
Patrizia ManciniSapienza University of Rome | la sapienza · Department of Sense Organs
Patrizia Mancini
MD, PhD
Director of the Audiology and Phoniatrics Residency Program at University Sapienza of Rome - Italy
About
125
Publications
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Introduction
Mancini Patrizia currently works at the Department of Sense Organs, Sapienza University of Rome. She does research in Otology, Cochlear Implants, Auditory Perception and Speech and Language Pathology. Current projects are: "Communication and language outcomes in children with cochlear implants.", "Pitch and speech perception with cochlear implants".
Additional affiliations
November 2020 - November 2020
October 2011 - present
January 2007 - March 2008
Education
October 2010 - October 2011
October 1998 - October 2000
November 1996 - November 1998
Publications
Publications (125)
Purpose
Upper airway (UA) surgery is commonly employed in the treatment of patients with obstructive sleep apnea (OSA). The intricate pathophysiology of OSA, variability in sites and patterns of UA collapse, and the interaction between anatomical and non-anatomical factors in individual patients may contribute to possible surgical failures. This cl...
Background:
Listening difficulties may frequently occur in school settings, but so far there were no tools to identify them for both hearing and hearing-impaired Italian students. This study performed cross-cultural adaptation and validation of the Listening Inventory for Education-Revised for Italian students (LIFE-R-ITA).
Methods:
The study pr...
Despite the proven effectiveness of cochlear implant (CI) in the hearing restoration of deaf or hard-of-hearing (DHH) children, to date, extreme variability in verbal working memory (VWM) abilities is observed in both unilateral and bilateral cochlear implant user children (CIs). Although the clinical experience has long observed deficits in this f...
Objectives
Emotional abilities (EAs) are particularly important during preadolescence/adolescence, two challenging periods characterized by significant biological, physical, and cognitive changes. The present study attempted to a holistic EA approach in preadolescents/adolescents with cochlear implants (CI) and typical hearing (TH), considering var...
Purpose
This study aimed to investigate the effects of low frequency (LF) pitch perception on speech-in-noise and music perception performance by children with cochlear implants (CIC) and typical hearing (THC). Moreover, the relationships between speech-in-noise and music perception as well as the effects of demographic and audiological factors on...
Objective This longitudinal study aims at assessing the predictive value of facial nerve high-resolution ultrasound (HRUS) for incomplete clinical recovery in patients with Bell’s palsy, the most common facial nerve disease. Methods We prospectively enrolled 34 consecutive patients with Bell’s palsy. All patients underwent neurophysiological testin...
Tinnitus is certainly a socially relevant problem, but, despite everything, even today we are witnessing a slightly too superficial management of the patient by the doctor, often as the clinical case is underestimated. All of this cannot be justified especially when there is tinnitus with sudden onset or rapid decompensation: in these cases, in fac...
Purpose: Executive functions (EF) play a fundamental role in planning and executing goal-driven
behaviours. The purpose of this systematic review and meta-analysis was to investigate EF skills
mastered by preschool/school-age cochlear implanted children (CIC) without morpho-functional
abnormalities and to compare their outcomes with typically heari...
Introduction: Tinnitus is one of the major complaints in patients with bilateral hearing loss or single-sided deafness (SSD). Several studies describe that cochlear implantation may play a role in tinnitus suppression. Results in the literature are heterogeneous for the role and level of success that Cochlear Implants (CI) plays in tinnitus suppres...
Objectives: Vocal singing skills in pediatric CI users are not much known due to the
limited number of studies. The principal aim of the present study was to evaluate vocal
singing skills in Italian pediatric CI users. A further aim was to investigate factors that
may significantly influence their performance.
Methods: The participants were twenty-...
Abstract: Gaucher disease (GD) has been increasingly recognized as a continuum of phenotypes with variable neurological and sensory involvement. No study has yet specifically explored the spectrum of neuropsychiatric and sensory abnormalities in GD patients through a multidisciplinary approach. Abnormalities involving the nervous system, including...
Objectives:
The present study aimed to investigate in a group of elderly CI users working memory and attention, conventionally considered as predictors of better CI performance and to try to disentangle the effects of these cognitive domains on speech perception, finding potential markers of cognitive decline related to audiometric findings. Metho...
