Pasupuleti Visweswara Rao

Universiti Malaysia Sabah (UMS) | ums · School of Medicine

This correction concerns the article "Surface Thermal Behavior and RT CO Gas Sensing Application of an Oligoacenaphthylene with p‑Hydroxyphenylacetic Acid Composite" published in ACS Omega, https://doi.org/10.1021/acsomega.2c03897. The Table of Contents and Abstract (TOC, p 36307), Figure 8 (p 36314), and Figure S1 (Supporting Information) contain...

Novel ethyl-4-(aryl)-6-methyl-2-(oxo/thio)-3,4-dihydro-1H-pyrimidine-5-carboxylates were synthesized from one-pot, three-component Biginelli reaction of aryl aldehydes, ethyl acetoacetate and urea/ thiourea by catalytic action of silica supported Bismuth(III) triflate, a Lewis acid. All the synthesized compounds were structurally characterized by s...

Two-dimensional graphitic carbon nitride (g-C3N4) have fascinated a tremendous attention in room temperature (RT) gas sensing applications because of their physicochemical characteristics. Especially, the tunable electronic structure of g-C3N4 nanostructures...

This study reports the design and synthesis of novel dialkyl (4-amino-5H-chromeno[2,3-d]pyrimidin-5-yl)phosphonates as potential antitumor agents against A549 (lung cancer), DU-145 (prostate cancer), PC-3 (prostate cancer), HeLa (cervical cancer) and MCF-7 (breast cancer), cell lines evidenced from the in vitro antitumor studies performed by MTT as...

Considerable efforts and concurrent studies have been made to substantiate the control of tuberculosis (TB). The control was not achieved significantly, as the stigma is one of the significant barriers to controlling tuberculosis. It hampers the TB treatment’s determined targeted completion. However, despite countless measures to improve therapy co...

In consideration of the emergence of novel drug-resistant microbial strains and the increase in the incidences of various cancers throughout the world, honey could be utilized as a great alternative source of potent bioactive compounds. In this context, this study pioneers in reporting the phytochemical profiling and the antimicrobial, antioxidant,...

In the current work, the surface thermodynamic properties of Amberlite XAD‐7 acrylic‐ester‐resin have been determined. The inverse gas chromatography (IGC) technique at infinite dilution was applied to estimate the London dispersive surface free energy γsd$$ {\gamma}_s^d $$ was estimated by using the well‐known Fowkes equation, Dorris–Gray relation...

Background: Diabetes mellitus is a chronic metabolic disorder characterized by elevated plasma glucose levels. It is often defined as a lifestyle disease having severe economic and physiological repercussions on the individual. One of the most prevalent clinical consequences of diabetes is the lagging pace of injury healing leading to chronic woun...

In many regions of the world, Leishmaniasis is a cause of substantial mortality and ailment. Due to impediment in available treatment, development of novel and effective treatments is indispensable. Significance of autophagy has been accentuated in infectious disease as well as in Leishmaniasis, and it is having capability to be manifested as a the...

Single amino-acid substitution in a protein affects its structure and function. These changes are the primary reasons for the advent of many complex diseases. Analyzing single point mutations in a protein is crucial to see their impact and to understand the disease mechanism. This has given many biophysical resources, including databases and web-ba...

A major global health risk has been witnessed with the development of drug-resistant bacteria and multidrug-resistant pathogens linked to significant mortality. Coumarins are heterocyclic compounds belonging to the benzophenone class enriched in different plants. Coumarins and their derivatives have a wide range of biological activity, including an...

This study was aimed to use extrusion cooking as a pretreatment for non-conventional seeds (Indian horse chestnut flour) to blend them with whole grain flours (whole wheat flour, whole barley flour, and whole corn flour) for the development of a pregelatinized cereal bar (PCB). In this study, date paste (7.5–17.5%) and walnut grits (2.5–12.5%) were...

