Pauline Favre

Pauline Favre
French Institute of Health and Medical Research (INSERM U955) - Neurospin (CEA Paris-Saclay) · Translational Neuropsychiatry

PhD

About

53
Publications
14,622
Reads
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948
Citations
Introduction
My research focuses on i) behavioural and cerebral correlates of emotion processing and regulation and ii) behavioural changes and cerebral plasticity that may occur after cognitive or mental trainings. I use a combination of cognitive paradigms as well as functional and anatomical MRI in both healthy and psychiatric populations in order to pursue these objectives.
Additional affiliations
October 2021 - present
French Institute of Health and Medical Research
Position
  • Senior Researcher
October 2018 - September 2021
French Institute of Health and Medical Research
Position
  • PostDoc Position
September 2018 - present
Paris Descartes University
Position
  • Lecturer

Publications

Publications (53)
Article
Full-text available
Received: February 23, 2015 Accepted: September 10, 2015 Published online: November 27, 2015 Issue release date: January 2016
Article
Full-text available
Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities th...
Article
Objectives: The existence of anatomo-functional brain abnormalities in Bipolar Disorder (BD) is now well established by magnetic resonance imaging (MRI) studies. To create diagnostic and prognostic tools, as well as identifying biologically valid subtypes of BD, research has recently turned towards the use of machine learning (ML) techniques. We a...
Article
Full-text available
Meditation-based mental training interventions show physical and mental health benefits. However, it remains unclear how different types of mental practice affect emotion processing at both the neuronal and the behavioural level. In the context of the ReSource project, 332 participants underwent an fMRI scan while performing an emotion anticipation...
Article
Neurofeedback using real-time functional MRI (RT-fMRI-NF) is an innovative technique that allows to voluntarily modulate a targeted brain response and its associated behavior. Despite promising results in the current literature, its effectiveness on symptoms management in psychiatric disorders is not yet clearly demonstrated. Here, we provide 1) a...
Article
Full-text available
Emotion dysregulation is central to the development and maintenance of psychopathology, and is common across many psychiatric disorders. Neurobiological models of emotion dysregulation involve the fronto-limbic brain network, including in particular the amygdala and prefrontal cortex (PFC). Neural variability has recently been suggested as an index...
Chapter
Traditional supervised learning with deep neural networks requires a tremendous amount of labelled data to converge to a good solution. For 3D medical images, it is often impractical to build a large homogeneous annotated dataset for a specific pathology. Self-supervised methods offer a new way to learn a representation of the images in an unsuperv...
Article
Full-text available
Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling bra...
Preprint
Full-text available
Traditional supervised learning with deep neural networks requires a tremendous amount of labelled data to converge to a good solution. For 3D medical images, it is often impractical to build a large homogeneous annotated dataset for a specific pathology. Self-supervised methods offer a new way to learn a representation of the images in an unsuperv...
Preprint
Background: Neurofeedback using real-time functional MRI (RT-fMRI-NF) is an innovative technique that allows to voluntarily modulating a targeted brain response and its associated behavior. Despite promising results in the current literature, its effectiveness on symptoms’ management in psychiatric disorders is not yet clearly demonstrated. This re...
Article
Full-text available
Objectives : Past research has suggested that mindfulness training reduces automaticity while processing socio-emotional stimuli. The present study aimed to analyze how mindfulness practice may reduce the use of prior knowledge during the recognition of emotional facial expressions. Based on a predictive brain model, we hypothesized that mindfulne...
Preprint
Full-text available
Background Emotion dysregulation is central to the development and maintenance of psychopathology, and is common across many psychiatric disorders. Neurobiological models of emotion dysregulation involve the fronto-limbic brain network, including in particular the amygdala and prefrontal cortex (PFC). Neural variability has recently been suggested...
Article
Full-text available
Abstract This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci as...
Article
Full-text available
Bipolar disorders (BDs) are among the leading causes of morbidity and disability. Objective biological markers, such as those based on brain imaging, could aid in clinical management of BD. Machine learning (ML) brings neuroimaging analyses to individual subject level and may potentially allow for their diagnostic use. However, fair and optimal app...
Preprint
Meditation-based mental training interventions show great benefits for physical and mental health. However, it remains unclear how different types of mental practice differentially affect emotion processing at both the neuronal and the behavioural level. In the context of the ReSource project, 332 participants underwent an fMRI scan while performin...
Preprint
Meditation-based mental training interventions show great benefits for physical and mental health. However, it remains unclear how different types of mental practice differentially affect emotion processing at both the neuronal and the behavioural level. In the context of the ReSource project, 332 participants underwent an fMRI scan while performin...
Article
Full-text available
MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder...
Article
Full-text available
Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling bra...
Article
Full-text available
The ENIGMA‐DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and developmental disorders on the white matter pathways of the human brain, as well as the effects of normal variation and its genetic associations. The seven ENIGMA disorder‐oriented working groups used the ENIGMA‐DTI workf...
Article
Full-text available
Background Lithium (Li) is the gold standard treatment for bipolar disorder (BD). However, its mechanisms of action remain unknown but include neurotrophic effects. We here investigated the influence of Li on cortical and local grey matter (GM) volumes in a large international sample of patients with BD and healthy controls (HC). Methods We analyz...
Article