Background:
Long-term assessments of children with cochlear implants (CI) are important inputs to help guide families and professionals in therapeutic and counselling processes. Based on these premises, the primary aim of the present study was to assess the long-term speech and language outcomes in a sample of prelingually deaf or hard of hearing...
This pilot study investigates the neurophysiological patterns of visual and auditory verbal working memory (VWM) in unilateral cochlear implant users (UCIs). We compared the task-related electroencephalogram (EEG) power spectral density of 7- to 13-year-old UCIs (n = 7) with a hearing control group (HC, n = 10) during the execution of a three-level...
Objective
The goal of this study was to investigate the performance correlations between music perception and speech intelligibility in noise by Italian-speaking cochlear implant (CI) users.
Materials and methods
Twenty postlingually deafened adults with unilateral CIs (mean age 65 years, range 46–92 years) were tested with a music quality questio...
Purpose
The aim of the study was to investigate the listening comprehension (LC) skills in deaf and hard of hearing children (DHH) using cochlear implants (CI). Besides, personal and audiological variables that could influence the levels of competence reached were analyzed.
Methods
Thirty-four children using CI were enrolled. LC skills were assess...
Purpose
Auditory selective attention (ASA) is crucial to focus on significant auditory stimuli without being distracted by irrelevant auditory signals and plays an important role in language development. The present study aimed to investigate the unique contribution of ASA to the linguistic levels achieved by a group of cochlear implanted (CI) chil...
This study investigated the psychological characteristics of online learning on Italian students with and without hearing loss (HL) and on their parents, who were forced into isolation during the Covid‐19 pandemic. An online survey collected information on socio‐demographic data and opinions concerning online learning from 61 children (mean age 11;...
Objectives
Hearing loss has been the most common sensory impairment and one of the most challenging disabilities in the elderly population, with a multitude of consequences for the quality of life and psychosocial well-being. The present work was a narrative review on the effectiveness of communicative/psychosocial interventions that were designed...
Background
Oropharyngeal dysphagia (OD) screening tests have improved patient management; however, the complex applicability and high percentage of false negatives do not allow these tests to be considered completely reliable if not supported by an instrumental investigation. The aim of the present study is to evaluate an OD screening test, the Dys...
Objective: This pilot case-control study is aimed to estimate ‘musical effort’ and ‘musical pleasantness’ in adults normal hearing (NH) and Unilateral Cochlear Implant (UCI) users via neurophysiological indices and a cognitive-behavioural approach.
Methods: 7 NH and 7 UCI subjects underwent electroencephalographic (EEG) recording with two EEG indic...
Introduction
The present study aimed to evaluate the effects of the Active Communication Education (ACE) program on the social/emotional impacts of hearing loss (HL) in a group of older adults with a cochlear implant (CI).
Design
Prospective cohort study design, with a “within-subject” control procedure.
Study Sample
Twenty adults over-65 post-li...
Objective:
To analyse hearing attention and quality of listening in a cohort of children affected by moderate to severe unilateral hearing loss, comparing a group of hearing aid users to children with no hearing aid.
Methods:
Twenty-four children (12 hearing aid users, and 12 without hearing rehabilitation) underwent audiological evaluation with...
Pathogenic variants in the PJVK gene cause the DFNB59 type of autosomal recessive non-syndromic hearing impairment (AR-NSHI). Phenotypes are not homogeneous, as a few subjects show auditory neuropathy spectrum disorder (ANSD), while others show cochlear hearing loss. The numbers of reported cases and pathogenic variants are still small to establish...
OBJECTIVE
Immune-mediated inner ear disease (IMIED) might cause severe/profound hearing loss and these patients are considered ideal candidates to cochlear implant (CI) surgery. The aim of the study was to evaluate impedance changes over time.
METHOD
The Study Group (SG) was composed of CI IMIED patients (31 ears) and a Control Group (CG) of CI pa...
Exploration of specific brain areas involved in verbal working memory (VWM) is a powerful but not widely used tool for the study of different sensory modalities, especially in children. In this study, for the first time, we used electroencephalography (EEG) to investigate neurophysiological similarities and differences in response to the same verba...
