Patrick Gérardin

Patrick Gérardin
Centre Hospitalier Universitaire de la Réunion · INSERM CIC1410 Epidémiologie Clinique

MSc, MD, MPH, PhD, HDR
Paediatrician - Epidemiologist - Infectious disease specialist

About

336
Publications
49,811
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4,279
Citations
Introduction
Research areas: infectious diseases and perinatal health. I am currently working as clinician researcher, epidemiologist, and methodologist at the Centre for Clinical Investigation (INSERM CIC1410), CHU Saint Pierre, Reunion island. Topics of interest: epidemiology and pathogenesis of chikungunya, arboviroses, zoonoses, influenza, malaria, preterm birth, postpartum hemorrhage and chronic fatigue syndrome. Skills: designing, conducting, and analyzing epidemiological studies and clinical research
Additional affiliations
October 2017 - present
Centre Hospitalier Universitaire de la Réunion, Saint-Paul, Reunion
Position
  • Researcher
Description
  • To coordinate and improve hospital research in clinical Infectious diseases and ID epidemiology. To foster the exchanges between researchers through the GEREMIE (Groupe d'Etudes et de Recherche Epidémiologique en Maladies Infectieuses et Emergentes).
April 2016 - April 2016
Université de La Réunion
Position
  • Teacher-Practitioner
Description
  • Première Année Commune aux Etudes de Santé (PACES): 24 heures de cours sur l'histoire de la santé publique. First year of Health Studies: 24-hour course dedicated to the history of public health
January 2014 - present
Université de La Réunion, CNRS 9192, INSERM U1187, IRD 249
Position
  • Senior Researcher
Description
  • To lead the academic research in Infectious Diseases Epidemiology. To bridge between academic and hospital researchers in Infectious Diseases to foster translational researches.

