Pauline Ann Siasat

Pauline Ann Siasat
University of Birmingham · Institute of Microbiology and Infection

Master of Science

About

7
Publications
1,823
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616
Citations
Introduction
I am currently working on finding novel methods to inhibit the expression of RND efflux pumps in Salmonella.
Additional affiliations
October 2014 - October 2017
University of Essex
Position
  • Undergraduate
Description
  • BSc Biomedical Sciences. Research Project in Biomolecular Science - Effects of L59H RHO gene mutation and its Role in Retinitis Pigmentosa. Supervised by Dr. Philip Reeves. Sponsored by the Wellcome Trust and Fight for Sight.
October 2018 - September 2019
University of Essex
Position
  • Postgraduate
Description
  • MSc Molecular Medicine. Research Project: In vivo characterisation of funtional MtrCDE efflux pump mutants of Neisseria gonorrhoeae. Supervised by Dr. Vassiliy N Bavro and Dr. Ricardo Corona-Torres. Sponsored by the Biotechnology and Biological Sciences Research Council (BBSRC).

Publications

Publications (7)
Article
Full-text available
Efflux pumps are well known to be an important mechanism for removing noxious substances such as antibiotics from bacteria. Given that many antibiotics function by accumulating inside bacteria, efflux pumps contribute to resistance. Efflux pump inactivation is a potential strategy to combat antimicrobial resistance, as bacteria would not be able to...
Article
Full-text available
Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside the cell. While involved in a variety of biological roles, they are primarily known for their contribution to antibiotic resistance by limiting the intracellular accumulation of antimicrobial...
Article
Full-text available
Escherichia coli is a facultative anaerobe found in a wide range of environments. Commonly described as the laboratory workhorse, E. coli is one of the best characterized bacterial species to date, however much of our understanding comes from studies involving the laboratory strain E. coli K-12. Resistance-nodulation-division efflux pumps are found...
Article
Full-text available
Introduction Antimicrobial peptides (AMPs) play an important role in defending against the attack of pathogenic microorganisms. Among them, the proline-rich antibacterial peptides (PrAMPs) have been attracting close attention due to their simple structure, strong antibacterial activity, and low cell toxicity. OaBac5mini is an active fragment of the...
Article
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. Understanding the molecular mechanisms that bacteria use to resist the action of antimicrobials is critical to recognize global patterns of resistance and to improve the use of current...
Article
Full-text available
Background: Resistance nodulation division (RND) family efflux pumps, including the major pump AcrAB-TolC, are important mediators of intrinsic and evolved antibiotic resistance. Expression of these pumps is carefully controlled by a network of regulators that respond to different environmental cues. EnvR is a TetR family transcriptional regulator...

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