
Pathirage Kamal PereraUniversity of Colombo · Faculty of Indigenous Medicine (FIM)
Pathirage Kamal Perera
PhD in Pharmacology (Nanjing-China) - Certified and trained in Pharmacovigilance and Drug safety (UMC - Uppsala Sweden) - Dip in Research & Development of Products to Meet Public Health Needs (Nagasaki -Japan)
Dean, Faculty of Indigenous Medicine, University of Colombo
About
242
Publications
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Introduction
Professor Pathirage Kamal Perera is a clinical researcher and consultant physician working to build research capacity in traditional medicine in Sri Lanka. His current research and consulting areas are Pharmacology and Therapeutics, Ayurveda Medicine, Internal Medicine, Clinical trials, Immunology, Clinical Product development, Phytomedicine, Nutraceuticals and Cosmeceuticals, Clinical Ethics, Pharmacovigilance, Rheumatology and Orthopedics, Pain Management, Oncology, and Integrative medicine
Additional affiliations
December 2005 - present
Unuversity of Colombo
Position
- Professor
August 2007 - August 2011
Publications
Publications (242)
To investigate the immunomodulating mechanisms of a Chinese herbal medicine Yi Shen Juan Bi (YJB) in treatment of adjuvant arthritis (AA) in rats.
Levels of serum tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were measured by the Enzyme-Linked Immunosorbent Assay (ELISA). Expression of TNF-alpha mRNA and IL-1beta mRNA in...
Chinese herbal pill Yi Shen Juan Bi (YJB), which is a compound herbal drug, has traditionally been used as an anti-rheumatic drug in Chinese local clinics. Thus, we investigated the therapeutic effect of the YJB in rheumatoid arthritis (RA), using Freund's complete induced adjuvant arthritis (AA) in rat model.
For that purpose, macrophage derived c...
The root of Clematis chinensis Osbeck has been used widely in rheumatoid arthritis in Chinese traditional medicine, and AR-6 is a triterpene saponin isolated from it. In this present study, we investigated the in vivo effects of oral AR-6 in chronic rat with collagen-induced arthritis (CIA) and possible molecular mechanism. CIA was induced by immun...
This study aims to assess the efficacy and safety of two Ayurveda drug regimens for the treatment of uterine fibroids (UF) in a randomized single-blind clinical trial. 120 participants with UF (volume ≥ 2 cm3) were randomly allocated at a 1 : 1 : 1 ratio to 2 experimental groups and the control group. The 12-week intervention period was followed by...
Sudarshana powder (SP) is an Ayurvedic preparation, which contains 53 herbal ingredients along with 50% of Andrographis paniculata and is clinically used with bees honey. This study was aimed to determine the safety profile of the SP, and its novel preparation Sudarshana suspension (SS) on male Wistar rats and tolerance studies were conducted for h...
Background and study aims
Aging is an irreversible process influenced by both internal (genetic) and external (environmental) factors. These factors contribute to differences in how individuals age. Aging is not just about a decline in physical and mental abilities but involves complex biological mechanisms. Aging can be explained through two main...
A case study on Endometriosis and Adenomyosis case and its successful management through Sri Lankan Traditional Medicine and Ayurveda Management.
There are uprising trends to use traditional medicinal interventions in treating chronic diseases such as osteoarthritis. Therefore, this study aimed to systematically review the scientific literature on different Traditional Medicine interventions for osteoarthritis. This systematic review was conducted by searching PubMed, Scopus and Science for...
Background
Increasing global interest in natural therapies has led to a rise in the use of herbal medicines for managing various ailments. However, concerns about scientific evaluation have prompted a study aiming to assess the study design of herbal medicine clinical trials. This study aimed to provide a descriptive overview of the study design, c...
Plants are a vital ingredient of traditional medicine in Sri Lanka, and the quantity of medicinal plants used as a
number differs in literature. Field identification of medicinal plants is carried out based on various plant characteristics.
