Patrice Clochon

Unité Inserm U1077

Background Patients with breast cancer (BC) exhibit circadian rhythm disruptions, mainly of rest-activity rhythm (RAR), of which sleep is an essential component, and cortisol rhythm. Sleep complaints such as insomnia and cognitive impairments are prevalent in BC. In general population, sleep is known to contribute greatly to cognition. Thus, improv...

Introduction: Deleterious effects of exercise close to bedtime could be due to increased physiological arousal that can be detected during sleep using sleep spectral analysis. Resistance and endurance exercises have different effects on cortisol release that may lead them to impact sleep spectral signatures differently. The present study aimed to i...

Background Many patients treated for breast cancer (BC) complain about cognitive difficulties affecting their daily lives. Recently, sleep disturbances and circadian rhythm disruptions have been brought to the fore as potential contributors to cognitive difficulties in patients with BC. Yet, studies on these factors as well as their neural correlat...

Encoding of visual scenes remains under-explored due to methodological limitations. In this study, we evaluated the relationship between memory accuracy for visual scenes and eye movements at encoding. First, we used data-driven methods, a fixation density map (using iMap4) and a saliency map (using GBVS), to analyse the visual attention for items....

In a recent study on visual episodic memory (Desaunay, Clochon, et al., 2020), we have shown event‐related potentials (ERPs) differences associated with priming (150–300 msec), familiarity (350–470 msec), and recollection (600–700 msec), in young people with autism spectrum disorders (ASD) compared with typical development (TD). To go further into...

Intrusive memories hijack consciousness and their control may lead to forgetting. However, the contribution of reflexive attention to qualifying a memory signal as interfering is unknown. We used machine learning to decode the brain's electrical activity and pinpoint the otherwise hidden emergence of intrusive memories reported during a memory supp...

Complaints of sleep disturbance are prevalent among breast cancer (BC) patients and are predictors of quality of life. Still, electrophysiological measures of sleep are missing in patients, which prevents from understanding the pathophysiological consequences of cancer and its past treatments. Using polysomnography, sleep can be investigated in ter...

Background Autism spectrum disorder (ASD) is associated with atypical neural activity in resting-state. Most of the studies have focused on abnormalities in alpha-frequency, as a marker of ASD dysfunctions. However, few have explored alpha synchronization, with a specific interest in resting-state networks: the default mode network (DMN), the senso...

Autism spectrum disorder (ASD) is characterized by atypical perception, including processing that is biased toward local details rather than global configurations. This bias may impact on memory. The present study examined the effect of this perception on both implicit (Experiment 1) and explicit (Experiment 2) memory in conditions that promote eit...

Efforts to exclude past experiences from conscious awareness can lead to forgetting. Memory suppression is central to affective disorders, but we still do not really know whether emotions, including their physiological causes, are also impacted by this process in normal functioning individuals. In two studies, we measured the after-effects of suppr...

Behavioral data on episodic recollection in autism spectrum disorders (ASD) point limited relational memory functioning. However, the involvement of successive memory processes in the profile of episodic memory in ASD needs more study. Here, we used event‐related potentials (ERP) to investigate the time course of episodic recollection with an assoc...

Affective theory of mind (ToM) depends on both the decoding of emotional expressions and the reasoning on emotional mental states from social situations. While previous studies characterized the neural substrates underlying these processes, it remains unclear whether the nature of the emotional state inferred from others can influence the brain act...

The subjective construction surrounding the perception of negative experience is partly build upon bodily afferent information, comprising heart, gut or respiratory signals. While this bottom-up influence has been extensively described, the opposite pathway, the putative influence of cognitive processes over autonomic response, is still debatable....

Encoding and retrieval processes in memory for pairs of pictures are thought to be influenced by inter-item similarity and by features of individual items. Using Event-Related Potentials (ERP), we aimed to identify how these processes impact on both the early mid-frontal FN400 and the Late Positive Component (LPC) potentials during associative retr...

L'utilisation d'un véhicule associé à la consommation de psychotropes relève de pratiques relativement courantes (21% des causes d'accident en 2013 selon l'Observatoire National Interministériel de Sécurité Routière). Les données épidémiologiques et les pourcentages de consommation de médicaments ne permettent pas de faire un lien de causalité dire...

While the current literature on children suffering from temporal lobe epilepsy (CTLE) mostly focuses on material-related episodic memory deficits according to seizure-onset lateralization, the present study examined associative episodic memory according to the type of information to memorize (e.g., factual, spatial, and sequential) and further inve...

Objective: To assess the specific prefrontal activity in comparison to those in the other main cortical areas in primary insomnia patients and in good sleepers. Methods: Fourteen primary insomnia patients and 11 good sleepers were included in the analysis. Participants completed one night of polysomnography in the sleep lab. Power spectra were c...

