Patrick W Chambers

Torrance Memorial Medical Center · Department of Pathology

Vitamin B6, magnesium, and vitamin D are important antioxidants. Mg is a required cofactor for the synthesis of vitamin D and the active forms of vitamins B1,2,3,5,6,9,12 (seven of the eight B vitamins). Five of the seven (and magnesium) are critical to the methylation cycle, compromised by MTHFR (methylene tetrahydrofolate reductase) variants, pre...

These three syndromes - long covid (LC), postural orthostatic tachycardia syndrome (POTS), and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) - have many symptoms in common. The common denominator remains elusive. The blood brain barrier (BBB) has been a barrier not only to microbes and toxins but also to understanding pathogenetic lin...

These three syndromes-long covid (LC), postural orthostatic tachycardia syndrome (POTS), and chronic fatigue syndrome (CFS)-have many symptoms in common. A common denominator remains elusive. The blood-brain barrier (BBB) has been a barrier not only to microbes and toxins but also to understanding pathogenetic links. There are several areas within...

These three syndromes - long covid (LC), postural orthostatic tachycardia syndrome (POTS), and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) - have many symptoms in common. The common denominator remains elusive. The blood brain barrier (BBB) has been a barrier not only to microbes and toxins but also to understanding pathogenetic lin...

Brain fog with compromised ability to concentrate has been the most frequent Long Covid (LC) complaint. This is due to an increased TGF beta/IFN gamma with consequently increased bradykinin (BKN), especially in Caucasian females. Brain and lung blood vessels "leak." This same ratio is increased in Alzheimer's disease (AD), but decreased in Parkin-s...

Brain fog with compromised ability to concentrate has been the most frequent Long Covid (LC) complaint. This is due to an increased transforming growth factor (TGF) β/interferon (IFN)-γ ratio with consequently increased bradykinin (BKN), especially in Caucasian females. Brain and lung blood vessels “leak.” This same ratio is increased in Alzheimer’...

Long Covid has many symptoms that overlap with ME (myalgic encephalo-myelitis)/CFS (chronic fatigue syndrome), FM (fibromyalgia), EBV (Eps-tein-Barr virus), CMV (cytomegalovirus), CIRS (chronic inflammatory response syndrome), MCAS (mast cell activation syndrome), POTS (postural orthostatic tachycardia syndrome), and post viral fatigue syndrome. Th...

Long Covid has many symptoms that overlap with ME(myalgic encephalomyelitis)/CFS(chronic fatigue syndrome), FM(fibromyalgia), EBV(Epstein-Barr virus), CMV(cytomegalovirus), CIRS (chronic inflammatory response syndrome), MCAS(mast cell activation syndrome), POTS(postural orthostatic tachycardia syndrome), and post viral fatigue syndrome. They all po...

Long Covid has many symptoms that overlap with ME(myalgic encephalomyelitis)/CFS(chronic fatigue syndrome), FM(fibromyalgia), EBV(Epstein-Barr virus), CMV(cytomegalovirus), CIRS (chronic inflammatory response syndrome), MCAS(mast cell activation syndrome), POTS(postural orthostatic tachycardia syndrome), and post viral fatigue syndrome. They all po...

Long Covid has many symptoms that overlap with ME(myalgic encephalomyelitis)/CFS(chronic fatigue syndrome), FM(bromyalgia), EBV(Epstein-Barr virus), CMV(cytomegalovirus), CIRS (chronic in ammatory response syndrome), MCAS(mast cell activation syndrome), POTS(postural orthostatic tachycardia syndrome), and post viral fatigue syndrome. They all porte...

The calcium to magnesium ratio plus adequate vitamin D greatly determine success or not in the immune battle against pathogens and cancer, not to mention cardiovascular disease. Ionized calcium and magnesium in normal, healthy individuals can be calculated and a ratio determined from serum levels. Using widely accepted laboratory reference range va...

The calcium to magnesium ratio plus adequate vitamin D largely determine success or not in the immune battle against pathogens and cancer, not to mention cardiovascular disease. Ionized calcium and magnesium in normal, healthy individuals can be calculated and a ratio determined from serum levels. Using widely accepted laboratory reference range va...

The article by Huțanu et al. [...]

Long Covid, now also reported in children, has become increasingly alarming. Perhaps a third of those who develop MIS-C go on to experience Long Covid. Etiology is elusive. The role of vitamin D in bone and immune health has been recognized but magnesium de ciency has escaped attention. A physiologic and biochemical argument for its culpability in...

Long Covid, now also reported in children, has become increasingly alarming. Perhaps a third of those who develop MIS-C go on to experience Long Covid. Etiology is elusive. The role of vitamin D in bone and immune health has been recognized but magnesium deficiency has escaped attention. A physiologic and biochemical argument for its culpability in...

The primary determinants of Covid severity are ACE genotype, the falciparum antigen (CD147), and vitamin D status. Specifically the I (insertion) and D (deletion) alleles, ACE polymorphisms, determine the balance between the RAS (Renin Angiotensin System) and the KKS (Kallikrein Kinin System) in the response to SARS CoV2 (SARS2). CD147, the falcipa...

Covid-19 is particularly mild with children, and its severity escalates with age. Several theories have been proposed to explain these facts. In particular, it was proposed that the lower expression of the viral receptor ACE2 in children protects them from severe Covid-19. However, other works suggested an inverse relationship between ACE2 expressi...

The Spike S/Basigin (BSG) interaction, validated in 2020, has since been called putative, postulated, and controversial. Two widely referenced articles have been largely responsible for this. The data presented here demonstrate that the exclusion of this interaction that these articles purport to show is due to an inappropriate binding affinity ref...

Covid-19 is particularly mild with children, and its severity escalates with age. Several theories have been proposed to explain these facts. In particular, it was proposed that the lower expression of the viral receptor ACE2 in children protects them from severe Covid. However, other works suggested an inverse relationship between ACE2 expression...

Covid-19 has presented the world with a multitude of different clinical faces. To date their linkage eludes. This article attempts to establish linkage using recent research results regarding blood groups, clinical findings, cytokines, epidemiology, and the CD147 receptor, the orphan sister of ACE2. The role of the immune system controlled by the R...

Covid-19 has presented the world with a multitude of different clinical faces. To date their linkage eludes. This article attempts to establish linkage using recent research results regarding blood groups, clinical findings, cytokines, epidemiology, and the CD147 receptor, the orphan sister of ACE2. The role of the immune system controlled by the R...

Covid-19 has presented the world with a multitude of different clinical faces. To date their linkage eludes. This article attempts to establish linkage using recent research results regarding blood groups, clinical findings, cytokines, epidemiology, and the CD147 receptor, the orphan sister of ACE2. The role of the immune system controlled by the R...

Atrial fibrillation risk has been strongly associated with increasing age and visceral obesity. These characteristics are strongly associated with diabetes, decreased heart rate variability, and chronic inflammation. Lone atrial fibrillation (LAF) on the other hand exhibits a predilection for the physically fit and the middle aged, especially males...

Five cases of carcinoma metastatic to intracranial meningioma or neurilemoma are presented and compared with 20 similar cases reported in the literature. The phenomenon was most often seen on autopsy (17 of 25 cases) and was found more commonly in females (3:2), with nearly 90% of donor cancers being found in breast or lung. The existence of the do...

Thirty cases of chordoma were reviewed with respect to the incidence of distant metastases. Follow-up information was obtained in 27 (90%), and the incidence of metastases was approximately 30%. The sites of the metastasizing primary tumors were predominantly sacral and vertebral. The sites of the metastases were predominantly skin and bone, althou...