Conventional identification keys are available for plant identification, but it is a complex and time consumi...
Sudarshana Suspension (SS) is a novel Ayurveda preparation. The main aim of this study was to evaluate the acute and chronic anti-inflammatory and anti-nociceptive potential of Sudarshana suspension in Wistar rats. The acute anti-inflammatory potential of the Sudarshana suspension was evaluated using the carrageenan-induced paw oedema method and th...
According to the WHO data sheet, endometriosis affects approximately 10% (190 million) of reproductive-age women and girls worldwide. Endometriosis has no known cure; thus, treatment focuses on symptom management. Ayurveda treatment for this condition is being practised in Sri Lanka. Significant numbers of cases were successes with Ayurveda treatme...
The report of the International Conference on Ayurveda, Unani, Siddha and Traditional Medicine (iCAUST 2024) Medicine is organized by the Faculty of Indigenous Medicine, University of Colombo, Sri Lanka.
Sri Lankan traditional medical system comprises many medicinal foods used to manage diabetes mellitus, dyslipidemia, and hypertension. Utilization of evidence-based knowledge of these foods in Western medical care needs acceptance of these medicinal foods by Western doctors. This survey was conducted as a descriptive cross-sectional knowledge, atti...
Background: Balabilvashunti decoction (BD) is an ayurvedic polyherbal formulation comprised of three plant ingredients: rhizome of Zingiber officinale, whole plant of Sida alnifolia, and root bark of Aegle marmelos. BD is widely utilized within clinical practice, particularly for addressing geriatric diseases. However, despite its prevalence, patie...
The medicinal foods used to manage non-communicable diseases in Sri Lankan traditional medicine are slowly but steadily disappearing from the country due to many reasons. This study is the first stage of the research project aimed to explore and analyze the medicinal foods used to manage dyslipidaemia in traditional medical practices of Sri Lanka....
Triphala: a polyherbal formulation used in both Ayurveda and Sri Lankan Traditional Medical practices. The aim of the present study was to compare the chemical characteristics of distinct compositions of Triphala powder as mentioned in various Ayurveda Authentic Texts. Dried fruits of Terminalia chebula Retz. (TC), Terminalia bellirica Gaertn. (TB)...
Sesamumindicum L. is a wildly used medicine in Ayurveda and traditional medicine in Sri Lanka. This study aims to analyse the most recent research findings about the pharmacological effects of S. indicum. The PubMed, Scopus, and Cochrane library databases were searched extensively and systematically for papers published between January 2011 and May...
Metal‐ and mineral‐containing drug preparations have been used abundantly in Sri Lankan traditional system of medicine from 3000 years to cure a number of diseases. A minute dose of such preparations can be used for a short period of time in relieving diseases, which emphasize the fact that metals and minerals act on human bodies efficiently. Metal...
Background: Since early nineties investigators in Sri Lanka have noticed an alarmingly high incidence of a new form of chronic kidney disease of uncertain etiology (CKDu) in North Central Region of the country. The purpose of the present study was to assess the treatment response profile of a selected traditional medicine used for Chronic Kidney Di...
Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine abnormalities in women of reproductive age. Due to fear of side effects and adverse effects of allopathic medicines, some patients prefer to take Ayurveda treatments for PCOS. Therefore, the aim of this research is to design a randomized, single-blind, three-arm, comparative clini...
Phoenix sylvestris Roxb. (Family: Palmae/Arecaceae) is a palm tree commonly distributed in the semi-desert areas of India, Sri Lanka, Pakistan, Bangladesh, Myanmar, Nepal, Bhutan, and China. Different plant parts of P. sylvestris are used in traditional medicines for the treatment of various ailments. The sap obtained from the tree is high in nutri...
Objectives:
To explain the bio-physiological mechanisms of the antidiabetic effect of betulinic acid in Lotus rhizome.
