Patricia Garcia-Canadilla

Patricia Garcia-Canadilla
Hospital Sant Joan de Déu · Servicio de Cardiología / Enfermedades del corazón

PhD
Working as a data scientist in the Pediatric Cardiology Unit at Hospital Sant Joan de Deu

About

53
Publications
14,336
Reads
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368
Citations
Additional affiliations
July 2019 - present
IDIBAPS August Pi i Sunyer Biomedical Research Institute
Position
  • PostDoc Position
July 2018 - June 2019
University College London
Position
  • PostDoc Position
January 2017 - July 2018
University College London
Position
  • PostDoc Position
Education
September 2012 - July 2015
University Pompeu Fabra
Field of study
  • PhD in Information and Communication Technologies
September 2010 - July 2011
University of Barcelona
Field of study
  • Biomedicine
September 2003 - July 2010
Universitat Politècnica de Catalunya
Field of study
  • Telecommunication

Publications

Publications (53)
Article
Full-text available
Pediatric congenital heart disease (CHD) patients are at higher risk of postoperative complications and clinical deterioration either due to their underlying pathology or due to the cardiac surgery, contributing significantly to mortality, morbidity, hospital and family costs, and poor quality of life. In current clinical practice, clinical deterio...
Article
Full-text available
Aims We investigated left ventricular (LV) remodelling, mechanics, systolic and diastolic function, combined with clinical characteristics and heart-failure treatment in association to death or heart-transplant (DoT) in paediatric idiopathic, genetic or familial dilated cardiomyopathy (DCM), using interpretable machine-learning. Methods and result...
Article
Full-text available
Cardiovascular research is in an ongoing quest for a superior imaging method to integrate gross-anatomical information with microanatomy, combined with quantifiable parameters of cardiac structure. In recent years, synchrotron radiation-based X-ray Phase Contrast Imaging (X-PCI) has been extensively used to characterize soft tissue in detail. The o...
Chapter
In humans, there is a well-established relationship between atrial fibrillation (AF), blood flow abnormalities and thrombus formation, even if there is no clear consensus on the role of left atrial appendage (LAA) morphologies. Cats can also suffer heart diseases, often leading to an enlargement of the left atrium that promotes stagnant blood flow,...
Conference Paper
In humans, there is a well-established relationship between atrial fibrillation (AF), blood flow abnormalities and thrombus formation, even if there is no clear consensus on the role of left atrial appendage (LAA) morphologies. Cats can also suffer heart diseases, often leading to an enlargement of the left atrium that promotes stagnant blood flow,...
Article
Full-text available
Background: Distinguishing the etiology of left ventricular hypertrophy (LVH) is clinically relevant due to patient outcomes and management. Easily obtained, echocardiography-based myocardial deformation patterns may improve standard non-invasive phenotyping, however, the relationship between deformation phenotypes and etiology-related, microstruct...
Conference Paper
Full-text available
Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): Horizon 2020 European Commission Project H2020-MSCA-ITN-2016 (764738) and the Clinical Research in Cardiology grant from the Spanish Cardiac Society. Background The aetiology of left ventricular hypertrophy (LVH) is a relevant clinical challenge...
Preprint
Full-text available
Background: Cardiovascular research is in an ongoing quest for a superior imaging method to integrate gross-anatomical information with microanatomy, combined with quantifiable parameters of cardiac structure. In recent years, synchrotron radiation-based X-ray Phase Contrast Imaging (X-PCI) has been extensively used to characterize soft tissue in d...
Article
Full-text available
Abstract Micro-computed tomography (micro-CT) is a high-resolution imaging modality that provides accurate tissue characterization. Hypertrophic cardiomyopathy (HCM) occurs as a spontaneous disease in cats, and is characterized by myocardial hypertrophy, disarray and fibrosis, as in humans. While hypertrophy/mass (LVM) can be objectively measured,...
Article
Full-text available
The heart is a complex multi-scale system composed of components integrated at the subcellular, cellular, tissue and organ levels. The myocytes, the contractile elements of the heart, form a complex three-dimensional (3D) network which enables propagation of the electrical signal that triggers the contraction to efficiently pump blood towards the w...
Article
Objective: Coarctation of the aorta (CoA) is associated with left ventricular (LV) dysfunction in neonates and adults; however cardiac structure and function in fetal CoA and the neonatal cardiac adaptation has not been described. We aimed to investigate the presence of cardiovascular structural remodeling and dysfunction in fetuses with CoA and t...
Article
