Paul Posadzki- PhD
- A/Prof at University School of Physical Education in Kraków
Paul Posadzki
- PhD
- A/Prof at University School of Physical Education in Kraków
I lead systematic literature reviews, clinical practice guidelines and health technology assessments and teach students.
About
159
Publications
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Introduction
A visionary and passionate scientist, determined to make a difference in people’s health and lives.
Current institution
Additional affiliations
October 2014 - June 2022
October 2013 - June 2014
August 2010 - August 2012
Publications
Publications (159)
Osteoarthritis (OA) affects hundreds of millions of people worldwide. The objective was to critically appraise the efficacy and safety of topical capsaicin in reducing pain in OA. MEDLINE (PubMed) and Embase (Ebsco) were searched from inceptions until February 2023. The eligibility criteria included randomized controlled trials (RCTs), evaluating t...
Background: Delayed onset muscle soreness (DOMS), also known as exercise-induced muscle damage (EIMD), is typically caused by strenuous and/or unaccustomed physical exercise. DOMS/EIMD manifests itself in reduced muscle strength and performance levels, increased muscle soreness, swelling, and elevated levels of inflammatory biomarkers. Numerous ran...
Background
The indication for this assessment is the use of the KardiaMobile six-lead electrocardiogram device for the assessment of QT interval-based cardiac risk in service users prior to the initiation of, or for the monitoring of, antipsychotic medications, which are associated with an established risk of QT interval prolongation.
Objectives
T...
Several new randomized trials evaluating the effectiveness and safety of spinal manipulative therapies (SMT) have been published since our previous systematic review (SR). Therefore, we aim at updating the evidence base for the effectiveness of SMT for migraine. An update searches were performed in the following electronic databases: Amed, Embase,...
Background: In health technology assessments (HTAs), matching-adjusted indirect comparisons (MAICs) are used when head-to-head randomised studies comparing a drug (therapy) in question and a comparator, e.g., standard care in the treatment of a disease, are not available. MAICs use individual patient data (IPD) from trials of one treatment to match...
The National Institute for Health and Care Excellence (NICE) invited the manufacturer (Roche) of pralsetinib (Gavreto®), as part of the single technology appraisal (STA) process, to submit evidence for the clinical effectiveness and cost effectiveness of pralsetinib for the treatment of adult patients with rearranged during transfection (RET) fusio...
I read with interest the article by Kuligowski et al., 2021 published in the Journal [...]
Fenfluramine, tradename Fintepla®, was appraised within the National Institute for Health and Care Excellence (NICE) single technology appraisal (STA) process as Technology Appraisal 808. Within the STA process, the company (Zogenix International) provided NICE with a written submission and a mathematical health economic model, summarising the comp...
Osteopathic manipulative treatment (OMT) continues to be used for a range of diseases in children.
Objectives:
The aim of this paper is to update our previous systematic review (SR) initially published in 2013 by critically evaluating the evidence for or against this treatment.
Methods:
Eleven databases were searched (January 2012 to November 2...
Background
Sedentary lifestyle is a major risk factor for noncommunicable diseases such as cardiovascular diseases, cancer and diabetes. It has been estimated that approximately 3.2 million deaths each year are attributable to insufficient levels of physical activity. We evaluated the available evidence from Cochrane systematic reviews (CSRs) on th...
The National Institute for Health and Care Excellence (NICE) invited the manufacturer (Celgene) of lenalidomide (Revlimid®), as part of the Single Technology Appraisal (STA) process, to submit evidence for the clinical effectiveness and cost-effectiveness of lenalidomide in combination with rituximab (MabThera®), together referred to as R2, for the...
[This corrects the article DOI: 10.2196/12968.].
There is a growing reliance on the systematic reviews (SRs) in the current evidence‐based medicine and public health. The aim of this chapter is to provide a comprehensive guideline for conducting a high‐quality SR. The authors draw on their own experience and expertise in the field to offer a set of concise recommendations for students, residents,...
Objective: This article is aimed at critically evaluating the evidence for or against the effectiveness of massage therapy on pain. Design: Review of systematic reviews. Methods: Six databases were searched from their inceptions to June 2013. Systematic reviews (SRs) of randomised controlled trials (RCTs) of any type of manual massage (MM) with any...
