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Introduction
Skills and Expertise
Publications
Publications (60)
Zusammenfassung
Das vorliegende Addendum zur Leitlinie zur Diagnostik und Therapie von Patienten mit Asthma (2017) ergänzt wichtige neue Erkenntnisse zur Diagnostik und Therapie von Asthma sowie zu neu für die Therapie des Asthmas zugelassenen Medikamenten. Es werden sowohl für Kinder und Jugendliche als auch für Erwachsene mit Asthma die aktuellen...
The present 2019 S2k consensus guideline of the German Respiratory Society was written for pneumologists – in contrast to the more general predecessor's S3 guidelines from 2004 to 2010 –, since 2014 the German College of General Practitioners and Family Physicians (DEGAM) published their own cough guidelines.
The guidelines contain 48 recommendatio...
Introduction Inhalative treatments with metered dose aerosols and dry powder inhalers are the backbone of the pharmacotherapy for asthma and COPD. In the last decade many new and generic inhalative bronchodilators were launched at the German market, both monotherapies and fixed dose double bronchodilator (LABA/LAMA, beta adrenergic and antimuscarin...
Zusammenfassung
Die vorliegende 2019 S2k-Leitlinie der DGP wurde im Gegensatz zu den S3-Vorgänger-Leitlinien aus dem Jahre 2004 und 2010 für Pneumologen verfasst, für Allgemeinärzte liegt eine Leitlinie der Deutschen Gesellschaft für Allgemeinmedizin aus dem Jahre 2014 vor.
Die Leitlinie enthält 48 im Konsensusverfahren abgestimmte Empfehlungen und...
The new S2k-guideline of the German Respiratory Society and the German Airway League for the management of patients with chronic obstructive pulmonary disease (COPD) was written by German and Austrian experts on the basis of actual published studies, meta-analyses as well as actual guidelines, especially the 2017 version of the document of the Glob...
Zusammenfassung
Das vorliegende Dokument ist eine Neufassung und Aktualisierung der Leitlinie zur Diagnostik und Therapie von Patienten mit COPD, die die bisherige Version aus dem Jahr 2007 ablöst. Die Fülle an neuen Erkenntnissen zu Risikofaktoren, Diagnostik, Schweregradeinschätzung, Prävention und medikamentösen sowie nicht medikamentösen Therap...
Zusammenfassung
Die vorliegende Leitlinie ist eine Neufassung und Aktualisierung der Leitlinie zur Diagnostik und Therapie von Patienten mit Asthma, welche die bisher für den deutschen Sprachraum gültige Version aus dem Jahr 2006 ablöst. Die Fülle an neuen Erkenntnissen zur Pathophysiologie und zu den Phänotypen von Asthma und das erweiterte Spektr...
Die chronisch obstruktive Lungenkrankheit (COPD) ist eine häufig unterdiagnostizierte Volkskrankheit mit erheblicher Morbidität, Mortalität und volkswirtschaftlicher sowie sozialmedizinischer Bedeutung. Nach den Empfehlungen der Weltgesundheitsorganisation (WHO) sind die Voraussetzungen für die Durchführung eines sinnvollen Screenings für die COPD...
Background
Treatment of asthma does not always comply with asthma guidelines (AG). This may be rooted in direct or indirect resistance on the doctors’ and/or patients’ side or be caused by the healthcare system. To assess whether patients’ concepts and attitudes are really an implementation barrier for AG, we analysed the patients’ perspective of a...
Introduction
The prospective, non-interventional DACCORD study collects data from a representative cohort of COPD out-patients across Germany who either initiated or changed COPD maintenance medication prior to entry. Initially, DACCORD consisted of two treatment groups (Glycopyrronium-based therapy vs. any other COPD maintenance medication with th...
Introduction
Although randomised, controlled trials are important in the development of new pharmacological treatments, they provide limited information on the ‘real life’ management of chronic diseases. Here, we analysed two-year follow-up data from the prospective, non-interventional, observational DACCORD study to evaluate the frequency of exace...
Einfuhrung: Das Absetzen von inhalativen Kortikosteroiden (ICS) in der COPD-Erhaltungstherapie wurde aktuell in kontrollierten Studien gepruft [1 – 3], insbesondere mit der Frage zum Nutzen einer ICS-Therapie bei geringem Exazerbationsrisiko. Die Ubertragung dieser Studienergebnisse auf die tagliche Praxis ist jedoch oft schwierig. In DACCORD wurde...
Einfuhrung: Im prospektiven DACCORD-Register werden Daten zu ambulant behandelten COPD Patienten, die bei Studieneinschluss ihre COPD-Erhaltungstherapie beginnen oder umstellen, dokumentiert. Eine Subgruppe von COPD Patienten mit hoher Symptomlast trotz erhaltener Lungenfunktion (FEV1 > 80%) wurde hier analysiert. Methoden: Daten von ambulanten COP...
Introduction Currently there is limited real-life data available regarding the distribution of COPD patients using the GOLD 2011 criteria. The German DACCORD registry that collects data from a large ‘real life’ population sample was used to categorise COPD patients according to GOLD 2011.
Methods To be eligible for entry into DACCORD, all patients...
Introduction In patients with COPD, exacerbations are among the most relevant safety measures. In this analysis of data from the observational DACCORD study, we report the frequency of exacerbations in a COPD population.
Methods To get insights into occurrence and frequency of exacerbations, data from 4,123 patients were obtained from 349 primary a...
Treatment with inhaled glucocorticoids in combination with long-acting bronchodilators is recommended in patients with frequent exacerbations of severe chronic obstructive pulmonary disease (COPD). However, the benefit of inhaled glucocorticoids in addition to two long-acting bronchodilators has not been fully explored.
Methods
In this 12-month,...
The concept of the minimal clinically important difference (MCID) is intended to provide a measure of relevance for a statistically applied in patients with COPD. Clinically important differences are those differences relevant to the individual patient and important to the patient's life. However, people's difference in a diagnostic parameter perce...
Immunoglobulin E (IgE) has a central role in the pathophysiology of the allergic inflammation. The monoclonal humanized anti-IgE antibody omalizumab offers the innovative therapeutic principle of an IgE neutralization. Omalizumab consists by 95% of a human IgG 1 protein, and only by 5% of murine molecules. Therefore, adverse events are rare. Omaliz...
This annual report presents the first year's accomplishments in the area of pulse-combustion-based high-efficiency commercial steam boilers with targeted inputs of 500,000 and 2,000,000 Btu/hr. Heat-transfer data, derived through the use of a specially designed test rig, are part of this report.
This final report presents the accomplishments in the area of pulse-combustion-based high-efficiency commerciaL/industrial water heaters with targeted inputs of 500,000, 750,000 and 1,000,000 Btu/hr. Four engineering models were completed; two for a single 500,000 Btu/hr input, one for 750,000 Btu/hr input, and one for 1,000,000 Btu/hr input. The l...
The final report presents the accomplishments in the area of pulse-combustion-based high-efficiency commercial steam boilers with targeted inputs of 500,000 and 2,000,000 Btu/hr. A fully functional 500,000 Btu/hr experimental low-pressure steam boiler, meeting all performance and cost objectives was developed and built. Equipped with a fully automa...
