Pascal Borget

Biomatlante · R&D

Biphasic calcium phosphate (BCP) bioceramics (hydroxyapatite/tricalcium phosphate, or HA/TCP) for tissue engineering and drug delivery systems is a unique know-how. A mechanical mixture of HA and TCP does not lead to such bioactive ceramics. The wet elaboration conditions of calcium-deficient apatite (CDA) or CDHA, followed by sintering, converts i...

Bioceramics draw attention in bone tissue engineering field since their biomimetic properties regarding bone attribute. In this context, a concept of smart bioceramics granules made of Hydroxyapatite have been set up, enhancing surface area available to body fluids containing proteins and cell adhesion for bone forming respectively thanks to microp...

There are numerous clinical indications for bone grafts. The ideal graft material should favor bone apposition and growth while simultaneously being degraded by body fluids and cells. Ultimately, the material should be replaced by mature bone tissue within a healing period of weeks. Because autologous and allogenic bone grafts fulfill some of these...

The present study focuses on the physico-chemical and structural properties of composite scaffolds composed of biopolymer matrices (collagen or polysaccharide) loaded with calcium phosphate granules. A systematic three-dimensional analysis method was used to quantitatively characterize a series of plugs, strips and putties in terms of percentage of...

Bioceramics combined with isolated stem cells, or with total bone marrow, constitute the main strategies under consideration in the field of bone tissue engineering. In the present preclinical study, two biphasic calcium phosphate scaffolds currently on the market, MBCP® and MBCP+®, with different hydroxyapatite/β-tricalcium phosphate ratio, were i...

It is often necessary to restore bone structure following the loss of osseous substance. Therefore, the use of bone substitutes made of synthetic calcium phosphate (CaP) ceramics has become more widespread. Granular forms of these biomaterials have demonstrated osteogenic capacities within various sites. Recently, a combination of CaP microporous g...

Heat-induced osteonecrosis represents a simple, rapid, and inexpensive method for reproducing the effects of bone disease. In the present study, we employed this technique to induce osteonecrosis in femoral defects in rabbits and assessed the efficacy of treatment using Biphasic Calcium Phosphate (BCP) granules (MBCP+™, Biomatlante SA). After 3 wee...

Physico-chemical characteristics impact directly or indirectly the bioactive properties of biomaterials, it is then essential to correlate it with their effect in vivo. A panel of biomaterials available on the market, based on Hydroxyapatite (HA) and Tricalcium phosphate (β-TCP) is studied in terms of surface area, hydrophilicity, porosity, zeta po...

Calcium phosphate bioceramic granules associated with hydrosoluble polymers formed putties currently more used in clinical applications as they are easy to handle (injectability, moldability). In this study, 2 kinds of materials were tested in rabbit bone defects. The first one is In'Oss (TM) (Biomatlante), a microporous biphasic CaP granules (BCP,...

The main goal of this study was to succeed in the relevant association of well-known osteoconductive biphasic calcium phosphate (BCP) made of Hydroxyapatite (20% HA) and β-Tricalcium Phosphate (80% β-TCP) crystallographic phases and resorbable poly (L-lactide-co-D,L-lactide)(PLDLLA) 3D matrices synthesized by electrospinning. Two types of mineral p...

The development of CaP ceramics involved a better control of the process of resorption and bone substitution. Micro Macroporous Biphasic CaP, (MBCP+) is a concept based on an optimum balance of the more stable phase of HA and more soluble TCP. The material is soluble and gradually dissolves in the body, seeding new bone formation as it releases Ca...

The objective of this study deals with preclinical and clinical cases of absorbable composite interference screws of next generation in osteoarticular surgery. These implants are made of resorbable polymers PLA either amorphous or semi-cristalline, associated with granules of microporous biphasic calcium phosphate ceramic. A preclinical study was p...

The GAMBA Consortium is developing a novel gene-activated matrix platform for bone and cartilage repair with a focus on osteoarthritis-related tissue damage. The scientific and technological objectives of this project are complemented with an innovative program of public outreach, actively linking patients and society to the evolvement of this proj...

Due to the lack of macroporosity in current available Calcium Phosphate cement used in osteoarticular surgery, Micro and Macroporous Biphasic CaP Cement (MCPC™) was developed. The MCPC™ concept was the association of a settable and a fast resorbable matrix and a sieved fraction of microporous biphasic calcium phosphate (BCP) granules, recognized fo...

Different resorbable apatitic calcium phosphate bone cements are currently used. They present good mechanical properties and reasonable setting times. However they remain dense and do not provide rapid bone substitution because of the lack of macroporosity. The present study compared 3 kinds of CaP cements presenting different crystallinity charact...

In this article we shall describe our quest and ultimate success in furthering our understanding of the action of superplasticizers on the rheology of cement and concrete. By specifically producing superplasticizers with varied architectures, we have been able to show the important structural features of the macromolecules that lead to a successful...

Researchers of various research institutes in Belgium have conducted a study for the treatment of bone defects using MG-63 osteoblast culture on poly (lactic acid) degradable textiles. MG-63 osteoblast-like cells were implanted in multi-wells plates containing fabrics and cultured for 3, 6, 12, and 24 days respectively. Deoxyribonucleic acid (DNA)...

Different polycarboxylate polymers (PCPs) have been characterised and their microstructure investigated by size exclusion chromatography, 1H and 13C nuclear magnetic resonance spectroscopy. These polymers are comb-like with a sodium polymethacrylate backbone (PMAANa) on which poly(ethylene oxide) (PEO) chains are randomly grafted as shown by 13C NM...

Industrial latex composed of a hydrophobic core surrounded by a charged hydrophilic layer exhibits excellent stability toward monovalent salt. That feature is classically attributed to a steric effect due to a loss of entropy during overlapping of coating materials. The so-called electrosteric stabilization is, however, not a straightforward functi...

Interactions between polycations and core-corona particles are governed by ion-exchange reactions, entropically favored by the release of counterions. This complexation process allows the chains to penetrate into the shell, leading to adsorbed amounts greater than 1 mg m(-2). The destabilization occurs quickly, the domain of flocculation becomes la...