Background:
Even though Sri Lankan native medicine uses Lotus rhizome as a medicinal food for diabetes mellitus, its antidiabetic property has not been scientifically explained yet. It is found to compose several medicinally act...
Plants are a vital ingredient of traditional medicine in Sri Lanka, and the number of medicinal plants used differs in the literature. Field identification of plants is carried out based on various plant characteristics. Conventional identification keys are available for plant identification, but it is a complex and time-consuming process for an or...
Abstract:
Sesamum indicum L. is one of the world's oldest oilseed crops. It is used for nutritional, medical, and industrial applications worldwide. There are three varieties of sesame red, white and black. Sesamum indicum is a wildly used medicine in Ayurveda and traditional medicine in Sri Lanka. Stalk, Leaves, Seeds, and Oil have medicinal valu...
Background
Knee osteoarthritis (KOA) is the most common form of arthritis, causing disability and impaired quality of life especially in the elderly. Sri Lankan traditional medicine (STM) is widely used to treat OA, but no clinical trial evaluated on STM regimens for KOA to discuss their safety and efficacy in the treatment. The aim of this study i...
The medicinal foods used to manage non-communicable diseases in Sri Lankan
traditional medicine is slowly but steadily disappearing from the country due
to many reasons. This study is the first stage of the research project aimed to
explore and analyze the medicinal foods used to manage diabetes mellitus in
traditional medical practices of Sri Lank...
Comprehensive search of previously published research was conducted in PubMed, Science Direct, Scopus, and google scholar databases for studies published between 2012 and August 2021. The keywords used in combination to search for articles included Nigella sativa and "Gynecology". In the first stage, the total articles obtained from searching the a...
Caryota urenswhich belongs to the Palmae family is used as a food, beverage, fiber, timber and for ornamental purposes in Sri Lanka. Jaggery and treacle made out from Caryota. urensis very abundantly used in the Sri Lankan communities since a long ago. Even though its usage as a food article has been broadly described in many instances, its medicin...
Abstract
Member States of the WHO South-East Asia (SEA) Region have prioritized attention to research in traditional medicine and supported substantial research activity to promote evidence-based traditional medicine practices. Many research reports have been published in national and international journals. However, despite many such research st...
First aid is the initial care given in an emergency , to protect life and to prevent worsening of the condition of the victims, until they are undertaken by a professional medical person. This research was done to assess the knowledge, attitudes and practices on first aid among advanced level students in government schools in Gampaha educational zo...
Decoction prepared from N. sativa, and S. indicum can be used to treat oligo/anovulation, a primary sign of PCOS. Up to date no scientific experiments were carried out to access the quality of this decoction. Therefore, an attempt was made to evaluate the quality of the decoction made from N. sativa seeds and S. indicum seeds in terms of (a) phytoc...
Cannabis sativa is an herbaceous plant which is mainly used as a remedy for neurological, digestive and immunological ailments in traditional medicine. Even though Cannabis is the most illicit plant around the world, its medicinal properties are beneficial in number of ways. Numerous beneficial effects of C. sativa have been demonstrated in
multipl...
Andrographis paniculata (A. paniculata) is a herbaceous plant used as a remedy for many diseases intraditional medicine. Numerous beneficial effects of A. paniculata have been demonstrated in multiplein vitro and in vivostudies, this study systematically reviews the relevant literature and provide a summaryon the antiviral properties of A. panicula...
This study was designed to validate a Prakriti assessment questionnaire through a scientific method. Prakriti is one of the basic concepts discussed in Ayurveda which can categories population into several subgroups based on phenotypic characteristics like appearance, temperament and habits. In this study, cases were selected randomly from the outp...
In the current healthcare system, antibiotic resistance has become one of the crucial health issues. Discovering a novel antibiotic is a very complex and time-consuming process. Hence there is an increasing trend of conducting researches using herbal sources to treat infections which are resistant to currently available antibiotics. The objective o...