Background: The World Health Organization states that 35% of women experience domestic violence at least once during their lifetimes. However, approximately 80% of health professionals have never received any training on management of this major public health concern.
Objective: The objective of this study was to evaluate the effectiveness of healt...
BACKGROUND
According to the World Health Organization (WHO) 35% of women experience domestic violence at least once during their lifetimes. Yet approximately 80% of healthcare professionals have never received any training on management of this major public health concern.
OBJECTIVE
The objective of this study is to evaluate the effectiveness of h...
Synthesizing evidence from randomized controlled trials of digital health education poses some challenges. These include a lack of clear categorization of digital health education in the literature; constantly evolving concepts, pedagogies, or theories; and a multitude of methods, features, technologies, or delivery settings. The Digital Health Edu...
Underground workplaces are an important element in modern urban planning. As a result, an increasing but unquantified proportion of the population is being regularly exposed to them. We narratively reviewed the literature on the range of possible environmental exposures, and the possible health effects, to identify future research directions. There...
BACKGROUND
Medical schools in low- and middle-income countries are facing a shortage of staff, learning infrastructure as well as access to fast and reliable Internet. Offline digital education may be an alternative solution for these issues allowing medical students to learn at their own time and pace, without the need for a network connection.
O...
Background:
Medical schools in low- and middle-income countries are facing a shortage of staff, limited infrastructure, and restricted access to fast and reliable internet. Offline digital education may be an alternative solution for these issues, allowing medical students to learn at their own time and pace, without the need for a network connect...
BACKGROUND
Globally, online and local area network-based (LAN) digital education (ODE) has grown in popularity. Blended learning is the use of ODE along with traditional learning. Studies have shown the increasing potential of these technologies in training medical doctors yet the evidence for its effectiveness and cost-effectiveness is unclear.
O...
Background:
Globally, online and local area network-based (LAN) digital education (ODE) has grown in popularity. Blended learning is used by ODE along with traditional learning. Studies have shown the increasing potential of these technologies in training medical doctors; however, the evidence for its effectiveness and cost-effectiveness is unclea...
BACKGROUND
Effective communication skills are essential in diagnosis and treatment processes and building of the doctor-patient relationship. We studied whether digital education can improve the quality of future doctors’ communication skills.
OBJECTIVE
The aim of this systematic review was to evaluate the effectiveness of digital education for co...
Background:
Effective communication skills are essential in diagnosis and treatment processes and in building the doctor-patient relationship.
Objective:
Our aim was to evaluate the effectiveness of digital education in medical students for communication skills development. Broadly, we assessed whether digital education could improve the quality...
BACKGROUND
Background: The widening gap between innovations in the medical field and the dissemination of such information to doctors may affect the quality of care. Offline computer-based digital education (OCDE) may be a potential solution to overcoming the geographical, financial and temporal obstacles faced by doctors.
OBJECTIVE
Objectives: Th...
Background:
The widening gap between innovations in the medical field and the dissemination of such information to doctors may affect the quality of care. Offline computer-based digital education (OCDE) may be a potential solution to overcoming the geographical, financial, and temporal obstacles faced by doctors.
Objective:
The objectives of thi...
BACKGROUND
The shortage and disproportionate distribution of healthcare workers worldwide is further aggravated by the inadequacy of training programmes, difficulties in implementing conventional curricula, deficiencies in learning infrastructure, or a lack of essential equipment/supplies. Offline digital education has the potential to reduce the s...
BACKGROUND
Virtual Reality (VR) is a technology that allows the user to explore and manipulate computer-generated real or artificial three-dimensional (3D) multimedia sensory environments in real time to gain practical knowledge that can be used in clinical practice.
OBJECTIVE
The aim of this systematic review was to evaluate the effectiveness of...
Background:
Virtual reality (VR) is a technology that allows the user to explore and manipulate computer-generated real or artificial three-dimensional multimedia sensory environments in real time to gain practical knowledge that can be used in clinical practice.
Objective:
The aim of this systematic review was to evaluate the effectiveness of V...
Background:
The shortage and disproportionate distribution of health care workers worldwide is further aggravated by the inadequacy of training programs, difficulties in implementing conventional curricula, deficiencies in learning infrastructure, or a lack of essential equipment. Offline digital education has the potential to improve the quality...