The present study is a systematic review on the effectiveness of Parent Training (PT) and coaching in deaf and hard of hearing (DHH) rehabilitation programs which reviews and synthesizes the existing body of evidence to assess the benefits of these programs in enhancing parents’ sensitivity, responsivity and promoting language development in DHH ch...
Gaucher Disease (GD) is a metabolic inherited disorder, that classically includes three clinical phenotypes. Type I GD (GD1) is considered as a non-neuronopathic variant and can mimic a hematologic disease; type II (GD2) is classified as an acute neuropathic form and type III (GD3) is characterized by a slower and progressive neurological involveme...
Introduction
Cervical spine anomalies can coexist with anomalies of the head and neck. The association of cervical vertebrae anomalies (CVA) with cleft lip and palate (CLP) has been described as probably the result of a failure in normal embryological segmentation. The most frequent congenital alterations of cervical spine CLP-related are vertebral...
Background
Little is known regarding fitting parameters and receptive and expressive language development in cochlear-implanted children (CCI) with profound sensorineural hearing loss (SHL) who are diagnosed with Autism Spectrum Disorder (ASD). The aim of the study was to evaluate a group of ASD CCI users in order to describe their ASD clinical fea...
Purpose:
Executive Functions (EFs) are fundamental to every aspect of life. The present study was implemented to evaluate factors influencing their development in a group of preschools orally educated profoundly deaf children of hearing parents, who received CI within 2 years of age.
Methods:
Twenty-five preschool CI children were tested using t...
Objective:
Limited low frequency (LF) pitch and temporal fine structure (TFS) sensitivity have been thought to contribute significantly to poor music perception in cochlear implant (CI) listeners. Thus, this study aimed to evaluate music perception in relation to LF pitch perception and temporal coding, specifically in people with bimodal stimulati...
Stereotactic radiosurgery (SRS) is currently the most common treatment for small- to medium-size vestibular schwannoma (VS). Despite favorable outcome, hearing deterioration still remains an underestimated problem, and the role of hearing rehabilitation is an underinvestigated topic. Among available technologies, cochlear implant (CI) should repres...
PurposeThe objectives of this study are to evaluate cochlear implant (CI) listeners’ ability to infer low frequency (LF) pitch information from temporal fine structure (TFS) cues and to gain insight into its effects on speech perception, especially in the presence of a fluctuating background noise. Pitch perception assessment using linguistic stimu...
Objective: Bimodal stimulation is a standard option for asymmetric hearing loss in adults. Questions
have been raised whether receiving two stimulations may conflict in elderly listeners where the
central integration of an acoustic/electrical signal may be very important to obtain benefit in terms of
speech perception.
Design: Clinical retrospectiv...
Gaucher Disease (GD), a metabolic inherited disorder, includes three clinical phenotypes. Type I GD (GD1), that can mimic a hematologic disease, has been classically considered as a non-neuropathic variant; type II (GD2) and type III (GD3) are classified as acute and chronic neuropathic forms, respectively. A protective role of N370S mutation again...
Background and purpose:
Using functional magnetic resonance imaging (fMRI), we explored cortical activation in patients with acute Bell's palsy (BP) and analyzed its correlates with clinical status in the acute phase, and with 6-month outcome.
Methods:
Twenty-four right-handed patients with acute BP within 15 days of onset and 24 healthy control...
Previous research has shown that the production of third-person singular
accusative object clitics (3DO clitics) might be taxing in Italian-speaking
pre-school children with cochlear implants (CIs). We investigated this
topic by assessing 3DO clitic production in 14 children with an average
age of 8 years, who had received CI between age 1 and 4. T...
Deaf children with cochlear implants (CIs) need a supportive family environment to facilitate language development. The present study was designed to assess the effects of parent training (PT) on enhancing children’s communication development. The PT was based on the “It Takes Two to Talk” model, with specific adaptations for families of deaf child...
https://sapienzamedica.uniroma1.it/silenziose-sinergie-uditive-ai-tempi-di-covid-19-limpianto-cocleare-lintegrazione-scolastica-e-la-didattica-online/
Objective
to investigate the effect of age at CI activation and to explore the role of other variables such as linguistic skills, stimulation modality and gender on reading comprehension.
