
Patrick W ChambersTorrance Memorial Medical Center · Department of Pathology
Patrick W Chambers
Doctor of Medicine
About
58
Publications
24,341
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543
Citations
Introduction
Education
June 1975 - June 1979
LAC-USC Medical Center
Field of study
- Pathology
September 1971 - June 1975
September 1967 - June 1971
Publications
Publications (58)
The gut microbiome has been the subject of increasing interest as integral to our health. Few realize that the enormous benefits of vitamin D (VD) and magnesium (Mg) are highly dependent on a healthy gut microbiome. Short chain fatty acids, especially butyrate, reflect not only a healthy gut microbiome but also VD status. Suboptimal VD, Mg, or buty...
Candida is traditionally considered an opportunistic pathogen. However, recent research,
accelerated by Covid-19, has raised provocative questions about such a limited view. Dietary
carbohydrates and ethanol have enabled its pathogenic transition. Its hyphae express epitopes
that can initiate celiac and Crohn’s disease. Hyphal mannan is potentially...
Magnesium (Mg) is not prominent among the list of well known anti-aging agents. Yet the signs and symptoms of aging mimic those of Mg deficiency. Mg is required for nearly a thousand enzymatic reactions. This narrative review does not correlate Mg status with clinical data on agents linked to longevity. The approach is more novel and highlights spe...
Magnesium (Mg) is not prominent among the list of well known anti-aging agents. Yet the signs and symptoms of aging mimic those of Mg deficiency. Mg is a required cofactor for over 800 enzymatic reactions (as of 2022). This review does not correlate Mg status with clinical data on agents linked to longevity. The approach is physiologic and highligh...
Candida is traditionally considered an opportunistic pathogen. However, recent research, supercharged by Covid-19, has raised provocative questions about such a limited view. Dietary carbohydrates and ethanol have enabled its pathogenic transition. Its hyphae express epitopes that can initiate celiac and Crohn’s disease. Hyphal mannan is potentiall...
The pandemic has supercharged growing awareness of the gut microbiome as a critical determinant of human health. "Long haulers" share microbiomes similar to those seen in myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia, all frequently associated with Candida overgrowth (CO). Candida can synthesize its own IDO, altering tryptopha...
The pandemic has supercharged growing awareness of the gut microbiome as a critical determinant of human health. Long haulers share microbiomes similar to those seen in myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia, all frequently associated with Candida overgrowth (CO). Candida can synthesize its own IDO, altering tryptophan...
The pandemic has supercharged growing awareness of the gut microbiome as a critical determinant of human health. Long haulers share microbiomes similar to those seen in myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia, all frequently associated with Candida overgrowth (CO). Candida has a unique relationship with indoleamine dioxy...
The pandemic has supercharged growing awareness of the gut microbiome as a critical determinant of human health. Long haulers share microbiomes similar to those seen in myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia, all frequently associated with Candida overgrowth (CO). Candida has a unique relationship with IDO and altered t...
The pandemic has supercharged growing awareness of the gut microbiome and the gut-brain-axis as determinants of human health. Zonulin, a circulating protein that increases intestinal and endothelial permeability, has emerged as a central player. This protein can be activated by proteases secreted by Candida, opening the door to myriad autoimmune an...
The pandemic has supercharged growing awareness of the gut microbiome and the gut-brain-axis as determinants of human health. Zonulin, a circulating protein that increases intestinal and endothelial permeability, has emerged as a central player. This protein can be activated by proteases secreted by Candida, opening the door to myriad autoimmune an...
“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via the gut-brain-axis elevates heart rate variability (HRV), a general measure of health and well-being. A dysbiotic gut microbiome, low in biodiversity and butyrate producers, can alter tryptophan metabolism (ATM) and increase the kynurenine to tryptophan ratio (KT...
All diseases originate in the gut." Hippocrates (400 BC) A healthy gut microbiome via the gut-brain-axis elevates heart rate variability (HRV), a general measure of health and well-being. A dysbiotic gut microbiome, low in biodiversity and butyrate producers, can alter tryptophan metabolism (ATM) and increase the kynurenine to tryptophan ratio (KTR...
