Paul M Parizel

Paul M Parizel
University of Western Australia | UWA · David Hartley Chair of Radiology

MD, PhD

About

693
Publications
385,320
Reads
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15,909
Citations
Citations since 2017
130 Research Items
8228 Citations
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Introduction
Paul M. Parizel graduated summa cum laude as M.D. from the University of Antwerp, Belgium, in 1982. After radiology residency, he completed fellowships in neuroradiology at Massachusetts General Hospital, Harvard Medical School (Prof. Dr. Juan M. Taveras), and Hôpital Erasme, University of Brussels (Prof. Dr. Danielle Balériaux). In 1994, he obtained a Ph.D. degree with a dissertation entitled “The influence of field strength on magnetic resonance imaging.”
Additional affiliations
September 2003 - present
University of Antwerp
Position
  • Chair
January 1992 - June 1992
The Children's Hospital of Philadelphia
Position
  • Professor
July 1986 - October 1987
Hôpital Erasme, Université Libre de Bruxelles
Position
  • Fellowship in Neuroradiology

Publications

Publications (693)
Article
Full-text available
The clinical and neuroimaging findings of a family with a variant ACTA2 gene (c351C > G), presenting with smooth muscle dysfunction in structures of neural crest derivation, are discussed. The combination of aortic abnormalities, patent ductus arteriosus, congenital mydriasis and distinctive cerebrovascular and brain morphological abnormalities cha...
Article
We report a patient with decompensated alcoholic liver cirrhosis (Child-Turcotte-Pugh class C) who developed a de novo left frontal cerebral AVM and a subcutaneous left temporal scalp spider naevus. Arteriovenous malformations (AVMs) are vascular abnormalities previously thought to be congenital in nature, although new research has revealed the pot...
Article
Full-text available
Long-duration spaceflight induces changes to the brain and cerebrospinal fluid compartments and visual acuity problems known as spaceflight-associated neuro-ocular syndrome (SANS). The clinical relevance of these changes and whether they equally affect crews of different space agencies remain unknown. We used MRI to analyze the alterations occurrin...
Article
Full-text available
The present review summarizes the available evidence on artificial intelligence (AI) algorithms aimed to the segmentation of epicardial and pericardial adipose tissues on computed tomography (CT) images. Body composition imaging is a novel concept based on quantitative analysis of body tissues. Manual segmentation of medical images allows to obtain...
Article
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Humans undergo extreme physiological changes when subjected to long periods of weightlessness, and as we continue to become a space-faring species, it is imperative that we fully understand the physiological changes that occur in the human body, including the brain. In this study, we present findings of brain structural changes associated with long...
Article
Background Frailty is known to be associated with poorer outcomes in individuals admitted to hospital for medical conditions requiring intensive care. However, little evidence is available for the effect of frailty on patients’ outcomes after traumatic brain injury. Many frailty indices have been validated for clinical practice and show good perfor...
Article
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Background Trauma-induced coagulopathy in traumatic brain injury (TBI) remains associated with high rates of complications, unfavorable outcomes, and mortality. The underlying mechanisms are largely unknown. Embedded in the prospective multinational Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) stu...
Article
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Background In traumatic brain injury (TBI), large between-center differences in treatment and outcome for patients managed in the intensive care unit (ICU) have been shown. The aim of this study is to explore if European neurotrauma centers can be clustered, based on their treatment preference in different domains of TBI care in the ICU. Methods P...
Article
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Background Prehospital care for patients with traumatic brain injury (TBI) varies with some emergency medical systems recommending direct transport of patients with moderate to severe TBI to hospitals with specialist neurotrauma care (SNCs). The aim of this study is to assess variation in levels of early secondary referral within European SNCs and...
Article
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Introduction Neurocognitive problems associated with posttraumatic stress disorder (PTSD) can interact with impairment resulting from traumatic brain injury (TBI). Research question We aimed to identify neurocognitive problems associated with probable PTSD following TBI in a civilian sample. Material and methods The study is part of the CENTER-TB...
Article
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Importance An interview is considered the gold standard method of assessing global functional outcomes in clinical trials among patients with acute traumatic brain injury (TBI). However, several multicenter clinical trials have used questionnaires completed by a patient or caregiver to assess the primary end point. Objective To examine agreement b...
Article
Background In patients with severe brain injury, withdrawal of life-sustaining measures (WLSM) is common in intensive care units (ICU). WLSM constitutes a dilemma: instituting WLSM too early could result in death despite the possibility of an acceptable functional outcome, whereas delaying WLSM could unnecessarily burden patients, families, clinici...
Article
Full-text available
Background In patients with severe brain injury, withdrawal of life-sustaining measures (WLSM) is common in intensive care units (ICU). WLSM constitutes a dilemma: instituting WLSM too early could result in death despite the possibility of an acceptable functional outcome, whereas delaying WLSM could unnecessarily burden patients, families, clinici...
