Patrice Péran

Patrice Péran
French Institute of Health and Medical Research | Inserm · ToNIC, Toulouse Neuroimaging Centre

PhD

About

182
Publications
18,068
Reads
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3,631
Citations
Citations since 2016
110 Research Items
2551 Citations
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
Introduction
Patrice Péran currently works at the ToNIC, Toulouse Neuroimaging Centre, French Institute of Health and Medical Research. Patrice does research in Neuroscience.
Additional affiliations
January 2016 - present
French Institute of Health and Medical Research
Position
  • Reasearcher, team leader
November 2010 - January 2016
French Institute of Health and Medical Research
Position
  • Researcher
February 2005 - November 2010
Foundation Santa Lucia
Position
  • PostDoc Position

Publications

Publications (182)
Article
Full-text available
Introduction Neurofibromatosis type 1 (NF1) is considered a model of neurodevelopmental disorder because of the high frequency of learning deficits, especially developmental coordination disorder. In neurodevelopmental disorder, Nicolson and Fawcett formulated the hypothesis of an impaired procedural learning system that has its origins in cortico-...
Article
Full-text available
Introduction Insula plays an integrating role in sensory, affective, emotional, cognitive and autonomic functions in migraine, especially in migraine with aura (MA). Insula is functionally divided into 3 subregions, the dorsoanterior, the ventroanterior and the posterior insula respectively related to cognition, emotion, and somatosensory functions...
Article
Objectives Children's ependymomas achieve a 5-years local control rate of 50% with a standard post-operative dose of 59.4 Gy. To decrease the dose to normal tissue, proton bean therapy (PBT) is preferred when available. Recently, retrospective studies reported higher rates of radionecrosis on the brainstem after PBT than photon radiation therapy (X...
Article
Objectives Specific brain structures are involved in the different mnesic systems: hippocampus in episodic and semantic memory, striatum in sequence learning part of procedural memory and cerebellum in motor adaptation part of procedural memory and working memory. The aim of this work was to explore the impact of irradiation at brain structures inv...
Article
Full-text available
High field MRI is an advanced technique for diagnostic and research purposes on animal models, such as the Beagle dog. In this context, studies on neuroscience applications, e.g. aging and neuro-pathologies, are currently increasing. This led to a need for reference values, in terms of volumetric assessment, for the structures typically involved. N...
Article
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Several postmortem studies have shown iron accumulation in the substantia nigra of Parkinson’s disease patients. Iron concentration can be estimated via MRI-R2∗ mapping. To assess the changes in R2∗ occurring in Parkinson’s disease patients compared to controls, a multicentre transversal study was carried out on a large cohort of Parkinson’s diseas...
Article
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Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) technique for measuring cerebral blood flow (CBF). This noninvasive technique has added a new dimension to the study of several pediatric tumors before, during, and after treatment, be it surgery, radiotherapy, or chemotherapy. However, ASL has three drawbacks, namely, a low signal-...
Article
Full-text available
Now that access of large domestic mammals to high-field MRI becomes more common, techniques initially implemented for human patients can be used for the structural and functional study of the brain of these animals. Among them, susceptibility-weighted imaging (SWI) is a recent technique obtained from gradient echo (GE) imaging that allow for an exc...
Article
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Language is usually characterized as the most preserved cognitive function during typical aging. Several neuroimaging studies have shown that healthy aging is characterized by inter-network compensation which correlates with better language performance. On the contrary, language deficits occur early in the course of Alzheimer’s disease (AD). Theref...
Article
Disease-modifying treatments are currently being trialed in multiple system atrophy (MSA). Approaches based solely on clinical measures are challenged by heterogeneity of phenotype and pathogenic complexity. Neurofilament light chain protein has been explored as a reliable biomarker in several neurodegenerative disorders but data in multiple system...
Preprint
Full-text available
Introduction : Insula plays an integrating role in sensory, affective, emotional, cognitive and autonomic functions in migraine, especially in migraine with aura (MA). Insula is functionally divided into 3 subregions, the dorsoanterior, the ventroanterior and the posterior insula respectively related to cognition, emotion, and somatosensory functio...
Article
Full-text available
Background There is an unfulfilled need to find the best way to automatically capture, analyze, organize, and merge structural and functional brain magnetic resonance imaging (MRI) data to ultimately extract relevant signals that can assist the medical decision process at the bedside of patients in postanoxic coma. We aimed to develop and validate...