Full-text available
Background Industrialization has led to more varied and attractive high-calorie foods. Health problems such as obesity and diabetes are partially attributed to eating-related self-regulation difficulties that may be caused by increasingly frequent cues for highly palatable foods. Research studies aim at understanding the factors underlying response...
Article
Le trouble bipolaire (TB) est une pathologie chronique de l’humeur, caractérisée par des perturbations du fonctionnement émotionnel et cognitif lors des périodes dépressives, maniaques, et intercritiques (euthymiques). Au niveau cérébral, ces troubles de la régulation émotionnelle pourraient être sous-tendus des anomalies structurelles et fonctionn...
Article
Although bipolar disorder (BD) is a relatively frequent, severe and disabling disease, we still lack reliable diagnostic tools. The existence of anatomo-functional brain abnormalities in BD is now well established by MRI studies [1]. Machine learning allows individual level analysis and could potentially lead to diagnostic applications [2]. This is...
Article
Le symposium soulignera l’intérêt de l’imagerie cérébrale dans l’évaluation de certaines fonctions comme le contrôle inhibiteur (CI), dont le rôle est essentiel dans l’adaptation comportementale au quotidien, ainsi que dans la physiopathologie de certaines pathologies psychiatriques. La première partie du symposium discutera le rôle clé du gyrus fr...
Article
Objective: The cerebellum is involved in cognitive processing and emotion control. Cerebellar alterations could explain symptoms of schizophrenia spectrum disorder (SZ) and bipolar disorder (BD). In addition, literature suggests that lithium might influence cerebellar anatomy. Our aim was to study cerebellar anatomy in SZ and BD, and investigate t...
Preprint
Full-text available
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics throughMeta Analysis) Consortium, a global alliance of over 1,400 scientists across 43 countries, studying the humanbrain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicatedgenetic loci associated wi...
Article
bold<>italic /italic<>/bold< MRI studies in patients with bipolar disorder have suggested that lithium is associated with grey matter increases that may underlie its therapeutic effects. However, the relationship between grey matter volume and cellular microstructural changes is not straightforward, as modifications of different cellular compartmen...
Preprint
Full-text available
Background Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in MDD patients, and whether this process is associated with clinical characteristics in a large multi-center international dataset. Methods We performed a mega-analysis...
Article
Full-text available
Objectives Brain sulcation is an indirect marker of neurodevelopmental processes. Studies of the cortical sulcation in bipolar disorder have yielded mixed results, probably due to high variability in clinical phenotype. We investigated whole‐brain cortical sulcation in a large sample of selected patients with high neurodevelopmental load. Methods...
Chapter
The investigation of the putative underlying brain substrates of compassion has only emerged recently within the field of social neuroscience. This chapter aims at summarizing the available brain data on compassion by developing a neurospsychological compassion model, and to delineate some possible future directions of neuroscientific compassion re...
Article
Introduction There is evidence that the right Inferior Frontal Gyrus (IFG) exerts an inhibitory influence over the left primary motor cortex (M1) when actions need to be inhibited. Patients with obsessive–compulsive disorder (OCD) present deficient motor inhibition and attentional control. We therefore hypothesized that in patients with OCD, inhibi...
Article
Deep brain stimulation (DBS) of the subgenual cingulate gyrus (area CG25) is beneficial in treatment resistant depression. Though the mechanisms of action of Cg25 DBS remain largely unknown, it is commonly believed that Cg25 DBS modulates limbic activity of large networks to achieve thymic regulation of patients. To investigate how emotional attent...
Article
Full-text available
Discrete yet overlapping frontal-striatal circuits mediate broadly dissociable cognitive and behavioural processes. Using a recently developed multi-echo resting-state functional MRI sequence with greatly enhanced signal compared to noise ratios, we map frontal cortical functional projections to the striatum and striatal projections through the dir...
Article
Full-text available
Patients with bipolar disorder experience cognitive and emotional impairment that may persist even during the euthymic state of the disease. These persistent symptoms in bipolar patients (BP) may be characterized by disturbances of emotion regulation and related fronto-limbic brain circuitry. The present study aims to investigate the modulation of...
Thesis
Le trouble bipolaire (TB) est une pathologie chronique de l'humeur, caractérisée par des perturbations du fonctionnement émotionnel et cognitif lors des périodes dépressives, maniaques, et intercritiques (euthymiques). L'essor récent des interventions psychosociales spécifiques, telles que la psychoéducation, dans la prise en charge du TB est dû à...
Conference Paper
Full-text available
Aims: Structural neuroimaging studies concerned with bipolar disorders (BD) have mainly reported grey matter abnormalities in prefrontal and limbic regions. Although psychosocial interventions such as psychoeducation therapy have shown great promise for relapses prevention in BD, little is know about the neural basis of its prophylactic effect. Thi...
Conference Paper
Full-text available
Background Neural substrates of bipolar disorder (BD) have frequently been characterized by dysregulation of fronto-limbic networks that may persist during euthymic periods. Only a few studies have investigated euthymic bipolar patients (BP) functional connectivity at rest. The current study aims to assess resting-state functional connectivity in e...

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Projects

Project (1)
Project
The ReSource Project is a unique, large-scale study on Eastern and Western methods of mental training. Over a period of three to eleven months, participants practice a wide range of mental exercises that are designed to enhance attentional control, body- and self-awareness, healthy emotion regulation, self-care, compassion, empathy, and perspective taking. Overall, the aim of the training is to improve mental health and social skills. It may reduce stress, improve mental clarity, increase life satisfaction, and lead to a better understanding of others’ views, values and actions.