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Publications (23)
Lonchocarpus sericeus (Poir.) Kunth ex DC., Fabaceae, is traditionally used to treat stomach disorders and constipation. Previous studies examined its anti-inflammatory, antinociceptive, and hepatoprotective properties, but its potential as a gastroprotective agent remains unexplored. This study aimed to investigate the gastroprotective and gastric...
Promover um relato de experiência de um farmacêutico residente no Programa de Residência Multiprofissional em Pediatria, no serviço de Pediatria Geral. Trata-se de um estudo descritivo, tipo relato de experiência, desenvolvido por um farmacêutico residente, realizado no cenário da enfermaria geral de um hospital pediátrico de referência do Estado d...
A Farmácia Clínica (FC) abrange as práticas farmacêuticas voltadas para a otimização da farmacoterapia, buscando melhores resultados clínicos, minimizando os riscos e custos envolvidos em sua utilização, além de estimular a prática do uso racional de medicamentos. Assim, este trabalhoteve como finalidade avaliar a influência e evolução nacional dos...
Insufficient sleep compromises lipid/glucose homeostasis. In opposition, exercise increases energy expenditure and has positive effects on glucose and fatty acid metabolism. Presently, it is hypothesized that exercise ameliorates metabolic dysfunction associated with sleep deprivation (SD). The effects of exercise (EX), SD and EX before SD. (EX+SD)...
Dermatitis is defined as a set of inflammatory diseases that affect the skin, with varied causes. Among the different types of dermatitis, contact dermatitis is the most prevalent. Although the current therapy is often effective, it is associated with adverse effects and the possibility of drug tolerance. N-Methyl-(2S, 4R)-trans-4-hydroxy-L-proline...
Oral candidiasis is a common fungal infection that affects the oral mucosa, and happens when Candida albicans interacts with bacteria in the oral microbiota, such as Streptococcus mutans, causing severe early childhood caries. C. albicans and S. mutans mixed biofilms are challenging to treat with conventional antimicrobial therapies, thus, new anti...
Unlabelled:
Diabetes is a disease linked to pathologies, such as chronic inflammation, neuropathy, and pain. The synthesis by the Claisen-Schmidt condensation reaction aims to obtain medium to high yield chalconic derivatives. Studies for the synthesis of new chalcone molecules aim at the structural manipulation of aromatic rings, as well as the r...
Ethnopharmacological relevance
Egletes viscosa (L.) (macela) is a native wild herb that can be found in different states of northeastern Brazil. The infusions of its flower buds are traditionally used for the treatment of gastrointestinal disorders. E. viscosa possesses two chemotypes (named A and B), distinguishable by the composition of the essen...
Methylmercury (MeHg) is highly toxic to the human brain. Although much is known about MeHg neurotoxic effects, less is known about how chronic MeHg affects hippocampal amino acids and other neurochemical markers in adult mice. In this study, we evaluated the MeHg effects on systemic lipids and inflammation, hippocampal oxidative stress, amino acid...
Withajardins, uncommon modified withanolide-type steroids, have been isolated exclusively from plants of the Solanaceae family so far. Two undescribed withajardins and the known tuboanosigenin were isolated from the hexane/EtOAc 1:1 extract from Athenaea velutina leaves. Their structures were established by an extensive analysis of 1D and 2D-NMR an...
Mercury (Hg) is one of the most toxic environmental pollutants, especially when methylated, forming methylmercury (MeHg). MeHg affects DNA repair, increases oxidative stress, and predisposes to cancer. MeHg neurotoxicity is well-known, but recently MeHg-associated cardiovascular effects were recognized. This study evaluated circulating lipids, oxid...
Nonalcoholic fatty liver disease (NAFLD), characterized by hepatosteatosis and steatohepatitis, is intrinsically related to obesity. Our previous study reported on the anti-obese activity of a,b-amyrin (AMY), a pentacyclic triterpene isolated from Protium heptaphyllum. This study investigated its ability to prevent fatty liver and the underlying me...
p>O sono é um estado fisiológico inato e recorrente do ser humano, sendo indispensável para garantir a sua qualidade de vida. Disfunções do sono podem afetar o ritmo biológico do indivíduo, implicando em vários agravos a saúde. Nesse contexto, surgem conceitos como a medicalização, buscando sanar este e outros problemas em nossa sociedade contempor...
p>Das alterações endócrinas encontradas na clínica, os distúrbios tireoidianos são considerados como um dos achados mais comuns relatados na literatura, sendo uma das principais causas da evolução de doenças crônicas, em decorrência de sua influência hormonal. A baixa adesão ao tratamento dos distúrbios da tireoide, situação característica no trata...
The gastroprotective property of (−)-myrtenol, a monoterpenoid, has been demonstrated previously against acute gastric ulceration induced by ethanol. However, the healing property of (−)-myrtenol in a chronic gastric ulcer model remains to be verified. This study evaluated its healing efficacy and the mechanism involved using the rat model of chron...
Dietary fiber intake plays an important role in the prevention of obesity. This study aimed to investigate the effect of cashew fiber without low molecular weight compounds (CABwc) on obesity prevention and metabolomics in a murine model of diet-induced obesity. Mice were fed a chow diet (CD), high-fat diet (HFD) or a high-fat diet supplemented wit...
p>Doenças Transmitidas por Alimentos (DTA) constituem síndromes resultantes de alimentos e/ou água contaminados. Assim, objetivou-se caracterizar os surtos alimentares no Estado do Ceará (CE) no período de 2014 a 2016, empregando-se de uma metodologia descritiva, do tipo transversal e de caráter retrospectivo, valendo-se dos dados da Secretaria de...
The objective of this study was to evaluate the effect of cashew fiber wheter or not associated with low molecular weight compounds on lipid profile, abdominal adiposity, glycemia and insulinemia and serum concentration of ghrelin and leptin hormones from normal mice. We evaluated the cashew fiber in its integral form (IcF) and the cashew fiber aft...
To characterize the protective effects of the triterpenoid mixture alpha, beta-amyrin (AMY, 20 mg/kg, during 15 days) on the reactivity of isolated aorta of high-fat diet (HFD)-induced obese mice. Male Swiss mice were fed with HFD or normal diet (ND) for 15 weeks. Contractions of thoracic aorta in response to KCl or phenylephrine (PHE) and relaxati...
Obesity remains a global problem. In search of phytochemicals that have antiobesity potential, this study evaluated α,β-amyrin, a triterpenoid mixture from Protium heptaphyllum, on high-fat diet-induced obesity in mice. Groups of mice (n = 8) were fed a normal diet or a high-fat diet, and were orally treated or not treated with either α,β-amyrin (1...
Objectives:
(-)-Myrtenol is a natural fragrance monoterpenoid structurally related to α-pinene found in diverse plant essential oils. This study was aimed to assess the anti-ulcerogenic potential of (-)-myrtenol against ethanol-induced gastric lesions and to elucidate the underlying mechanism(s).
Methods:
Gastroprotective activity of (-)-myrteno...
