Paula Carrasco Espí

Jaume I University | UJI · Predepartmental Medicine Unit

Background The use of ecological momentary assessment (EMA) designs has been on the rise in mental health epidemiology. However, there is a lack of knowledge of the determinants of participation in and compliance with EMA studies, reliability of measures, and underreporting of methodological details and data quality indicators. Objective This stud...

Since its emergence, the COVID-19 pandemic has profoundly and extensively affected global health and society. Numerous studies have focused on detecting SARS-CoV-2 in air samples collected in healthcare indoor spaces, but few have analysed its presence in air samples from other public community spaces. In addition, limited studies have surveyed ind...

BACKGROUND There is a lack of knowledge on the determinants of participation, compliance, and completion rates in ecological momentary assessment (EMA) studies as well as on the reliability of EMA measures and responses. OBJECTIVE To assess ecological momentary assessment data quality in a large sample of university students. METHODS A total of 1...

Context: Triiodothyronine (T3) is the bioactive form of thyroid hormone. In contrast to TSH and FT4, we lack knowledge on the association of gestational T3 with adverse obstetric outcomes. Methods: We collected individual participant data from prospective cohort studies on gestational free and/or total T3 (FT3 or TT3), adverse obstetric outcomes...

International sharing of cohort data for research is important and challenging. We explored the feasibility of multi-cohort federated analyses by examining associations between three pregnancy exposures (maternal education, exposure to green vegetation and gestational diabetes) with offspring BMI from infancy to 17 years. We used data from 18 cohor...

Sleep problems and attention deficit hyperactivity disorder (ADHD) are interrelated during childhood and preadolescence. The objective of this work is assessing if sleep problems at ages 8–9 represent an alarm sign for presenting ADHD problems at ages 10–11 in three cohorts from INMA Study. Participants were 1244 children from Gipuzkoa, Sabadell, a...

Introduction There is a high prevalence of mental health problems among university students. Better prediction and treatment access for this population is needed. In recent years, short-term dynamic factors, which can be assessed using experience sampling methods (ESM), have presented promising results for predicting mental health problems. Method...

Background: Maternal obesity has been associated with shorter breastfeeding duration, but little is known about mediating factors explaining this association. It is important to assess these relationships across diverse populations because breastfeeding is culturally patterned. Objectives: We investigated the association of prepregnancy maternal...

Operating rooms are critical environments in which asepsis must be ensured. The COVID-19 pandemic entailed the implementation of additional preventative measures in health care settings, including operating theaters.

Ingested inorganic arsenic (iAs) is a human carcinogen that is also linked to other adverse health effects, such as respiratory outcomes. Yet, among populations consuming low-arsenic drinking water, the impact of iAs exposure on childhood respiratory health is still uncertain. For a Spanish child study cohort (INfancia y Medio Ambiente—INMA), low-a...

Background International sharing of cohort data for research is important and challenging. The LifeCycle project aimed to harmonise data across birth cohorts and develop methods for efficient federated analyses of early life stressors on offspring outcomes. Aim To explore feasibility of federated analyses of associations between four different typ...

The standard treatment for advanced ovarian cancer (AOC) is cytoreduction surgery and adjuvant chemotherapy. Tumor volume after surgery is a major prognostic factor for these patients. The ability to perform complete cytoreduction depends on the extent of disease and the skills of the surgical team. Several predictive models have been proposed to e...

Effects of mercury on maturing immune system have been reported, however the association with respiratory and allergy problems during infancy remains unclear. The aim of this study is to evaluate the association between pre and postnatal mercury exposure and respiratory and allergy problems among preschool children and to examine the role of potent...

Background Advanced ovarian cancer (AOC) requires an aggressive surgery with large visceral resections in order to achieve an optimal or complete cytoreduction and increase the patient’s survival. However, the surgical aggressiveness in the treatment of AOC is not exempt from major complications, such as the gastrointestinal fistula (GIF), which st...

Antecedentes/Objetivos: La evidencia sugiere que la dieta Mediterránea (DM) tiene un efecto beneficioso en el desarrollo infantil, aunque es aún insuficiente. Se han descrito un gran número de índices para medir la adherencia a DM en adultos, no así en niños. Por ello, hemos adaptado tres índices de adherencia a la DM de uso en adultos para niños...