In this present work, the synthesis of nitrogen doped multi walled carbon nanotubes (N-MWCNTs) grafted Sodium-carboxy methyl cellulose (Na-CMC) hybrid composite was carried out via thermal reduction process. The hybrid composites were thermodynamically characterized by inverse gas chromatography (IGC) and compared to Na-CMC particles. The results w...

Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR is involved in several cancer developments, including NSCLC. The EGFR pathway regulates the Bax/Bcl-2 cascade in NSCLC. Increasing understanding of the molecular mechanisms of fundamental tumor progression has guided the development of numerous antitumor drugs. The d...

Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their natural healing and medicinal properties. CA possesses various biological and pharmacological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. T...

Caffeic acid (CA) has been present in many herbs, vegetables, and fruits. CA is a bioactive compound and exhibits various health advantages that are linked with its anti-oxidant functions and implicated in the therapy and prevention of disease progression of inflammatory diseases and cancer. The anti-tumor action of CA is attributed to its pro-oxid...

In this work, an eco-friendly, cheap, and sensitive analytical procedure magnetic solid phase extraction (MSPE) and deep eutectic solvent (DES) was developed for isolation and detection of parabens in water and urine. The parabens were determined by liquid chromatography equipped with ultraviolet detector (HPLC-UV). The magnetic-activated carbon (M...

The Co3O4@N-MWCNT composite was synthesized by a sonication-supported thermal reduction process for supercapacitor applications. The structural and morphological properties of the materials were characterized via Raman, XRD, XPS, SEM–EDX, and FE-TEM analysis. The composite electrode was constructed into a three-electrode configuration and examined...

Phytochemicals of Christia vespertilionis plant is known for medicinal properties and used to treat various health problems. The present study revealed medicinal properties of the leaf extract of Christia vespertilionis plant as its total phenolic content derived is screened for their antioxidant, antidiabetic and toxicity properties by Folin-Cioca...

2022): An insilico ADMET, molecular docking study and microwave-assisted synthesis of new phosphorylated derivatives of thiazolidinedione as potential anti-diabetic agents, Synthetic Communications, ABSTRACT A series of new phosphorylated derivatives of thiazolidinedione was synthesized for the first time with high yields (92-96%) in short reaction...

Nanotechnology is one of the advanced technologies, which undoubtedly contributes to various fields, including agriculture, biotechnology, engineering, architecture, medical sciences, food security, food technologies, etc. Nanotechnology, nanomaterials, and nanoparticle research play important roles in producing quality nano-based products for the...

Honey has several pharmacological effects, including anti-diabetic activity. However, the effectiveness of bitter gourd honey (BGH) in the treatment of diabetes mellitus (DM) is unknown. The aim of this study was to determine the antioxidant, anti-inflammatory, and anti-apoptotic properties of BGH on the kidney and liver of a streptozotocin-induced...

A series of thirty new thiazole-pyridine derivatives were synthesized by reaction of 4,4,7,7-tetra-methyl-4,5,6,7-tetrahydrobenzo[d]thiazol-2-amine with 6-chloronicotinate followed by condensing with benzaldehydes and screened for their anti-diabetic activity by in vivo housing Swiss albino mice. All synthesized compounds resulted in reducing the g...

This study constitutes a new development of surface thermodynamic methods to determine the London dispersive surface free energy component γsd, the specific free energy of adsorption and the Lewis acid-base properties of polymers by using inverse gas chromatography (IGC) at infinite dilution. The net retention volumes Vn of n-alkanes and polar solv...

This study is designed to investigate the combination of gallocatechin (GC) and silver nanoparticles (AgNPs) for its wound healing ability in diabetic rats. Thirty male Sprague Dawley rats were randomly divided into 5 groups: 1. Normal control rats dressed with blank CGP1; 2. Diabetic rats dressed with blank CGP1; 3. Diabetic rats dressed with 13.0...

Studies on green biosynthesis of newly engineered nanoparticles for their prominent medicinal applications are being the torch-bearing concerns of the state-of-the-art research strategies. In this concern, we have engineered the biosynthesized Luffa acutangula silver nanoparticles of flavonoid O-glycosides in the anisotropic form isolated from aque...