Article
Background Fluid therapy—the administration of fluids to maintain adequate organ tissue perfusion and oxygenation—is essential in patients admitted to the intensive care unit (ICU) with traumatic brain injury. We aimed to quantify the variability in fluid management policies in patients with traumatic brain injury and to study the effect of this va...
Article
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Demyelinating diseases are more common in Indonesia than previously believed. However, it is still a challenge for a country such as Indonesia to implement the scientific medical advances, especially in the diagnostic process of demyelinating diseases, to achieve the best possible outcome for these groups of patients, within the constraints of what...
Article
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Invasive infection with Lancefield group C streptococci in humans is extremely rare, with the vast majority of clinical isolates belonging to Streptococcus dysgalactiae subsp. equisimilis. We report a case of meningoencephalitis in a 69-year-old man caused by Streptococcus equi subsp. equi, a microbe that causes strangles in Equus caballus (i.e., t...
Article
Several clinical subtypes of progressive supranuclear palsy (PSP) have been described. We present a PSP patient with predominant cerebellar ataxia (PSP-C) and a pathologically confirmed PSP diagnosis. Cerebellar ataxia was observed at disease onset in this patient of European descent. The patient developed a symmetric akinetic-rigid syndrome with s...
Article
Background Fatigue is one of the most commonly reported subjective symptoms following traumatic brain injury (TBI). The aims were to assess frequency of fatigue over the first 6 months after TBI, and examine whether fatigue changes could be predicted by demographic characteristics, injury severity and comorbidities. Methods Patients with acute TBI...
Chapter
Cervical spine injuries are extremely common in athletes and range from minor strains and sprains to severe, life-threatening cervical fractures with spinal cord injuries. A basic understanding of cervical spine anatomy and biomechanics, imaging indications, and most appropriate imaging techniques, as well as of the most common types of injury, is...
Article
Introduction Pseudo-subarachnoid hemorrhage is a radiological term used to describe increased attenuation values on computed tomography within the basal cisterns and subarachnoid spaces, simulating true subarachnoid hemorrhage. Cases We present two cases of drug users, both showing a pseudo-subarachnoid hemorrhage pattern on computed tomography af...
Preprint
Full-text available
Our motivating application is a real-world problem: COVID-19 classification from CT imaging, for which we present an explainable Deep Learning approach based on a semi-supervised classification pipeline that employs variational autoencoders to extract efficient feature embedding. We have optimized the architecture of two different networks for CT i...
Article
Purpose The Quality of Life after Brain Injury overall scale (QOLIBRI-OS) measures health-related quality of life (HRQoL) after traumatic brain injury (TBI). The aim of this study was to derive value sets for the QOLIBRI-OS in three European countries, which will allow calculation of utility scores for TBI health states. Methods A QOLIBRI-OS value...
Article
Full-text available
To test the hypothesis of washout from the anterior pituitary (AP) gland after serial injections of gadodiamide. We included 59 patients with history of at least 5 injections of gadodiamide. Values of mean signal intensity of the AP and of the central pons were measured on unenhanced sagittal T1-weighted images. AP-to-pons signal intensity ratios w...
Article
Full-text available
Long-duration spaceflight causes widespread physiological changes, although its effect on brain structure remains poorly understood. In this work, we acquired diffusion magnetic resonance imaging to investigate alterations of white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) compositions in each voxel, before, shortly after, and 7...
Article
Background Although rehabilitation is beneficial for individuals with traumatic brain injury (TBI), a significant proportion of them do not receive adequate rehabilitation after acute care. Objective Therefore, the goal of this prospective and multicenter study was to investigate predictors of access to rehabilitation in the year following injury i...
Chapter
In the last 20 years, magnetic resonance angiography (MRA) has emerged as a valid tool for vascular imaging, augmented by improvements made in MR software and hardware. MRA has proven to be a safe and non-invasive vascular imaging method, which provides images similar to those obtained by classical catheter angiography. MRA methods can be subdivide...
Article
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PurposeGadolinium is a rare-earth lanthanide metal that is known to have a direct neurotoxic effect. The scope of the present review is to summarize the current preclinical and clinical evidence on the association between exposure to gadolinium of the central nervous system and neurotoxicity.MethodsA literature review was performed by searching for...
Preprint
Full-text available
Recent research on COVID-19 suggests that CT imaging provides useful information to assess disease progression and assist diagnosis, in addition to help understanding the disease. There is an increasing number of studies that propose to use deep learning to provide fast and accurate quantification of COVID-19 using chest CT scans. The main tasks of...