Article
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Objectives : To identify, categorize and analyze the methodological issues of cognitive rehabilitation of patients with moderate to severe traumatic brain injury and its efficacy. Data sources : Pubmed and PsycINFO were searched for studies published between 2015 and 2021 using keywords for cognitive intervention and traumatic brain injury. Study...
Article
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Although free‐water diffusion reconstruction for diffusion‐weighted imaging (DWI) data can be applied to both single‐shell and multishell data, recent finding in synthetic data suggests that the free‐water indices from single‐shell acquisition should be interpreted with care, as they are heavily influenced by initialization parameters and cannot di...
Preprint
Neurodegenerative diseases are characterized by numerous markers of progression and clinical endpoints. For instance, Multiple System Atrophy (MSA), a rare neurodegenerative synucleinopathy, is characterized by various combinations of progressive autonomic failure and motor dysfunction, and a very poor prognosis. Describing the progression of such...
Article
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Neuroinflammation is a significant contributor to Alzheimer’s disease (AD). Until now, PET imaging of the translocator protein (TSPO) has been widely used to depict the neuroimmune endophenotype of AD. The aim of this review was to provide an update to the results from 2018 and to advance the characterization of the biological basis of TSPO imaging...
Preprint
Full-text available
High field MRI represents an advanced technique both for diagnostic and research purposes on animal models such as the Beagle dog. The increasing interest in non-invasive neuroscience, aging, and neuropathological research led to a need of reference values (in terms of volumetric assessment) for the typical brain structures involved and, nowadays,...
Article
Abstract Purpose Proton magnetic resonance spectroscopic imaging (1H MRSI) is a noninvasive technique for assessing tumor metabolism. Manual inspection is still the gold standard for quality control (QC) of spectra, but it is both time-consuming and subjective. The aim of the present study was to assess automatic QC of glioblastoma MRSI data using...
Article
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Microgravity induces a cephalad fluid shift that is responsible for cephalic venous stasis that may increase intracranial pressure (ICP) in astronauts. However, the effects of microgravity on regional cerebral blood flow (rCBF) are not known. We therefore investigated changes in rCBF in a 5-day dry immersion (DI) model. Moreover, we tested thigh cu...
Article
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RationaleDonepezil is a potent, noncompetitive, reversible, clinically effective acetylcholinesterase inhibitor. The effects of this drug on healthy brains have seldom been investigated.Objectives The primary objective of the present study was to identify possible functional connectivity markers of the effect of donepezil in healthy young adult vol...
Article
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Background Posterior fossa tumors represent two thirds of brain tumors in children. Although progress in treatment has improved survival rates over the past few years, long-term memory impairments in survivors are frequent and have an impact on academic achievement. The hippocampi, cerebellum and cerebellar-cortical networks play a role in several...
Article
Full-text available
Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their longitudinal change following electroconvulsive ther...
Article
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Treatment with human pituitary-derived growth hormone (hGH) was responsible for a significant proportion of iatrogenic Creutzfeldt–Jakob disease (iCJD) cases. France and the UK experienced the largest case numbers of hGH-iCJD, with 122 and 81 cases respectively. Differences in the frequency of the three PRNP codon 129 polymorphisms (MM, MV and VV)...
Article
Age of acquisition and proficiency have been identified as possible determinants in the neural localization of second language representation and in the nature of control mechanisms. However, the relationship is not yet clear between age of acquisition and proficiency on the one hand, and language switching and executive functions on the other. In...
Poster
Les dysfonctionnements cognitifs sont fréquemment signalés par les patients qui souffrent d’une pathologie neurologique. Parmi les difficultés cognitives rapportées, nous retrouvons des troubles du langage appelés aphasie. L’identification des troubles phasiques nécessite une évaluation spécifique par le biais de tests lexicaux, évaluant l’accès au...
Article
Full-text available
Background: Language production deficits occur early in the course of Alzheimer's disease (AD); however, only a few studies have focused on language network's functional connectivity in mild cognitive impairment (MCI) due to AD. Objective: The current study aims to uncover the extent of language alteration at the MCI stage, at a behavioral and n...