Full-text available
In fetal cardiology, imaging (especially echocardiography) has demonstrated to help in the diagnosis and monitoring of fetuses with a compromised cardiovascular system potentially associated with several fetal conditions. Different ultrasound approaches are currently used to evaluate fetal cardiac structure and function, including conventional 2-D...
Article
Full-text available
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
Full-text available
Myoarchitectural disarray-the multiscalar disorganisation of myocytes, is a recognised histopathological hallmark of adult human hypertrophic cardiomyopathy (HCM). It occurs before the establishment of left ventricular hypertrophy (LVH) but its early origins and evolution around the time of birth are unknown. Our aim is to investigate whether myoar...
Article
Full-text available
Intrauterine growth restriction (IUGR) is a fetal condition that affects up to 10% of all pregnancies and is associated with cardiovascular structural and functional remodelling that persists postnatally. Some studies have reported an increase in myocardial coronary blood flow in severe IUGR fetuses which has been directly associated to the dilatat...
Conference Paper
Introduction: Understanding the complexity of heart morphogenesis and the associated functional consequences of congenital heart disease is essential for providing appropriate treatment strategies. Since our knowledge on the microstructure of the whole fetal & paediatric heart is limited, novel imaging approaches offered by synchrotron facilities c...
Article
Full-text available
Cardiovascular diseases (CVDs) affect the myocardium and vasculature, inducing remodelling of the heart from cellular to whole organ level. To assess their impact at micro and macroscopic level, multi-resolution imaging techniques that provide high quality images without sample alteration and in 3D are necessary: requirements not fulfilled by most...
Article
Full-text available
Aortic wall remodelling is a key feature of both ageing and genetic connective tissue diseases, which are associated with vasculopathies such as Marfan syndrome (MFS). Although the aorta is a 3D structure, little attention has been paid to volumetric assessment, primarily due to the limitations of conventional imaging techniques. Phase-contrast mic...
Article
Background: In the era of increasingly successful corrective interventions in patients with congenital heart disease (CHD), global and regional myocardial remodeling are emerging as important sources of long-term morbidity/mortality. Changes in organization of the myocardium in CHD, and in its mechanical properties, conduction, and blood supply, r...
Article
Aims Myocardial structural and functional abnormalities are known to occur in fetuses of mothers with diabetes mellitus (FMDM). The main aim of this investigation was to explore the cardiovascular circulatory patterns in FMDM using a validated lumped computational model of the cardiovascular system. Methods This was a multi-institutional study inv...
Article
Full-text available
Experimental studies on isolated cardiomyocytes from different animal species and human hearts have demonstrated that there are regional differences in the Ca²⁺ release, Ca²⁺ decay and sarcomere deformation. Local deformation heterogeneities can occur due to a combination of factors: regional/local differences in Ca²⁺ release and/or re-uptake, intr...
Data
Fitting SL-active tension relationship. Fitting of the experimental data obtained by Weiwad et al [33], highlighting the SL-active tension relationship for skinned cardiac cells with the expression Tact given by equation S1.22 in S1 Appendix. Data points series correspond to pCa values of 5.7, 5.46 and 4.9. Solid lines indicate the best solution ob...
Conference Paper
Introduction: Aortic coarctation is one of the most difficult cardiac defects to diagnose before birth, and it accounts for 8% of congenital heart diseases. Antenatal diagnosis is crucial for early treatment of the neonate and to decrease the risk of morbidity and mortality; however the fetal hemodynamic changes are not fully understood and current...
Conference Paper
Nowadays, unexplained cardiovascular diseases (CVD) and heart transplant response are assessed by qualitative histological analysis of extracted endomyocardial biopsies (EMB), which is a time consuming procedure involving structural damage of the tissue and the analysis in only a few slices of a 3D structure. In this paper we propose synchrotron ra...
Article
Background: While individual cardiac myocytes only have a limited ability to shorten, the heart efficiently pumps a large volume-fraction thanks to a cell organization in a complex 3D fibre structure. Subclinical subtle cardiac structural remodelling is often present before symptoms arise. Understanding and early detection of these subtle changes...
Article
Full-text available
