Paulo Caramelli

Paulo Caramelli
Federal University of Minas Gerais | UFMG · Departamento de Clínica Médica

MD, PhD

About

486
Publications
92,923
Reads
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10,812
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Introduction
Professor of Neurology and Coordinator of the Behavioral and Cognitive Neurology Unit at the Faculty of Medicine of the Federal University of Minas Gerais, in Belo Horizonte, Brazil. Vice-chair (2021-2022) and chair-elect (2022-2024) of ISTAART. My group's research activities are focused on epidemiological, clinical and translational studies on brain aging, cognitive impairment and dementia, particularly Alzheimer's disease and frontotemporal dementia.
Additional affiliations
December 2012 - present
Federal University of Minas Gerais
Position
  • Professor
December 2005 - December 2012
Federal University of Minas Gerais
Position
  • Professor
December 2005 - present
Federal University of Minas Gerais
Position
  • Professor
Education
September 1992 - October 1994
Université de Montréal
Field of study
  • Cognitive Neurology
March 1992 - January 1997
University of São Paulo
Field of study
  • Neurological Sciences
February 1988 - January 1992
University of São Paulo
Field of study
  • Neurology

Publications

Publications (486)
Article
Full-text available
Atualmente não há tratamento curativo para as demências neurodegenerativas ou para a demência vascular, mas algumas intervenções farmacológicas e não farmacológicas podem contribuir para aliviar os sintomas, retardar a progressão da doença e melhorar a qualidade de vida. As abordagens terapêuticas atuais são baseadas na etiologia, no perfil dos sin...
Article
Full-text available
Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by...
Article
Background Studies have shown that the prevalence of dementia in Latin America and the Caribbean (LAC) may be higher than in high-income countries. Thus, we sought to systematically analyse the prevalence of dementia and explore possible drivers that lead to this disparity in LAC countries. Method We searched Pubmed, Web of Knowledge, Scopus, Lila...
Article
Mentalizing and emotion recognition are impaired in behavioral variant frontotemporal dementia (bvFTD). It is not clear whether these abilities are also disturbed in other conditions with prominent frontal lobe involvement, such as progressive supranuclear palsy (PSP). Our aim was to investigate social cognition (facial emotion recognition, recogni...
Article
Full-text available
Alzheimer's disease (AD) and other dementias are a global challenge. Early diagnosis is important to manage the disease. However, there are barriers to diagnosis that differ by region. Researchers from Brazil, China, Nigeria, Spain, and Sweden have identified key barriers to AD diagnosis in their countries. In Brazil, socioeconomic inequalities and...
Article
Full-text available
Measures of social cognition have now become central in neuropsychology, being essential for early and differential diagnoses, follow-up, and rehabilitation in a wide range of conditions. With the scientific world becoming increasingly interconnected, international neuropsychological and medical collaborations are burgeoning to tackle the global ch...
Article
Background: A cheap and minimum-invasive method for early identification of Alzheimer's disease (AD) pathogenesis is key to disease management and the success of emerging treatments targeting the prodromal phases of the disease. Objective: To develop a machine learning-based blood panel to predict the progression from mild cognitive impairment (...
Article
Full-text available
Measures of social cognition have now become central in neuropsychology, being essential for early and differential diagnoses, follow-up and rehabilitation in a wide range of conditions. With the scientific world becoming increasingly interconnected, international neuropsychological and medical collaborations are burgeoning to tackle the global cha...
Article
Background: Episodic memory impairment may occur in progressive supranuclear palsy (PSP). However, it remains uncertain whether this is due to executive dysfunction or to the involvement of brain areas responsible for memory. Objectives: To investigate the specific brain regions underlying episodic memory impairment in PSP. Methods: Twenty-one...
Article
Research capacity and capability for dementia in many low‐ and middle‐income countries (LMIC) is still developing and often involves collaborations with high‐income countries (HIC). Such collaborations may present equity risks and result in partnership imbalances. We developed a Charter of Conduct and researcher checklist to guide future internatio...