Article
Full-text available
Purpose: Patients with Crohn's disease (CD) undergo multiple gadolinium-based contrast agent injections across their lifespan to enhance signal intensity of the intestinal wall and differentiate active from quiescent inflammatory disease. Thus, CD patients are prone to gadolinium accumulation in the brain and represent a non-neurological populatio...
Article
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Background We aimed to study the associations between pre- and in-hospital tracheal intubation and outcomes in traumatic brain injury (TBI), and whether the association varied according to injury severity. Methods Data from the international prospective pan-European cohort study, Collaborative European NeuroTrauma Effectiveness Research for TBI (C...
Article
Background Brain irradiation is considered a cofactor influencing the dentate nucleus (DN) signal intensity (SI) on unenhanced T1‐weighted images in patients exposed to gadolinium‐based contrast agents (GBCAs). Purpose To assess the effect of gadodiamide and whole‐brain radiation therapy (WBRT) on T1‐weighted images and on apparent diffusion coeff...
Article
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Purpose The craniocervical junction (CCJ) is a complex of bony and ligamentous structure stabilizing CCJ. Nearly one-third of all traumatic injuries to the cervical spine involve the CCJ. Only little literature is available on this topic, and most of the studies are focused on anatomy, biomechanics or ligamentous injury in whiplash-associated disor...
Chapter
Intracranial nonmalignant mass lesions are not uncommon on imaging, often as an incidental finding. Many of these entities do not cause symptoms and do not require surgical intervention. It is therefore important to recognize them and differentiate them from truly malignant lesions. A diagnostic approach combining location and imaging characteristi...
Article
Background: Electroconvulsive therapy (ECT) is the most effective biological treatment for depression. Aside the well-known therapeutic effect on mood symptoms, it has also a unique positive impact on psychomotor agitation and retardation, which are core symptoms of depression. The neurobiology behind these effects, however, remains unclear. The b...
Article
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Objective We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury. Study Design and Setting We performed logistic (LR), lasso, and ridge regression with key baseline predictors in the IMPACT-II database (15 studies, n=11,022). ML algorithms included sup...
Article
Introduction: Electroconvulsive therapy (ECT) influences the concentration of peripheral inflammatory markers, such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). In which way this immune effect contributes to the impact of ECT on the central nervous system in depression remains unknown. Objective: The aim of this study was to exam...
Chapter
Traumatic brain injury (TBI) remains a leading cause of mortality and disability among young individuals, especially in high-income countries [1]. According to a meta-analysis, combining reports from 23 European countries between 1980 and 2003, the incidence rate is about 235 per 100,000 [2]. Increasingly, imaging techniques play a crucial role in...
Article
Full-text available
Magnetic resonance imaging (MRI) based T1 mapping allows spatially resolved quantification of the tissue-dependent spin-lattice relaxation time constant T1, which is a potential biomarker of various neurodegenerative diseases, including Multiple Sclerosis, Alzheimer disease, and Parkinson’s disease. In conventional T1 MR relaxometry, a quantitative...
Article
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Background: Alveolar flooding and airway obstruction are present in the acute respiratory distress syndrome. The impact of positive end-expiratory pressure on regional airway aeration has not been described. Aim: To assess bronchial and lung recruitment and distension during an incremental positive end-expiratory pressure trial in patients with...
Article
Purpose: To aim of this study is to investigate the prognostic value of using the NINDS standardized imaging-based pathoanatomic descriptors for the evaluation and reporting of acute TBI lesions. Methods: For a total of 3,392 patients (2,244 males and 1,148 females, Median = 51 years) enrolled in the Collaborative European NeuroTrauma Effectiven...
Article
Full-text available
During the last decade, the management of acute ischemic stroke has changed dramatically, from an expectant bedside “wait and see” attitude towards active treatment, thanks to the continuous improvement of new therapeutic options. In addition to the use of intravenous (IV) thrombolysis in emergent large vessel occlusion (ELVO), endovascular therapy...
Article
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Purpose: A newly developed image processing technique fuses conventional windows into a single 'All-In-One' (AIO) window. This study aims to evaluate variability of CT measurement of lesions in thoracic oncology patients on this novel AIO-window. Methods: Six radiologists with different levels of expertise measured 368 lesions of various size, o...
Article
‘Lung cancer associated with cystic airspaces’ is a rare radiological entity that is more frequently encountered on imaging studies and is gaining more attention since the widespread use of CT for lung cancer screening. Numerous aspects of this entity remain unraveled, including molecular profiling. The goal of this observational retrospective sing...
Article
Background The burden of traumatic brain injury (TBI) poses a large public health and societal problem, but the characteristics of patients and their care pathways in Europe are poorly understood. We aimed to characterise patient case-mix, care pathways, and outcomes of TBI. Methods CENTER-TBI is a Europe-based, observational cohort study, consisti...