Objective: The aortic isthmus (AoI) blood flow has a characteristic shape with a small end-systolic notch observed during the third trimester of pregnancy. However, what causes the appearance of this notch is not fully understood. We used a lumped model of the fetal circulation to study the possible factors causing the end-systolic notch and the c...
Article
Full-text available
Background Intrauterine growth restriction (IUGR) induces fetal cardiac remodelling and dysfunction, which persists postnatally and may explain the link between low birth weight and increased cardiovascular mortality in adulthood. However, the cellular and molecular bases for these changes are still not well understood. We tested the hypothesis tha...
Article
Full-text available
Intrauterine growth restriction (IUGR) due to placental insufficiency is associated with blood flow redistribution in order to maintain delivery of oxygenated blood to the brain. Given that, in the fetus the aortic isthmus (AoI) is a key arterial connection between the cerebral and placental circulations, quantifying AoI blood flow has been propose...
Article
Automatic quantification of cardiac muscle properties in tissue sections might provide important information related to different types of diseases. Second harmonic generation (SHG) imaging provides a stain-free microscopy approach to image cardiac fibers that, combined with our methodology of the automated measurement of the ultrastructure of musc...
Article
To assess whether abnormal cardiac function in human fetuses with intrauterine growth restriction (IUGR) is associated with ultrastructural differences in the cardiomyocyte sarcomere. Nine severe early-onset IUGR and nine normally grown fetuses (AGA, appropriate growth for gestational age) that died in the perinatal period were prospectively includ...
Article
Full-text available
Intrauterine growth restriction (IUGR) affects 7-10% of pregnancies and is associated with cardiovascular remodeling and dysfunction which persists into adulthood. The underlying subcellular remodeling and cardiovascular programming events are still poorly documented. Cardiac muscle is central in the fetal adaptive mechanism to IUGR given its high...
Conference Paper
Full-text available
Intrauterine Growth Restriction due to placental insufficiency leads to cardiac dysfunction in utero which can persist postnatally. Brain sparing by flow redistribution is an adaptive mechanism used by the restricted fetus to ensure delivery of oxygenated blood to the brain. The quantification of reversed flow in the aortic isthmus is used in clini...
Article
Polarization Second Harmonic Generation enables to quantify some of the underlying molecular details of key biological structures within muscle, axons and collagen at suboptical scales. However, it is only available in dedicated labs. In this work we detail a procedure to adapt and calibrate a commercial multiphoton microscope (Leica TCS-SP5) to ac...
Conference Paper
Purpose: Intrauterine growth restriction (IUGR) is associated with cardiovascular remodelling and dysfunction persisting into adulthood, resulting in dilated and less efficient hearts. However, evidence of direct fetal programming of cardiac cytoarchitecture is scarce, and the underlying molecular mechanisms remain to be elucidated. Here we show th...
Conference Paper
Purpose: As it has been reported that ultrasound (US) backscattering changes according to tissue microstructure, we evaluated whether exists an association between invariant image features of B-mode ultrasound (US) and histological changes in arteries of rabbits with induced Atherosclerotic Vascular Disease (AVD) at early stages. Methods: AVD was...
Article
Full-text available
cAMP generated in response to β-adrenoceptor stimulation modulates excitation-contraction coupling via activation of PKA. It is now widely accepted that cAMP signalling is compartmentalised in the heart and that PDEs, the only cAMP degrading enzyme, play a central role in spatial control of signal propagation. We have previously demonstrated that P...
Conference Paper
Cardiovascular diseases are one of the main causes of mortality in the world. For this reason it is important to develop techniques that allow for better understanding of cardiac remodelling prior to heart failure. In this line, Second Harmonic Imaging (SHI) provides a label-free microscopy approach to image cardiac fibers. In this work, we automat...

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Projects

Projects (4)
Project
Synchrotron X-ray Phase Contrast micro-tomography, as implemented at the TOMCAT beamline (SLS, PSI, Switzerland), provide essential and unique 3D reconstructions of complete hearts for understanding cardiac microstructure and its influencing factors, both on small animals or human fetal hearts. The aim of the Heart Imaging Project is to quantify cardiac structures and tissues at micrometre scale, non-destructively, without the use of contrast agents and in 3D.
Project
Evaluation of inter-generational transmission of disease with focus on cardiovascular system in maternal diabetes
Project
Synchrotron X-ray Phase Contrast Imaging allows to get insides on the cardiac structure in 3D.