The dermatological manifestations of Long Covid (LC) have languished in the shadows of chronic fatigue and brain fog. Yet they are all linked by gut dysbiosis and the cytokine triad of TNF-α, IL-1β, and IL-6. The gut microbiome common not only to LC, psoriasis, AA, and vitiligo but also to neurodegenerative disease has been recently described. This...
“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via the gut-brain-axis (GBA) elevates heart rate variability (HRV), a general measure of health and well-being. A dysbiotic gut microbiome, low in biodiversity and butyrate producers, alters tryptophan metabolism with release of proinflammatory cytokines, predominant...
“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via the gut-brain-axis (GBA) elevates heart rate variability (HRV), a general measure of health and well-being. A dysbiotic gut microbiome, low in biodiversity and butyrate producers, alters tryptophan metabolism with release of proinflammatory cytokines, predominant...
"All diseases originate in the gut." Hippocrates (400 BC)
“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via the gut-brain-axis (GBA) elevates heart rate variability (HRV), a general measure of health and well-being. A dysbiotic gut microbiome, low in biodiversity and butyrate producers, triggers altered tryptophan metabolism and release of proinflammatory cytokines, pr...
Long Covid has become a blight, its economic consequences overwhelming. But Long Covid (LC) may represent persistent Covid-19 in those with preexisting Candida overgrowth (CO). The features shared by both are striking. LC may be a growing subset of CO. The altered tryptophan metabolism encountered in LC is driven by IFN-γ in reaction to CO. Females...
TNFα in partnership with glycosylated CD147 conspires to create the fertile soil for de novo and recurrent cancer. CD147 is present on the spike protein S (virus or vaccine) [1], despite claims to the contrary [2,3]. These claims have been discredited [4]. Pro and con arguments for the connection between cancer and Covid-19 or its vaccines continue...
Long Covid has become a blight, its economic consequences overwhelming. But Long Covid (LC) may represent persistent Covid-19 in those with preexisting Candida overgrowth (CO). The features shared by both are striking. LC may be a growing subset of CO. The altered tryptophan metabolism encountered in LC is driven by IFN-γ in reaction to CO. Females...
Long Covid has become a blight, its economic consequences overwhelming. But Long Covid (LC) may represent persistent Covid-19 in those with preexisting Candida overgrowth (CO). The features shared by both are striking. LC may be a growing subset of CO. The altered tryptophan metabolism encountered in LC is driven by IFN-γ in reaction to CO. Females...
Long Covid has become a blight, its economic consequences overwhelming. But Long Covid (LC) may represent persistent Covid-19 in those with preexisting Candida overgrowth (CO). The features shared by both are striking. LC may be a growing subset of CO. The altered tryptophan metabolism encountered in LC is driven by IFN-γ in reaction to CO. Females...
Vitamin B6, magnesium, and vitamin D are important antioxidants. Mg is a required cofactor for the synthesis of vitamin D and the active forms of vitamins B1,2,3,5,6,9,12 (seven of the eight B vitamins). Five of the seven (and magnesium) are critical to the methylation cycle, compromised by MTHFR (methylene tetrahydrofolate reductase) variants, pre...
Vitamin B6, magnesium, and vitamin D are important antioxidants. Mg is a required cofactor for the synthesis of vitamin D and the active forms of vitamins B1,2,3,5,6,9,12 (seven of the eight B vitamins). Five of the seven (and magnesium) are critical to the methylation cycle, compromised by MTHFR (methylene tetrahydrofolate reductase) variants, pre...
These three syndromes - long covid (LC), postural orthostatic tachycardia syndrome (POTS), and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) - have many symptoms in common. The common denominator remains elusive. The blood brain barrier (BBB) has been a barrier not only to microbes and toxins but also to understanding pathogenetic lin...
Long Covid (LC), Chronic Fatigue Syndrome (CFS), Postural Orthostatic Tachycardia Syndrome (POTS), Mast Cell Activation Syndrome (MCAS), Small Intestine Bacterial Overgrowth (SIBO), and Ehlers-Danlos Syndrome (EDS) are all loosely connected, some poorly defined, some with overlapping symptoms. The female preponderance, the prominence of fatigue and...