UNSTRUCTURED
Synthesizing evidence from randomized controlled trials of digital health education poses some challenges. These include a lack of clear categorization of digital health education in the literature, overarching term with constantly evolving concepts, pedagogies, or theories as well as a multitude of methods, features, technologies, or...
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The primary objective of this systematic review is to evaluate the effectiveness of offline computer-based eLearning educational interventions compared to traditional classroom learning and/or other types of eLearning or no intervention, for improving medical do...
Background: Overviews of reviews (or simply overviews) have become an increasingly established approach to synthesising research. Overviews are becoming prevalent because they have potential advantages over systematic reviews. However, they impose unique methodological challenges due to undeveloped synthesis method. While significant empirical work...
This study described the differences in prevalence of poor sleep quality in workers in underground workspaces (without presence of natural sunlight or aboveground view) in Singapore and the United States (US).
Background:- Sleep quality is associated with cardiovascular disease (CVD) and addressing sleep behaviour could promote cardiovascular health (1). In this study, we compared the differences in prevalence of poor sleep quality in workers in underground workspaces (without presence of natural sunlight or aboveground view) in Singapore and the United...
Background:
There will be a lack of 18 million healthcare workers by 2030. Multiplying the number of well-trained healthcare workers through innovative ways such as eLearning is highly recommended in solving this shortage. However, high heterogeneity of learning outcomes in eLearning systematic reviews reveals a lack of consistency and agreement o...
Clinical Question
Are light therapies effective and safe for treating acne?
Bottom Line
The evidence for all light therapies remains weak and inconclusive. Red-light methyl aminolevulinate-photodynamic therapy (MAL-PDT) was the only treatment associated with a small though clinically insignificant reduction in the number of inflamed lesions and in...
Background:
Our aims were to evaluate critically the evidence from systematic reviews as well as narrative reviews of the effects of melatonin (MLT) on health and to identify the potential mechanisms of action involved.
Methods:
An umbrella review of the evidence across systematic reviews and narrative reviews of endogenous and exogenous (supple...
Acne vulgaris is a common skin condition causing blackheads and whiteheads and red spots. Acne often leads to scarring, which is extremely difficult to treat. Acne can produce significant psychological and social problems, including lower self-esteem, anxiety, depression and low mood. Many light-based therapies have been tried for acne vulgaris, bu...
寻常痤疮是一种常见的皮肤问题,可导致黑头、白头以及红斑。痤疮通常会留下非常难治的痘印。痤疮可能导致严重的心理和社交问题,包括自尊心受挫、焦虑、沮丧以及情绪低落。许多光疗法已试验用于治疗寻常痤疮,但其效果和安全性尚不明确。光疗法使用具有不同性质(比如波长和强度)的光。虽然具体机理尚未完全弄清,但有三个因素至关重要:光、感光剂(即:吸收并随后通过光激化的分子)以及通过激化产生的氧化应激。大家认为,这种氧化应激有助于破坏致菌痤疮并防止毛孔堵塞。该研究综述了不同的光疗祛痘试验。研究人员发现,有关使用光疗祛痘的高质量证据尚且缺乏。有证据表明甲基氨基酮戊酸盐光动力疗法(红光)有效,证据质量尚可。此外,有证据表明氨基酮戊酸光动力疗法(蓝光)在作为标准疗法治疗中度到重度痤疮方面有效,但证据质量不高。通过该综...
We undertook a Cochrane review of randomized controlled trials (RCTs) evaluating the effects of light-based interventions for acne vulgaris. We searched the Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase, LILACS, ISI Web of Science, and grey literature sources (September 2015). We used the Grading of Recommendations Assessment, Develo...
Background
Automated telephone communication systems (ATCS) can deliver voice messages and collect health-related information from patients using either their telephone's touch-tone keypad or voice recognition software. ATCS can supplement or replace telephone contact between health professionals and patients. There are four different types of ATC...
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:
The primary objective of this systematic review is to evaluate the effectiveness of offline computer-based eLearning educational interventions compared to traditional classroom learning and/or other types of eLearning or no intervention, for improving medical d...