Publications

Publications (336)
Article
Full-text available
Background: As coronavirus 2019 (COVID-19) is spreading globally, several countries are handling dengue epidemics. As both infections are deemed to share similarities at presentation, it would be useful to distinguish COVID-19 from dengue in the context of co-epidemics. Hence, we performed a retrospective cohort study to identify predictors of bot...
Article
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Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (...
Article
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Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare, biochemically deleterious X-linked TLR7 variants in 16 unrelated male individuals aged 7 to 71 years (mean: 36.7 years) from a cohort of 1,202 male patients aged 0.5 to 99 years (...
Article
Objectives The purpose of this cohort study was to develop two scores able to differentiate coronavirus 2019 (COVID-19) from dengue and other febrile illnesses (OFIs). Methods All subjects suspected of COVID-19 who attended the SARS-CoV-2 testing center of Saint-Pierre hospital, Reunion, between March 23 and May 10, 2020, were assessed for identif...
Article
Contexte Le chikungunya peut être grave chez le patient diabétique de type 2. De plus, le chikungunya à sa phase aiguë peut déséquilibrer la glycémie et compliquer le diabète. Par contre, les conséquences de l'infection sur le risque cardiovasculaire du diabétique restent méconnues. Nos objectifs étaient d'estimer l’évolution du risque cardiovascul...
Article
Contexte Le chikungunya peut être grave chez le patient diabétique de type 2. De plus, le chikungunya à sa phase aiguë peut déséquilibrer la glycémie et compliquer le diabète. Par contre, les conséquences de l'infection sur l’évolution à long terme des anomalies glycémiques restent à ce jour méconnues. Nos objectifs étaient d'estimer les risques in...
Article
Invited Commentary to the article " Prevalence, risk factors and short-term consequences of adverse birth outcomes in Zimbabwean pregnant women: a secondary analysis of a cluster-randomized trial." by Chasekwa B, Ntozini R, Church JA, Majo FD, Tavengwa N, Mutasa B, Noble C, Koyratty N, Maluccio JA, Prendergast AJ, Humphrey JH, Smith LE; Sanitation...
Preprint
Full-text available
SARS-CoV-2 infection fatality rate (IFR) doubles with every five years of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ~20% of deceased patients across age groups. In the general population, they are found in ~1% of individuals aged 20-70 years and in >4% of those >70 years old. With a s...
Article
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Background: Low socio-economic settings are characterized by high prevalence of diabetes and difficulty in accessing healthcare. In these contexts, proximity health services could improve healthcare access for diabetes prevention. Our primary objective was to evaluate the usefulness of home screening for promoting awareness of impaired glycemic st...
Article
Introduction Estimer la prévalence de Chlamydia trachomatis (Ct) dans un département d’outre-mer (DOM) et identifier les facteurs de risque (FDR) associés à l’infection. Matériels et méthodes Étude transversale, multicentrique dans les quatre Centres Gratuits d’Information, de Dépistage et de Diagnostic des infections sexuellement transmissibles (...
Article
Full-text available
Introduction La dengue est la maladie virale transmise par les moustiques, qui se propage le plus rapidement dans les pays tropicaux et subtropicaux. Des millions de personnes sont infectées par la dengue chaque année. L’île de la Réunion a connu d’importantes épidémies de dengue ces dernières années. Objectifs Décrire les caractéristiques cliniqu...
Article
Background Syphilis is a sexually transmitted infection (STI) with a global prevalence estimated at 0.5% in 2012. Syphilis has been on the rise among men who have sex with men (MSM) in high-income countries and remains at endemic levels in low- and middle-income countries. This trend, however, has not been observed in Reunion Island. Objectives To...
Article
Introduction L’infection par le coronavirus 2019 (COVID-19) et la dengue sont difficiles à différencier cliniquement dans le contexte des co-épidémies en zone tropicale. Dans une étude de cohorte rétrospective, nous avons précédemment distingué les facteurs associés au coronavirus 2019 (COVID-19) et à la dengue de ceux associés à d’autres maladies...
Article
Objectives: To determine the prevalence of Chlamydia trachomatis (CT) in the population screened at sexually transmitted infection (STI) clinics on Reunion Island and to identify risk factors for CT infection. Patients and methods: This cross-sectional multicenter study was conducted in 2017-2018. Data were obtained from self-administered questi...
Article
Full-text available
Background Mycoplasma genitalium (MG) is an emerging sexually transmitted infection (STI) for whose management remains controversial. We aimed to assess the prevalence and risk factors of MG infection in patients attending an STI clinic in Reunion Island. Methods Between January 2017 and December 2018, all patients attending the Saint-Pierre STI c...
Article
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Objective: To evaluate pregnancy and neonatal outcomes, disease severity, and mother-to-child transmission of pregnant women with Chikungunya infection (CHIKV). Design: Retrospective observational study. Setting: Grenada. Population: Women who gave birth during a Chikungunya outbreak between January 2014 to September 2015 were eligible. Methods: Th...
Article
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Objectives To describe and estimate the frequency of pregnancy outcomes, clinical and laboratory characteristics of vertical transmission of CHIKV in the neonate. Study design We performed a systematic review evaluating the clinical presentation of perinatally-acquired CHIKV infection in neonates. The search was performed using Medline (via PubMed...
Article
Full-text available
In this multicentre cohort study, we evaluated the risks of maternal ZIKV infections and adverse pregnancy outcomes among exposed travellers compared to women living in areas with ZIKV circulation (residents). The risk of maternal infection was lower among travellers compared to residents: 25.0% (n = 36/144) versus 42.9% (n = 309/721); aRR 0.6; 95%...
Article
Full-text available
Background Recommendations for sexually transmitted infection (STI) screening vary significantly across countries. This study evaluated the prevalence of urogenital and extragenital infections with Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Mycoplasma genitalium (MG) in patients visiting a French STI clinic in the Indian Ocean regi...
Article
Introduction La syphilis est une infection sexuellement transmissible dont la prévalence mondiale est estimée à 0,5 % en 2012. Alors que la syphilis est en augmentation dans la littérature nationale et internationale dans les pays développés parmi les hommes ayant des rapports sexuels avec des hommes, la situation semble différer à la Réunion. L’ob...
