Pauline Michel-Flutot

Pauline Michel-Flutot
Université de Versailles Saint-Quentin | UVSQ

PhD
Post-doctoral fellow in U1173, LARENES Team, France

About

18
Publications
699
Reads
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24
Citations
Introduction
Skills and Expertise
Education
October 2019 - January 2022
Université Paris-Saclay
Field of study
  • Cervical spinal cord injury

Publications

Publications (18)
Article
Full-text available
High cervical spinal cord injuries induce permanent neuromotor and autonomic deficits. These injuries impact both central respiratory and cardiovascular functions through modulation of the sympathetic nervous system. So far, cardiovascular studies have focused on models of complete contusion or transection at the lower cervical and thoracic levels...
Article
Full-text available
The majority of spinal cord injuries (SCIs) are cervical (cSCI), leading to a marked reduction in respiratory capacity. We aimed to investigate the effect of hemicontusion models of cSCI on both diaphragm activity and respiratory function to serve as preclinical models of cervical SCI. Since phrenic motoneuron pools are located at the C3-C5 spinal...
Article
Full-text available
High spinal cord injuries (SCIs) lead to permanent diaphragmatic paralysis. The search for therapeutics to induce functional motor recovery is essential. One promising noninvasive therapeutic tool that could harness plasticity in a spared descending respiratory circuit is repetitive transcranial magnetic stimulation (rTMS). Here, we tested the effe...
Thesis
Full-text available
Les traumas spinaux cervicaux induisent non seulement une insuffisance respiratoire en raison de la déafférentation des motoneurones innervant le diaphragme, mais aussi des déficits cardiovasculaires dus à la réduction des efférences sympathiques innervant le cœur et le système vasculaire. La mise au point de thérapeutiques visant à améliorer ces f...
Article
Introduction Les lésions de la moelle épinière au niveau cervical entraînent une insuffisance respiratoire permanente. Une axotomie des voies respiratoires spinales descendantes induit une déafférentation des motoneurones phréniques innervant le diaphragme (principal muscle inspiratoire) [1]. La stimulation magnétique transcrânienne répétée (rTMS)...
Article
Repetitive transcranial magnetic stimulation (rTMS) is a promising, innovative, and non-invasive therapy used clinically. Efficacy of rTMS has been demonstrated to ameliorate psychiatric disorders and neuropathic pain through neuromodulation of affected neural circuits. However, little is known about the mechanisms and the specific neural circuits...
Article
Full-text available
Cervical spinal cord injury (SCI) results in permanent life-altering motor and respiratory deficits. Other than mechanical ventilation for respiratory insufficiency secondary to cervical SCI, effective treatments are lacking and the development of animal models to explore new therapeutic strategies are needed. The aim of this work was to demonstrat...
Article
Ultrasound imaging is a non-invasive technique to assess organ function. Its potential application in rodents to evaluate respiratory function remains poorly investigated. We aimed to assess and validate ultrasound technique in rats to analyze inspiratory and expiratory muscles. We measured respiratory parameters to provide normal eupneic values. H...
Article
High spinal cord injuries (SCI) lead to permanent respiratory insufficiency, and the search for new therapeutics to restore this function is essential. To date, the most documented preclinical model for high SCI is the rat cervical C2 hemisection. However, molecular studies with this SCI model are limited due to the poor availability of genetically...
Conference Paper
Full-text available
Cervical spinal cord injury (SCI) results in permanent life-altering motor and respiratory deficits. Exercise training is the most frequently used strategy to improve the recovery of stepping in both animal models and clinical studies (Loy et al, Neural Regen Res. 2019). The rat model of partial cervical spinal hemisection at the second cervical me...
Conference Paper
High spinal cord injuries (SCI) induce respiratory deficits, often leading to death of patients. They disrupt the respiratory bulbospinal pathways innervating the phrenic motoneurons connected to the diaphragm, resulting in respiratory failure. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive device used in clinic practice to n...
Conference Paper
Full-text available
Les lésions médullaires hautes peuvent interrompre la commande nerveuse des muscles respiratoires et squelettiques. A ce jour, aucun traitement n'est disponible chez les patients victimes de troubles moteurs et respiratoires suite à une lésion médullaire haute. Notre équipe développe un modèle d'hémisection spinale cervicale entrainant une insuffis...
Conference Paper
Full-text available
Repetitive transcranial magnetic stimulation (rTMS) is a cortical neuromodulatory technique shown to be effective in a clinical setting. However, the underlying mechanisms are poorly understood, thus emphasizing the need to reverse translate the technique to prelinical animal models. We have recently demonstrated the feasibility of using TMS to eva...
Conference Paper
Full-text available
High cervical spinal cord injuries induce several permanent deficits of vital functions, often leading to the death of the patient. The injury immediately disrupts the bulbospinal pathways innervating phrenic motoneurons that connect to the diaphragm and also causes damages to the sympathetic innervation of the vascular system. The subsequent funct...

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Projects

Projects (2)
Project
To assess the value of ultrasound in the assessment of respiratory muscles in animal's models of disease.