Background:
Acne vulgaris is a very common skin problem that presents with blackheads, whiteheads, and inflamed spots. It frequently results in physical scarring and may cause psychological distress. The use of oral and topical treatments can be limited in some people due to ineffectiveness, inconvenience, poor tolerability or side-effects. Some s...
Background:
The aim of this article is to summarize and critically evaluate the evidence from systematic reviews (SRs) of complementary and alternative medicine (CAM) for lowering blood lipid levels (BLL).
Methods:
Eight electronic databases were searched until March 2016. Additionally, all the retrieved references were inspected manually for fu...
Background:
Wet cupping is a widely used traditional therapy in many countries, which justifies a continuous scientific evaluation of its efficacy and safety.
Objectives:
To perform a systematic review to critically evaluate and update the available evidence of wet cupping in traditional and complementary medicine.
Methods:
Ten electronic data...
Background
Complementary and alternative medicine (CAM) is popular among individuals with a variety of addictions.
Objective
To critically evaluate the evidence from systematic reviews (SRs) of the effectiveness of CAM for addictions.
Methods
Ten electronic databases were searched from their inception to January 2015. Systematic reviews of any ty...
Since the Women's Health Initiative report of 2002, there has been reluctance to provide women with hormone replacement therapy due to a lack of clarity about the potential risks. This book reviews all aspects of the menopause and places the benefits and risks of hormone therapy into perspective. It fully informs the reader regarding the evidence b...
The objective of this systematic review is to summarize and critically assess the effects of yoga on heart rate variability (HRV). Nine databases were searched from their inceptions to June 2014. We included randomized clinical trials (RCTs) comparing yoga against any type of control intervention in healthy individuals or patients with any medical...
Background
Complementary and alternative medicine (CAM) is very popular among migraineurs.Objectives
The aim of this article is to summarise and critically evaluate the evidence from systematic reviews (SRs) of CAM for the prevention and treatment of migraine headache.Method
Ten electronic databases were searched from 1946 to August 2014. Retrieved...
About 100 years ago, natural herbs were the main remedy for treating human diseases. It has been estimated that 25% of modern medicines are made from plants first used traditionally [1], such as aspirin, artemisinin, ephedrine, and paclitaxel. However, there is limited scientific evidence to establish the safety and efficacy of most herbal products...
The aim of this systematic review was to determine the effectiveness of acupuncture for the treatment of whiplash associated disorder (WAD). Twenty databases were searched from their inceptions to Oct. 2013. Randomised clinical trials (RCTs) of acupuncture (AT), electroacupuncture (EA), or dry needling (DN) for the treatment of WAD were considered...
Although yoga is frequently used by patients with asthma, its efficacy in alleviating asthma remains unclear.
To systematically assess and meta-analyze the available data on efficacy and safety of yoga in alleviating asthma.
MEDLINE/PubMed, Scopus, the Cochrane Central Register of Controlled Trials, PsycINFO, CAM-Quest, CAMbase, and IndMED were sea...
Objective:
The increased prevalence of obesity has resulted in the current high popularity of dietary supplements marketed as weight reducing agents. The efficacy of most of these supplements is not established. The soluble fiber, glucomannan, is often recommended for weight loss. The aim of this systematic review is to evaluate the evidence for o...
Background
It has been suggested that yoga may be effective in the management of mental health disorders including addictions. Objective
To critically evaluate the evidence of effectiveness of yoga as a treatment for addictions. Methods
Fourteen electronic databases were searched from inception to January 2013. Randomised controlled trials (RCTs) t...
Molassiotis is the author of about 40 reviews, all of which are
prone to the shortcomings he highlights. His statement, “I urge
researchers in the field not to proliferate publications of ‘systematic’
reviews of a very small number and of admittedly
poor/low quality level trials”, is thus surprising to say the least.
The main point of his response...
Background and objectives:
Most osteopaths are trained in pediatric care, and osteopathic manipulative treatment (OMT) is available for many pediatric conditions. The objective of this systematic review was to critically evaluate the effectiveness of OMT as a treatment of pediatric conditions.
Methods:
Eleven databases were searched from their r...
This systematic review is aimed at estimating the prevalence of complementary and alternative medicine (CAM)-use by paediatric populations in the United Kingdom (UK).
