Patricia Clement

• Doctor of Medicine
• PostDoc Position at Universitair Ziekenhuis Ghent

Background To date, multiple advanced magnetic resonance imaging (MRI) methods beyond conventional qualitative structural imaging for the diagnosis, prognosis, and treatment follow-up of glioma have demonstrated their utility for clinical studies. However, these methods often rely on complex off-scanner processing to yield the most information and...

This guide summarizes the state-of-the-art processing software solutions and the repositories/communities for the following advanced MRI methods: DSC; DCE; ASL; diffusion MRI; relaxometry; MRF; MRS; CEST; SWI; QSM; MRE; and task-based and resting-state fMRI. For each of those, after a short introduction about the method and output parameters, the r...

The Brain Imaging Data Structure (BIDS) is a community-driven standard for the organization of data and metadata from a growing range of neuroscience modalities. This paper is meant as a history of how the standard has developed and grown over time. We outline the principles behind the project, the mechanisms by which it has been extended, and some...

Introduction Loss of blood-brain barrier (BBB) integrity is hypothesised to be one of the earliest microvascular signs of Alzheimer’s disease (AD). Existing BBB integrity imaging methods involve contrast agents or ionising radiation, and pose limitations in terms of cost and logistics. Arterial spin labelling (ASL) perfusion MRI has been recently a...

The 2015 consensus statement published by the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group and the European Cooperation in Science and Technology ( COST) Action ASL in Dementia aimed to encourage the implementation of robust arterial spin labeling (ASL) perfusion MRI for clinical applications and promote co...

Background Perfusion imaging has the potential to identify neurodegenerative disorders in a preclinical stage. However, to correctly interpret perfusion-derived parameters, the impact of perfusion modifiers should be evaluated. Objective In this systematic review, the impact of acute and chronic intake of four acetylcholinesterase inhibitors (AChE...

Preoperative clinical MRI protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness about the state of the art of ad...

Preoperative clinical magnetic resonance imaging (MRI) protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness abo...

Preoperative clinical magnetic resonance imaging (MRI) protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness abo...

https://researchdata.springernature.com/posts/asl-bids-harmonizing-asl-data-structure-to-foster-collaboration?utm_source=like_mailer&utm_medium=email&utm_campaign=notify_author_of_like

Arterial spin labeling (ASL) is a non-invasive MRI technique that allows for quantitative measurement of cerebral perfusion. Incomplete or inaccurate reporting of acquisition parameters complicates quantification, analysis, and sharing of ASL data, particularly for studies across multiple sites, platforms, and ASL methods. There is a strong need fo...

Arterial spin labeling (ASL) is a non-invasive and cost-effective MRI technique for brain perfusion measurements. While it has developed into a robust technique for scientific and clinical use, its image processing can still be daunting. The 2019 Ann Arbor ISMRM ASL working group established that education is one of the main areas that can accelera...

Background: Alzheimer’s disease patients spend on average 4.1 years of their time in nursing homes, putting an enormous economic burden on a healthcare system. This can be reduced by 3–8 months, using acetylcholinesterase inhibitors (AchE-Is). However, only 40% of patients are responsive, highlighting the importance of treatment evaluation1. Curren...

How can we involve stakeholders outside our scientific community, such as legal experts and patient organisations in our research? During this talk, GliMR will share its experiences. Don't compete, but collaborate!

The COST Actions provide funding to create networks, building bridges between researchers, clinicians, and other stakeholders across Europe and beyond. But how do you successfully apply for one? Which opportunities do these Actions offer for marginalised groups, such as early-career researchers and researchers from less research-intensive countries...

Patient data is crucial to discover more about illnesses and develop new treatments. Your medical data can be used for such purposes but your privacy is always protected. By sharing your medical data, you can make a difference! Find more information about this video on https://glimr.eu/gdpr-video/. Acknowledgements: This video is part of the COS...

Cancer therapy for both central nervous system (CNS) and non-CNS tumors has been previously associated with transient and long-term cognitive deterioration, commonly referred to as ‘chemo fog’. This therapy-related damage to otherwise normal-appearing brain tissue is reported using post-mortem neuropathological analysis. Although the literature on...

https://www.youtube.com/watch?v=UN5JxGpqppc&feature=youtu.be

Many patients are unaware of the implications of the General Data Protection Regulation (GDPR) on their medical data, including the transparency principle stating that individuals should be informed about the use of their personal data in a clear, concise and accessible manner. In order to overcome this challenge, the COST Action ‘Glioma MR Imaging...

