Paul Slowey

Background Multimodal interventions targeting modifiable disease‐associated risk factors may support large‐scale population brain health. The landmark Finnish‐Geriatric‐Intervention‐Study‐to‐Prevent‐Cognitive‐Impairment‐and‐Disability(FINGER) demonstrated improvements in cognition and health outcomes 2‐years post‐intervention. Researchers now seek...

Citation: Warsi, I.; Khurshid, Z.; Shazam, H.; Umer, M.F.; Imran, E.; Khan, M.O.; Slowey, P.D.; Goodson, J.M. Saliva Exhibits High Sensitivity and Specificity for the Detection of SARS-COV-2. Abstract: In the wake of the COVID-19 pandemic, it is crucial to assess the application of a multitude of effective diagnostic specimens for conducting mass t...

In the wake of the COVID-19 pandemic, it is crucial to assess the application of a multitude of effective diagnostic specimens for conducting mass testing, for accurate diagnosis and to formulate strategies for its prevention and control. As one of the most versatile and amenable specimen options, saliva offers great advantages for widespread scree...

Background Few randomized controlled trials have investigated the effects of mindfulness intervention on older adults diagnosed with mild cognitive impairment (MCI). Specifically, scarce literature exists on the potential benefits of mindfulness intervention on biomarkers representing AD hallmarks. Our previous studies showed the potential of Mindf...

Background Few randomized controlled trials investigated the effects of mindfulness intervention on older adults diagnosed with mild cognitive impairment (MCI). Specifically, there has been a scarcity of literature on the potential benefit of a mindfulness intervention on biomarker for AD hallmark. Thus, we conducted a secondary analysis on bio‐ban...

The field of diagnostics using invasive blood testing represents the majority of diagnostic tests used as part of routine health monitoring. The relatively recent introduction of salivary diagnostics has lead to a major paradigm shift in diagnostic analyses. Additionally, in this era of big data, oral fluid testing has shown promising outcomes in a...

A large proportion of ongoing malaria parasite transmission is attributed to low-density subclinical infections not readily detected by available rapid diagnostic tests (RDTs) or microscopy. Plasmodium falciparum gametocyte carriage is subclinical, but gametocytemic individuals comprise the parasite reservoir that leads to infection of mosquitoes a...

www.sciencetranslationalmedicine.org/cgi/content/full/11/473/eaan4479/DC1 Materials and Methods Fig. S1. The correlation of PAR and female gametocyte abundance per microliter of blood (based on pfs25 transcript number). Table S1. The complete list of P. falciparum proteins identified in the saliva from children with subclinical infection in Yaound...

Table S3. Description of samples collected from schools in Cameroon.

Table S4. Description of samples collected from homes in Zambia.

Table S5. Quantification of gametocytes per μl of blood in a subset (n = 100) of samples from Cameroon.

Oral cancers are the sixth most frequent cancer with a high mortality rate. Oral squamous cell carcinoma accounts for more than 90% of all oral cancers. Standard methods used to detect oral cancers remain comprehensive clinical examination, expensive biochemical investigations, and invasive biopsy. The identification of biomarkers from biological f...

Saliva is an easily accessible fluid that has led to increasing interest in the development of salivary diagnostics. This chapter describes some of the newer tools and procedures for collection, stabilization, and storage of oral fluid matrices that aid in the successful use of saliva as a test specimen. This chapter focuses particularly on nucleic...

Saliva is an emerging biofluid with a significant number of applications in use across research and clinical settings. The present paper explores the reasons why saliva has grown in popularity in recent years, balancing both the potential strengths and weaknesses of this biofluid. Focusing on reasons why saliva is different from other common biolog...

Objectives: The aim of the current study was to carry out a preliminary validation of devices for standardized collection of whole mouth fluid (WMF) in comparison to the passive drooling method for protein analysis in healthy subjects. Methods: A carefully designed sample collection/pretreatment protocol is crucial to the success of any saliva prot...

Salivary diagnostic technology offers a number of advantages over other testing methods.

