Pascale Mauriège

Laval University | ULAVAL · Department of Kinesiology

Purpose While some work has been done on Health-Related Quality of Life (HRQoL) in statin users, none has focused specifically on statin-associated muscle symptoms (SAMS) sufferers. The objective was to assess self-reported HRQoL, before and after statin withdrawal, in patients reporting SAMS. We hypothesized that the presence of SAMS associated wi...

Background and Aims: Statin-associated muscle symptoms (SAMS) are frequently reported. Nevertheless, few data on objective measures of muscle function are available. Recent data suggesting an important nocebo effect with statin use could confound such effects. The objective was to assess if subjective and objective measures of muscle function impro...

Adipose tissue (AT) dysfunctions, such as adipocyte hypertrophy, macrophage infiltration and secretory adiposopathy (low plasma adiponectin/leptin, A/L, ratio), associate with metabolic disorders. However, no study has compared the relative contribution of these markers to cardiometabolic risk in women of varying age and adiposity. Body composition...

Vitamin D supplementation has been proposed to reduce the frequently reported statin-associated muscle symptoms (SAMS). The purpose of this study was to evaluate the potential benefits of this supplement in a randomized controlled trial. Men (n=23) and women (n=15) (50.5 ± 7.7 years [mean ± SD]) in primary cardiovascular prevention, self-reporting...

Although severe obesity is associated with insulin resistance (IR) and inflammation, secretory function of intra-abdominal adipose tissues and their relationships with IR and inflammation markers remain poorly understood. Aims were to measure gene expression of adipogenic (C/EBPα/β, PPARγ-1/2, SREBP-1c, LXRα), lipogenic (SCD1, DGAT-1/2), angiogenic...

Statins are benchmark lipid-lowering drugs, reducing blood cholesterol by controlling its synthesis. Numerous side effects are linked to statin use, notably at the level of skeletal muscle. The present study evaluated the subjective and objective effects of statin withdrawal in patients. Thirty-eight men and twenty-three women (53.0 ± 8.5 years [me...

Numerous classifications are used to discern metabolically healthy obese (MHO) from metabolically abnormal obese (MAO) individuals. The goal of this study was to compare a single phenotype approach, adiposopathy (i.e., the plasma adiponectin/leptin ratio), with four commonly used classifications (International Diabetes Federation (IDF), Karelis, Ly...

Optimizing traditional training methods to elicit greater adaptations is paramount for athletes. Ischemic preconditioning (IPC) can improve maximal exercise capacity and up-regulate signaling pathways involved in physiological training adaptations. However, data on the chronic use of IPC are scarce and its impact on high-intensity training is still...

Background: Methylamine, a natural soluble amine present in foods, is known to be a substrate of primary amine oxidase (PrAO) widely expressed in animal tissues. Methylamine has been reported to activate glucose transport in fat cells and to facilitate glucose disposal in rabbits but the interests and limits of such insulin-mimicking actions have n...

Purpose: Apolipoprotein D (ApoD) is a lipocalin participating in lipid transport. It binds to a variety of ligands, with a higher affinity for arachidonic acid, and is thought to have a diverse array of functions. We investigated a potential role for ApoD in insulin sensitivity, inflammation, and thrombosis-processes related to lipid metabolism-in...

The objective of this pilot study was to compare the effects of a high-intensity interval training (HIIT) and a moderate intensity continuous training (MICT) performed within a fitness center, on various health indices of 49 sedentary and moderately obese women (age 37 ± 7 years; BMI 32 ± 4 kg/m2) randomly assigned to supervised exercise on a cycle...

The contribution of adiposopathy to glucose-insulin homeostasis remains unclear. This longitudinal study examined the potential relationship between the adiponectin/leptin ratio (A/L, a marker of adiposopathy) and insulin resistance (IR: homeostasis model assessment (HOMA)), insulin sensitivity (IS: Matsuda), and insulin response to an oral glucose...

PURPOSE: Physical activity in elderly persons contributes to prevention and treatment of the negative effects of age on muscle performance and, in turn, increases physical capability and improves muscle function and condition. This pilot study evaluated the effects of six weeks of supramaximal-exercise training (SET) on fitness variables and Rating...

This study evaluated the effects of 6 weeks of high-intensity interval training (HIIT) on mechanical efficiency (ME) in young and older groups. Seventeen healthy young adults [26.2(2.4) year], and thirteen healthy older adults [54.5(2.3) year] completed a 6-week HIIT intervention (three sessions per week) on an electromagnetically braked cycle ergo...

The purpose of this study was to evaluate the effects of 6 weeks of supramaximal exercise training (SET) on performance variables and metabolic changes in sedentary obese adults. Twenty-four obese adults were randomly allocated into a non-trained (NT) [n = 12; body mass index (BMI) = 33(3)] and SET group [n = 12; BMI = (33(2)]. After baseline metab...

Semicarbazide-sensitive amine oxidase (SSAO), identical to primary amine oxidase or vascular adhesion protein-1, is a membrane enzyme that generates hydrogen peroxide. SSAO is highly expressed at the adipocyte surface, and its plasma levels increase with type 2 diabetes. Since visceral adipose tissue (AT) is more tightly associated with obesity com...