The Natural Resources for Human Health (NRFHH): An interdisciplinary new journal dedicated to natural sciences is published by Visagaa Publishing House. The editorial board is leaded by Highly Cited Researcher Prof. Jesus Simal-Gandara, together with many other internationally recognised researchers. The editorial board comprises of 38 editors from...

The current investigation highlights the green synthesis of silver nanoparticles (AgNPs) by the insectivorous plant Drosera spatulata Labill var.bakoensis , which is the first of its kind. The biosynthesized nanoparticles revealed a UV visible surface plasmon resonance (SPR) band at 427 nm. The natural phytoconstituents which reduce the monovalent...

In this study, a novel nanohybrid composite containing nitrogen-doped multiwalled carbon nanotubes/carboxymethylcellulose (N-MWCNT/CMC) was synthesized for supercapacitor applications. The synthesized composite materials were subjected to an ultrasonication-mediated solvothermal hydrothermal reaction. The synthesized nanohybrid composite electrode...

A series of 3-amino-2-hydroxybenzofused 2-phosphalactones (4a–l) has been synthesized from the Kabachnik–Fields reaction via a facile route from a one-pot three-component reaction of diphenylphosphite with various 2-hydroxybenzaldehyes and heterocyclic amines in a new way of expansion. The in vitro anti-cell proliferation studies by MTT assay have...

A new series of urea/ thiourea derivatives have been efficiently synthesized from the reaction of L-3-hydroxytyrosine with selective isocyanates/ isothiocyanates and characterized by Infra-red, proton & carbon-13 nuclear magnetic resonance spectral and mass spectrometry studies. All the synthesized compounds have been screened for their antioxidant...

A series of novel α-furfuryl-2-alkylaminophosphonates have been efficiently synthesized from the one-pot three-component classical Kabachnik–Fields reaction in a green chemical approach by addition of an in situ generated dialkylphosphite to Schiff’s base of aldehydes and amines by using environmental and eco-friendly silica gel supported iodine as...

The novel Coronavirus disease (COVID-19) is an epidemic disease which appeared at the end of the year 2019 in a sudden increase in number and considered as a pandemic disease caused by a viral infection and it has threatened most countries towards the emergency search for new anti-SARS-COV drugs /vaccines. At present, the number of clinical trials...

Cinnamon is one of the most important tropical spices, which has different types of essential oils, bioactive compounds to help the human health in numerous ways. Cinnamic acid and cinnamaldehyde are the major derivatives present in this spice and possess antioxidants to combat several diseases and their complications. Antioxidants present in cinna...

Malaysia started the polio immunization programme since 1972 and achieved polio-free certification in 2000. After 27 years from the last reported polio case in 1992, on 8 December 2019, the Ministry of Health Malaysia announced the return of polio into the country when the first polio case detected in Sabah involving a 3-month-old male child. The c...

Acridone based synthetic and natural products with inherent anticancer activity advancing the research and generating a large number of structurally diversified compounds. In this sequence we have designed, synthesized a series of tetracyclic acridones with amide framework viz., 3-(alkyloyl/ aryloyl/ heteroaryloyl/ heteroaryl)-2,3-dihydropyrazino[3...

Despite the availability of various antidiabetic drugs, diabetes mellitus (DM) remains one of the world's most prevalent chronic diseases and is a global burden. Hyperglycaemia, a characteristic of type 2 diabetes mellitus (T2DM), substantially leads to the generation of reactive oxygen species (ROS), triggering oxidative stress as well as numerous...

BACKGROUND: Iodine can reduce breast tumor progression by mediates an antiproliferative effect. AIM: This study aimed to investigate the effect of iodine (I2), Lugol (I3K), and the combination of both on cell proliferation of three different types of breast cancer cell lines. METHODS: The samples were MCF7, SKBR3, and MDA-MB 213 cell lines. Cell pr...

The Inverse Gas Chromatography (IGC) technique has been employed for the surface thermo-dynamic characterization of the polymer Poly(vinylidene chloride-co-acrylonitrile) (P(VDC-co-AN)) in its pure form. IGC attributes, such as London dispersive surface energy, Gibbs free energy, and Guttman Lewis acid-base parameters were analyzed for the polymer...