Background
Osteoarthritis (OA) has become a burden globally for the healthcare sector due to its high prevalence and incidence. Among that Knee Osteoarthritis (KOA) is the most common form of arthritis causing disability and impaired quality of life especially in elderly. Currently pharmacological, non-pharmacological and surgical measures are cons...
Introduction: Dengue is the most prevalent infectious mosquito-borne viral infection in the world. Over time dengue has caused
high mortality and morbidity.
Methods: A cross-sectional study was conducted to assess the level of knowledge, attitude, and practice among 510 residents of
Ja-Ela MOH area using an interviewer-administered questionnaire. E...
Introduction and objectives: Munronia pinnata is a rare perennial medicinal herb widely used in Sri Lanka, China, and India. It belongs to the family Meliaceae, which has many ecotypes in leaflets such as 3,5,7,9 and 11. M. pinnata is widely used throughout traditional medicine to treat various diseases like fever, general pain, haemorrhoids, dysen...
Covid-19, caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is a life-threatening disease that has been declared a global pandemic. Even with the intervention of numerous medical systems to combat Covid-19, an effective remedy is not yet in sight rather than supportive therapies accompanied with anti-viral drugs and vaccines....
Background and study aims:
Osteoarthritis (OA) has become a burden globally for the healthcare sector due to the number of people developing or living with the condition. Knee osteoarthritis (KOA) is the most common form of arthritis causing disability and impaired quality of life especially in the elderly. The WHO report on priority diseases and...
Munronia pinnata is a rare perennial medicinal herb widely used in Sri Lanka, China and India. It belongs to the family Meliaceae, which has many ecotypes in leaflets such as 3,5,7,9 and 11. Munronia pinnata has been used in an array of diseases like fever, general pain, haemorrhoids, dysentery, eczema, cough, asthma, oedema, circulatory disorders,...
Paederia foetida (Prasarini) under the family Rubiaceae is a herb used in Ayurveda
preparations with hepatoprotective, anthelmintic, antibacterial, hypoglycaemic,
anti-inflammatory, antioxidant, antitussive, anti-ulcer, antinociceptive, diuretic, laxative
and thermogenic properties. Hence, standardization parameters are required in the quality
cont...
Uterine fibroids (UF) are the most common neoplasm affecting women in reproductive
age. Although many studies on the epidemiological factors of UF have been published,
such studies are limited on UF cases attended to by the Sri Lankan Ayurveda system. The
objective of this study was the clinical characterization of UF patients who visited the
Ayurv...
In Sri Lanka there are specific families: “Weda Parampara '', who practice their own
treatment methods with the use of specific remedies. They have a long history of use in
disease prevention and treatment, particularly for chronic diseases like Joint disorders,
Sandiroga. The aim of this study was to find out current practices and knowledge on
San...
Traditional medicinal systems are being practiced as successful treatments for many
diseases over centuries in many countries, especially in Asia. Sri Lankan Traditional
medicine (STM) has biomedical fermentation; Basna Kalpana which is less explored and
explained in terms of scientific concepts. A comprehensive search of the literature was
conduct...
Sarpagandha Churna is a herbal medicine given to patients suffering from hypertension,
psychosis and insomnia. It consists of pericarp of T. chebula fruits and R. serpentine roots
at a ratio of 1:2 (w/w). In the present study, an attempt was made towards
standardizingSarpagandha Churna in terms of phytochemical and physico-chemical
analysis and det...
Dhathri Rasayana (DR) is a polyherbal formula mentioned in authentic traditional
medicine text. It consists of 7 plant ingredients and some other herbal materials. DR is
widely used in Sri Lankan traditional medical systems and it is considered as an effective
drug that has lesser side effects compared to modern drugs for many diseases. Free
radica...
