Patrick Timmons

• Doctor of Philosophy
• Bioinformatic & AI Scientist at Nuritas Inc.

Maximin 3 is a 27-residue-long cationic antimicrobial peptide found in the skin secretion and brain of the Chinese red-belly toad Bombina maxima. The peptide is of biological interest as it possesses anti-HIV activity, not found in the other maximin peptides, in addition to antimicrobial, antitumor and spermicidal activities. The three-dimensional...

Good knowledge of a peptide's tertiary structure is important for understanding its function and its interactions with its biological targets. APPTEST is a novel computational method that employs a neural network architecture and simulated annealing methods for the prediction of peptide tertiary structure from the primary sequence. APPTEST works fo...

Viruses represent one of the greatest threats to human health, necessitating the development of new antiviral drug candidates. Antiviral peptides often possess excellent biological activity and a favourable toxicity profile, and therefore represent a promising field of novel antiviral drugs. As the quantity of sequencing data grows annually, the de...

Brevinin-1BYa (FLPILASLAAKFGPKLFCLVTKKC), first isolated from skin secretions of the foothill yellow-legged frog Rana boylii, shows broad-spectrum activity, being particularly effective against opportunistic yeast pathogens. The structure of brevinin-1BYa was investigated in various solution and membrane-mimicking environments by proton nuclear mag...

Brevinin-1BYa is a 24-amino acid residue host-defense peptide, first isolated from skin secretions of the foothill yellow-legged frog Rana boylii. The peptide is of interest, as it shows broad-spectrum antimicrobial activity, and is particularly effective against opportunistic yeast pathogens. Its potential for clinical use, however, is hindered by...

Molecular modelling is a vital tool in the discovery and characterisation of bioactive peptides, providing insights into their structural properties and interactions with biological targets. Many models predicting bioactive peptide function or structure rely on their intrinsic properties, including the influence of amino acid composition, sequence,...

Palustrin-Ca (GFLDIIKDTGKEFAVKILNNLKCKLAGGCPP) is a host defence peptide with potent antimicrobial and anticancer activities, first isolated from the skin of the American bullfrog Lithobates catesbeianus. The peptide is 31 amino acid residues long, cationic and amphipathic. Two-dimensional NMR spectroscopy was employed to characterise its three-dim...

Maximin 1 is a cationic, amphipathic antimicrobial peptide found in the skin secretions and brains of the Chinese red belly toad Bombina maxima. The 27 amino acid residue-long peptide is biologically interesting as it possesses a variety of biological activities, including antibacterial, antifungal, antiviral, antitumour and spermicidal activities....

Good knowledge of a peptide's tertiary structure is important for understanding its function and its interactions with its biological targets. APPTEST is a novel computational protocol that employs a neural network architecture and simulated annealing methods for the prediction of peptide tertiary structure from the primary sequence. APPTEST works...

Viruses represent one of the greatest threats to human health, necessitating the development of new antiviral drug candidates. Antiviral peptides often possess excellent biological activity and a favourable toxicity profile, and therefore represent a promising field of novel antiviral drugs. As the quantity of sequencing data grows annually, the de...

Palustrin-Ca (GFLDIIKDTGKEFAVKILNNLKCKLAGGCPP) is a host defense peptide with potent antimicrobial and anticancer activities, first isolated from the skin of the American bullfrog Lithobates catesbeianus . The peptide is 31 amino acid residues long, cationic and amphipathic. Two-dimensional NMR spectroscopy was employed to characterise its three-di...

The prevalence of cancer as a threat to human life, responsible for 9.6 million deaths worldwide in 2018, motivates the search for new anticancer agents. While many options are currently available for treatment, these are often expensive and impact the human body unfavourably. Anticancer peptides represent a promising emerging field of anticancer t...

The search for novel anticancer agents is motivated by the prevalent threat to human life posed by cancer, responsible for 9.6 million deaths worldwide in 2018. Although a number of treatment options are currently available, these are typically costly and have severe impact on the human body. Antimicrobial peptides are a diversiform class of well-s...

The prevalence of cancer as a threat to human life, responsible for 9.6 million deaths worldwide in 2018, motivates the search for new anticancer agents. While many options are currently available for treatment, these are often expensive and impact the human body unfavourably. Anticancer peptides represent a promising emerging field of anticancer t...

The growing prevalence of resistance to antibiotics motivates the search for new antibacterial agents. Antimicrobial peptides are a diverse class of well-studied membrane-active peptides which function as part of the innate host defence system, and form a promising avenue in antibiotic drug research. Some antimicrobial peptides exhibit toxicity aga...

The increasing prevalence of multi-drug antibiotic resistance provides the motivation for the pursuit of new antibacterial agents. As few cases of bacterial resistance to antimicrobial peptides (AMPs) have been identified to-date, this diversiform class of membrane-active peptides, which in nature function as part of the innate host defence system,...

Brevinin-1BYa (FLPILASLAAKFGPKLFCLVTKKC) is a 24-amino acid residue host-defence peptide, first isolated from the skin secretions of the foothill yellow-legged frog Rana boylii. The peptide is of interest as it shows broad-spectrum antimicrobial activity, and is particularly effective against opportunistic yeast pathogens. Its potential for clinica...

We have studied structural properties of maximin 3, a 27-residue long cationic antimicrobial peptide which possesses antimicrobial, antitumor, spermicidal and anti-HIV activities. The three-dimensional structural model was obtained using NMR and molecular modelling techniques. Maximin 3 possesses amphipathic character and adopts α-helical conformat...

Maximin-3 (GIGGKILSGLKTALKGAAKELASTYLH) is a 27-residue long cationic antimicrobial peptide found in the skin secretion and brain of the Chinese red belly toad Bombina maxima. The peptide is interesting as it possesses anti-HIV activity, not found in the other maximin peptides, in addition to its antimicrobial, antitumor, and spermicidal activities...

Brevinin-1BYa (FLPILASLAAKFGPKLFCLVTKKC), first isolated from skin secretions of the foothill yellow-legged frog Rana boylii, is particularly effective against C. albicans, and is also active against E. coli and S. aureus. The structures of brevinin-1BYa and its less-potent analogue [C18S,C24S]brevinin-1BYa were investigated in various solution and...

Brevinin-1BYa (FLPILASLAAKFGPKLFCLVTKKC), first isolated from skin secretions of the foothill yellow-legged frog Rana boylii, is particularly effective against C. albicans, and is also active against E. coli and S. aureus. The structures of brevinin-1BYa and its less-potent analogue [C18S,C24S]brevinin-1BYa were investigated in various solution and...

Brevinin-1BYa (FLPILASLAAKFGPKLFCLVTKKC), first isolated from skin secretions of the foothill yellow-legged frog Rana boylii, is particularly effective against C. albicans, and is also active against E. coli and S. aureus. The structures of brevinin-1BYa and its less-potent analogue [C18S,C24S]brevinin-1BYa were investigated in various solution and...