A series of 1-aryl-2,3,4,9-tetrahydro-1H-_-carbolines were synthesized using green ultrasonic synthetic approach in aqueous medium via the Pictet-Spengler reaction. The condensation reaction of tryptamine and various aromatic aldehydes at 80oC in aqueous medium produced the corresponding 1-aryl-2,3,4,9-tetrahydro-1H-β-carbolines by means of heterog...

Since the Coronavirus disease 2019 (COVID-19) pandemic unfolded in China (Huang et al., 2020) back in December 2019, thus far, more than five million people were infected with the virus and 333,401 death were recorded worldwide (WHO, 2020b). The exponential increase in number shows that COVID-19 spreads faster compared to Severe Acute Respiratory S...

Emerging technologies such as computer vision and Artificial Intelligence (AI) are estimated to leverage the accessibility of big data for active training and yielding operational real time smart machines and predictable models. This phenomenon of applying vision and learning methods for the improvement of food industry is termed as computer vision...

Honey is a matrix of vegetal origin processed by various types of bees. Besides physical properties honey constitutes of several minor chemical constituents such as polyphenols and flavonoids. Phenolic compounds or polyphenols are basically products of the secondary metabolism of plants and so a major group of compounds occurring in honey. The colo...

A series of novel α-methyl-L-DOPA urea derivatives viz., 3-(3,4-dihydroxyphenyl)-2-methyl-2-(3-halo/ trifluoromethyl substituted phenyl ureido)propanoic acids (6a-e) have been synthesized from the reaction of α-methyl-L-DOPA (3) with various aryl isocyanates (4a-e) by using triethylamine (5, TEA) as a base catalyst in THF at reflux conditions. The...

Introduction: Interprofessional scientific communication skills are an essential part of the medical profession. Multiple research suggests poor interprofessional communication has direct correlations with poor patient outcomes. As part of the inaugural Multiple Mini Interview (MMI) at Universiti Malaysia Sabah, a 5-minute station on science commun...

A series of 1-(2,3-dihydro-1H-indan-1-yl)-3-aryl urea/thiourea derivatives (4a-j) have been synthesized from the reaction of 2,3-dihydro-1H-inden-1-amine (2) with various aryl isocyanates/isothiocyanates (3a-j) by using N,N-DIPEA base (Hunig's base) catalyst in THF at reflux conditions. All of them are structurally confirmed by spectral (IR, 1H &13...

A series of new α-aminophosphonates containing a potential anticancer active 4-chloro-6-methylpyrimidin-2-amino pharmacophore were synthesized. Background: α-Aminophosphonates are ever appealing to the interest of researchers due to their biological activities. Besides aminophosphoryl functionality which is responsible for the vital activity, inco...

Processed foods, generally known as modified raw foods produced by innovative processing technologies alters the food constituents such natural enzymes, fatty acids, micronutrients, macronutrients and vitamins. In contrast to fresh and unprocessed foods, processed foods are guaranteed to be safer, imperishable, long lasting and consist high level o...

Microwave heating technology is widely used in food catering and domestic households. Nonuniformity of microwave temperature distribution causes the formation of hot and cold spots in heated product has led to the survival of foodborne pathogens which may later cause food borne diseases. It is the aim of this study to determine the effect of differ...

Abstract The disposal of spent activated carbon (AC) will inevitably create secondary pollution. In overcoming this problem, the spent AC can be regenerated by means of biological approach. Bioregeneration is the phenomenon in which through the action of microorganisms, the adsorbed pollutants on the surface of the AC will be biodegraded and this e...

Background There are several health benefits that honeybee products such as honey, propolis, and royal jelly claim toward various types of diseases in addition to being food. Scope and Approach In this paper, the effects of honey, propolis, and royal jelly on different metabolic diseases, cancers, and other diseases have been reviewed. The modes o...

