Paula Verneri

Paula Verneri
Universidad de Buenos Aires | UBA · IQUIBICEN

Master of Science

About

7
Publications
862
Reads
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52
Citations
Citations since 2017
7 Research Items
52 Citations
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Introduction
MSc. in Biological Sciences. PhD Student at IQUIBICEN - CONICET. Working on transcription factors dynamics during the differentiation process as regulation of cell fate, using advanced microscopy techniques as fluorescence correlation spectroscopy.
Education
August 2011 - March 2017
Universidad de Buenos Aires
Field of study
  • Biology

Publications

Publications (7)
Article
Full-text available
Background The cytoskeleton is a key component of the system responsible for transmitting mechanical cues from the cellular environment to the nucleus, where they trigger downstream responses. This communication is particularly relevant in embryonic stem (ES) cells since forces can regulate cell fate and guide developmental processes. However, litt...
Article
The transcription factors (TFs) OCT4, SOX2 and NANOG are key players of the gene regulatory network of pluripotent stem cells. Evidence accumulated in recent years shows that even small imbalances in the expression levels or relative concentrations of these TFs affect both, the maintenance of pluripotency and cell fate decisions. In addition, many...
Article
Full-text available
Akt/PKB is a kinase involved in the regulation of a wide variety of cell processes. Its activity is modulated by diverse post-translational modifications (PTMs). Particularly, conjugation of the small ubiquitin-related modifier (SUMO) to this kinase impacts on multiple cellular functions, such as proliferation and splicing. In embryonic stem (ES) c...
Article
Full-text available
Real-time reverse transcription PCR (RT-qPCR) is the gold-standard technique for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection in nasopharyngeal swabs specimens. The analysis by RT-qPCR usually requires a previous extraction step to obtain the purified viral RNA. Unfortunately, RNA extraction constitutes a bottleneck for ea...
Preprint
Full-text available
Real-time reverse transcription PCR (RT-qPCR) is the gold-standard technique for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection in nasopharyngeal swabs specimens. The analysis by RT-qPCR usually requires a previous extraction step to obtain the purified viral RNA. Unfortunately, RNA extraction constitutes a bottleneck for ea...
Article
Full-text available
Pluripotency maintenance requires transcription factors (TFs) that induce genes necessary to preserve the undifferentiated state and repress others involved in differentiation. Recent observations support that the heterogeneous distribution of TFs in the nucleus impacts on gene expression. Thus, it is essential to explore how TFs dynamically organi...
Article
Pluripotent stem cells (PSCs) are capable of self-renewing and producing all cell types derived from the three germ layers in response to developmental cues, constituting an important promise for regenerative medicine. Pluripotency depends on specific transcription factors (TFs) that induce genes required to preserve the undifferentiated state and...

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Cited By

Projects

Project (1)
Project
I focus my doctoral thesis on transcription factors dynamics at the onset of the differentiation process. I work with mouse embryonic stem cells and specialize in the key regulators of pluripotency, Sox2, Nanog and Oct4.