Patricia Cristine Heyn

Patricia Cristine Heyn
Marymount University | MU · Health Sciences

PhD, FGSA, FACRM -Deputy Director, Rocky Mountain U.S. Cochrane Affiliated Center
Founding Director, Center for Optimal Aging, Marymount University

About

163
Publications
22,680
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2,042
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Introduction
I have important and relevant research expertise in activity-induced brain function and lifestyle behavior medicine. My investigations include the associations between lifestyle behavior, sex hormone, metabolic syndrome, and interactive technology on cognitive function. I also studied the effects of a multi-sensory therapy and virtual-reality intervention on cognitive and physiological function of cognitively impaired individuals. Professional website: https://www.cudoctors.com/Find_A_Doctor/Profile/18394
Additional affiliations
September 2013 - present
Children's Hospital Colorado
Position
  • Research Associate
August 2004 - August 2007
University of Colorado Denver
Position
  • PostDoc Position
January 2002 - August 2004
University of Texas Medical Branch at Galveston
Position
  • PostDoc Position

Publications

Publications (163)
Article
Aim To investigate the prevalence of metabolic syndrome and cardiovascular disease (CVD) risk factors and the association between common metabolic markers and Gross Motor Function Classification System (GMFCS) levels in ambulatory adults with cerebral palsy (CP). Method Metabolic markers and GMFCS levels were evaluated in a cross‐sectional study o...
Article
Full-text available
Technological advances have allowed a variety of computerized cognitive training tools to be engineered in ways that are fun and entertaining yet challenging at a level that can maintain motivation and engagement. This revolution has created an opportunity for gerontological scientists to evaluate brain gaming approaches to improve cognitive and ev...
Article
Full-text available
Background Animal models of exercise and Parkinson’s disease (PD) have found that the physiologic use of exercise may interact with the neurodegenerative disease process, likely mediated by brain derived neurotrophic factor (BDNF). No reviews so far have assessed the methodologic quality of available intervention studies or have bundled the effect...
Article
Full-text available
To determine by meta-analysis whether physical exercises are beneficial for people with dementia and related cognitive impairments. Published articles and nonpublished manuscripts from 1970 to 2003 were identified by using electronic and manual searches. Key search words included exercise, rehabilitation, activities of daily living, dementia, Alzhe...
Article
Background: There is a need for an overview of systematic reviews (SRs) examining randomized clinical trials (RCTs) of pharmacological interventions in the treatment of intracranial pressure (ICP) post-TBI. Objectives: To summarize pharmacological effectiveness in decreasing ICP in SRs with RCTs and evaluate study quality. Methods: Comprehensi...
Article
Full-text available
Background Adolescent idiopathic scoliosis (AIS) is a structural lateral spinal curvature of ≥ 10° with rotation. Approximately 2–3% of children in most populations are affected with AIS, and this condition is responsible for approximately $1.1 billion in surgical costs to the US healthcare system. Although a genetic factor for AIS has been demonst...
Article
Full-text available
Objective Adults with cerebral palsy (CP) often have impaired cognitive functions. CP also has deteriorations in multiple quality-of-life (QoL) domains. The bio-psycho-social health psychology model posits that biological factor interacts with social and psychological functions. However, the biological determinant of psycho-social and functional ou...
Article
Full-text available
Objective: To examine the evidence levels, study characteristics, and outcomes of nonpharmacologic complementary and integrative medicine (CIM) interventions in rehabilitation for individuals with traumatic brain injury (TBI). Data sources: MEDLINE (OvidSP), PubMed (NLM), EMBASE (Embase.com), CINAHL (EBSCO), PsycINFO (OvidSP), Cochrane Library (...
Article
Aim: To examine the relationship between quantitative gait measurements and self-reported physical, psychological, cognitive, and social function status in young adults with cerebral palsy (CP). Method: Seventy-two adults with CP (range 18-48y; median age 23y [interquartile range 21-27y]; 34 males, 38 females), in Gross Motor Function Classifica...
Article
Full-text available
Purpose The World Health Organization (WHO) declared severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a pandemic in March 2020, causing almost 3.5 million coronavirus disease (COVID-19) related deaths worldwide. The COVID-19 pandemic has imposed a significant burden on healthcare systems, economies, and social systems in many countries...
Article
Research Objectives To evaluate gender differences in cognitive function and physiological outcomes associated with physical function on the Cerebral Palsy Adult Transition Study (CPAT) cohort. Design Cross-sectional, cohort, study. Setting Accredited clinical motion analysis laboratory at a regional Children's Hospital. Participants 72 ambulato...
