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Publications (27)
Primary cytomegalovirus (CMV) infection during pregnancy is associated with an increased risk of congenital CMV (cCMV). Hyperimmune globulin (HIG) therapy has been proposed as a potential prophylaxis to reduce maternal–fetal transmission. Data on whether the administration of HIG every 2 weeks offers benefits over HIG administration every 4 weeks a...
While previous research has demonstrated a link between the corpus callosum (CC) and theory of mind (ToM) abilities in individuals with corpus callosum agenesis (ACC), the relationship between CC volume and ToM remains unclear in healthy children. The present study examined whether CC volume influences children’s performance on ToM tasks that asses...
Objective:
To provide initial quantitative magnetic resonance (MR) super-resolution-based three-dimensional volumetric reference data on the growth dynamics of the ganglionic eminence (GE) in relation to cortical (CV) and total fetal brain volumes (TBV).
Methods:
This retrospective study investigated 120 fetuses (undergoing 127 MRI scans, mean g...
Using morphological imaging and DTI in utero different phenotypes of pCCA could be distinguished: pCCA with no alternative pathways, Probst bundle, Sigmoid bundle, Probst and Sigmoid bundle. These alternative fiber tracts, in particular, cannot be adequately assessed in standard protocols. The forceps minor, which is formed in most cases, seems to...
Prenatal alcohol exposure (PAE) can change the normal trajectory of human fetal brain development and may lead to long-lasting neurodevelopmental changes in the form of fetal alcohol spectrum disorders. Currently, early prenatal patterns of alcohol-related central nervous system changes are unclear and it is unknown if small amounts of PAE may resu...
In most humans, the superior temporal sulcus (STS) shows a rightward depth asymmetry. This asymmetry can not only be observed in adults, but is already recognizable in the fetal brain. As the STS lies adjacent to brain areas important for language, STS depth asymmetry may represent an anatomical marker for language abilities. This study investigate...
Background
There are known complications for fetuses after infection with SARS-CoV-2 during pregnancy. However, previous studies of SARS-CoV-2 in pregnancy have largely been limited to histopathologic studies of placentas and prenatal studies on the effects of different SARS-CoV-2 variants are scarce to date. To examine the effects of SARS-CoV-2 va...
Importance:
Fetal/perinatal brain damage following maternal SARS-CoV-2 has been reported in single cases. Vertical virus transmission from mother to fetus occurs in only 0-3%, suggesting that the placenta serves as a sufficient immunologic barrier. However, pathohistological studies found placental abnormalities corresponding to malperfusion syndro...
While the core principles of medical education remain the same, the students’ socioecological backgrounds, values and learning requirements are constantly changing. Bridging the generation gap between teachers and students is a key challenge of medical didactics. To meet the demands of today’s classroom, we piloted a novel three-stage peer teaching...
Background Photon-counting detector (PCD) CT allows ultra-high-resolution lung imaging and may shed light on morphologic correlates of persistent symptoms after COVID-19. Purpose To compare PCD CT with energy-integrating detector (EID) CT for noninvasive assessment of post-COVID-19 lung abnormalities. Materials and Methods For this prospective stud...
Deep learning models for medical image segmentation can fail unexpectedly and spectacularly for pathological cases and images acquired at different centers than training images, with labeling errors that violate expert knowledge. Such errors undermine the trustworthiness of deep learning models for medical image segmentation. Mechanisms for detecti...
Deep learning models for medical image segmentation can fail unexpectedly and spectacularly for pathological cases and for images acquired at different centers than those used for training, with labeling errors that violate expert knowledge about the anatomy and the intensity distribution of the regions to be segmented. Such errors undermine the tr...
Knowledge about structural brain asymmetries of human fetuses with body lateralization defects—congenital diseases in which visceral organs are partially or completely incorrectly positioned—can improve our understanding of the developmental origins of hemispheric brain asymmetry. This study investigated structural brain asymmetry in 21 fetuses, wh...
We investigated the predictive value of prenatal superior temporal sulcus (STS) depth asymmetry in a special case of a female dizygotic twin that showed inverted prenatal asymmetry of this structure. For this purpose, we performed a follow-up investigation in this former fetus at the age of seven, where we assessed the functional language lateraliz...