Piceatannol is a hydroxylated derivative of resveratrol. While both dietary polyphenols coexist in edible plants and fruits, and share equivalent concentrations in several wines, the influence of piceatannol on adiposity has been less studied than that of resveratrol. Though resveratrol is now recognized to limit fat deposition in various obesity m...

Adiposopathy, or sick fat, refers to adipose tissue dysfunction that can lead to several complications such as dyslipidemia, insulin resistance, and hyperglycemia. The relative contribution of adiposopathy in predicting insulin resistance remains unclear. We investigated the relationship between adiposopathy, as assessed as a low plasma adiponectin...

Gene expression (qPCR) was compared in round ligament (RL), omental (OME) and mesenteric (MES) ATs from 48 severely obese women (BMI, 54±11 kg/m2; 38±9 yrs). The mRNA levels of enzymes of lipid metabolism (LPL, HSL, and PDE-3B), cortisol production (11βHSD-1), adipogenesis (PPAR-γ/ thrombosis and inflammation (PAI-1, IL-6, TNF-α and adiponectin) we...

Despite well-established variations in the health risks posed by visceral vs. subcutaneous abdominal (SCABD) fat depots, surprisingly little is known on the differences within a given adipose tissue (AT) among severely obese patients displaying varying metabolic dysfunction. We thus compared, by quantitative PCR, the expression profile of a number...

Background: Sarcopenic obese (SO) individuals are a unique subset of subjects that combines obesity and sarcopenia. Traditional weight loss programmes including aerobic exercises may worsen their condition by further reducing their lean mass. The objective of this observational and retrospective study was to verify the effect of a mixed weight los...

The aim of this study was to evaluate the impact of brisk walking on physical fitness, body composition and fasting lipid-lipoprotein profile of women 50-65 years-old, once adherence or exercise intensity is considered. A sample of 159 healthy, sedentary, obese postmenopausal women (body mass index [BMI]=29-35kg/m(2)) was subjected to 3 sessions/we...

Numerous controversies surround the peptide hormone irisin. Although implicated as a myokine promoting the browning of adipose tissue in rodents, its roles in humans remain unclear. Contradictory results have also been found with respect to the relationships between adiposity or metabolic health and plasma irisin levels in humans. We investigated t...

The objective of the study was to examine the effects of a 16-week walking program on food group preferences and energy balance of sedentary, moderately obese (body mass index, 29-35 kg/m(2)), postmenopausal Caucasian women, aged 60 ± 5 years old. One hundred and fifty-six volunteers were subjected to 3 sessions/week of 45 min of walking at 60% of...

The first objective of this study was to evaluate the impact of brisk walking on moderately obese (body mass index, 29-35 kg/m) postmenopausal women's perceived health, assessed through a novel short perceived health questionnaire (SPHQ), and to verify whether improvements in six items examined were related to cardiorespiratory fitness (CRF) and/or...

This study was performed to examine whether changes in subcutaneous adipose tissue (SCAT) metabolism indices after weight loss were related to the magnitude of weight regain. Nine men and ten premenopausal women whose body mass index ranged from 30 to 42 kg/m(2), 35-48 years old, were studied before and after a 15-week weight loss program, as well...

Background The effects of an intensive lifestyle intervention including Mediterranean diet nutritional counseling and high-intensity interval training (HIIT) on body composition, cardiometabolic and exercise parameters were studied in metabolically non-healthy obese (MNHO) and metabolically healthy but obese (MHO) subjects. Methods Fifty five MHO...

Objective The aim of this study was to examine the effects of a dancing-therapy associated with a 3-week weight-reducing program which combined aerobic physical activity and diet, on eating behaviors and self-esteem, in obese and sedentary women. Methods Eating behaviors (Three-Factor Eating Questionnaire, TFEQ) and self-esteem (Rosenberg scale),...

Objective: The aim of this study was to examine the effect of brisk walking on cardiometabolic risk profile and on the gene expression (ie, messenger RNA [mRNA] levels) of inflammatory and thrombotic markers in abdominal and femoral subcutaneous adipose tissues (SATs) among sedentary overweight to obese women with different menopause statuses. Me...

Fatty acids (FAs) and adipokines such as adiponectin or interleukin-6 (IL-6) are known to modulate inflammation and the development of metabolic syndrome. Whether FA composition assessed in plasma triacylglycerols (TAGs), phospholipids (PLs) and non-esterified fatty acids (NEFAs) and adipose tissue (AT) PLs differed between dysmetabolic and non-dys...

Venn diagrams showing the number of genes differentially expressed in the three pairwise comparisons. A) and B) shows the number of differentially up- and down-regulated genes, respectively. There was no significant gene down-regulated in EAT compared to MAT. (JPG)

Heat map showing the expression of inflammatory and immune cell markers in the microarray experiment. A) EAT vs MAT, B) EAT vs SAT, and C) MAT vs SAT. The samples and genes are illustrated in columns and rows, respectively. Red and green represent high and low expression, respectively. Gene symbols are provided on the right side of each panel with...

