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Publications (48)
Objective
To apply a network medicine‐based approach to analyze the phenome of the prenatal fetal MRI and biometric findings in the Chiari II malformation (CM II) to detect specific patterns and co‐occurrences.
Method
A single‐center retrospective review of fetal MRI scans obtained in fetuses with CM II was performed. Co‐occurrence analysis was ut...
Background
Intrauterine transfusions (IUTs) are a life-saving treatment for fetal anemia. However, with each transfusion, iron bypasses uptake regulation through the placenta and accumulates in fetal organs. Unlike other imaging modalities, fetal magnetic resonance imaging (MRI) is capable of non-invasively assessing fetal liver disease and/or orga...
Aim
To investigate the impact of cerebellar haemorrhage (CBH) and atrophy in infants born extremely preterm with intraventricular haemorrhage (IVH) on neurodevelopment at 2 years of age.
Method
This retrospective case–control study included infants born at less than 28 weeks' gestation with IVH over a 10‐year period. CBH, along with the assessment...
Objectives
To assess the feasibility, characteristics and prognostic value of prenatal visualization of the corticospinal tracts (CSTs) using diffusion‐weighted magnetic resonance imaging (MRI)‐based tractography in fetuses with intraventricular hemorrhage (IVH).
Methods
This was a retrospective single‐center cohort study of singleton fetuses diag...
Aim
To assess the effect of ventricular decompression on cerebral oxygenation in preterm neonates with intraventricular haemorrhage (IVH) and posthemorrhagic ventricular dilatation (PHVD) using near‐infrared spectroscopy (NIRS).
Methods
Fifty‐three preterm neonates born <34 weeks' gestation between 2013 and 2023 with IVH and subsequent PHVD were p...
Objectives Novel quantitative magnetic resonance imaging (MRI) modalities provide relaxometric properties that are linked to myelinogenesis. This retrospective post-mortem imaging study aimed to investigate the process of myelination and myelin maturation in fetuses using Synthetic MRI versus MR Fingerprinting (MRF).
Materials and Methods
In 26 ca...
Background and purpose:
Intracranial hemorrhage (ICH) has emerged as a notable concern in Chiari II malformation (CM II), yet its origins and clinical implications remain elusive. This study aims to validate the in-utero prevalence of ICH in CM II and investigate contributing factors, and visualize the findings in a network format.
Materials and...
Objectives
This retrospective study aimed to identify quantitative magnetic resonance imaging markers in the brainstem of preterm neonates with intraventricular hemorrhages. It delves into the intricate associations between quantitative brainstem magnetic resonance imaging metrics and neurodevelopmental outcomes in preterm infants with intraventric...
Objective
To identify brain edema in fetuses with Chiari II malformation using a multiparametric approach including structural T2-weighted, diffusion tensor imaging (DTI) metrics, and MRI-based radiomics.
Methods
A single-center retrospective review of MRI scans obtained in fetuses with Chiari II was performed. Brain edema cases were radiologicall...
Purpose
Neonates born at < 28 weeks of gestation are at risk for neurodevelopmental delay. The aim of this study was to identify quantitative MR-based metrics for the prediction of neurodevelopmental outcomes in extremely preterm neonates.
Methods
T1-/T2-relaxation times (T1R/T2R), ADC, and fractional anisotropy (FA) of the left/right posterior li...
Primary cytomegalovirus (CMV) infection during pregnancy is associated with an increased risk of congenital CMV (cCMV). Hyperimmune globulin (HIG) therapy has been proposed as a potential prophylaxis to reduce maternal–fetal transmission. Data on whether the administration of HIG every 2 weeks offers benefits over HIG administration every 4 weeks a...
While previous research has demonstrated a link between the corpus callosum (CC) and theory of mind (ToM) abilities in individuals with corpus callosum agenesis (ACC), the relationship between CC volume and ToM remains unclear in healthy children. The present study examined whether CC volume influences children’s performance on ToM tasks that asses...
Objective:
To provide initial quantitative magnetic resonance (MR) super-resolution-based three-dimensional volumetric reference data on the growth dynamics of the ganglionic eminence (GE) in relation to cortical (CV) and total fetal brain volumes (TBV).
Methods:
This retrospective study investigated 120 fetuses (undergoing 127 MRI scans, mean g...
Using morphological imaging and DTI in utero different phenotypes of pCCA could be distinguished: pCCA with no alternative pathways, Probst bundle, Sigmoid bundle, Probst and Sigmoid bundle. These alternative fiber tracts, in particular, cannot be adequately assessed in standard protocols. The forceps minor, which is formed in most cases, seems to...
Prenatal alcohol exposure (PAE) can change the normal trajectory of human fetal brain development and may lead to long-lasting neurodevelopmental changes in the form of fetal alcohol spectrum disorders. Currently, early prenatal patterns of alcohol-related central nervous system changes are unclear and it is unknown if small amounts of PAE may resu...
In most humans, the superior temporal sulcus (STS) shows a rightward depth asymmetry. This asymmetry can not only be observed in adults, but is already recognizable in the fetal brain. As the STS lies adjacent to brain areas important for language, STS depth asymmetry may represent an anatomical marker for language abilities. This study investigate...
Background
There are known complications for fetuses after infection with SARS-CoV-2 during pregnancy. However, previous studies of SARS-CoV-2 in pregnancy have largely been limited to histopathologic studies of placentas and prenatal studies on the effects of different SARS-CoV-2 variants are scarce to date. To examine the effects of SARS-CoV-2 va...
Importance:
Fetal/perinatal brain damage following maternal SARS-CoV-2 has been reported in single cases. Vertical virus transmission from mother to fetus occurs in only 0-3%, suggesting that the placenta serves as a sufficient immunologic barrier. However, pathohistological studies found placental abnormalities corresponding to malperfusion syndro...
While the core principles of medical education remain the same, the students’ socioecological backgrounds, values and learning requirements are constantly changing. Bridging the generation gap between teachers and students is a key challenge of medical didactics. To meet the demands of today’s classroom, we piloted a novel three-stage peer teaching...
Background Photon-counting detector (PCD) CT allows ultra-high-resolution lung imaging and may shed light on morphologic correlates of persistent symptoms after COVID-19. Purpose To compare PCD CT with energy-integrating detector (EID) CT for noninvasive assessment of post-COVID-19 lung abnormalities. Materials and Methods For this prospective stud...
Deep learning models for medical image segmentation can fail unexpectedly and spectacularly for pathological cases and images acquired at different centers than training images, with labeling errors that violate expert knowledge. Such errors undermine the trustworthiness of deep learning models for medical image segmentation. Mechanisms for detecti...
Deep learning models for medical image segmentation can fail unexpectedly and spectacularly for pathological cases and for images acquired at different centers than those used for training, with labeling errors that violate expert knowledge about the anatomy and the intensity distribution of the regions to be segmented. Such errors undermine the tr...
Knowledge about structural brain asymmetries of human fetuses with body lateralization defects—congenital diseases in which visceral organs are partially or completely incorrectly positioned—can improve our understanding of the developmental origins of hemispheric brain asymmetry. This study investigated structural brain asymmetry in 21 fetuses, wh...
We investigated the predictive value of prenatal superior temporal sulcus (STS) depth asymmetry in a special case of a female dizygotic twin that showed inverted prenatal asymmetry of this structure. For this purpose, we performed a follow-up investigation in this former fetus at the age of seven, where we assessed the functional language lateraliz...