The recent pandemic has energized research spotlighting chronic fatigue disorders. Thesimilarities between Long COVID (LC) and Chronic Fatigue Syndrome (CFS), often accompanied by postural orthostatic tachycardia syndrome (POTS) are striking. Furthermore, the majority afflicted with LC and CFS may be those with methylenetetrahydrofolate reductase (...
Long Covid (LC), Chronic Fatigue Syndrome (CFS), Postural Orthostatic Tachycardia Syndrome (POTS), Mast Cell Activation Syndrome (MCAS), Small Intestine Bacterial Overgrowth (SIBO), and Ehlers-Danlos Syndrome (EDS) are all loosely connected, some poorly defined, some with overlapping symptoms. The female preponderance, the prominence of fatigue and...
These three syndromes-long covid (LC), postural orthostatic tachycardia syndrome (POTS), and chronic fatigue syndrome (CFS)-have many symptoms in common. A common denominator remains elusive. The blood-brain barrier (BBB) has been a barrier not only to microbes and toxins but also to understanding pathogenetic links. There are several areas within...
These three syndromes - long covid (LC), postural orthostatic tachycardia syndrome (POTS), and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) - have many symptoms in common. The common denominator remains elusive. The blood brain barrier (BBB) has been a barrier not only to microbes and toxins but also to understanding pathogenetic lin...
These three syndromes - Long Covid (LC), Postural Orthostatic Tachycardia Syndrome (POTS), and Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) have many symptoms in common. The common denominator remains elusive. The Blood Brain Barrier (BBB) has been a barrier not only to microbes and toxins but also to understanding pathogenetic link...
Brain fog with compromised ability to concentrate has been the most frequent Long Covid (LC) complaint. This is due to an increased TGF beta/IFN gamma with consequently increased bradykinin (BKN), especially in Caucasian females. Brain and lung blood vessels "leak." This same ratio is increased in Alzheimer's disease (AD), but decreased in Parkin-s...
Brain fog with compromised ability to concentrate has been the most frequent Long Covid (LC) complaint. This is due to an increased transforming growth factor (TGF) β/interferon (IFN)-γ ratio with consequently increased bradykinin (BKN), especially in Caucasian females. Brain and lung blood vessels “leak.” This same ratio is increased in Alzheimer’...
Long Covid has many symptoms that overlap with ME (myalgic encephalo-myelitis)/CFS (chronic fatigue syndrome), FM (fibromyalgia), EBV (Eps-tein-Barr virus), CMV (cytomegalovirus), CIRS (chronic inflammatory response syndrome), MCAS (mast cell activation syndrome), POTS (postural orthostatic tachycardia syndrome), and post viral fatigue syndrome. Th...
Long Covid has many symptoms that overlap with ME(myalgic encephalomyelitis)/CFS(chronic fatigue syndrome), FM(fibromyalgia), EBV(Epstein-Barr virus), CMV(cytomegalovirus), CIRS (chronic inflammatory response syndrome), MCAS(mast cell activation syndrome), POTS(postural orthostatic tachycardia syndrome), and post viral fatigue syndrome. They all po...
Long Covid has many symptoms that overlap with ME(myalgic encephalomyelitis)/CFS(chronic fatigue syndrome), FM(fibromyalgia), EBV(Epstein-Barr virus), CMV(cytomegalovirus), CIRS (chronic inflammatory response syndrome), MCAS(mast cell activation syndrome), POTS(postural orthostatic tachycardia syndrome), and post viral fatigue syndrome. They all po...
Long Covid has many symptoms that overlap with ME(myalgic encephalomyelitis)/CFS(chronic fatigue syndrome), FM(bromyalgia), EBV(Epstein-Barr virus), CMV(cytomegalovirus), CIRS (chronic in ammatory response syndrome), MCAS(mast cell activation syndrome), POTS(postural orthostatic tachycardia syndrome), and post viral fatigue syndrome. They all porte...