Article
Research Objectives Adults with cerebral palsy (CP) have higher risk of developing geriatric syndromes. Mild cognitive impairment (MCI) is an intermediate stage between healthy aging and dementia, often co-morbid with cardiovascular disease (CVD). We recently showed an “accelerated aging model”, where CP shares similar CVD risk factors with MCI, po...
Article
Full-text available
Purpose: The coronavirus disease-19 (COVID-19) was declared a pandemic by the World Health Organization in March 2020. COVID-19, caused by SARS-CoV-2 has imposed a significant burden on health care systems, economies, and social systems in many countries around the world. The provision of rehabilitation services for persons with active COVID-19 inf...
Article
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Following disruptions to research, clinical trials, and support for individuals with Alzheimer’s disease and related dementias (ADRD), 2020 taught us important lessons about the need for creativity, flexibility, and resourcefulness during an urgent and global public health crisis. The COVID-19 pandemic showed that we have knowledge and technology t...
Article
Full-text available
Adults with cerebral palsy (CP) have higher risk of developing geriatric syndromes. Mild cognitive impairment (MCI) is an intermediate stage between healthy aging and dementia, often co-morbid with cardiovascular disease (CVD). We recently showed an “accelerated aging model”, where CP shares similar CVD risk factors with MCI, potentially accounting...
Article
Full-text available
The goal of the GSA NIA R13 Diversity Mentoring and Career Development Technical Assistance Workshop (GSA Diversity TAW) is to support, promote, and advance the training of diverse students in aging research. The program’s main aim is to increase the number of early career scientists who are historically underrepresented in gerontological research....
Article
Full-text available
Living environments profoundly influence the aging process. This symposium presents research on two main aspects of the living environment and their relationships with cognitive health. The living environment is broadly defined, including both physical and social aspects. The physical environment is the characteristics of the built environment, suc...
Poster
Full-text available
References People with Alzheimer's Disease and Related Dementias (ADRDs), older adults and those with disabilities face substantial challenges adapting to their physical, psychological and social and contextual environments. These persons prefer to age-in place in their familiar environment. Aging in one's own habitat comes with the potential for l...
Article
Across the spectrum of Alzheimer’s disease (AD), we previously conducted a meta‐analysis and concluded significantly decreased brain‐derived neurotrophic factor (BDNF) in AD. However, there are inconsistent findings on peripheral BDNF levels in mild cognitive impairment (MCI), even across different meta‐analyses, which have been attributed to the h...
Article
Full-text available
Aim To report on the results of the online international consensus process to develop the comprehensive and brief International Classification of Functioning, Disability and Health (ICF) Core Sets for adults with cerebral palsy (CP). Method An online iterative decision-making and consensus process involved 25 experts, including clinicians and rese...
Article
Full-text available
Background: Previous meta-analyses examining the continuum of Alzheimer's disease (AD) concluded significantly decreased peripheral brain-derived neurotrophic factor (BDNF) in AD. However, across different meta-analyses, there remain inconsistent findings on peripheral BDNF levels in individuals with mild cognitive impairment (MCI). This issue has...
Article
Full-text available
Older adults with poor physical or cognitive function often require support from their caregivers. Proper care can improve function, safety, and quality of life. Many caregivers are unable to attend to the needs of their loved one in person because of time constraints or physical distance yet are still committed to overseeing their loved one's well...
Article
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Objectives: This systematic review and meta-analysis was designed to determine the overall mean blood pressure and prevalence of hypertension among a representative sample of adults living with cerebral palsy by combining individual participant data. Additional objectives included estimating variations between subgroups and investigating potential...
Article
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Introduction: Hearing, vision, and cognitive impairment commonly co-occur in older people. However, the rate of recognition and appropriate management of combined hearing and vision impairment in people with dementia impairment is low. The aim of this work was to codevelop internationally relevant, multidisciplinary practice recommendations for pr...
Article
Full-text available
Objective This systematic review and meta-analysis evaluates the evidence from randomized clinical trials (RCTs) that designed brain gaming interventions to improve cognitive functions of older adults with cognitive impairments, including mild cognitive impairments and dementia. Design Systematic review and meta-analysis. Setting and Participants...
Preprint
Full-text available
Background Adolescent idiopathic scoliosis (AIS) is a structural lateral spinal curvature of ≥ 10° with rotation. Approximately 2–3% of children in most populations are affected with AIS, and this condition is responsible for approximately $1.1 billion in surgical costs to the U.S. healthcare system. Although a genetic factor for AIS has been demon...