Study Design
Prospective observational nonrandomized study.
Methods
89 children with profound congenital sensorineural hearing loss were included in the study....
Gaucher Disease (GD) is an autosomal recessive metabolic disorder due to glucocerebrosidase deficit. There are three main clinical phenotypes: type I (GD1: non-neuronopathic form), characterized by a visceral involvement that can mimic a hematologic disease; type II (GD2: acute neuropathic form) and type III (GD3) characterized by a slower and prog...
Plain-language-summary
Recurrent Bell’s palsy (RBP) has been reported to range from 2.6 to 15.2% of primary Bell’s palsy (BP) and has been associated with systemic comorbidities such as diabetes and hypertension. A retrospective analysis of patients affected by BP and RBP were performed to define the signs and symptoms associated with recurrence an...
Abstract
Purpose
Cochlear implant (CI) users show great difficulty for understanding speech in noise and this fact may partly stem from their poor low-frequency (LF) pitch perception and temporal fine structure (TFS) processing. Clinical assessment of pitch perception is usually based on non-speech tasks. However, linguistically relevant contexts...
Objectives: To evaluate the effectiveness of an adjuvant therapy (CoQ10 in its water-soluble form and vitamin A) in supporting voice rehabilitation in a large group of patients with muscle tension dysphonia (MTD).
Study Design: Twelve-week, double-blind, randomized, controlled, three-period cross-over pilot study. The primary endpoint was the chang...
The role of the immune system in mediating cochleovestibular pathologies has received increasing attention in recent years. Autoimmune vertigo may be an invalidating condition and may worsen the quality of life of affected patients, especially in the cases of delayed diagnosis. Since the etiopathogenesis is still not clear, also the treatment is no...
This study investigated the effect of speech rate for Italian-speaking cochlear implant (CI) users with the
aim of gaining insight into everyday listening situations where speaker’s rate may vary considerably
together with speech level in fluctuating background noise. The test material was prepared by processing
the Italian STARR test with temporal...
Patients affected by aggressive neoplasms with a high propensity to metastasize to the skin, such as some head and neck cancers, can benefit from electrochemotherapy, a modality that combines electroporation of cell membranes and chemotherapy to facilitate the transport of non-permeant molecules into cells; the host immune response consequently par...
Objectives:
The aim of the study was to investigate the link between temporal fine structure (TFS) processing, pitch, and speech perception performance in adult cochlear implant (CI) recipients, including bimodal listeners who may benefit better low-frequency (LF) temporal coding in the contralateral ear.
Design:
The study participants were 43 a...
Background: Recently, the use of transcutaneous bone conduction implants (BCIs) has been increased. However, scarce data about BCI hearing recovery in noise conditions have been reported.
Objectives: To investigate the audiological benefits obtained with transcutaneous BCI-Sophono Alpha System in noise conditions. To evaluate post-implantation clin...
The objective of this study was to review our current knowledge relative to the correlation between sensorineural hearing loss (SNHL) and autoimmune diseases, focusing on the prevalence of hearing loss in different pathologies and possible therapeutic approaches. A review of the literature on hearing loss in different forms of autoimmune disease ha...
Behçet’s disease (BD) is a rare systemic vasculitis characterized by oral aphthous ulcers, genital ulcers, ocular lesions and other systemic manifestations. BD occurs most frequently in Eurasian populations along the ancient trading route known as the “Silk Road” which extends from eastern Asia to the Mediterranean basin. The causes of BD are unkno...
Objective:
Tinnitus is an auditory phantom sensation experienced in the absence of a sound source. Cognitive dysfunctions, especially in working memory and attention, are frequently reported to be associated with tinnitus. The aim of this study was to investigate attentional functioning in a group of subjects with chronic tinnitus using ERPs, and...
A retrospective review of post-op cone beam CT (CBCT) of 8 adult patients and 14 fresh temporal bones that underwent cochlear implantation with straight flexible electrodes array was performed to determine if the position of a long and flexible electrodes array within the cochlear scalae could be reliably assessed with CBCT. An oto-radiologist and...