AMED, CINAHL, COCHRANE, EMBASE and MEDLINE were searched for English language peer-reviewed surveys published between 01 January 2000 and September 2011. Additionally, relevant book c...
Dietary supplements are popular among patients with prostate cancer (PC). The objective of this systematic review was to critically examine double-blind, placebo-controlled randomised clinical trials (RCTs) of non-herbal dietary supplements and vitamins (NHDS) for evidence that prostate specific antigen (PSA) levels were reduced in PC patients. Fiv...
Linked Comment: Jackson. Int J Clin Pract 2013; 67: 385.
Linked Comment: Walach et al. Int J Clin Pract 2013; 67: 385–6.
Linked Comment: Posadzki and Ernst. Int J Clin Pract 2013; 67: 386–7.
Linked Comment: Grimes. Int J Clin Pract 2013; 67: 387.
Linked Comment: Tournier et al. Int J Clin Pract 2013; 67: 388–9.
This systematic review aimed to estimate the prevalence of use of complementary and alternative medicine (CAM) in the UK. Five databases were searched for English language, peer-reviewed surveys published between 1 January 2000 and 7 October 2011. In addition, relevant book chapters and files from our own departmental records were searched by hand....
Objectives:
The aim of this overview of systematic reviews (SRs) is to evaluate critically the evidence regarding interactions between herbal medicinal products (HMPs) and synthetic drugs.
Methods:
Four electronic databases were searched to identify relevant SRs.
Results:
Forty-six SRs of 46 different HMPs met our inclusion criteria. The vast...
Purpose:
The aim of this overview of systematic reviews is to summarise and critically evaluate the evidence from systematic reviews of the adulteration and contamination of herbal medicinal products (HMPs).
Methods:
Five electronic databases were searched to identify all relevant systematic reviews.
Results:
Twenty-six systematic reviews met...
ABSTRACT The aim of this systematic review was to evaluate the evidence from randomized controlled trials (RCTs) involving the use of the African Bush Mango, Irvingia gabonensis for body weight reduction in obese and overweight individuals. Electronic and nonelectronic searches were conducted to identify relevant RCTs. The bibliographies of located...
Objective
To estimate the prevalence of herbal medicine (HM) use in the UK. Methods
The databases AMED, CINAHL, COCHRANE, EMBASE and MEDLINE were searched for peer-reviewed surveys published between January 2000 and September 2011. The authors’ own departmental files were also manually searched for relevant references. ResultsTen surveys were inclu...
Objective
To update a systematic review evaluating the safety of massage therapy. MethodsA literature search was carried out using four electronic databases for the period December 2001 to May 2012. All articles reporting adverse effects of massage therapy were retrieved. Adverse effects relating to atypical massage, aromatherapeutic massage oil or...
Purpose:
Managing cancer-related fatigue (CRF) is an important element of the palliative care of cancer patients. The aim of this systematic review was to critically evaluate the effectiveness of acupuncture (AT) or electroacupuncture (EA) for CRF.
Methods:
Fourteen databases were searched from their respective inception to November 2012. Random...
This overview of systematic reviews (SRs) aims to evaluate critically the evidence regarding the adverse effects of herbal medicines (HMs). Five electronic databases were searched to identify all relevant SRs, with 50 SRs of 50 different HMs meeting our inclusion criteria. Most had only minor weaknesses in methods. Serious adverse effects were note...
Aim:
The aim of this systematic review was to critically evaluate the evidence regarding the adverse effects (AEs) of homeopathy.
Method:
Five electronic databases were searched to identify all relevant case reports and case series.
Results:
In total, 38 primary reports met our inclusion criteria. Of those, 30 pertained to direct AEs of homeop...
This systematic review aims to estimate the prevalence of use of complementary and alternative medicine (CAM) by physicians in the UK. Five databases were searched for surveys monitoring the prevalence of use of CAM, which were published between 1 January 1995 and 7 December 2011. In total, 14 papers that reported 13 separate surveys met our inclus...
The aim of this overview was to critically evaluate the literature on complementary and alternative medicine (CAM) for Alzheimer's disease.