Uterine fibroids are common reproductive track tumors of women and they are managed by the Ayurveda system of medicine. Reference on this condition is limited in Ayurveda texts. This study was aimed at collecting research and concept evidence to justify uterine fibroids, with the most similar diseases described in Ayurveda. A review of selected Ayu...
Background: Indigofera tinctoria (Nil Aweriya) under the family Fabaceae is an herb used in
traditional medicine which holds laxative, expectorant, diuretic, anthelmintic, hypoglycaemic
and thermogenic properties. It is also used as a natural hair colorant. Hence, standardization
parameters are required in the identification of herbal raw materials...
Oral diseases can be considered a major health problem worldwide. As oral health represents the general well-being of an individual, the attention direct towards it is very much significant in the community. Among the oral health problems dental caries, periodontal diseases, oral cancers, cracked or broken teeth, sensitive teeth can be explained as...
The antioxidant, cytotoxic, and anti-cancer potential of aqueous root and rhizome extract (ARRE) of Smilax zeylanica was investigated against human liver carcinoma cells. The phytochemical composition was evaluated by standard methods, and confirmed by thin-layer chromatography. Free radical scavenging activity was determined by DPPH assay, cytotox...
The majority of Sri Lankan population rely on herbal medicine. Hence,
standardization of raw materials is required in Ayurveda preparations.
Plectranthus amboinicus (Lour.) Spreng (Kapparawalliya) is a herb having
morphological ambiguity with other Plectranthus species. Thus, the present
study was aimed at establishing standardization parameters fo...
Nervous system disorders are increasing in global prevalence. The prevention and treatment of nervous system disorders by modern medicines are insufficient, facilitating the rapid growth and use of traditional medicines. Plant-derived herbal preparations are used for the well-being and treatment of nervous system disorders by a large proportion of...
Tinospora cordifolia (wild) Hook.f. (Thomas) is an important medicinal plant distributed throughout in Sri Lanka and commonly known as Rasakinda in Sinhala and Giloy in English. It is widely used in Sri Lankan traditional medical system and Ayurveda for the treatment of diabetes mellitus, fever, arthritis, skin diseases and for Rasayana (rejuvenati...
This study aimed to provide comprehensive review on current progress of treating uterine fibroids with Ayurveda treatments. Present review adhered to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines. Literature
was searched in PubMed®, MEDLINE, and Web of Science® up to October 2019 with specific keywords. Arti...
Acronychia pedunculata (L.) (Ankenda) under family RUTACEAE is widely used in Traditional medicine system. The present study was aimed at the development of quality control parameters for identification and authentication of A. pedunculata. Hence, standardization is important in maintaining the purity, quality, safety and efficacy of Ayurvedaformul...
Plants have been utilized as medicines to treat various ailments since ancient times. Formulations made by plant materials have been used in traditional, complementary, and alternative medicine and remain widespread in both developing and developed countries. In developing countries, traditional medicines are widely practiced due to its accessibili...
Abstract: The present study was aimed at developing several tools in proper identification,
authentication and maintenance of quality control standards of raw materials of I. tinctoria. Leaf extracts were obtained following cold maceration with methanol, acetone and hot soxhlet extraction with distilled water. Each extract was subjected to phytoche...
Background
First aid is the initial care given in an emergency, to protect life and to prevent worsening of the condition of the victims, until they are undertaken by a professional medical person. It is essential to know basic first aid as a responsible person in society. The current study was conducted to assess the knowledge, attitudes and pract...
Background and objectives: Tragia involucrata L. (Family: Euphorbiaceae, S. Wel Kahambiliya) is a highly used medicinal plant in both systems of Sri Lankan traditional medicine and Ayurveda medicine. This plant is used for the treatment of diseases such as diabetes, wounds, dysuria, and epilepsy. The aim of this study was to evaluate the efficacy a...
Cochrane Central Register of Controlled Trials:
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Cochrane Central Register of Controlled Trials:
https://www.cochranelibrary.com/search