SAM output listing all the significant up- and down-regulated probes in the comparisons EAT vs MAT. (XLS)

SAM output listing all the significant up- and down-regulated probes in the comparisons EAT vs SAT. (XLS)

Top 10 genes significantly up- and down-regulated in EAT vs SAT. (DOC)

Top 10 genes significantly up- and down-regulated in MAT vs SAT. (DOC)

SAM output listing all the significant up- and down-regulated probes in the comparisons MAT vs SAT. (XLS)

Top 10 genes significantly up- and down-regulated in EAT vs MAT. (DOC)

A) EAT, B) MAT, and C) SAT intrapair correlation coefficients obtained from normalized expression data. (PNG)

RNA extraction yields and RNA integrity of the microarrays samples measured with the 2100 Bioanalyzer (Agilent). (DOC)

The biological functions of epicardial adipose tissue (EAT) remain largely unknown. However, the proximity of EAT to the coronary arteries suggests a role in the pathogenesis of coronary artery disease (CAD). The objectives of this study were to identify genes differentially regulated among three adipose tissues, namely EAT, mediastinal (MAT) and s...

Cardiac rehabilitation programs are well recognized as being essential to the comprehensive care of patients with cardiovascular disease and chronic heart failure. These programs aim at reducing cardiovascular risks, promoting healthy lifestyle behaviours and compliance as well as limiting disability and increasing quality of life (QoL) of cardiac...

The aim of this study was to examine regional variation in adipose tissue lipoprotein lipase (AT-LPL) activity and expression in pre-and postmenopausal women, before and after training, once differences in chronological age or obesity degree are taken into account. Sixteen late pre- and 14 early postmenopausal (49 +/- 2 vs. 52 +/- 2 years; p < 0.00...

Plasminogen activator inhibitor type-1 (PAI-1) has already been associated with atherosclerosis; myocardial infarction; and cardiovascular disease risk factors such as obesity, insulin resistance, and dyslipidemia. However, factors regulating PAI-1 adipose tissue (AT) gene expression and plasma levels are not yet well defined. This study aims to as...

Aerobic exercise is known to improve health-related quality of life (QoL). The aim of this study was to compare the effects of a 16-week walking program on eating behaviors and QoL between late premenopausal and early postmenopausal obese and sedentary women, once chronological aging is taken into account. Sixteen women 49 +/- 2 years old and 14 wo...

Menopause transition is associated with an increased prevalence of metabolic syndrome (MS), which may partly explain the higher coronary heart disease risk. The aim of this study was to examine the impact of a 16-week walking program on the metabolic risk profile of women 50 to 65 years old whose body mass index ranged from 29 to 35 kg/m. A total o...

In order to better understand the link between obesity and type 2 diabetes, lipolysis and its adrenergic regulation was investigated in various adipose depots of obese adult females SHR/N-cp rats. Serum insulin, glucose, free fatty acids (FFA), triglycerides (TG) and glycerol were measured. Adipocytes were isolated from subcutaneous (SC), parametri...

To examine the effects of a short-term weight reducing program on body composition, eating behaviors, and health-related quality of life (HRQL) of sedentary obese women characterized by different obesity degrees. 44 women with a BMI under 34.9 kg/m(2) and 39 women with a BMI above 35 kg/m(2) were studied. Fat mass and lean mass (electrical bioimped...

A moderate weight loss of 5 to 10% has been shown to induce several improvements in the cardiometabolic profile of high risk obese patients and is therefore generally recommended as a clinically meaningful therapeutic target. The SYNERGIE study is a lifestyle modification program which aims at reshaping the nutritional and physical activity habits...

The duration of the numerous weight-loss studies that combine physical activity and diet varies from 3 to 14 months, and these studies have often considered pre- and postmenopausal women separately. The purpose of this study was to compare the effects of a 3-week weight-reducing program that combines caloric restriction and exercise on the metaboli...

The increased prevalence of obesity is a key factor in the emergence of metabolic syndrome and its associated comorbidities in women. In addition, menopause is often accompanied by a number of physiological changes including increased body weight and increased visceral fat mass, which are reflected by an increase in waist circumference, one of the...

Obese Zucker rat is often used as a model of genetic obesity to understand the mechanism of the development of obesity. In the present work, in order to better understand the regulation of lipolysis in the Zucker rat, the lipolytic activities of adipocytes isolated from different adipose depots of lean and obese Zucker rats, in the basal state or a...

The present retrospective study aims to provide additional evidence supporting the fact that waist circumference, in severe obesity, is not a good clinical marker to identify individuals with the metabolic syndrome or an altered metabolic profile. Relationships between waist circumference and metabolic profile of pre- (n=165) and postmenopausal (n=...

IntroductionTo study the effect of age and obesity on the physical condition, functional capacities and eating behaviors of premenopausal, sedentary women.

To examine the impact of a 3-week weight-reducing program on body composition, physical condition, health-related quality of life, and eating behaviors of sedentary, obese (body mass index, 29-35 kg/m) women, according to menopausal status and menopause duration (<5, >or=5, and >or=10 y). Thirteen premenopausal and 27 postmenopausal women received...