Article
Objective: The aim of this study was to assess the signal intensity of the anterior pituitary (AP) gland on unenhanced T1-weighted images in patients with history of serial intravenous injections of gadodiamide and normal renal function. Materials and methods: We included 53 patients who had undergone at least 5 injections of gadodiamide and a c...
Article
Full-text available
Introduction Based on the advances in the treatment of multiple sclerosis (MS), currently available disease-modifying treatments (DMT) have positively influenced the disease course of MS. However, the efficacy of DMT is highly variable and increasing treatment efficacy comes with a more severe risk profile. Hence, the unmet need for safer and more...
Article
Purpose: The purpose of this study was to investigate if lesion detection using a single "All-in-One" (AIO) window was non-inferior to lesion detection on conventional window settings in thoracic oncology chest computed tomography (CT) examinations. Materials and methods: In a retrospective study, 50 consecutive chest CT examinations of 50 patie...
Article
Background Due to their crucial role in many diagnostic processes, a considerable number of papers in non-radiological medical journals contain images. We noticed that radiologists are seldom mentioned as co-authors. Purpose To investigate how often radiologists are involved as co-authors and to measure the influence of their involvement on the ch...
Article
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Subperiosteal orbital hematoma is a rare entity mainly seen in pediatric patients with sickle cell disease and occurs secondary to local vascular disturbances following facial bone infarction Sickle cell disease is the most common hemoglobinopathy. Homozygous patients are prone to vaso-occlusive crises. A 19-year-old male patient with the homozygou...
Article
Full-text available
Significance Long-duration spaceflight induces detrimental changes in human physiology due to microgravity. One example is a cephalic fluid shift. Here, we prospectively investigated the quantitative changes in cerebrospinal fluid (CSF) volume of the brain ventricular regions in space crew by means of a region of interest, observer-independent anal...
Article
Primary repair of the anterior cruciate ligament (ACL) is being performed increasingly in the treatment of acute proximal ACL ruptures. Advantages of ACL repair over surgical reconstruction with a tendon graft include preservation of the anatomy and proprioceptive function of the native ACL, and therefore, faster rehabilitation. The addition of an...
Article
Abnormal fine motor function is a frequent finding in schizophrenia and has been linked to structural and functional brain alterations. However, whether fine motor function is related to functional alterations within the motor system remains unclear. The aim of this study was to assess whether abnormalities in resting-state functional connectivity...
Article
Full-text available
“Lung cancer associated with cystic airspaces” is an uncommon manifestation, in which lung cancer presents on imaging studies with a cystic area with associated consolidation and/or ground glass. With the widespread use of computed tomography (CT), both in clinical practice and for lung cancer screening, these tumors are being more frequently recog...
Article
Purpose: To assess anterolateral complex (ALC) injuries in patients with acute anterior cruciate ligament (ACL) rupture on magnetic resonance imaging (MRI). Methods: Patients with acute ACL rupture who underwent ACL surgery between 2015 and 2017 and underwent MRI within 6 weeks of the initial trauma were included. Two radiologists assessed magne...
Article
In congenital Zika virus syndrome (CZS), the most frequent radiological findings are calcifications in the cortical-white matter junction and malformations of cortical development (pachygyria or polymicrogyria, which occur predominantly in the frontal lobes, or a simplified gyral pattern), ventriculomegaly, enlargement of the cisterna magna and the...
Article
In the present case series, the cause of death of infants diagnosed with congenital Zika syndrome (CZS) was lung disease (pneumonia and sepsis with massive pulmonary aspiration), probably secondary to dysphagia and reflux. The main findings in infants with a confirmed diagnosis of CZS who died were as follows: (1) calcification and hypoplasia of th...
Article
Background The dentate nuclei of the cerebellum are the areas where gadolinium predominantly accumulates. It is not yet known whether gadolinium deposition affects brain functions. Purpose/Hypothesis To assess whether gadolinium‐dependent high signal intensity of the cerebellum on T1‐weighted images of nonneurological adult patients with Crohn's d...
Article
Background Diffusion tensor imaging (DTI) parameters, such as fractional anisotropy (FA), allow examining the structural integrity of the brain. However, the true value of these parameters may be confounded by variability in MR hardware, acquisition parameters, and image quality. Purpose To examine the effects of confounding factors on FA and to e...
Conference Paper
While the effect of long-duration spaceflight has been extensively studied with respect to bone loss, muscle atrophy as well as several other physiological systems, the existence of an effect on the brain has been reported only very recently. We performed a prospective study using MRI scans pre and post flight to investigate the impact of prolonged...
Article
Full-text available
Ten cosmonauts, who spent an average of 189 days in space, had changes in brain volumes — mainly decreased cortical volume and increased CSF subarachnoid and ventricular volume — with some changes persisting up to an average of 7 months after return to Earth.