Parviz Deyhimi

• Isfahan University of Medical Sciences

Statement of the problem: The biologic behavior and histopathological features of fibromatosis are intermediate between those of fibroma and fibrosarcoma. Purpose: The aim of the present study was to determine useful histopathologic and immunohistochemical characteristics for the differentiation of these lesions. Materials and method: In this...

Statement of the problem: Pemphigus vulgaris is characterized by intraepithelial vesicles, but pathogenesis of vesicle formation in this disease has not been substantiated yet. Purpose: The present study investigate extrinsic apoptotic pathway in oral pemphigus vulgaris using TUNEL and important immunohistochemical markers of extrinsic pathway,...

Objective The exact pathogenesis of lichen planus (LP) is still unknown and there are some controversies concerning role of apoptosis in its creation. The purpose of the present study is to investigate extrinsic apoptotic pathway in oral lichen planus(OLP). Methods In the present cross-sectional study, the presence of apoptosis was investigated on...

Introduction: Spindle cell carcinoma (SpCC) is an unusual subtype of squamous cell carcinoma with an aggressive behavior. The occurrence of this tumor in maxillary sinus has rarely been reported. Case Presentation: This case report describes the diagnosis, management, and follow-up of a 35-year-old female, who presented with Spindle cell carcinoma...

Primary oral melanomas are uncommon malignant neoplasm of melanocytes origin. The most common site of oral melanoma is maxillary gingiva and hard palate. Oral mucosal melanoma exhibit a pathobiological behavior and clinical features different from cutaneous melanomas. Oral melanomas are often clinically silent which may consequently result in delay...

Stafne bone cavities (SBCs) are uncommon well-demarcated defects of the mandible, which often occur in the posterior portion of the jaw bone and are usually asymptomatic. Furthermore, SBC is found in men aged 50-70-year-old. Anterior mandibular variants of SBC are very rare. This article describes a case of anterior SBC in a 45-year-old man that re...

Introduction: Small cell neuroendocrine carcinomas (SmCCs) of the salivary glands are rare high grade malignant neoplasms, and the identification of these lesions is often difficult. Histopathological features alone are not sufficient for the diagnosis of SmCCs, and immunohistochemical (IHC) staining is almost always mandatory for confirming the di...

Statement of the Problem: When the body defense is compromised, wounds can act as a route for entrance and colonization of microorganisms in the body. Photodynamic therapy with methylene blue is known as a promising antimicrobial modality. Purpose: The present study aimed to investigate the effects of this procedure on wound healing processes. Ma...

Primitive neuroectodermal tumors (PNETs) are a family of highly malignant soft tissue neoplasms mostly occurring in children and young adults. PNETs usually develop in the thoracopulmonary region, abdomen, pelvis, and rarely in the head and neck region. Here, a case of PNET located in the parotid gland is reported. © 2015, Academy of Medical Scienc...

Oral squamous cell carcinoma is the most common malignant lesion of the oral cavity, and it involves various molecular mechanisms. The development of oral squamous cell carcinoma is influenced by the host immune cells, such as eosinophils. The present study was conducted to compare the presence of eosinophils in normal mucosa, dysplastic mucosa, an...

Background: Fibromatosis includes a variety of fibroblastic proliferation whose biological trend and histopathological patterns are at intermediate level between benign fibroblastic lesions and fibrosarcoma. Accordingly, because of overlapping of histopathologic features of fibrosarcoma, particularly low-grade type, with fibromatosis, the present s...

Leukemia is a neoplastic disease with early oral and periodontal manifestations such as ulceration, infection, bleeding and gingival hyperplasia. This paper describes a 39-year-old pregnant woman with a diagnosis of acute myelomonocytic leu-kemia (AML), with gingival enlargement in the upper and lower jaws. A gingival biopsy was performed, followed...

Background: The association of Epstein-Barr virus (EBV) with Burkitt's lymphoma (BL) is variable in different geographic regions. In developing countries, the association of EBV with BL is regarded to be of an endemic-type in equatorial Africa (> 95%) and sporadic-type in the developed countries (15-30%). The purpose of this study is to assess the...

Oral squamous cell carcinoma (SCC) is the most common cancer of oral region. The characteristic feature of SCC is invasion of dysplastic epithelium into the connective tissue. Oral SCC is more common in old patients. It is believed that etiology and pathogenesis of SCC in young patients differ from old patients and it is related to different molecu...

Odontogenic keratocyst (OKC) is an aggressive cyst, and its recurrence rate is higher than that of other odontogenic cysts. Orthokeratinized odontogenic cyst (OOC) is less aggressive than OKC, but bears the probability of carcinomatous changes. In this study, we evaluated the expression and intensity of the P53 and TGF-alpha in order to compare the...

Lymphoma is a malignant neoplasm of lymphoid tissue which is divided into 2 groups: Hodgkin and non-Hodgkin. About 85% of non-Hodgkin lymphomas are B-cell lymphomas, and T-cell lymphomas are unusual. Anaplastic large cell lymphoma (ALCL) is a kind of non-Hodgkin lymphoma with T or NK cell origin that is rarely seen in the oral cavity and only 10 ca...

Odontogenic keratocyst (OKC) is an aggressive cyst and its recurrence is higher than other odontogenic cysts, orthokeratinized odontogenic cyst (OOC) is a cyst with moderate biological behavior in comparison with OKC, but with the probability of carcinomatous changes. The present study aims to evaluate the quantity and intensity of the expression o...

Background Pemphigus vulgaris (PV) is an autoimmune mucocutaneous disease presenting clinically with blisters or erosions of the skin and mucous membrane. The main histopathologic characteristic of this disease is suprabasal vesicles due to loss of cell–cell adhesion between keratinocytes named acantholysis. Studies have shown that apoptosis is inc...

Heat shock proteins (HSPs) are a family of proteins that are known to play a significant role in the repair of denatured proteins in the cell. It seems that cytoprotective properties of HSPs may help in malignant progression by facilitating tumor cell growth and survival. The purpose of this study is to evaluate HSP27 and HSP70 expression in variou...

The aim of this study was to identify the specific markers of T helper 17 (Th17) cells and their variations in people suffering from chronic periodontal disease in comparison with normal control subjects. In 30 patients with periodontitis and 30 normal control subjects, the mRNA expressions of interleukin (IL)-17A and retinoic orphan receptor C2 (R...

حفره دهانی به سبب موقعیت آناتومیک ویژه و اعمال مختلف خود، مانند جویدن، به طور مداوم در معرض تحریکات مزمن و مستمر گوناگون است. به همین دلیل، ضایعات بسیاری در دهان به نام ضایعات واکنشی یا تحریکی (Reactive) یا شبه تومورال در واکنش به این تحریکات مزمن و مستمر ایجاد می‌شوند. عوامل محرک مزمن حفره دهان شامل عوامل میکروبی، عوامل شیمیایی و دارویی، عوامل ترو...

Introduction: Primary extracranial and extraspinal meningioma is a rare tumor which is usually limited to head, neck or paravertebral soft tissues. Case report: This is the report of a 47-year-old man with a swelling on the right side of his face over the mandibular area. On examination a mass with firm consistency and an approximate diameter of 4...

•Introduction: Ewing's Sarcoma is a distinctive primary malignant tumor of bone that is composed ofsmall undifferentiated round cells of uncertain histogenesis. 4% of cases involve craniofacial bone, and1% is seen in jaws.•Case report: The patient was a 16 years old girl that referred for a nodule in the soft tissue ofvestibule near the roots of ca...