Article
Full-text available
Sentence-comprehension deficits have been described in patients with primary progressive aphasia (PPA). However, most instruments to address this domain in more detail and in a clinical context have not been adapted and translated into several languages, posing limitations to clinical practice and cross-language research. Objectives The study aime...
Article
Full-text available
Background: Due to the early and prominent behavioral changes which characterize behavioral variant frontotemporal dementia (bvFTD), patients are more likely to seek psychiatric help and are often initially diagnosed with a primary psychiatric disorder (PPD). Differentiating these conditions is critical because of the dramatically different outcom...
Article
Full-text available
Repeated cognitive assessment in longitudinal studies favors the occurrence of retest effects, usually increasing the scores obtained at the follow-up assessments when compared to baseline. Therefore, retest effects can compromise the evaluation of cognitive decline in older adults. Objectives: We aimed to verify the occurrence of the retest effe...
Article
Full-text available
Background A comprehensive meta-analysis quantitatively examining the effects of group Acceptance and Commitment Therapy (ACT) on anxiety and depressive symptoms is required to advance our understanding of its efficacy and moderating factors. Methods Four electronic databases were searched in August 2018. An update search was conducted in November...
Article
The association between alcohol intake and cognitive decline has been widely studied. Sex differences and cognitive domains affected by alcohol intake patterns make this topic overly complex. Objective: To investigate the effect of alcohol intake on cognition of middle-aged participants from ELSA-Brasil by sex during four-years of follow-up. Met...
Article
Background: Progressive supranuclear palsy (PSP) is the most common atypical parkinsonism and has executive dysfunction as a core feature. The magnitude of episodic memory disturbance in PSP is yet to be clarified. Objectives: To investigate how impaired is episodic memory in PSP compared to healthy controls and other neuropsychiatric disorders....
Article
Full-text available
Primary Progressive Aphasia (PPA) is a neurological syndrome characterized by impaired language due to neurodegeneration. It is subdivided into three variants: semantic, agrammatic or nonfluent, and logopenic. Pieces of evidence have suggested that learning disabilities in childhood, such as dyslexia, might be susceptibility factors in the occurren...
Article
Background: Alzheimer's disease (AD) comprises 60-70% of diagnosed dementia cases, and is characterized by the deposition of β-amyloid peptide and the formation of neurofibrillary tangles of tau protein. Resveratrol is a neuroprotective agent acting in the prevention of redox impairment in addition to exerting anti-apoptotic actions on brain cells...
Article
Background: The relationship between the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) diet and cognition has not been widely investigated in low- to middle-income countries. We investigated the relationship between MIND diet and cognition in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline data. M...
Article
Adherence to healthy dietary patterns such as the MIND diet has been associated with better cognition, but little is known about this relationship in studies from low‐ to middle‐income countries. This study aims to investigate the association between adherence to the MIND diet and cognitive performance in the ELSA‐Brasil study baseline. Adherence t...
Article
The role of hippocampal connectivity for good memory performance is well known in persons with high educational level. However, it is understudied the role of hippocampal connectivity in illiterate populations. Thirty‐nine illiterate adults underwent resting state functional MRI and an episodic memory test (Free and Cued Selective Reminding Test)....
Article
The increase in life expectancy implies the emergence of chronic‐degenerative and disabling conditions, such as cognitive impairment and dementia. Among the frequent disorders in clinical practice, the differential diagnosis between Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) may be challenging, which justifies t...
Article
Full-text available
Background: Validation of cognitive instruments for detection of Alzheimer's disease (AD) based on correlation with diagnostic biomarkers allows more reliable identification of the disease. Objectives: To investigate the accuracy of the Brief Cognitive Screening Battery (BCSB) in the differential diagnosis between AD, non-AD cognitive impairment...
Article
The significant increment in life expectancy, associated to the existence of high-performing older adults, and the appropriate diagnosis of early dementias, lead to an uncommon scenario, of healthy parents accompanying their children with Alzheimer’s disease or another dementia to medical consultations. Here, we reported three peculiar clinical vig...
