Patti J Miller

Patti J Miller
University of Georgia | UGA · Department of Population Health, College of Veterinary Medicine

DVM, PhD

About

224
Publications
49,247
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5,048
Citations
Citations since 2017
80 Research Items
3640 Citations
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20172018201920202021202220230100200300400500600
20172018201920202021202220230100200300400500600
20172018201920202021202220230100200300400500600
Introduction
Patti J Miller currently works for the Department of Population Health, College of Veterinary Medicine, University of Georgia helping with the on line Master of Health and Avian Medicine program.

Publications

Publications (224)
Article
Full-text available
Newcastle disease virus (NDV) infects a wide range of bird species worldwide and is of importance to the poultry industry. Although certain virus genotypes are clearly associated with wild bird species, the role of those species in the movement of viruses and the migratory routes they follow is still unclear. In this study, we performed a phylogene...
Article
Full-text available
In ovo vaccination has been employed by the poultry industry for over 20 years to control numerous avian diseases. Unfortunately, in ovo live vaccines against Newcastle disease have significant limitations, including high embryo mortality and the inability to induce full protection during the first two weeks of life. In this study, a recombinant li...
Article
Background There is evidence that chicken IL4 (chIL4) functions similarly to its mammalian analogue by enhancing type 2 T helper (Th2) humoral immunity and promoting protection against parasitic infections; however, no studies have been performed to assess the effect of chIL4 on the pathogenesis of Newcastle disease (ND). To assess the role of chIL...
Article
Full-text available
The efficacy of an adenovirus-vectored Newcastle disease virus (NDV) vaccine expressing the fusion (F) NDV protein (adeno-F) was evaluated against challenges with virulent heterologous and homologous NDV strains to the F protein. In a preliminary study, two different doses (low and high) of adeno-F were tested against a virulent NDV strain containi...
Chapter
The Paramyxoviridae family has several genera that include important human and veterinary pathogens such as Rubulavirus, Respiroviruses, Henipavirus, and the Avulavirus genus that contains Newcastle disease virus (NDV) and other avian paramyxoviruses (APMV). This chapter focuses on infections of poultry with NDV. It offers detailed coverage of the...
Article
Full-text available
Background: Newcastle disease (ND), which is caused by infections of poultry species with virulent strains of Avian orthoavulavirus-1, also known as avian paramyxovirus 1 (APMV-1), and formerly known as Newcastle disease virus (NDV), may cause neurological signs and encephalitis. Neurological signs are often the only clinical signs observed in bir...
Article
Chickens in live bird markets (LBMs) from six different regions of Tanzania were surveyed for Newcastle disease (ND) virus (NDV) and avian influenza virus in 2012. ELISA-based serology, virus isolation, and characterization, including pathotyping was conducted. Virulent NDV was isolated from almost 10% of the tested samples, with two distinct genot...
Article
Full-text available
Newcastle disease (ND) infects wild birds and poultry species worldwide, severely impacting the economics of the poultry industry. ND is especially problematic in Latin America (Mexico, Colombia, Venezuela, and Peru) where it is either endemic or re-emerging. The disease is caused by infections with one of the different strains of virulent avian Ne...
Article
Full-text available
Several Avian paramyxoviruses 1 (synonymous with Newcastle disease virus or NDV, used hereafter) classification systems have been proposed for strain identification and differentiation. These systems pioneered classification efforts; however, they were based on different approaches and lacked objective criteria for the differentiation of isolates....
Article
Full-text available
Our prior work has shown that live poultry vaccines have been intermittently isolated from wild birds sampled during field surveillance studies for Newcastle disease virus (NDV). Thus, we experimentally investigated the susceptibility of four native agriculturally-associated wild bird species to the NDV LaSota vaccine and evaluated the shedding dyn...
Presentation
Full-text available
BACKGROUND— Highly virulent Newcastle disease viruses (NDV), including their genetic variants (e.g., pigeon paramyxoviruses) cause Newcastle disease (ND), which is a threat to poultry production worldwide. Next-generation sequencing (NGS) has emerged as a research tool for thorough genetic characterization of infectious organisms; however, the util...
Article
Full-text available
Our prior work has shown that live poultry vaccines have been intermittently isolated from wild birds sampled during field surveillance studies for Newcastle disease virus (NDV). Thus, we experimentally investigated the susceptibility of four native agriculturally associated wild bird species to the NDV LaSota vaccine and evaluated the shedding dyn...
Presentation
A virus isolated from a white-fronted Goose in Ukraine in 2011was previously identified as a novel avian paramyxovirus serotype 13 (APMV-13). Whole genome random next-generation sequencing was performed, and phylogenetic analysis revealed that the isolate was most closely related to isolates from Japan and Kazakhstan, showing 98 and 97% nucleotide...
Article
Turkey herpesvirus (HVT) is widely used as a vaccine against Marek's disease in chickens and recently as a vector for foreign genes from infectious bursal disease virus, Newcastle disease (ND) virus, infectious laryngotracheitis (ILT) virus, and avian influenza virus. Advantages of HVT-vector vaccines are that the vaccines do not contain live respi...
Article
Full-text available
Background Newcastle disease (ND) outbreaks are global challenges to the poultry industry. Effective management requires rapid identification and virulence prediction of the circulating Newcastle disease viruses (NDV), the causative agent of ND. However, these diagnostics are hindered by the genetic diversity and rapid evolution of NDVs. Methods A...
Poster
Full-text available
Newcastle disease virus is closely associated with poultry, and increasingly recognized as a virus of wild birds. We have previously shown that live NDV vaccine viruses can escape and transmit into pigeons and other wild bird species. Therefore, under controlled conditions, we tested the susceptibility of wild song birds to infection with the live...
