Paul Monsarrat

Paul Monsarrat
Paul Sabatier University - Toulouse III | UPS Toulouse · Dental Faculty

Full Professor, DMD, PhD
Researcher at the Restore Institute

About

75
Publications
12,868
Reads
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813
Citations
Citations since 2016
68 Research Items
776 Citations
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2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
Additional affiliations
September 2017 - September 2017
Paul Sabatier University - Toulouse III
Position
  • Professor (Associate)
October 2016 - September 2017
Paul Sabatier University - Toulouse III
Position
  • Fellow

Publications

Publications (75)
Article
Full-text available
Background: In medicine, effect sizes (ESs) allow the effects of independent variables (including risk/protective factors, or treatment interventions) on dependent variables (e.g., health outcomes) to be quantified. Given that many public health decisions and health care policies are based on ES estimates, it is important to assess how ESs are used...
Article
Aim: The primary aim of the study was to systematically map registration records on periodontal medicine in clinical trial registers. The secondary aim was to assess the evolution of periodontal medicine in clinical periodontal research as a whole. Material and methods: We searched all registration records related to periodontology in the World...
Article
Background aims: Using innovative tools derived from social network analysis, the aims of this study were (i) to decipher the spatial and temporal structure of the research centers network dedicated to the therapeutic uses of mesenchymal stromal cells (MSCs) and (ii) to measure the influence of fields of applications, cellular sources and industry...
Article
Full-text available
Significance: Except for a few trials concerning specific tissue stem cells used in their corresponding tissues, this global analysis revealed no real specificity of stem cell uses (including mesenchymal stromal cells). This raised the question of the physiopathological rationale for these uses and the lack of a global strategy despite the regulat...
Article
Significance: Human periodontitis is a chronic, highly prevalent infectious disease characterized by the loss of both soft and hard tissues supporting the teeth. Current available treatments are insufficient, associated with a high degree of variability in clinical outcomes. The data in this study suggest that adipose-derived mesenchymal stromal/s...
Article
Full-text available
Despite artificial intelligence used in skin dermatology diagnosis is booming, application in oral pathology remains to be developed. Early diagnosis and therefore early management, remain key points in the successful management of oral mucosa cancers. The objective was to develop and evaluate a machine learning algorithm that allows the prediction...
Article
Full-text available
Traditional thin sectioning microscopy of large bone and dental tissue samples using demineralization may disrupt structure morphologies and even damage soft tissues, thus compromising the histopathological investigation. Here, we developed a synergistic and original framework on thick sections based on wide-field multi-fluorescence imaging and spe...
Article
Full-text available
L'intelligence artificielle prend une place croissante dans nos vies, que ce soit au niveau de nos téléphones ou ordinateurs, mais aussi dans notre métier. Au-delà de l'enthousiasme de départ que suscitent ces technologies, une certaine prudence semble nécessaire pour intégrer, accompagner ou remplacer intelligemment certains aspects cliniques de n...
Article
Full-text available
Early diagnosis is crucial for individuals who are susceptible to tooth-supporting tissue diseases (e.g., periodontitis) that may lead to tooth loss, so as to prevent systemic implications and maintain quality of life. The aim of this study was to propose a personalized explainable machine learning algorithm, solely based on non-invasive predictors...
Article
Introduction et but de l’étude Le tissu adipeux blanc (TA) est doué d’une plasticité remarquable qui lui permet d’adapter sa taille et sa fonction selon le contexte nutritionnel, métabolique ou à la suite d’un stress. Les cellules immunitaires et notamment les macrophages jouent un rôle important dans la biologie de ce tissu et sa plasticité. Dans...
Chapter
Background: Periodontitis is a chronic inflammatory disease characterized by the loss of tooth-supporting tissues (or periodontium) leading to the formation of periodontal pocket then to tooth loss. Conventional therapies that involve tooth root debridement are still disappointing because they are more centered on periodontal repair than disease p...
Article