In the present study, silver nanoparticles (AgNPs) were synthesised by adding 1 mM Ag nitrate solution to different concentrations (1%, 2.5%, 5%) of branch extracts of Eurycoma longifolia, a well known medicinal plant in South-East Asian countries. Characterisation of AgNPs was carried out using techniques such as ultraviolet-visible spectrophotome...

The inverse gas chromatography study on the fluconazole drug surface was performed, and the net retention volumes, polar probes, and VN of n-alkanes are determined at four temperatures over the range 318.15–333.15 K. The net retention values of n-alkanes were used to evaluate the London dispersive surface free energy γSL by three different methods,...

Simultaneous biosorption and bioreduction experienced by Cr(VI) species was initially validated by mixing 500 µM of Cr(VI) with 0.20 g of sawdust biosorbent. Accordingly, a complete disappearance of Cr(VI) species with emerging of 25% of Cr(III) ions were recorded; evidencing both processes transpired simultaneously. Increasing of initial Cr(VI) co...

Methods: SLBH at 1 and 2g/kg/b.w. was given orally to streptozotocin (STZ)-nicotinamide-induced male diabetic rats for 28days. Metabolic parameters (fasting blood glucose-FBG and lipid profiles-LP and serum insulin) were measured by biochemical assays. Distribution and expression level of insulin, oxidative stress marker i.e. catalase, inflammator...

Background Coronary artery bypass graft (CABG) surgery is one of the major surgeries requiring long-term stay in hospital. This generally leads to the detrimental effects of bed-rest, including dependency in self-care, transfer, and locomotion. Our aim was to compare the effect of high-frequency and low-frequency exercise therapy in patients who ha...

Street-vended beverages are commonly prepared by mechanical extraction of the pulp, usually unpasteurised and requires multiple handling steps. Foodborne pathogens transmitted via skin of street vendors or via faecal-oral route may contaminate the preparation surfaces and beverages. The aim of this study is to identify Escherichia spp. strains of s...

Colon cancer is the third most common cancer and causes major mortality and morbidity throughout the world. Several factors including lifestyle, diet, obesity, heredity and increasing age increase the risk for colon cancer. Cancer nanotechnology is a new emerging field which has the potential to improve the detection, diagnosis, and treatment of co...

Advancement in materials synthesis largely depends up on their diverse applications and commercialisation. Antifungal effects of phytogenic silver nanoparticles (AgNPs) were evident, but the reports on the effects of the same on agricultural crops are scant. Herein, we report for the first time, size dependent effects of phytogenic AgNPs (synthesis...

Honey is a natural product produced by both honey bees and stingless bees. Both types of honey contain unique and distinct types of phenolic and flavonoid compounds of variable biological and clinical importance. Honey is one of the most effective natural products used for wound healing. In this review, the traditional uses and clinical application...

Background: Diabetes mellitus is a chronic disease and is one of the main public health concerns worldwide. To date, the potential of many natural products in its treatment are not fully explored. Materials and Methods: In this study, major phytochemicals present in the leaves and stems of Diospyros buxifolia were determined following extraction us...

Traditional medicinal plants have been consumed and practised by the Orang Asli of Peninsular Malaysia for centuries. Temiar is one of the sub-ethnics under the Orang Asli (Senoi) tribe. The Temiar ethic tribe utilises indigenous plants for treatment of illnesses and general healthcare. Since the indigenous people transmit knowledge orally; their k...

Effect of Rhinacanthin C on hyperglycemia, hyperlipidemia and pancreatic dysfunction in diabetes were investigated. In-vitro effect of Rhinacanthin C on glucose uptake was studied in 3T3-L1 cell line. Meanwhile, in-vivo effect of 28-days treatment with 5mg/kg/day or 20mg/kg/day Rhinacanthin C was studied in streptozotocin-nicotinamide induced male...

Cancer is a leading cause of death worldwide. Several classes of drugs are available to treat different types of cancer. Currently, researchers are paying significant attention to the development of drugs at the nanoscale level to increase their target specificity and to reduce their concentrations. Nanotechnology is a promising and growing field w...