Arterial spin labeling (ASL) is a non-invasive MRI technique, allowing quantitative measurement of cerebral perfusion. Incomplete or inaccurate reporting of acquisition parameters complicates quantification, analysis, and sharing of ASL data, particularly for studies across multiple sites, platforms, and ASL methods. Therefore, there is a strong ne...

https://www.youtube.com/watch?v=ukgiAP2Hn3E

Patricia Clement and Henk Mutsaerts tell us about their work to extend BIDS to support arterial spin labeling data. Watch the video: https://www.youtube.com/watch?v=mMTI_2In7xY

This is part of the OpenMR Science Communication Flash Talks on March 26th 2021, where we learn about communicating science through presentation, design, song and citizen science. In this talk, Moss and Patricia present tips for making a successful science podcast. Watch the presentation: https://www.youtube.com/watch?v=nNmgWbFrxHY

In this special episode for World Cancer Day (4 February), we spoke with members of one of the largest glioma research groups in Europe. Members of this group share their events and opportunities for collaboration. You may find more about Glioma MR Imaging 2.0 here: https://glimr.eu/ Listen to the podcast here: https://anchor.fm/esmrmb-ecrc/episo...

Having the means to share research data openly is essential to modern science. For human research, a key aspect in this endeavor is obtaining consent from participants, not just to take part in a study, which is a basic ethical principle, but also to share their data with the scientific community. To ensure that the participants' privacy is respect...

Purpose There is an annual incidence of 50,000 glioma cases in Europe. The optimal treatment strategy is highly personalised, depending on tumour type, grade, spatial localization, and the degree of tissue infiltration. In research settings, advanced magnetic resonance imaging (MRI) has shown great promise as a tool to inform personalised treatment...

Having the means to share research data openly is essential to modern science. For human research, a key aspect in this endeavour is obtaining consent from participants, not just to take part in a study, which is a basic ethical principle, but also to share their data with the scientific community. To ensure that the participants’ privacy is respec...

Arterial spin labeling (ASL) has undergone significant development since its inception, with a focus on improving standardization and reproducibility of its acquisition and quantification. In a community-wide effort towards robust and reproducible clinical ASL image processing, we developed the software package ExploreASL, allowing standardized ana...

Purpose To determine whether sacrificing part of the scan time of pseudo‐continuous arterial spin labeling (PCASL) for measurement of the labeling efficiency and blood T1 is beneficial in terms of CBF quantification reliability. Methods In a simulation framework, 5‐minute scan protocols with different scan time divisions between PCASL data acquisi...

Arterial spin labeling (ASL) has undergone significant development since its inception, with a focus on improving standardization and reproducibility of its acquisition and quantification. In a community-wide effort towards robust and reproducible clinical ASL image processing, we developed the software package ExploreASL, allowing standardized ana...

Multi-post-labeling-delay pseudo-continuous arterial spin labeling (multi-PLD PCASL) allows for absolute quantification of the cerebral blood flow (CBF) as well as the arterial transit time (ATT). Estimating these perfusion parameters from multi-PLD PCASL data is a non-linear inverse problem, which is commonly tackled by fitting the single-compartm...

To overcome long acquisition times of Chemical Shift Imaging (CSI), a new Magnetic Resonance Spectroscopic Imaging (MRSI) technique called Reduction of Acquisition time by Partition of the sIgnal Decay in Spectroscopic Imaging (RAPID-SI) using blipped phase encoding gradients inserted during signal acquisition was developed. To validate the results...

Calculated CRLB values of NAA, Cr and Cho peak amplitude estimates in vivo with CSI and RAPID-SI (R = 8). (XLSX)

Diagram showing the map of linewidth variations due to the effect of field inhomogeneity across all the voxels in the ROI. (A) difference in linewidth of the NAA, Cr, Cho peaks from two voxels inside the ROI, (B) voxel near the edge and (C) voxel near the centre. (TIF)

A 3D 16x16x4 in vivo data (one slice shown). Selected spectra from the red boxes near the ventricle region are shown for the CSI (left) in red and RAPID-SI (R = 8) (right) in blue. (TIF)

Calculated SNR values in vivo with CSI and RAPID-SI (R = 8). (XLSX)

Quantitative measurements of brain perfusion are influenced by perfusion-modifiers. Standardization of measurement conditions and correction for important modifiers is essential to improve accuracy and to facilitate the interpretation of perfusion-derived parameters. An extensive literature search was carried out for factors influencing quantitativ...