Article
Introduction L’infection à Mycoplasma genitalium (Mg) est une infection sexuellement transmissible (IST) émergente avec peu de données disponibles. Responsable de vaginite, cervicite, inflammation chronique du pelvis chez les femmes et d’urétrite chez les hommes ainsi que de troubles de la fertilité, Mg est asymptomatique chez 75 % des femmes et 30...
Article
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Objectives Molecular assays on nasopharyngeal swabs remain the cornerstone of COVID-19 diagnostic. The high technicalities of nasopharyngeal sampling and molecular assays, as well as scarce resources of reagents, limit our testing capabilities. Several strategies failed, to date, to fully alleviate this testing process (e.g. saliva sampling or anti...
Preprint
Full-text available
In the Coronavirus 19 (COVID-19) dengue co-epidemic setting of Reunion island, southwestern Indian ocean, a cohort study conducted between March 23 and May 10, 2020, within a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) testing center found that non severe dengue was more symptomatic than mild to moderate COVID-19 and was associated...
Article
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Background: The 2005-06 chikungunya virus (CHIKV) outbreak in La Réunion suggested that mothers could transmit CHIKV to their neonates while viremic during the intrapartum period, and more than half of the infected neonates showed impaired neurodevelopment at two years of age. However, data sparsity precluded an overview of the developmental impac...
Article
This commentary describes the creation of the Zika Virus Individual Participant Data Consortium, a global collaboration to address outstanding questions in Zika virus (ZIKV) epidemiology through conducting an individual participant data meta-analysis (IPD-MA). The aims of the IPD-MA are to (1) estimate the absolute and relative risks of miscarriage...
Article
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Introduction Le diagnostic étiologique des pneumonies aiguës communautaires (PAC) demeure inexpliqué pour près de 40 % des formes graves. Dans ce contexte, les nouvelles techniques de biologie moléculaire ont permis d’améliorer le diagnostic étiologique. L’objectif principal était d’estimer la performance diagnostique d’une PCR multiplex pour les P...
Article
Introduction Les premiers cas d’infection à SARS-CoV-2 ont été diagnostiqués à partir du 11 mars 2020 sur notre territoire ultramarin. Celui ci est par ailleurs touché par une épidémie de dengue depuis l’année 2017, dont le pic est habituellement situé entre mars et juin. L’objectif de cette étude était d’identifier les symptômes discriminants entr...
Article
Introduction La fièvre Q est une pathologie négligée. La présence de Coxiella burnetii a été documentée à La Réunion avec une séropositivité chez les ruminants (13,4 % chez les chèvres) et une séroprévalence humaine pondérée à 6,81 % (IC entre 4,0 % et 9,6 %). Cependant, peu de données cliniques sont disponibles sur la présentation des cas et l’épi...
Article
Introduction L’infection par le virus chikungunya (CHIKV) peut être grave et ses manifestions prolongées chez le patient diabétique de type 2 (DT2). De plus, il a été démontré que le chikungunya à sa phase aigüe pouvait déséquilibrer la glycémie des patients DT2 et être source de complications du diabète. Par contre, les conséquences de l’infection...
Article
Objective We aim to illustrate and evaluate the prevalence and distribution pattern of cervical human papilloma virus (HPV) genotypes on La Réunion Island, a French overseas territory, with the aim to guide future vaccination policies. Study design Between January 2008 and July 2012, files of women undergoing gynaecological examination were retros...
Article
Résumé Introduction De nombreuses études sur la communication insuffisante et la qualité de vie altérée des patients atteint de bronchopneumopathie chronique obstructive (BPCO) amènent à conclure que leur prise en charge palliative reste à améliorer. L’objectif de cette étude était de réaliser un état des lieux des perceptions et des pratiques de...
Article
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Background: Q fever (Coxiella burnetii infection) has been associated with adverse perinatal outcomes. After investigating the obstetrical importance of Q fever on Reunion island and demonstrating an association between incident Q fever and miscarriage, we conducted a cross-sectional serosurvey to assess the prevalence of Coxiella burnetii infecti...
Article
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Background Severe postpartum haemorrhage (S-PPH) is the leading cause of maternal death worldwide. We aimed to provide an up-to-date summary about S-PPH determinants. Methods We performed a systematic review following the Preferred Reporting Items for Systematic reviews and Meta-analysis (PRISMA) guidelines. We searched the terms “risk factor”, “d...
Article
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Background. Q fever has been associated with perinatal complications. We conducted a prospective follow-up study to assess both the incidence of adverse pregnancy outcomes (APOs) associated with Coxiella burnetii infection and the contribution of Q fever to APOs. Methods. Between May 1 and October 31, 2013, within the regional perinatal health care...
Preprint
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Systematic review of the literature of the determinants of severe postpartum hemorrhage. Accepted article in Journal of Global Health Reports.
Article
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Background: In Reunion Island, a French overseas department, the burden of preterm birth and perinatal mortality exceed those observed in mainland France, despite similar access to standard perinatal care. The purpose of the study was to compare the outcome of two cohorts of NICU-admitted very preterm infants born between 24 and 31 weeks of gestat...
Preprint
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Preprint describing the seroprevalence of Q fever in parturient women in south Reunion island, a low endemic setting
Preprint
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Postprint describing the incidence of Q fever associated pregnancy outcomes in south Reunion island. First article confirming the relationship between exposure to acute Q fever and early miscarriage previously found in a Spanish study and to a lesser extern, the association between acute Q fever and ante partum fetal death. In press article for BMC...
Article
Full-text available
Objective Hepatitis E virus (HEV) has been scarcely investigated in the Indian Ocean. Following a nationwide serosurvey among blood donors, we conducted a population-based serosurvey to assess the magnitude of HEV exposure on Reunion Island. Methods Four hundred and sixty-six archived frozen human sera from the 2009 CoPanFlu-RUN cohort were analyse...