Article
Introduction L’atrophie multisystématisée (AMS) est caractérisée par une dysautonomie sévère essentiellement d’origine centrale. Objectifs Étudier le lien entre différentes variables de dysautonomie et l’atrophie du tronc cérébral (TC). Patients et méthodes Analyse de patients ayant eu : IRM cérébrale, score UMSARS et exploration du système nerve...
Article
Full-text available
Iron plays an important role in many neurobiological processes, especially in the basal ganglia, the brain structures with the highest concentration. Composed of the pallidum and putamen, the lentiform nucleus plays a key role in the basal ganglia circuitry. With MRI advances, iron-based sequences such as R2* and quantitative susceptibility mapping...
Preprint
Full-text available
Purpose Neuro-ophthalmological changes defined as spaceflight-associated neuro-ocular syndrome have been reported after long duration space flights. The pathophysiology of this syndrome remains unclear, with the possible involvement of elevated intracranial pressure. Changes in blood flow in the brain, evaluated indirectly by Doppler, have been rep...
Preprint
Full-text available
Language production deficits occur early in the course of Alzheimer’s disease (AD); however, only few studies have focused on language functional networks in prodromal AD. The current study aims to uncover the extent of language alteration at a prodromal stage, on a behavioral, structural and functional level, using univariate and multivariate anal...
Article
Full-text available
Multiple system atrophy (MSA) is a rare neurodegenerative disorder characterized by the widespread aberrant accumulation of α‐synuclein (α‐syn). MSA differs from other synucleinopathies such as Parkinson's disease (PD) in that α‐syn accumulates primarily in oligodendrocytes, the only source of white matter myelination in the brain. Previous MSA ima...
Article
Although language is quite preserved from aging, it remains unclear whether age-related differences lead to a deterioration or reorganization in language functional networks, or to different dynamics with other domains (e.g. the Multiple-Demand system). The current study is aimed at examining language networks, using resting-state fMRI in typical a...
Article
Full-text available
Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disease with limited symptomatic treatment options. Aggregation of α‐synuclein in oligodendrocytes is believed to be a central mechanism of the neurodegenerative process. PD01A and PD03A are 2 novel therapeutic vaccine candidates containing short peptides as antigenic moieties that...
Article
Full-text available
The brainstem is the earliest vulnerable structure in many neurodegenerative diseases like in Multiple System Atrophy (MSA) or Parkinson's disease (PD). Up-to-now, MRI studies have mainly focused on whole-brain data acquisition. Due to its spatial localization, size, and tissue characteristics, brainstem poses particular challenges for MRI. We prov...
Article
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Tractography, a noninvasive technique tracing brain pathways from diffusion tensor magnetic resonance imaging (DTI) data, is increasingly being used for brain investigation of domestic mammals. In the equine species, such a technique could be useful to improve our knowledge about structural connectivity or to assess structural changes of white matt...
Article
Introduction NF1 children have cognitive disorders, especially in executive functions, visuospatial, and language domains, the pathophysiological mechanisms of which are still poorly understood. Materials and methods A correlation study was performed from neuropsychological assessments and brain MRIs of 38 NF1 patients and 42 controls, all right-h...
Article
Rhythmic abilities are impaired in Developmental Coordination Disorder (DCD) but learning deficit of procedural skills implying temporal sequence is still unclear. Current contradictory results suggest that procedural learning deficits in DCD highly depends on learning conditions. The present study proposes to test the role of sensory modality of s...
Article
Full-text available
sCJD occurrence is currently assumed to result from spontaneous and stochastic formation of a misfolded PrP nucleus in the brains of affected patients. This original nucleus then recruits and converts nascent PrP C into PrP Sc , leading to the propagation of prions in the patient’s brain. Our study demonstrates the coexistence of two prion strains...
Article
Background Multiple sclerosis (MS) is characterized by a range of symptoms, including motor, sensorimotor and cognitive impairments, that limit the quality of life. A multidisciplinary rehabilitation approach in people affected by multiple sclerosis was recently reported to improve the functional abilities of MS patients in daily activities. The pu...
Article
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Objectives: Recovery from coma might critically depend on the structural and functional integrity of frontoparietal networks. We aimed to measure this integrity in traumatic brain injury and anoxo-ischemic (cardiac arrest) coma patients by using an original multimodal MRI protocol. Design: Prospective cohort study. Setting: Three Intensive Cri...