Improvements in public health and health care have resulted in significant increases in lifespan globally, but also in a significant increase in chronic disease prevalence. This has led to a focus on healthy ageing bringing a shift from a pathology-centered to an intrinsic capacity and function-centered view. In parallel, the emerging field of gero...
Article
The purpose of this study was to assess the impact, and students’ and teachers’ perceptions, of using smartphones as clickers during formal lectures. This was an observational study based on a qualitative analysis of semi-structured interviews. Forty French dental students received conventional lectures, and 40 additionally used the Socrative® digi...
Article
Full-text available
Tissue repair after lesion usually leads to scar healing and thus loss of function in adult mammals. In contrast, other adult vertebrates such as amphibians have the ability to regenerate and restore tissue homeostasis after lesion. Understanding the control of the repair outcome is thus a concerning challenge for regenerative medicine. We recently...
Preprint
UNSTRUCTURED Machine Learning (ML), a branch of Artificial Intelligence, now competes with human experts in many specialized biomedical fields and will play an increasing role in precision medicine. As with any other technological advance in medicine, the keys to understanding must be integrated into practitioner training. To respond to this challe...
Article
Background During interventions for deep caries lesions without severe symptoms, preserving pulpal vitality is important to ensure treatment success, improve organ prognosis, and decrease cost-effectiveness. Current pre-operative radiographs allow visual estimation but not accurate measurement of lesion depth.PurposeInvestigate the ability of ratio...
Article
Full-text available
ContextDental age, one of the indicators of biological age, is inferred by radiological methods. Two of the most commonly used methods are using Demirjian’s radiographic stages of permanent teeth excluding the third molar (Demirjian’s and Willems’ method). The major drawbacks of these methods are that they are based on population-specific conversio...
Article
Objectives: For more than twenty years, dental practice-based research networks (D-PBRN) have helped to structure clinical research in private practice. They bring together practitioners working in several structures and may include a greater number of subjects. The aims of this study were thus to systematically explore the scientific production fr...
Article
La complexité de la régénération tissulaire en odontologie a conduit à l'utilisation de molécules bioactives naturellement retrouvées dans la nature : les facteurs de croissance (VEGF, EGF, TGF-ß…). Cependant, l'implantation de telles protéines d'origine exogène est limitée par le cadre réglementaire. Les plaquettes étant une source alternative int...
Conference Paper
Full-text available
Introduction : Le plasma atmosphérique froid est un gaz ionisé produit à pression atmosphérique. Plusieurs applications médicales sont étudiées, notamment la cicatrisation des plaies chroniques et l’effet antimicrobien. En effet, le traitement par plasma permet de générer de nombreuses espèces réactives de l’oxygène et de l’azote. L’application d’u...
Article
Résumé Objectifs Évaluer l’effet du traitement parodontal sur les paramètres cliniques et biochimiques de la polyarthrite rhumatoïde (PR) et la qualité de vie chez des patients atteints d’une PR modérément active et d’une parodontite. Méthodes Dans cet essai ouvert, randomisé et contrôlé, des sujets atteints de PR (n = 22) ont été affectés à un t...
Article
Full-text available
Introduction: Many pathological conditions may benefit from cell therapy using mesenchymal stromal cells, particularly from adipose tissue (ASCs). Cells may be grafted in an environment with a remnant polymicrobial component. The aim is to investigate the behavior of ASCs when brought in contact with a large panel of bacteria. Materials and metho...
Article
Full-text available
Cone Beam Computerized Tomography (CBCT) is an imaging technology increasingly used in dentistry. Depending on the size of the examination area, visualization of anatomical structures outside the indication area may reveal incidental findings (IF). The aims of this systematic review and meta-analysis were to 1) evaluate the frequency, location and...
Conference Paper
Selon l’OMS, en 2016, la moitié de la population mondiale souffrait d’affections bucco-dentaires, la lésion carieuse en chef de file. La dentisterie minimalement invasive tend à se développer et s’appliquer à la carie profonde, en diminuant les effractions pulpaires et, dans les meilleurs cas, conserver la vitalité pulpaire. L’objectif de ce travai...
Presentation
Full-text available