The calcium to magnesium ratio plus adequate vitamin D greatly determine success or not in the immune battle against pathogens and cancer, not to mention cardiovascular disease. Ionized calcium and magnesium in normal, healthy individuals can be calculated and a ratio determined from serum levels. Using widely accepted laboratory reference range va...
The calcium to magnesium ratio plus adequate vitamin D largely determine success or not in the immune battle against pathogens and cancer, not to mention cardiovascular disease. Ionized calcium and magnesium in normal, healthy individuals can be calculated and a ratio determined from serum levels. Using widely accepted laboratory reference range va...
Long Covid, now also reported in children, has become increasingly alarming. Perhaps a third of those who develop MIS-C go on to experience Long Covid. Etiology is elusive. The role of vitamin D in bone and immune health has been recognized but magnesium de ciency has escaped attention. A physiologic and biochemical argument for its culpability in...
Long Covid, now also reported in children, has become increasingly alarming. Perhaps a third of those who develop MIS-C go on to experience Long Covid. Etiology is elusive. The role of vitamin D in bone and immune health has been recognized but magnesium deficiency has escaped attention. A physiologic and biochemical argument for its culpability in...
The primary determinants of Covid severity are ACE genotype, the falciparum antigen (CD147), and vitamin D status. Specifically the I (insertion) and D (deletion) alleles, ACE polymorphisms, determine the balance between the RAS (Renin Angiotensin System) and the KKS (Kallikrein Kinin System) in the response to SARS CoV2 (SARS2). CD147, the falcipa...
Covid-19 is particularly mild with children, and its severity escalates with age. Several theories have been proposed to explain these facts. In particular, it was proposed that the lower expression of the viral receptor ACE2 in children protects them from severe Covid-19. However, other works suggested an inverse relationship between ACE2 expressi...
The Spike S/Basigin (BSG) interaction, validated in 2020, has since been called putative, postulated, and controversial. Two widely referenced articles have been largely responsible for this. The data presented here demonstrate that the exclusion of this interaction that these articles purport to show is due to an inappropriate binding affinity ref...
Covid-19 is particularly mild with children, and its severity escalates with age. Several theories have been proposed to explain these facts. In particular, it was proposed that the lower expression of the viral receptor ACE2 in children protects them from severe Covid. However, other works suggested an inverse relationship between ACE2 expression...
Covid-19 has presented the world with a multitude of different clinical faces. To date their linkage eludes. This article attempts to establish linkage using recent research results regarding blood groups, clinical findings, cytokines, epidemiology, and the CD147 receptor, the orphan sister of ACE2. The role of the immune system controlled by the R...
Covid-19 has presented the world with a multitude of different clinical faces. To date their linkage eludes. This article attempts to establish linkage using recent research results regarding blood groups, clinical findings, cytokines, epidemiology, and the CD147 receptor, the orphan sister of ACE2. The role of the immune system controlled by the R...
Covid-19 has presented the world with a multitude of different clinical faces. To date their linkage eludes. This article attempts to establish linkage using recent research results regarding blood groups, clinical findings, cytokines, epidemiology, and the CD147 receptor, the orphan sister of ACE2. The role of the immune system controlled by the R...
Atrial fibrillation risk has been strongly associated with increasing age and visceral obesity. These characteristics are strongly associated with diabetes, decreased heart rate variability, and chronic inflammation. Lone atrial fibrillation (LAF) on the other hand exhibits a predilection for the physically fit and the middle aged, especially males...
Five cases of carcinoma metastatic to intracranial meningioma or neurilemoma are presented and compared with 20 similar cases reported in the literature. The phenomenon was most often seen on autopsy (17 of 25 cases) and was found more commonly in females (3:2), with nearly 90% of donor cancers being found in breast or lung. The existence of the do...
Thirty cases of chordoma were reviewed with respect to the incidence of distant metastases. Follow-up information was obtained in 27 (90%), and the incidence of metastases was approximately 30%. The sites of the metastasizing primary tumors were predominantly sacral and vertebral. The sites of the metastases were predominantly skin and bone, althou...