Paula Casal Beiroa

Paula Casal Beiroa
Instituto de Investigación Biomédica de A Coruña | INIBIC · Department of Rheumatology

BSc Chemical Sciences and PhD Advanced Biotechnology

About

8
Publications
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19
Citations

Publications

Publications (8)
Article
Full-text available
Osteoarthritis (OA) is the most common rheumatic disease, characterized by progressive articular cartilage degradation. Raman spectroscopy (RS) has been recently proposed as a label-free tool to detect molecular changes in musculoskeletal tissues. We used cartilage samples derived from human femoral heads to perform an ex vivo study of different Ra...
Chapter
Full-text available
Osteoarthritis (OA) is the most common rheumatic disease, characterized by progressive cartilage degradation. Current gold-standard diagnosis present limitations for detecting early stages of the disease, apart from being subjective to the reader. Raman spectroscopy (RS) has been recently described as a label-free, non-invasive tool to detect chemi...
Article
Introduction Osteoarthritis (OA) is a highly heterogenous disease influenced by different molecular, anatomic and physiologic imbalances. Some of the bottlenecks for enhanced diagnosis and therapeutic assessment are the lack of validated biomarkers and early diagnosis tools. In this narrative review, we analyze the potential of Raman spectroscopy (...
Conference Paper
Osteoarthritis (OA) is a rheumatic disease characterized by articular cartilage degradation. Current gold-standard diagnosis tools present limitations to detect very early OA for which biomarkers discovery has become a pivotal research field. Raman spectroscopy (RS) is a non-invasive tool able to detect molecular changes in biological tissues, prod...
Article
Full-text available
Osteoarthritis is the most prevalent rheumatic disease. During disease progression, differences have been described in the prevalence of chondroitin sulfate (CS) isomers. Marine derived-CS present a higher proportion of the 6S isomer, offering therapeutic potential. Accordingly, we evaluated the effect of exogenous supplementation of CS, derived fr...
Conference Paper
Background Osteoarthritis (OA) is an incurable disease and methods for its early diagnosis are still an unmet clinical need. Raman spectroscopy (RS) presents potential as a diagnosis technique based on the detection of peaks that can be assigned to cartilage components and molecular rearrengements during disease progression.¹Mankin score (MS) is th...

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