Article
Background Intracerebral hemorrhage (ICH) is a devastating presentation of Cerebral Amyloid Angiopathy (CAA), but mechanisms leading from vascular amyloid deposition to ICH are not well known. We investigated whether amyloid burden and MRI markers of small vessel disease (SVD) are increased in the ICH‐affected hemisphere compared to ICH‐free hemisp...
Article
Full-text available
Developmental dyslexia (DD) and developmental coordination disorder (DCD) are distinct diagnostic disorders. However, they also frequently co-occur and may share a common etiology. It was proposed conceptually a neural network framework that explains differences and commonalities between DD and DCD through impairments of distinct or intertwined cor...
Article
Introduction La microgravité induit une migration thoraco-céphalique des fluides corporels qui a des conséquences sur le système cérébrovasculaire. L’autorégulation cérébrale est altérée chez les astronautes après un vol spatial et le débit sanguin cérébral (CBF) est perturbé en microgravité. Aucune étude n’a jusqu’à présent mesuré le débit sanguin...
Article
Introduction: The locus coeruleus (LC) is one of the brainstem nuclei that may be activated during migraine attack. As LC contains neuromelanin, a by-product of norepinephrine synthesis, it can be delineated in vivo using neuromelanin sensitive magnetic resonance imaging (MRI). The neuromelanin content in LC has been suggested to reflect previous...
Article
Purpose of review: In Parkinson's disease and parkinsonian disorders, the differential diagnosis is still challenging. We aim to review current developments in MRI quantitative markers and their potential in a clinical and neuroscientific setting. Recent findings: There have been efforts to improve MRI acquisition methods and to explore new prom...
Article
Full-text available
Neurofibromatosis type 1 (NF1) is one of the most frequent monogenetic disorders. It can be associated with cognitive dysfunctions in several domains such as executive functioning, language, visual perception, motor skills, social skills, memory and/or attention. Neuroimaging is becoming more and more important for a clearer understanding of the ne...
Article
Full-text available
Background: Sporadic cerebral amyloid angiopathy shows progressive amyloid-β deposition in the wall of small arterioles and capillaries of the leptomeninges and cerebral cortex. Objective: To investigate whether amyloid load and distribution, assessed by florbetapir positron emission tomography, differs between patients with probable CAA-related...
Article
Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder characterized by a variable combination of parkinsonism, cerebellar impairment, and autonomic dysfunction. The pathologic hallmark is the accumulation of aggregated α‐synuclein in oligodendrocytes, forming glial cytoplasmic inclusions, which qualifies MSA as a synucleinopa...
Article
Introduction Le putamen est une structure profonde du cerveau multipliant les connexions réciproques avec toutes les zones du cerveau et du tronc cérébral dévolues à la planification, l’exécution et le contrôle du mouvement. Comme la plupart des noyaux gris centraux il est riche en fer. Ce fer se révèle être une mine d’information pour les neurosci...
Article
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Purpose Enlarged perivascular spaces in the centrum semiovale (CSO-EPVS) have been linked to cerebral amyloid angiopathy (CAA). To get insight into the underlying mechanisms of this association, we investigated the relationship between amyloid-β deposition assessed by 18F-florbetapir PET and CSO-EPVS in patients with acute intracerebral hemorrhage...
Article
Full-text available
Objective: Posterior Cortical Atrophy (PCA) is a neurodegenerative disease characterized predominantly by visual impairment. However, diagnosis of PCA remains complicated with an interval of several years between initial reporting of symptoms and diagnosis. The aim of the present study is to define if patients' visual and gestural complaints are co...
Article
Full-text available
Introduction: The hippocampus plays a key role in depressive disorder, and the amygdala is involved in depressive disorder through the key role that it plays in emotional regulation. Electroconvulsive therapy (ECT) may alter the microstructure of these two regions. Since mean diffusivity (MD), is known to be an indirect marker of microstructural in...
Article
Background and purpose: Quantitative susceptibility mapping (QSM) of the brain has become highly reproducible and has applications in an expanding array of diseases. To translate QSM from bench to bedside, it is important to automate its reconstruction immediately after data acquisition. In this work, a server system that automatically reconstruct...
Article
Full-text available
Iron levels in the brain can be estimated using newly developed specific magnetic resonance imaging (MRI) sequences. This technique has several applications, especially in neurodegenerative disorders like Alzheimer's disease or Parkinson's disease. Coupling ex vivo MRI with histology allows neuroscientists to better understand what they see in the...