Connaissez-vous ReCOL ? Ce réseau de Recherche Clinique en Odontologie Libérale permet à la recherche clinique de sortir des box de l'hôpital et de s’inviter dans les cabinets dentaires ! L’implication des praticiens libéraux en recherche clinique permettra de faire plus vite progresser la dentisterie fondée sur la preuve et de tenir compte de la d...
Article
In biomedical research, epidemiological measures of risk/effect [effect sizes (ESs)] are predominantly derived from risk (or rate) ratios (RRs), odds ratios (ORs), or hazard ratios (HRs). Using the whole PubMed database, we detailed in this paper a phenomenon not yet described: a massive trend for HRs to be globally used as substitutes for RRs. All...
Article
Objectives: To assess the effect of periodontal treatment on clinical and biochemical parameters of rheumatoid arthritis (RA) and quality of life (QoL) in patients with moderately active RA who were diagnosed with periodontitis. Methods: In this open-label randomised controlled trial, RA subjects (n = 22) were allocated to "immediate" or "delaye...
Article
Background: The cone-beam computed tomography (CBCT) technology has continuously evolved since its appearance in oral medicine in the early 2000s. Objectives: To present recent advances in CBCT in oral medicine: i) selection of recent and consensual evidence-based sources, ii) structured summary of the information based on an iterative framework...
Article
Full-text available
Objectives The scoring and analysis of dental nonmetric traits are predominantly accomplished by using the Arizona State University Dental Anthropology System (ASUDAS), a standard protocol based on strict definitions and three‐dimensional dental plaques. However, visual scoring, even when controlled by strict definitions of features, visual referen...
Article
Aim To assess whether periodontal treatment can lead to clinical, glycemic control and quality of life improvements in metabolically unbalanced diabetic patients (Type 1 or Type 2) diagnosed with periodontitis. Methods In this open‐labeled randomized controlled trial, diabetic subjects (n=91) were given “immediate” or “delayed” periodontal treatme...
Article
Full-text available
Background Cold-atmospheric plasma (CAP) is an ionized gas produced at an atmospheric pressure. The aim of this systematic review is to map the use of CAP in oncology and the implemented methodologies (cell targets, physical parameters, direct or indirect therapies). Methods PubMed, the International Clinical Trials Registry Platform and Google Sc...
Data
2017_02_19_Table_S1 – Supplemental material for Use of cold-atmospheric plasma in oncology: a concise systematic review
Data
2018_02_18_Table_S2 – Supplemental material for Use of cold-atmospheric plasma in oncology: a concise systematic review
Data
Supplementary_figures – Supplemental material for Use of cold-atmospheric plasma in oncology: a concise systematic review
Poster
Full-text available
Main objective: assess whether periodontal treatment could lead to clinical improvements in metabolically unbalanced diabetic patients diagnosed with periodontitis. Analyses will be particularly focused on Type 1 diabetes. Secondary objectives: determine the effect of periodontal treatment on oral and general quality of life.
Article
Objectives: To describe tooth brushing frequency and its association with a wide range of socioeconomic and behavioral characteristics, using a nationally representative sample of school-aged children in France. Methods: Our sample included 11,337 students aged from 10 to 16 years, who answered the HBSC questionnaire. Some variables were grouped...
Article
Full-text available
La principale cause d'échec des obturations à base de résine composite provient des variations volumétriques. Pour limiter ces inconvénients, de nouvelles matrices ont été mises au point comme les matrices à base d'Ormocer. Elles contiennent des polymères issus de l'adjonction de petites unités monomères dont le noyau est essentiellement constitué...
Poster
Full-text available
The aim of the study is to: Assess the integrity of the interface with a bulk-fill hybrid ORMOCER material and compare results obtained with an universal dental composite and a bulk-fill packable composite.
Poster
Full-text available
Aim of this work: to develop a new biomaterial, which could be grafted into periodontal defects --> A fibrin-based hydrogel (derived from growth factors-rich platelet lysates) and adipose mesenchymal stromal cells.
Article
Full-text available
Periodontal diseases (gingivitis and periodontitis), result from a disruption of the host–oral microbiome homoeostasis. Whereas the pathological role of some specific bacterial strains during periodontal diseases is well documented, the impact of parasites in periodontium pathophysiology is still under debate. This review aims to collect data about...