Presentation
Four viral isolates from Rockhopper Penguins were previously identified as members of a novel avian paramyxovirus serotype 10 (APMV-10). Whole genome random next-generation sequencing was performed and phylogenetic analysis showed that the isolates were most closely related to APMV-2 and APMV-8. Intracerebral pathogenicity index test indicated that...
Article
Full-text available
Newcastle disease (ND), caused by virulent strains of Newcastle disease virus (NDV), is a devastating disease of poultry worldwide. The pathogenesis of ND in quail is poorly documented. To characterize the ability of virulent NDV strains to replicate and cause disease in quail, groups of 14 two-week-old Japanese quail (Coturnix japonica) were exper...
Article
Full-text available
Here, we present the draft genome sequences of three Ochrobactrum sp. strains with multidrug-resistant properties, isolated in 2015 from a pigeon and two chickens in Pakistan.
Article
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Here, we present the draft genome sequences of five multidrug-resistant novel Ochrobactrum species strains isolated from a pigeon, a duck, and chickens from Nigeria in 2009.
Chapter
Avian influenza (AI) and Newcastle disease (ND) viruses severely impact egg production. Decreased egg yield and hatchability, as well as misshapen eggs, are often observed in egg-laying flocks infected with AI and ND, even with low-virulence strains or in vaccinated flocks. To prevent a decrease in egg production upon challenge with either highly p...
Article
Full-text available
Background The remarkable diversity and mobility of Newcastle disease viruses (NDV) includes virulent viruses of genotype VI. These viruses are often referred to as pigeon paramyxoviruses 1 because they are normally isolated and cause clinical disease in birds from the Columbidae family. Genotype VI viruses occasionally infect, and may also cause c...
Article
Full-text available
The first complete genome sequences of four avian paramyxovirus serotype 10 (APMV-10) isolates are described here. The viruses were isolated from rockhopper penguins on the Falkland Islands, sampled in 2007. All four genomes are 15,456 nucleotides in length, and phylogenetic analyses show them to be closely related.
Chapter
This chapter focuses on viruses of avian paramyxovirus serotype-1 (APMV-1). All isolates of APMV-1 are of one serotype and are referred to as Newcastle disease viruses (NDVs). The virulent NDVs seem to be the major exception of a wild bird reservoir, with the virulent viruses being endemic in poultry and domestic and feral pigeons. NDV strains can...
Article
Full-text available
Background Next-generation sequencing (NGS) allows ultra-deep sequencing of nucleic acids. The use of sequence-independent amplification of viral nucleic acids without utilization of target-specific primers provides advantages over traditional sequencing methods and allows detection of unsuspected variants and co-infecting agents. However, NGS is n...
Article
Background Next-generation sequencing (NGS) allows ultra-deep sequencing of nucleic acids. The use of sequence-independent amplification of viral nucleic acids without utilization of target-specific primers provides advantages over traditional sequencing methods and allows detection of unsuspected variants and co-infecting agents. However, NGS is n...
Article
Full-text available
Virulent viruses of the panzootic Newcastle disease virus of sub-genotype VIIi were repeatedly isolated (2011-2016) from commercial chickens and from multiple non-poultry avian species in Pakistan. These findings provide evidence for the existence of epidemiological links between Newcastle disease outbreaks in commercial poultry and infections with...
Article
Globally, poultry producers report that birds well-vaccinated for Newcastle disease (ND) often present clinical disease and mortality after infection with virulent strains of Newcastle disease (vNDV), which is contrary to what is observed in experimental settings. One hypothesis for this discrepancy is that the birds in the field may be exposed to...
Poster
Full-text available
Here, we report the isolation and characterization of virulent Newcastle disease viruses (vNDV) isolated from backyard chickens in Bulgaria and Ukraine between 2002 and 2013. Nineteen isolates were submitted to the Southeast Poultry Research Laboratory of the USDA in Athens, GA, USA. Viruses were propagated in 9-to-11-day-old specific-pathogen-free...
Presentation
While all Newcastle disease viruses (NDV) are contained within one serotype and different NDV provide cross-protection against others, antigenically matched strains have been shown to decrease viral shedding. Therefore, using recombinant technology, some companies have directed efforts in developing genotype specific Newcastle disease vaccines targ...
Presentation
Full-text available
Newcastle disease viruses (NDV) with panzootic potential continue to circulate and cause problems in vaccinated Pakistani poultry. In addition, virulent NDV were repeatedly isolated (2012-2016) at multiple locations in Pakistan from non-poultry avian species from farms, parks, backyard, zoos and wildlife. The wide variety of involved bird species s...
Article
Full-text available
Newcastle disease (ND) has been defined by the World Organisation for Animal Health as infection of poultry with virulent strains of Newcastle disease virus (NDV). Lesions affecting the neurological, gastrointestinal, respiratory, and reproductive systems are most often observed. The control of ND must include strict biosecurity that prevents virul...
Article
Full-text available
Here, we report the circulation of highly related virulent Newcastle disease viruses (NDV) in Bulgaria and Ukraine from 2002 until 2013. All of these NDV isolates have the same virulence-associated cleavage site ("113RQKR↓F117"), and selected ones have intracerebral pathogenicity index values ranging from 1.61 to 1.96. These isolates are most close...
Article
Full-text available
Our study demonstrates the repeated isolation of vaccine-derived Newcastle disease viruses from different species of wild birds across four continents from 1997 through 2014. The data indicate that at least 17 species from ten avian orders occupying different habitats excrete vaccine-derived Newcastle disease viruses. The most frequently reported i...
Data
Pairwise nucleotide distance analysis of vaccine-derived viruses to PHY-LMV vaccine. (XLS)
Data
Demographic and correlated viral data of Rock Pigeons sampled in Atlanta, GA. (DOCX)