Introduction: Copper (Cu) is an essential element involved in biological processes; however, excessive Cu could be harmful because of its reactive nature. Very few studies have evaluated its potential neurotoxic effects. We aimed to evaluate the association between maternal Cu levels and children's neuropsychological development. Methods: Study...

Data S1. Mediterranean diet in a primary cardiovascular prevention research plan.

Table S1. Concordance of Estimated Cardiovascular Risk Between Framingham‐REGICOR and SCORE Strategies in the Whole Population Table S2. Concordance of Estimated Cardiovascular Risk Between Framingham‐REGICOR and SCORE Strategies in the Nondiabetic Population Table S3. Main Cardiovascular Risk Factors, Medication Use, and Treatment Goals by Frami...

Background Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain n‐3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consump...

We previously reported diet‐gene interactions of the Mediterranean diet (MedDiet) in modulating the effects of polymorphisms in the TCF7L2‐rs7903146 and FTO‐rs9939609 genes on stroke and diabetes. Our aims were: 1) to analyze the influence of adherence to the MedDiet at baseline on the DNA‐methylation of the TCF7L2 and FTO genes and 2) to study the...

OBJECTIVE Transcription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) on these associations are unknown. We investigated whether the TCF7L2-rs7903146 (C>T) polymorphism associations with type 2 d...

Introduction and objective: CD36 is a scavenger receptor that facilitates the membrane transport of long chain fatty acids into muscle and adipose tissue. Polymorphisms in this gene have been related to abnormal serum fatty acids and obesity-related phenotypes with inconsistent results. Gene-diet interactions could modulate these associations. Our...

Background: Fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) and are relevant genes associated with obesity. This could be through food intake, but results are contradictory. Modulation by diet or other lifestyle factors is also not well understood. Objective: To investigate whether MC4R and FTO associations with body-weight are mod...

Interaction between the FTO rs9939609 and adherence to the Mediterranean Diet (AdMedDiet) on BMI (A) or waist circumference (B). Adjusted means (n = 7,052) of BMI or waist circumference according to the strata of AdMedDiet (below and above 9 points). Means were adjusted for sex, age, field center, diabetes, total energy intake and physical activity...

Association between the FTO rs9939609 and MC4R rs17782313 polymorphisms and food and alcohol intake in the studied population. (PDF)

Statistical interaction between the FTO rs9939609 polymorphism and physical activity (PA) in determining BMI (A) or waist circumference (B). Adjusted means (n = 7,052) of BMI or waist circumference depending on the FTO genotypes according to the strata of physical activity (below and above 230 kcal/d). Means were adjusted for sex, age, center, diab...

IntroductionType 2 diabetes (T2D) can induce the expression of cell adhesion molecules (ICAM, VCAM) and cytokines (IL-6 and CRP). Possibly related to these mechanisms, the transcription factor 7-like 2 (TCF7L2) gene has been associated with T2D in distinct populations, but there are few data for the Mediterranean population. Our objective was to st...

To define whether the rs9939609 FTO (fat mass and obesity associated) single nucleotide polymorphism (SNP) is associated with anthropometric measurements and its modulation by educational level in a Mediterranean population. We studied 3 independent adult samples: a random sample (n = 1580) from the general population (GP), obese hospital patients...

The -13910C>T polymorphism (rs4988235) upstream from the lactase (LCT) gene, strongly associated with lactase persistence (LP) in Europeans, is emerging as a new candidate for obesity. We aimed to analyze the association of this polymorphism with obesity-related variables and its modulation by dairy product intake in an elderly population. We studi...

The role that hyperhomocysteinemia (HH) and the C677T mutation in 5,10-methylenetetrahydrofolate reductase (MTHFR) play in splanchnic vein thrombosis (SVT) remains unclear due to this unusual thrombotic location. To analyse the possible association of HH with the C677T mutation in the MTHFR gene in SVT. We determined homocysteine levels and the C67...