Article
Objectives: In-vitro experiments on ormocers (ORganically MOdified CERamics) have provided controversial results. Consequently, the objectives of this meta-analysis were to (1) compare clinical performances of first generation ormocers versus conventional composite restorations, (2) explore the influence of various clinical factors and the impact...
Article
Background: Adipose-derived mesenchymalstromal cells (ASC) are currently tested in regenerative medicine to promote tissue reconstruction after injury. Regardingautologous purpose, the possible loss of therapeutic function and cell properties during aging have been questioned in adults. To date no reliable information is available concerning ASC f...
Article
Objective: The aim of this study was to evaluate the attitude of parents towards the oral health of their children before oral rehabilitation under general anesthesia (GA). Study design: Children receiving dental treatment under GA between November 2013 and July 2014 in the Pediatric Dentistry Department (University Hospital Center, Toulouse, Fr...
Article
Full-text available
Objectives In endodontic practice, clinicians should be aware of possible root canal anatomic variations. The aim of this study was to assess using CBCT acquisitions regarding whether one root canal anatomy of a tooth is associated with a specific anatomy of another tooth. Methods A total of 106 CBCT acquisitions were obtained using a CBCT scanner...
Data
Considering the presence or absence of variability in each tooth group, the mean number ± standard deviation of canals and roots for each tooth were provided. (DOCX)
Data
For each tooth, the mean number ± standard deviation of canals and roots was presented, for men and women. (DOCX)
Poster
Full-text available
Objectif : Comparer l’intérêt porté par la population générale à l’amalgame et l’utilisation qui en est faite par les chirurgiens-dentistes.
Article
Objectives: The primary aim of this work was to determine the duration of ultra-low-frequency transcutaneous electrical nerve stimulation (ULF-TENS) application necessary to achieve sufficient relaxation of the masticatory muscles. A secondary aim was to analyze the influence of stimulation on muscle relaxation in pathological subjects and determi...
Article
Periodontitis is a chronic infectious disease of the soft and hard tissues supporting the teeth. Recent advances in regenerative medicine and stem cell biology have paved the way for periodontal tissue engineering. Mesenchymal stromal cells (MSCs) delivered in situ to periodontal defects may exert their effects at multiple levels, including neovasc...
Article
Full-text available
BACKGROUND: Observational studies and clinical trials are increasingly highlighting significant associations between periodontitis (chronic, infectious, inflammatory disease affecting tooth supporting tissues) and rheumatoid arthritis (chronic systemic autoimmune disease). OBJECTIVE: The aim of the study was to describe the dental, periodontal and...
Article
Association between maternal periodontitis and preterm delivery according to causes: the case-control EPIPAP study Résumé L'objectif de l'étude était d'analyser l'association entre la parodontite maternelle et l'accouchement prématuré, selon les causes de prématurité. L'étude EPIPAP a été menée dans six maternités françaises sur 1108 femmes (cas) a...
Article
Full-text available
Periodontitis is a chronic inflammatory disease affecting the soft and hard tissues supporting the teeth, which often leads to tooth loss. Its significant impact on the patient's general health and quality of life point to a need for more effective management of this condition. Existing treatments include scaling/root planning and surgical approach...
Article
Full-text available
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disorder that leads to joint damage, deformity, and pain. It affects approximately 1% of adults in developed countries. Periodontitis is a chronic oral infection, caused by inflammatory reactions to gram-negative anaerobic bacteria, and affecting about 35 to 50% of adults. If left unt...
Article
The aims of the Oral Status And Rheumatoid Arthritis (OSARA) cross-sectional study were to study the oral health-related quality of life and to assess the associated factors in a population of outpatients with rheumatoid arthritis in France. The data were collected by five trained and standardised dentists who asked each subject the questions of a...
Article
This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the efficacy and safety of periodontal treatment in reducing rheumatoid arthritis disease activity and pain, and improving function, and reducing periodontitis in patients with both rheumatoid arthritis and periodontitis.

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