Article
Irisin is a recently discovered adipomyokine involved in the regulation of glucose and lipid, which also exhibits anti-inflammatory and neuroprotective properties. Here we aimed to compare irisin peripheral levels between individuals with behavioral variant frontotemporal dementia (bvFTD) and cognitively healthy matched controls, in addition to inv...
Article
Language and its associated disorders have puzzled humanity since the dawn of civilization. The first descriptions of aphasia go back to classical antiquity. The Egyptians and Babylonians believed speech was a divine gift to mortals, and their descriptions of aphasia attributed these events to their Gods' anger and disfavor. The Edwin Smith Surgica...
Article
Objective Teleneuropsychology (teleNP) could potentially expand access to services for patients who are confined, have limited personal access to healthcare, or live in remote areas. The emergence of the COVID-19 pandemic has significantly increased the use of teleNP for cognitive assessments. The main objective of these recommendations is to ident...
Preprint
Full-text available
Background: Studies have shown that the prevalence of dementia in Latin America and the Caribbean (LAC) may be higher than in high-income countries. Thus, we sought to systematically analyse the prevalence of dementia and explore possible drivers that lead to this disparity in LAC countries. Method: We searched Pubmed, Web of Knowledge, Scopus, Lil...
Article
Objective: To compare social cognition performance between patients with amyotrophic lateral sclerosis (ALS) and those patients with behavioural variant frontotemporal dementia (bvFTD). Methods: We included 21 participants with ALS, 20 with bvFTD and 21 healthy controls who underwent a comprehensive cognitive battery, including the short version o...
Article
Full-text available
Introduction: Neuropsychiatric symptoms in patients with frontotemporal dementia (FTD) are highly prevalent and may complicate clinical managements. Objective: To test whether the Neuropsychiatry Inventory (NPI) could detect change in neuropsychiatric symptoms and caregiver's distress in patients diagnosed with behavioral variant frontotemporal dem...
Article
Full-text available
Background: Practice-based evidence can inform and support clinical decision making. Case-report series about the implementation of programs in real-world clinical settings may contribute to verifying the effectiveness of interventions for treating PPA in specific contexts, as well as illustrating challenges that need to be overcome. Objective:...
Article
Introduction Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are frequent causes of dementia and, therefore, instruments for differential diagnosis between these two conditions are of great relevance. Objective To investigate the diagnostic accuracy of Addenbrooke’s Cognitive Examination-Revised (ACE-R) for differen...
Article
Full-text available
Frontotemporal dementia (FTD) is a progressive neurodegenerative disorder accompanied by behavioral and personality changes and/or language deterioration. Its behavioral variant (bvFTD) is the main clinical presentation. Objective: This study aims to investigate the treatment alternatives for bvFTD available so far. Methods: We conducted a narr...
Article
Introduction: Synaptophysin, already related to X-linked intellectual disability, is expressed mainly in the central nervous system. Studies in humans indicate that the downregulation of synaptophysin could be involved in the development of dementia. Our study presents the first familial case of behavioral variant frontotemporal dementia associate...
Article
Full-text available
Background: Primary Progressive Aphasia (PPA) is characterized by progressive language impairment due to focal degeneration of brain areas related to linguistic processing. The detection and differential diagnosis of PPA can be difficult with clinical features that may overlap with features of other neurological conditions, such as Alzheimer's dise...
Article
Full-text available
Alzheimer’s disease (AD) is associated with memory impairment and altered peripheral metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery metabolic axis plays a role in AD pathophysiology. The activation of pro-inflammatory pathways in the brain, including the interleukin-6 (IL-6) pathway, comprises a potential point...
Article
Full-text available
Amyotrophic lateral sclerosis and behavioural variant frontotemporal dementia are two different diseases recognized to overlap at clinical, pathological and genetic characteristics. Both conditions are traditionally known for relative sparing of episodic memory. However, recent studies have disputed that with the report of patients presenting with...
Article
Full-text available
Introduction Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Despite the extensive research, its pathophysiology remains largely unelucidated. Currently, more attention is being given to the disease’s vascular and inflammatory aspects. In this context, the renin-angiotensin system (RAS) emerges as a credible player in AD pathog...