Four electronic databases were searched to identify all relevant systematic reviews of effectiveness of CAM for Alzheimer's disease. Reviews were defined as systematic if they included explicit and repeatable c...
Background
Many authors have explored the intriguing possibility that the regular intake of Allium sativum (garlic) might reduce cancer risk. Most of this evidence is based on epidemiological data which, by its very nature, may not be fully convincing in establishing causality. Objective
To critically evaluate the evidence of effectiveness of garli...
Aims:
This systematic review is aimed at assessing surveys which monitor the prevalence of complementary and alternative medicine (CAM) use by climacteric women living in the UK.
Method:
Five databases were searched for English-language, peer-reviewed surveys published between 1 January 2000 and 7 October 2011. In addition, the bibliographies of...
Aims: The objective of this systematic review was to evaluate all placebo (sham)-controlled studies of surgery. Method: Six databases were searched from their inception to March 2011. All placebo(sham)-controlled randomized clinical trials of surgery in human subjects were considered. The selection of studies, data extraction, and validation were p...
Asthma patients often try some form of alternative medicine. This article questions whether this is good or bad. Systematic reviews fail to demonstrate that the treatments in question are demonstrably effective. Other data raise considerable concern over the safety of some forms of alternative medicine. Thus the risk-benefit balance fails to be pos...
Questions
Questions (8)
Hi Folks, Would anyone of you have access to these three papers, please:
MESSERKLINGER W. Professor Dr. Gustav Hofer zum 70. Geburtstag [To Prof. Gustav Hofer on his 70th birthday]. Wien Klin Wochenschr. 1957 Jun 21;69(25):439. German. PMID: 13456496.
Messerklinger W. Prof. Dr. med. Dr. med. h.c. Gustav Hofer [Professor Gustav Hofer, M.D., M.D. h.c]. Monatsschr Ohrenheilkd Laryngorhinol. 1971;105(1):1-8. German. PMID: 4926220..
Leicher H. Prof. Dr. Dr. h. c. Gustav Hofer 80 Jahre alt [Prof. Gustav Hofer is 80 years old]. Z Laryngol Rhinol Otol. 1967 Aug;46(8):549-51. German. PMID: 4876079.
much appreciated.
Best wishes,
Pawel
Does anyone have an access to the full text of this paper "The efficacy of spinal manipulation, amitriptyline and the combination of both therapies for the prophylaxis of migraine headache." J Manipulative Physiol Ther. 1998 Oct;21(8):511-9. Much appreciated, Best wishes,
Interestingly, the EIC of @JCompEffRes wrote to me that they ”we will be contacting the authors to discuss whether a correction notice [for the following paper doi/10.2217/cer-2022-0031by @magdalena zeglen @tomasz brzostek] is appropriate” even though the letter to the editor was denied publication. The EIC said “the criticism in the Letter is not valid” but when I asked for a list of examples in which points I made are not "valid", I received no response. Another example of silencing a constructive debate on #evidencebasedmedicine #evidencebasedpractice #systematicreview #evidencesynthesis #Parkinson’sDisease #Opicapone
I have the pleasure of sharing the letter here.
Any comments regarding the alleged “lack of valid points”, highly welcomed. Best wishes, Pawel Posadzki, PhD
The EIC of @nutritionreviews did not encourage scientific debate on #evidencebasedmedicine #evidencebasedpractice #systematicreview #evidencesynthesis and refused to publish a letter to the editor, in which I criticised lack of rigour in the systematic review on dietary phytoestrogens and biomarkers and cancer survival and recurrence (rather important health topic) by @tomasz brzostek @agnieszka micek. I have the pleasure of sharing the aforementioned letter here. Any comments, highly welcomed. Best wishes, Pawel Posadzki, PhD
Anyone interested in updating/writing systematic reviews or overviews of reviews in complementary medicine area? No financial incentives but possible publications in high quality peer-reviewed journals. With all my best wishes, Paul
Dear All, is anyone interested in updating a systematic review on massage (rejected with minor comments from PAIN)? (registered at: CRD42013004982) Kindly please let me know. Thank you very much indeed. With all my best wishes, Paul
Does anyone would like to contribute a chapter on treatments used in CAM for the 38th ed of SEDA?
There is little evidence that spinal manipulation is an effective treatment for headaches.