Genome-wide association studies show that cholesteryl ester transfer protein (CETP) single nucleotide polymorphisms (SNPs) are more strongly associated with HDL cholesterol (HDL-C) concentrations than any other loci across the genome. However, gene-environment interactions for clinical applications are still largely unknown. We studied gene-environ...

Despite the consistent association between cholesteryl ester transfer protein (CETP) gene variation and plasma HDL-C, huge controversy still rages on its association with coronary heart disease (CHD). We investigated the association between the CETP-TaqIB polymorphism, HDL-C and incident CHD in a Mediterranean population. A nested case-control stud...

Introduction: Coffee and tea consumption recommendations for a healthy diet have been changing in recent years as it has increased the level of evidence on their benefits has increased. Objective: To know the frequency of coffee and tea consumption of in a high cardiovascular risk Mediterranean population (CVR) and to analyze whether there are diff...

Introduction: Coffee and tea consumption recommendations for a healthy diet have been changing in recent years as it has increased the level of evidence on their benefits has increased. Objective: To know the frequency of coffee and tea consumption of in a high cardiovascular risk Mediterranean population (CVR) and to analyze whether there are diff...

The aim of the present study was to assess reproducibility and relative validity of a self-administered FFQ used in the PREDIMED Study, a clinical trial for primary prevention of CVD by Mediterranean diet in a population at high cardiovascular risk. The FFQ was administered twice (FFQ1 and FFQ2) to explore reproducibility at 1 year. Four 3 d dietar...

Coffee and tea consumption recommendations for a healthy diet have been changing in recent years as it has increased the level of evidence on their benefits has increased. To know the frequency of coffee and tea consumption of in a high cardiovascular risk Mediterranean population (CVR) and to analyze whether there are differences between the consu...

The impact of classic cardiovascular risk factors on oxidative stress status in a high-risk cardiovascular Mediterranean population of 527 subjects was estimated. Oxidative stress markers (malondialdehyde, 8-oxo-7'8'-dihydro-2'-deoxyguanosine, oxidized/reduced glutathione ratio) together with the activity of antioxidant enzyme triad (superoxide dis...

Inflammation is involved in cardiovascular diseases. Some studies have found that the Mediterranean diet (MD) can reduce serum concentrations of inflammation markers. However, none of these studies have analyzed the influence of genetic variability in such a response. Our objective was to study the effect of the -765G>C polymorphism in the cyclooxy...

Introduction: Plasma viscosity (PV) constitutes an independent important predictor of initial and recurrent cardiac events and mortality. It has been suggested that there is a geographical variation in PV values related to coronary event rates. Little information exists regarding PV in Spain. Therefore, our objective was to determine PV in a large...

Introduction Serum adiponectin concentrations have been inversely associated with abdominal obesity, a more favorable lipid profile, and less insulin resistance. Nevertheless, recent studies in the population at high cardiovascular risk, especially that with altered renal function, show that high adiponectin concentrations are an unfavorable indica...

The final phenotype of patients with cystinuria depends on the absence or molecular defect, more or less acute, of the transport of cystine and dibasic aminoacids, and, also on environmental factors. The objective of this work is to study the effect of the modulation of some environmental factors (urinary pH, intake of liquids, pharmacological trea...

Objetivo: El fenotipo final del paciente con cistinuria depende, por una parte, de la ausencia o defecto molecular más o menos grave en el transporte de cistina y aminoácidos dibásicos; y por otra parte también de factores ambientales. El objetivo del presente estudio es conocer el efecto de la modulación de diversos factores ambientales (pH urinar...

The aim of this study was to investigate the presence of the most prevalent mutation in the SLC7A9 gene in families of the Mediterranean Spanish population and their association with clinical phenotypes. Twenty cystinuria families were studied (6 type I, 12 non type I, and 2 unknown type), including 48 cystinuria patients and 44 relatives. DNA was...

Background and objective The aim of this study was to investigate the presence of the most prevalent mutation in the SLC7A9 gene in families of the Mediterranean Spanish population and their association with clinical phenotypes. Patients and method Twenty cystinuria families were studied (6 type I, 12 non type I, and 2 unknown type), including 48...