Article
Full-text available
Diagnosis of cognitive impairment is usually difficult in low-educated individuals. The Brief Cognitive Screening Battery (BCSB) was designed as a screening tool for the evaluation of cognitive impairment in low-educated individuals, but it may also be used for evaluating individuals with high educational level. Objectives: To perform a narrative...
Article
Background: People with dementia and their family caregivers may face a great burden through social isolation due to the COVID-19 pandemic, which can be manifested as various behavioral and clinical symptoms. Objective: To investigate the impacts of social isolation due to the COVID-19 pandemic on individuals with dementia and their family careg...
Chapter
Covering the spectrum of cognitive decline in aging using illustrative cases, from mild impairment to dementia, this set of case studies offers a wide-ranging guide for trainees and clinicians. This second volume includes updated research diagnostic criteria and details of new imaging technology, including novel biomarkers such as PET amyloid and t...
Chapter
Covering the spectrum of cognitive decline in aging using illustrative cases, from mild impairment to dementia, this set of case studies offers a wide-ranging guide for trainees and clinicians. This second volume includes updated research diagnostic criteria and details of new imaging technology, including novel biomarkers such as PET amyloid and t...
Chapter
Covering the spectrum of cognitive decline in aging using illustrative cases, from mild impairment to dementia, this set of case studies offers a wide-ranging guide for trainees and clinicians. This second volume includes updated research diagnostic criteria and details of new imaging technology, including novel biomarkers such as PET amyloid and t...
Article
Full-text available
Objective: 1) To characterize individuals with memory complaints in a mid-sized city in Brazil, through clinical, cognitive and functional assessment; 2) to compare SCD individuals with MCI and dementia patients in terms of clinical and cognitive variables. Methods: We consecutively included individuals aged ≥50 years, with memory complaints (spon...
Article
Full-text available
Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean...
Article
Background: Differentiating patients with behavioral variant frontotemporal dementia (bvFTD) from Alzheimer's Disease (AD) is important as these two conditions have distinct treatment and prognosis. Using episodic impairment and medial temporal lobe atrophy as a tool to make this distinction has been debatable in the recent literature, as some pat...
Article
Frontotemporal dementia (FTD) is the second most frequent cause of young-onset dementia. Even though immune-mediated and neuroinflammatory factors have been recognized as potential pathophysiological mechanisms, the role of specific immune molecules, such as the tumor necrosis factor (TNF) superfamily, remains elusive. The aim of this study was to...
Article
Objectives To investigate the rates of diabetes mellitus (DM) and impaired fasting glucose (IFG) in a population-based sample of individuals aged 75 + years old and their associations with cognitive performance, depression, functionality, and quality of life (QoL).Study designOverall, 350 people participated in the study. Assessments of cognition,...
Chapter
Single nucleotide polymorphisms (SNPs) are the most common genetic variation in human genome. Although the phenotypic meaning of many SNPs remains not fully understood, these variants can alter the production of several proteins, including cytokines. Cytokines are multifunctional mediators highly active in healthy and pathological contexts. Some de...
Conference Paper
Background: Cognitive and functional decline are important health problems in older adults. Objectives: To investigate Machine Learning (ML) algorithms of routine laboratory variables in predicting cognitive and functional decline in a population-based sample aged 75+ years within one-year. Methods: 132 individuals were selected from a population-b...
Conference Paper
Background: Recent studies showed that episodic memory is impaired in behavioral variant of Frontotemporal dementia (bvFTD), but in contrast to Alzheimer disease (AD) it is assumed to be caused primarily by deficits in executive control. Objective: Our goal was to probe this possibility by testing bvFTD and AD patients in a source memory task which...
Conference Paper
Background: Mentalizing and emotion recognition are impaired in behavioral variant frontotemporal dementia (bvFTD). It is not clear whether these abilities are disturbed in progressive supranuclear palsy (PSP). Objective: To investigate social cognition (SC) between bvFTD and PSP. The neural basis of SC in PSP and bvFTD groups were also investigate...