Article
Full-text available
We designed a feasibility study to evaluate a mobile-based vocational skill building coaching technology (aka Mobile Coach) intervention by using an ecological design approach. We compared the Mobile Coach to a standard job coach (no Mobile Coach technology) assistance in a facility that employs adults with significant cognitive disabilities (CDs)....
Preprint
Full-text available
Clinically, individuals with cerebral palsy (CP) experience symptoms of accelerated biological aging. Accumulative deficits in both molecular underpinnings and functions in young adults with CP can lead to premature aging, such as heart disease and mild cognitive impairment (MCI). MCI is an intermediate stage between healthy aging and dementia that...
Article
Full-text available
Background The growing societal and economic impact of Alzheimer’s disease (AD) is further compounded by the present lack of disease-modifying interventions. Non-pharmacological intervention approaches, such as exercise, have the potential to be powerful approaches to improve or mitigate the symptoms of AD without added side effects or financial bu...
Chapter
Chapter available at [https://link.springer.com/chapter/10.1007/978-3-030-56934-1_17]. Living longer is not the equivalent to living healthier. The quality of health on ageing is strongly modulated by social barriers. The World Health Organisation implemented the Decade of Healthy Ageing from 2020 to 2030 targeting healthy ageing as a public healt...
Article
Full-text available
Since the publishing of our meta-analysis evaluating the effects of randomized exercise trials on cognitive function of Older Adults with Cognitive Impairments (OAwCIs) (Heyn et al 2004), several meta-analysis reviews were published addressing similar question. We currently appraised this evidence and preliminary synthesis of twelve, well-designed...
Article
Full-text available
Adherence to exercise prescription for older adults (OAs) is a significant problem and can have a detrimental effect on key health outcomes. Exercise adherence for OAs is a multifactorial problem encompassing many factors affecting adherence such as socioeconomic status, education, physical fitness, and mental and health status. Improving exercise...
Article
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Individuals with disabilities usually have difficulty in finding and maintaining employment prospects and thus, they are extremely underrepresented in the workforce. These challenges are even greater when the person has both cognitive and physical disabilities. While there is evidence supporting the benefits of employing individuals with disabiliti...
Article
Full-text available
Effective exercise training and regular physical activity (PA) practice are important for healthy aging and are key modalities for chronic disease management. Approaches that enhance exercise prescriptions and adherence for older adults should be innovative and based on evidence. Thus, the exercise prescription should be tailored accordingly to the...
Article
Full-text available
People with disabilities are underrepresented in health research and usually they are explicitly excluded from research participation. There are no longitudinal studies that follows cohorts with disabilities to learn about their healthspan and aging processes. Thus, we know very little about how people with early onset disability age, and the medic...
Article
Full-text available
Brain Gaming (BG) Interventions have been shown to improve the cognitive function of older adults with cognitive impairments (CIs). However, rigorous evaluation supporting BG effectiveness is needed. Thus, we used meta-analysis to evaluate the effectiveness of BG. Several search databases (i.e. Pubmed) were used to identify relevant randomized cont...
Article
Cognitive impairments are common in cerebral palsy (CP), however the evidence on the biological underpinnings of these impairments in CP has been scarce. Although insulin‐like growth factor‐1 (IGF‐1) is involved in cognitive deficits, its roles in cognitive functions in CP is unknown. We aimed to examine whether IGF‐1 is a biomarker of objective an...
Article
Cerebral palsy (CP) patients have accelerated aging, impairments in various pathology and anthropometry, and may develop geriatric syndromes, particularly cognitive impairment. Mild cognitive impairment (MCI) is an intermediate stage between healthy aging and dementia. Owing to their intriguingly parallel yet “inverted” disease trajectories, CP and...
Article
Full-text available
The objective of this review is to determine the effects of brain gaming intervention on cognitive function in older adults with cognitive impairments following a systematic review and meta-analysis.
Technical Report
Full-text available
The GSA KAER Toolkit, Fall 2020 Edition, is intended to support primary care teams in implementing a comprehensive approach to initiating conversations about brain health, detecting and diagnosing dementia, and providing individuals with community-based supports. It includes practical approaches, educational resources, and validated clinical tools...
Article
Full-text available
Age-related hearing and vision problems are common in people living with dementia, but these problems are often not detected or properly managed. Untreated hearing or vision impairment worsens a person’s ability to function and live independently and interferes with their ability to remember things and engage in social activities. It can also impac...