A multi-center self-assessment survey was conducted to evaluate patient satisfaction with the Advanced Bionics Neptune™ waterproof sound processor used with the AquaMic™ totally submersible microphone.
Subjective satisfaction with the different Neptune™ wearing options, comfort, ease of use, sound quality and use of the processor in a range of acti...
Objectives:
To introduce the Italian adaptation of the STARR test based on a roving-level adaptive method to mimic challenging real-life listening conditions for use in people with auditory prostheses.
Design:
Normative data were collected and interlist-variability, as well as learning effects, were investigated using a within-subject design wit...
Objectives/hypothesis:
Social conversational skills are a salient aspect of early pragmatic development in young children. These skills include two different abilities, assertiveness and responsiveness. This study investigated the development of these abilities in early implanted children and their relationships with lexical development and some l...
The aim of this study was to investigate the amount of binaural squelch effect (BSE) and head shadow effect (HSE) in children who use unilateral cochlear implants (CI) and contralateral hearing aids (HA). The study group consisted of 19 CI recipient children who consistently wore a contralateral HA. Speech sounds were used to evaluate speech percep...
The aim of this study is to investigate whether, in addition to intratympanic steroid therapy, additional hyperbaric oxygen therapy (HBOT) sessions per day (twice a day for 5 days) is more useful than one session per day for 10 days in patients affected by severe and profound idiopathic sudden sensorineural hearing loss (ISSNHL). A total of 55 pati...
This individual prospective cohort study aims to report and analyze the symptoms preceding and accompanying the facial paresis in Bell’s palsy (BP). Two hundred sixty-nine patients affected by BP with a maximum delay of 48 hours from the onset were enrolled in the study. The evolution of the facial paresis expressed as House-Brackmann grade in the...
Objectives/hypothesis:
The study was designed to verify if one or more electrophysiological parameters could predict a risk of nonrecovery of normal facial function and the development of synkinesis in Bell's palsy (BP) subjects.
Study design:
Prospective case series.
Methods:
A total of 120 subjects ranging from 18 to 70 years with unilateral...
Bell's palsy is the most common cause of facial paralysis. Although it has been associated with diabetes mellitus, hypertension, pregnancy, and preeclampsia, the etiology of Bell's palsy remains unknown. The reactivation of latent herpes simplex virus (HSV) or varicella-zoster virus (VZV) with subsequent inflammation and entrapment of the facial ne...
The aim of the present study was to investigate the application of two new pitch perception tests in children with cochlear implants (CI) and to compare CI outcomes to normal hearing (NH) children, as well as investigating the effect of chronological age on performance. The tests were believed to be linked to the availability of Temporal Fine Struc...
l’impianto cocleare (Ic) costituisce la terapia più efficace nella sordità grave/profonda. vi è un in-teresse crescente del mondo scientifico che riguarda i risultati uditivi e l’influenza dell’Ic sulla qualità della vita. lo scopo dello studio è stato valutare l’influenza dell’Ic sulla percezione uditiva ed alcuni aspetti della qualità della vita...
Objective. The paper aims to demonstrate the feasibility of defining a substantial set of psychoacoustic outcome measures with preset targets and to adopt a systematic methodology for reaching these targets in a large group of subjects, by more than one clinical centre. Design. Retrospective data analysis. Setting. Multicentre with 14 participating...
Objectives:
To assess skills in inferences during conversations and in metaphors comprehension of unilaterally cochlear implanted children with adequate abilities at the formal language tests, comparing them with well-matched hearing peers; to verify the influence of age of implantation on overall skills.
Methods:
The study was designed as a mat...
The programming of CIs is essential for good performance. However, no Good Clinical Practice guidelines exist. This paper reports on the results of an inventory of the current practice worldwide. A questionnaire was distributed to 47 CI centers. They follow 47600 recipients in 17 countries and 5 continents. The results were discussed during a debat...
To analyze the presence of chronic cerebrospinal venous insufficiency parameter and vascular abnormalities, in the internal jugular veins (IJVs) and/or vertebral veins in sitting and supine posture, in patients with Meniere's disease compared to healthy general population. A prospective study on 32 patients affected by definite Ménière was performe...