Conference Paper
Background: Apathy is a multidimensional syndrome that impairs motivation and mechanisms of behavioural regulation. As apathy is almost ubiquitous in neurodegenerative disorders, understanding the neural basis is required to expand knowledge and ameliorate our instruments. Objective: Verify the feasibility, safety, and adherence of a remote physica...
Conference Paper
Background: Progressive supranuclear palsy (PSP) has been classically considered a “subcortical dementia” with a frontal pattern of cognitive decline, but episodic memory dysfunction also occurs in most patients. However, it remains uncertain whether this is due to executive dysfunction or to the involvement of key brain areas responsible for memor...
Conference Paper
Background: The differential diagnosis between Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) is challenging, justifying improvement of cognitive tools for use in clinical practice. Objective: To develop a new logarithm based on discriminative items of the ACE-R. Methods: The ACE-R was administered to 102 patients w...
Conference Paper
Background: The National Institute on Aging and Alzheimer’s Association (NIA-AA) proposed the AT(N) model to diagnose Alzheimer’s disease (AD) considering some biomarkers: amyloid beta (A), phosphorylated tau (T), and neurodegeneration (N). Still, AT(N) correlation with cognitive markers is not yet covered. Objective: To investigate the neuropsycho...
Conference Paper
Background: The role of hippocampal connectivity for good memory performance is well known in persons with high educational level. However, it is understudied the role of hippocampal connectivity in illiterate populations. Objectives: To determine whether the hippocampal connectivity correlate with episodic memory in illiterate adults. Methods: Thi...
Conference Paper
Background: Alzheimer’s disease (AD) is characterized by a deposition of β-amyloid peptide and the neurofibrillary tangles of tau protein. Resveratrol is a neuroprotective agent, acting in the prevention of redox impairment, and could reduce neuronal damage in patients with AD. Objectives: Systematic review and meta-analysis about the effects of re...
Conference Paper
Introduction: The relationship between alcohol and cognition is complex. Objective: To investigate the association of alcohol consumption with cognitive impairment, functionality, psychiatric and neurological diagnoses. Methods: Cross-sectional population-based study. 602 subjects 75+ years were categorized according to the number of drinks consume...
Conference Paper
Background: Alzheimer’s disease (AD) is a pathological process that begins many years prior to the emergence of symptoms. Thus, an effective risk model for AD should aim at detecting at-risk individuals in the prodromal stage, when treatments and lifestyle interventions are more likely to be successful, and should be minimally invasive and inexpens...
Conference Paper
Background: The increased incidence of Type 2 Diabetes Mellitus (T2DM) in the 21st century, along with the higher risk of developing Alzheimer’s disease (AD) in diabetic patients have stimulated the search for pathways that link glycemic disorders to neurodegeneration. MicroRNAs (miRNAs) are non-coding RNAs that play key roles in regulating gene ex...
Conference Paper
Background: We observe Subjective Cognitive Decline (SCD) when patients perceive a decline in their cognitive functions, but this decline is not detected in neuropsychological assessments. Few studies have investigated the prevalence of SCD in the Brazilian population. Objective: Analyze the profile of 50+ years Brazilian people regarding SCD throu...
Conference Paper
Background: Neuropsychiatric symptoms in patients with frontotemporal dementia (FTD) are highly prevalent and may complicate clinical managements. Objective: We tested whether the Neuropsychiatry Inventory (NPI) could detect change in neuropsychiatric symptoms and caregiver´s distress in patients diagnosed with behavioral variant frontotemporal dem...
Conference Paper
Background: Soccer is the most popular sport worldwide, in which players purposely hit the ball with the head. Although researchers have focused on the effects of concussions in contact sports, the role of sub-concussive impacts (e.g., heading) has gained attention. Objective: To investigate the effects of soccer heading on cognitive functioning in...
Conference Paper
Background: Neuropsychological tests are important tools for the diagnosis of mild cognitive impairment or dementia due to Alzheimer’s disease (AD). Objective: To investigate the accuracy of common neuropsychological tests used in the clinical setting for AD diagnosis. Methods: Forty two patients with diagnosis of AD continuum [A+T+/-(N)+/-] and 32...