, and can be used on a wide variety of fruit and vegetables for sanitization or pathogen control. In addition to these applications, other effects also are detected in vegetal cells, including changes in metabolism and secondary metabolite production, which direct...

Thermally-processed coconut water often develop a commercially-undesirable pink color, thus, NMR, UPLC-HRMS, GC-MS analyses combined with chemometrics approach were applied to evaluate chemical variations in comparison to tender water (control) that could explain such color change. Chemometrics on negative ionization mode dataset showed trimeric an...

Ethnopharmacological relevance: Himatanthus drasticus is an important medicinal plant whose latex is traditionally used in Northeast Brazil to treat various diseases, including diabetes. The use of α-amylase and α-glucosidase inhibitors can be an effective strategy to modulate levels of postprandial hyperglycemia via control of starch metabolism....

Licania tomentosa is a Brazilian plant species that produces edible fruits, yet there is little information available concerning their nutritional and/or bioactive composition. This study aimed to evaluate the nutritional and polyphenol composition of L. tomentosa fruits (pulp and seeds) and measure antioxidant activity in ethanolic extracts.The pu...

The aim of this study was to identify and evaluate the chemical compositions and effects of the S. tuberosa leaf and root hydroalcoholic extracts (HELST and HERST) against different strains of Candida. Chemical analysis was performed by Ultra-Performance Liquid Chromatography Coupled to Quadrupole/Time of Flight System (UPLC-MS-ESI-QTOF). The Inhib...

Chalcones containing amino or acetamide groups on ring A and electron donating/withdrawing groups on ring B have been shown to have great cytotoxic potential against human cancer cell lines. In this work, a series of twenty chalcones, including nine 1-(4′-aminophenyl)-3-(substituted aryl)-2-propen-1-ones (1–9), nine 1-(4′-acetamidophenyl)-3-(substi...

Passiflora tenuifila Killip is a wild species, with no studies regarding to functional properties. The objective of this work was to evaluate the chemical composition, including NMR and UPLC, toxicity and functional effect in a Parkinsonism model. The fruits (peel, pulp, and seed) were crushed, lyophilized and characterized. The subchronic toxicity...

The search for natural substances such as plant extracts with antimicrobial properties has considerably increased, given that biofilms constitute a barrier against antifungal therapy, where these can be formed on any surface, such as acrylic resin prosthesis. The objective of this study was to identify the chemical composition of the Persea america...

Several Passiflora species are known for their sedative and anxiolytic properties. However, the functional properties of Passiflora tenuifila Killip are still unexplored. The objective of this work was to evaluate the phenolic composition and acute toxicity, anxiolytic, sedative, and anticonvulsant effects using in vivo assays. The whole fruit (pee...

The leaves of Lantana camarawere submitted to preliminary phytochemical study obtaining essential oil and methanolic extract. In the analysis of the essential oil (hydrodistillation), they identified cariophilene (7.3%), Germacrene B (37.5%) and Germacrene D (21.7%) as the most relevant of the nine components obtained. The ethyl acetate (EtOAc) rev...

Introduction: Momordica charanthia L., Curcubitaceae, is a pantropical food and medicinal plant. The plant is included in the Official List of Brazilian Medicinal Plants of interest to the Brazilian Unified Health System. The study aimed to perfom microbiological studies with extracts of Momordica charanthia L. including chemical characterizatio...

The leaves of Lantana camarawere submitted to preliminary phytochemical study obtaining essential oil and methanolic extract. In the analysis of the essential oil (hydrodistillation), they identified cariophilene (7.3%), Germacrene B (37.5%) and Germacrene D (21.7%) as the most relevant of the nine components obtained. The ethyl acetate (EtOAc) rev...

As the chemical profiling of common beans (Phaseolus vulgaris) modify according to storage conditions, the aim of this study was to analyze the physicochemical parameters and composition variability of the cotyledon by NMR, and coat by LC-MS, all submitted to different storage atmosphere of O2, CO2, and humidity. Through NMR, chemometrics along wit...

Pulsed light, as a postharvest technology, is an alternative to traditional fungicides, and can be used on a wide variety of fruit and vegetables for sanitization or pathogen control. In addition to these applications, other effects also are detected in vegetal cells, including changes in metabolism and production of secondary metabolites, which di...

Plant extracts are defined as complex heterogeneous mixtures composed of diverse active ingredient categories which characterize their bioactivities. Ziziphus joazeiro Mart., belonging to the Rhamnaceae family, is an endemic caatinga species with a wide economic potential and application in medicine. In the search for new antibacterial drugs, due t...

The objective of the present work was to develop an advanced fast phenotyping tool to explore the cashew apple compositions from different genotypes, based on a portable near-infrared (MicroNIR) spectroscopy. This will be in addition to associating the variability of the respective cashew apple pulps with the genotypes by ultra-performance liquid c...

Different compounds were sequentially extracted from mango seed kernels, namely, mango kernel fat (MKF), a phenolic extract (MKPE), and starch (MKS), with yields of about 11%, 17%, and 39% respectively. The main fatty acids in MKF were oleic and stearic. Gallic acid and its derivatives were the predominant phenolics in MKPE. Glycerol-plasticized fi...

Egletes viscosa (L.) Less (Asteraceae) is a tropical aromatic herb whose flower buds are used for gastrointestinal disorders. Its gastroprotective properties have been attributed to the flavonoid ternatin and the furan diterpenes tanabalin and centipedic acid. The aim of this study was to develop a method of ultra-performance liquid chromatography...

São Francisco River Valley (SFRV) is a wine-producing semi-arid region in Brazil. Therefore, we used a ¹ H NMR and UPLC-MS-based metabolomic approach coupled to chemometrics to evaluate the variability in Chenin Blanc and Syrah wines for two harvest seasons, two vine training system and six rootstocks. Overall, the secondary metabolites were influe...

Our study aimed at the development of a method based on ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-ESI-MS) using selected ion monitoring for the simultaneous quantitation of the alkaloids galantamine, pseudolycorine, sanguinine and narciclasine in Amaryllidaceae species (Hippeastrum elegans, Habranthus cf. irwinianus...

Myracrodruon urundeuva (“aroeira-do-sertão”) is a species threatened with extinction due to anthropogenic exploitation. Phytochemical analysis of bark, branch and leaf extracts revealed the presence of several compounds such as flavonoids, phenols, tannins, quercetin derivatives and anacardic acids. Dereplication methodology was performed to tentat...

Glioblastoma is the most devastating primary brain tumor. Current treatment is palliative, making necessary the development of new therapeutic strategies to offer alternatives to patients. Therefore, endophytes represent an interesting source of natural metabolites with anticancer potential. These microorganisms reside in tissues of living plants a...

Metabolites produced by the endophytic fungus isolated from Achyrocline satureioides inhibit cell proliferation by inducing changes in the cell cycle, apoptosis and by reducing oxidative stress.

Helminthiasis is a common disease in which parasite resistance is frequently caused by inadequate administration of anthelmintics in small ruminant production. Since phytotherapy may be an adjuvant for parasite control, we assessed whether the ingestion of cashew apple fiber (Anacardium occidentale) would reduce Haemonchus contortus infection in Sa...

Potato peels are rich in α-solanine and α-chaconine, which are glycoalkaloids with known pharmacological activity but that have high cytotoxicity. Their aglycones (β-solanine and β-chaconine) have the same pharmacological activity but with a much lower cytotoxicity. In this work, we applied ultrasound technology to extract α-solanine and α-chaconin...