L'utilisation d'un Îhicule associé à la consommation de psychotropes relève de pratiques relativement courantes (21% des causes d'accident en 2013 selon l'Observatoire National Interministériel de Sécurité Routière). Les données épidémiologiques et les pourcentages de consommation de médicaments ne permettent pas de faire un lien de causalité direc...

Introduction Primary insomnia is characterized by complaints of non-restorative and/or insufficient sleep during at least one month in the absence of other pathologies according to the DSM-IV. However, the pathophysiology of insomnia is not well understood. According to a number of studies, primary insomniacs display cortical hyperarousal during wa...

Episodic memory refers to the capacity to bind multimodal memories to constitute a unique personal event. Most developmental studies on episodic memory focused on one specific component, i.e., the core factual information. The present study examines the relevance of a novel episodic paradigm to assess its developmental trajectories in a more compre...

"Travelling in time," a central feature of episodic memory is severely affected among individuals with Post Traumatic Stress Disorder (PTSD) with two opposite effects: vivid traumatic memories are unorganized in temporality (bottom-up processes), non traumatic personal memories tend to lack spatio-temporal details and false recognitions occur more...

Patients with obstructive sleep apnea (OSA) show neuropsychological impairments ranging from vigilance decrements, attentional lapses and memory gaps to decreased motor coordination, but their cognitive profile, and the origin of the impairments, remain unclear. We sought to establish the neuropsychological profile of 16 newly diagnosed apneics and...

Familiarity is better preserved than recollection in ageing. The age at which changes first occur and the slope of the subsequent decline, however, remain unclear. In this study, we investigated changes in episodic memory, by using event-related potentials (ERPs) in young (m=24), middle-aged (m=58) and older (m=70) adults. Although behavioural perf...

Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD patients. Postlearning sleep was...

This study set out to establish the relationship between changes in episodic memory retrieval in normal aging on the one hand and gray matter volume and (18)FDG uptake on the other. Structural MRI, resting-state (18)FDG-PET, and an episodic memory task manipulating the depth of encoding and the retention interval were administered to 46 healthy sub...

The purpose of this study was to examine the effects of sleep on long-term priming. We report the results of a preliminary experiment that enabled us to verify that priming can last for 4 hours, and we also report the results of a study of partial sleep-deprivation. Subjects performed 2 tasks: within-format and cross-format priming. Sleep laborator...

MR-based diffusion- and perfusion-weighted imaging (DWI/PWI) has become the standard imaging technique to assess the individual brain pathophysiological status in acute ischemic stroke. The finding of a “mismatch” with larger PWI than DWI abnormality is thought to reflect the presence of tissue at-risk of infarction, i.e., penumbra. However, there...

MR-based diffusion- and perfusion-weighted imaging (DWI/PWI) has become the standard imaging technique to assess the individual brain pathophysiological status in acute ischemic stroke. The finding of a "mismatch" with larger PWI than DWI abnormality is thought to reflect the presence of tissue at-risk of infarction, i.e., penumbra. However, there...

The aim of this paper was to investigate and compare the EEG mechanisms underlying the perceptual and semantic processes involved in environmental and language sounds perception by manipulating the degree of identification of sounds and using the ERD (event-related desynchronization) method in healthy subjects. Four types of stimuli were analyzed:...

A new method of instantaneous EEG analysis based on amplitude modulation (AM-EEG) was applied to analyze the AM-EEG changes in the alpha frequency band (8.20-12.89 Hz) for successive 5 ms epochs. Repeated auditory tone-burst stimuli (of 220 ms duration) were presented at fixed 2.56 second intervals to 12 attending right-handed young female voluntee...

The aim of this study was to analyze the timing and topography of brain activity in relation to the cognitive processing of different types of auditory information. We specifically investigated the effects of familiarity on environmental sound identification, an issue which has been little studied with respect to cognitive processes, neural substra...

Amplitude modulation (AM) analysis defines precisely the EEG signal envelope changes at sampling frequency. Here we demonstrate mathematically that event-related desynchronization (ERD) corresponds to the integration of AM-EEG. We applied this new approach to a group of 12 healthy human volunteers hearing repeated auditory stimuli and statistically...

Amplitude modulation (AM) analysis defines precisely the EEG signal envelope changes at sampling frequency. Here we demonstrate mathematically that event-related desynchronization (ERD) corresponds to the integration of AM-EEG. We applied this new approach to a group of 12 healthy human volunteers hearing repeated auditory stimuli and statistically...

The recent development of micro-computers in association with the improvement of data acquisition techniques and signal treatment has made easier the analysis of cerebral electrical activity. But the methods based on classical harmonic analysis reveal ineffective to detect some activities as epileptiform spike-and-waves of paroxystic origin. In ord...