There has been a rapid growth in the interest and adaptation of saliva as a diagnostic specimen over the last decade, and in the last few years in particular, there have been major developments involving the application of saliva as a clinically relevant specimen. Saliva provides a “window” into the oral and systemic health of an individual, and li...

The reproducibility of the standardized collection of saliva using a novel device, Super-SAL is demonstrated for 5 different analytes by performing serial collections from individuals one after the other, 5 minutes apart. In addition to showing no differences between the three serially collected specimens, equivalence is demonstrated to the gold st...

• Saliva has become an attractive specimen for disease diagnosis. In this study we evaluated the option to utilize saliva to accurately differentiate patients with Parkinson’s disease from normal healthy individuals. • A small comparative study was performed on saliva patient samples using two collection methods: passive drool and Super•SAL™ saliva...

Oral and oropharyngeal cancers (OPC) are the most common types of head and neck cancers (HNC), accounting for 263,900 new cases and 128,000 deaths worldwide (1). These cancer subtypes are highly curable if detected early. The most common treatments include surgery, radiation therapy, chemotherapy or a combination of these treatments. Tobacco smokin...

Purpose: Saliva is a reliable, noninvasive, and cost-effective alternative to biomarkers measured in other biological fluids. Within certain populations, saliva sampling may be difficult because of insufficient saliva flow, which may compromise disease diagnosis or research integrity. Methods to improve flow rates (eg, administering citric acid, c...

Cortisol is frequently assayed as a stress-responsive biomarker which changes over the course of minutes to meet the demands of a person's social context. Salivary cortisol is often used as a noninvasive sampling method that possesses important health implications. A critical barrier to psychobiological research that involves salivary cortisol is a...

Over the last few years, there has been a tremendous growth in less invasive diagnostic testing as a replacement for painful and expensive blood draws. The role of saliva in this growth trend has been enormous, and this has been driven in part by a growing awareness of the broad utility of saliva as a diagnostic medium and reinforced by a rapidly g...

With an increasing recognition of the link between oral and systemic disease, attention has turned to saliva as an alternative diagnostic medium for a diverse array of health conditions [1]. Compared with blood, saliva collection is non-invasive, easy sampling with multiple sampling opportunities, does not need pre-processing and is ideal for 3 rd...

Oasis Diagnostics has developed two products to address the need for providing a saliva sample for use in final quantitative analysis of relevant biological analytes in a Point-of-Care (POC) or Point–of-Use (POU) environment. The first product is a real-time quantitative POC/POU Salivary Cortisol test (VerOFy®) that utilizes a fluorescent Lateral F...

With an increasing recognition of the association between oral and systemic diseases, attention has turned to saliva as an alternative diagnostic medium for a diverse array of health conditions [Malamud D, Tabak LA, 1993]. Compared with blood, saliva collection is non-invasive, easy to collect with multiple sampling opportunities, does not need pre...

Objective: Salivary transcriptomic and proteomic biomarker profiles have been proven to detect oral and other systemic diseases; however, current standard operation procedure (SOP) limits saliva samples and disease variety to research facilities. The universal iSCPSS System provides simultaneous self-collection of RNA and protein collection, proces...

A biological sample collection system is described comprising a biological sample collecting wand and a buffer container with a buffer solution. The biological sample collecting wand includes a handle and a sample collector detachably coupled to the handle. The sample collector include one or more sample protrusions, one or more sample apertures, o...

The stabilization and processing of salivary transcriptome and proteome biomarkers is a critical challenge due to the ubiquitous nature of nucleases and proteases as well as the inherent instability of these biomarkers. Furthermore, extension of salivary transcriptome and proteome analysis to point-of-care and remote sites requires the availability...

Saliva as a biological fluid is gaining wider acceptance for diagnosing diseases. The growing interest in saliva as a biological fluid is due to its noninvasiveness, ease of use, cost-effectiveness, and multiple sample collection possibilities as well as minimal risk to health care professionals of contracting infectious organisms such as HIV and H...