Article
Full-text available
Cardiovascular disease (CVD) remains the leading cause of global mortality. Individuals with disabilities are at increased risk of CVD in part due to their musculoskeletal and/or cognitive impairments that can challenge their participation in physical activities. Gait ability has been associated to several key health outcomes including morbidity. U...
Article
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We developed a Comprehensive Health Assessment and Motivation program (CHAMP-D) focused on self-health promotion and management for people aging with disabilities. The goal of the CHAMP-D is to enhance healthy lifestyle, self-health management and communications with the care team by a person-centered Health Passport tool. All study participants un...
Article
Full-text available
Objectives: To investigate the association between childhood surgical interventions, walking ability, and gross motor function in adults with Cerebral Palsy. Design: Prospective cross-sectional study. Participants: Male (47.2%) and female (52.8%) adults (Mean age: 25.0�5.3; Range: 18.5-48.7) all with CP (NZ72). Interventions: N/A. Setting: An accre...
Article
Full-text available
Objectives: To examine the meaning of selfeidentity post-acquired brain injury/ABI Design: Phenomenological qualitative methodology in accordance with principles of participatory action research. Setting: Community-based. Participants (or Animals, Specimens, Cadavers): Individuals with ABI, NZ4 (two females), 17-41yrs post-injury. Interventions: N/...
Article
Purpose: To understand the relationship of walking speed to self-reported pain, fatigue, and physical function in adults with CP. Methods: Design: Cross-sectional study. Setting: Accredited clinical motion analysis laboratory in a regional children's hospital. Participants: 72 ambulatory patients ⩾ 18 years of age, diagnosed with CP, who pre...
Article
Full-text available
Background and objectives: People are now spending longer in retirement than ever before and retirement has been found to influence health. This study systematically reviewed the impact of retirement on cardiovascular disease (CVD) and its risk factors (metabolic risk factors, blood biomarkers, physical activity, smoking, drinking, and diet). Res...
Article
Full-text available
The purpose of this study was to conduct an overview of systematic reviews (SRs) to appraise the published evidence related to pharmacological interventions after traumatic brain injury (TBI). Searches were conducted with Medline, Embase, PsycINFO, Web of Science, PubMed. 780 retrieved SRs underwent a two-level screening to determine inclusion. Dat...
Chapter
Full-text available
Adults with intellectual disability and their families are required to manage their disabilities in addition to a variety of secondary conditions, such as diabetes, heart disease, dental problems, and movement and cognitive decline. Secondary health conditions can limit the ability of adults with intellectual disability to live a healthy and produc...
Article
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FiEffective approaches to promote self-health and wellness empowerment for individuals with complex health conditions must be person-focused and multi-disciplinary to be successful. The goal of such program is to support patients and caregivers with decision making power over their health to increase utilization of low cost and accessible community...
Article
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This presentation will discuss the findings from a person-focused health and wellness approach to healthspan called Comprehensive Health Assessment and Motivation Program for Individuals with Disabilities (CHAMP-D). The CHAMP-D is a health passport platform tool designed to screen early chronic disease development associated to accelerated aging (i...
Article
Full-text available
We investigated cardiovascular disease risk factors (CVDRFs) and the association between CVDRFs and gross motor function with the Gross Motor Function Classification System (GMFCS) in 70 adults with cerebral palsy (CP) who were ambulatory. Metabolic syndrome (MetSyn) was identified in 17.1% of the cohort and it was higher than the 10% in age-matche...
Article
Individuals with disability are living longer than ever before and face unique circumstances later in life, including accelerated aging, and developing secondary health conditions1-3. Policy and service systems have been traditionally set up to treat older adults and younger individuals with disability as separate populations2,3. However, there is...
Article
Full-text available
There is accumulative evidence supporting the benefits of regular physical activity along the cognitive role of older adults with cognitive impairments (OAwCIs). Since the publishing of our meta-analytic review evaluating the effects of randomized exercise trials on cognitive function of OAwCIs (Heyn, Abreu & Ottenbacher, 2004), a plethora of meta-...
Conference Paper
Full-text available
Alzheimer's disease and related dementias (ADRD) are debilitating neurodegenerative disorders affecting one in every ten older Americans. In the United States, roughly 35.6 million Americans have dementia and approximately 5.7 million have Alzheimer's. By 2050, the count is expected to increase to 13.2 million older Americans. Alzheimer's is the to...