An apparatus for generating and collecting saliva samples containing enhanced cell concentrations includes a mouthpiece having a mouth contact portion and a flow channel which may include a tapered basin, a conduit in fluid communication with the flow channel, and one or more collectors couplable to the conduit. The mouth contact portion and basin...

An embodiment is a fluid sample collection system. More specifically, an embodiment is a fluid sample collection system to facilitate collection of biological specimens and particularly to facilitate collection of saliva, urine, and stool specimens from human or animal species for the purpose of extracting purified DNA and/or RNA.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world based on its mortality, and approximately 900,000 new cases are diagnosed each year with 300,000 deaths per annum. The known major risk factors for the development of SCC include smoking, drinking and human papilloma viral infections. Currently there are no b...

Within the mismatch hypothesis, and specifically the Adaptive Calibration Model (Del Guidice, Ellis, Shirtcliff, 2011), individuals vary both in their environmental stressors and biological sensitivity to those experiences. Functioning of the Hypothalamic-Pituitary-Adrenal (HPA) axis via salivary cortisol reactivity provides one measure of biologic...

Saliva has been used as a specimen for diagnostics purposes for many years, but it has only been in the last 10 years that a number of new tools have been developed that promise to greatly increase the use of oral specimens for broad-based diagnosis and potentially screening applications. This article focuses on tools that are commercially viable o...

Head and neck squamous cell carcinoma (HNSCC) accounts for a bulk of the oral and laryngeal cancers, the majority (70%) of which are associated with smoking and excessive drinking, major known risk factors for the development of HNSCC. In contrast to reports that suggest an inverse relationship between smoking and global DNA CpG methylation, hyperm...

Utile (lAttifed fate ot J[tyietttect Has received an application for a patent for a new and useful invention. The title and description of the invention are enclosed. The requirements of law have been com-plied with, and it has been determined that a patent on the invention shall be granted under the law Therefore, this United States Patent Grants...

AbstractA synthetic procedure for [3H]ciprofibrate is described. The radiolabel was introduced by catalytic dehalogenation of bromociprofibrate with tritium gas, as shown in the Scheme.

A new route to dihydropyrene precursors, 1,3-bis(bromomethyl)-2-substituted-benzenes, has been found, which starts from the readily available hexachlorocyclopentadiene and 3-substituted acrylic esters. Utilization of an intermediate in this sequence, 1,3-bis(bromomethyl)-4,5-dichlorotoluenc, has opened up a route to the relatively inaccessible cis-...

Reaction of (I) with methyl crotonoate (II) gives a mixture of the exo-endo isomers (III), which is hydrolysed to yield the ketones (IV).

Halogenocycloalkenes are converted into polyhalogenocyclopropanes by reaction with dichloro- or dibromocarbenes, generated from the haloform and aqueous base in the presence of a phasetransfer catalyst.

Reaction of the dibromides (5) and (10) with methyl lithium in ether leads to products derived by 1,3-dehalogenation, (6) and (11), whereas (15) and (16) undergo 1,1-dehalogenation and rearrangement to allenes, (17) and (18).

Aus den Dibromcyclopropylmethylchloriden (I) ′bzw. (VII) werden mit Methyllithium bei -40°C die Brom-bicyclobutane (III) bzw. (VIII) neben den Dienen (IV) bzw. (IX) erhalten.

Durch Cyclisierung des Dichlorids (Ia) mit dem daraus hergestellten Dimercaptan (Ib) wird ein Gemisch der syn- und anti-Isomere von (II) und (III) erhalten, deren anti- Komponenten einer Wittig-Umlagerung mit nachfolgender Hofmann-Eliminierung unterworfen werden.

Eliminierungsreaktionen an den bicyclischen Trihalogen-cyclopropanen (I) werden untersucht.

Thermolysis of a number of bicyclic trihalocyclopropanes (1; X, Y = halogen) in the presence of quinoline leads either to 3-(dihalomethylene)cyclo-alkenes (8,9,10) with loss of halogen X to ring expanded 1,2-dihalocycloalka-1,3-dienes (11,13) with loss of halogen Y, depending on ring size and on the nature of the halogen.