Parvin Kumar

Parvin Kumar
Kurukshetra University | KUK · Department of Chemistry

Ph.D.

About

116
Publications
9,430
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1,166
Citations
Citations since 2016
81 Research Items
1021 Citations
20162017201820192020202120220100200300
20162017201820192020202120220100200300
20162017201820192020202120220100200300
20162017201820192020202120220100200300
Introduction
Parvin Kumar currently works at the Department of Chemistry, Kurukshetra University. Their current project is 'hypervalent iodine'. And QSAR BASED Design of bioactive heterocyclic compounds
Additional affiliations
November 2010 - present
Kurukshetra University
January 2009 - present
Gurur nanak khalsa college
Position
  • oxidation of 1,4-DHP derivatives using different reaction conditions
April 2007 - July 2008
Bharat Rasayan Limited
Position
  • agrochemicals pesticide synthesis
Description
  • Bharat Rasayan Limited

Publications

Publications (116)
Article
In the present manuscript, uncoated and citric acid-coated magnetic nanoparticles were synthesized and characterized using various techniques. The manuscript mainly focuses on the adsorption study of the citric acid-modified magnetic nanoparticles for dye adsorption from the solution. The effect of several factors, including adsorbent amount, adsor...
Article
Full-text available
Extensive dispersal of the pesticides to shield the different types of vegetation from pests has increased the production but at the same it has resulted into increase in environmental pollution. Consequently, it is necessary to eliminate these undesired pollutants from the environment. The current investigation offers the synthesis of humic acid-c...
Article
Monoamine oxidase enzyme is necessary for the management of brain functions. It oxidatively metabolizes monoamines and produces ammonia, aldehyde and hydrogen peroxide as by-products. Excessive production of by-products of monoamine metabolism generates free radicals which cause cellular apoptosis and several neurodegenerative disorders for example...
Article
A series of macrocyclic Cu²⁺, Ni²⁺, and Co²⁺ complexes was synthesized using a template reaction between triethylenetetramine and dibenzoylmethane. These complexes may be represented by the general formula [M(C21H26N4)X2], where M = Cu²⁺, Ni2+, and Co²⁺ and X = NO3ˉ, Clˉ, and CH3COOˉ. Various techniques, including elemental analysis, molar conducta...
Article
Heteroleptic ternary terbium complexes with general representation as [Tb(acac)3 L] have been prepared through single step path with acetylacetone (acac) as chromophoric and substituted 2,2ꞌ-bipyridine as auxiliary (L) moieties. The synthesized complexes are characterized systematically through elemental, spectroscopic and thermogravimetric analyse...
Article
In the present manuscript, we have endeavored to construct quantitative structure Gibb’s free energy of activation relationship (QSGFEAR) models having general applicability and thorough validation. The experimental data of Gibb’s free energy of activation (∆G‡) at seven different temperatures was employed as the endpoint and the descriptor of corr...
Article
The application of QSAR along with other in silico tools like molecular docking, and molecular dynamics provide a lot of promise for finding new treatments for life-threatening diseases like Type 2 diabetes mellitus (T2DM). The present study is an attempt to develop Monte Carlo algorithm-based QSAR models using freely available CORAL software. The...
Article
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In the ecotoxicological risk assessment, acute toxicity is one of the most significant criteria. Green alga Pseudokirchneriella subcapitata has been used for ecotoxicological studies to assess the toxicity of different toxic chemicals in freshwater. Quantitative Structure Activity Relationships (QSAR) are mathematical models to relate chemical stru...
Article
Health and environmental hazards by benzene and nitrobenzene derivatives has remained topic of interest of researchers. In silico methods for prediction of toxicity of chemicals have proved their worth in accurate forecast of environmental as well as health toxicity and are strongly recommended by regulatory authorities. Two quantitative structure-...
Article
In the present manuscript, a novel 2-((4-chlorophenyl)amino)-N'-(4-(diethylamino)-2-hydroxybenzylidene)thiazole-4-carbohydrazide (H1) has been synthesized and characterized using various spectroscopic techniques including 1D, 2D NMR, FT-IR and single-crystal XRD. Various electrostatic parameters such as frontier molecular orbital (FMO), natural bon...
Article
A series of lanthanide (samarium and terbium) β‐diketonates with heteroaromatic auxiliary ligands have been synthesized. The prepared complexes were characterized through electrochemical, thermal and spectroscopic analyses. Infrared analysis reveals the binding of respective metal ion to oxygen and nitrogen atoms of diketone and ancillary ligands r...
Article
The 1,4-naphthoquinone skeleton is an important pharmacophoric unit found in many biologically active natural products and many well-known chemotherapy agents, such as alkannin, shikonin, and doxorubicin. Among naphthoquinones, 1,4-naphthoquinones with electron donor amino substituents on 2- and 3- positions are captodatively substituted biradicalo...
Article
Octacoordinated ternary heteroleptic lanthanide (Sm and Tb) complexes have been synthesized with diacetylmethane (DAM) and substituted 1,10-phenanthroline auxiliary units. The synthesized complexes were thoroughly characterized through electrochemical, thermal and spectroscopic studies. Photoluminescence emission spectral profiles have demonstrated...
Article
The quantitative structure-retention relationship (QSRR) is a significant approach in chromatography and is used to predict the retention time of unknown compounds. In the present research article, the QSRR approach is employed to develop robust models of 1176 flavor and fragrance compounds on the OV-101 glass capillary gas chromatography column us...
Article
A series of samarium β-diketonates comprising nitrogen-heterocyclic auxiliary moiety were synthesized and characterized spectroscopically. A comprehensive analysis of complexes suggests the octacoordinated environment about samarium ion and similar structural behavior of complexes. The samarium ion is coordinated via carbonyl oxygen of diketone uni...
Article
The photophysical and optoelectronic characteristics of a series of ternary europium complexes having general formula [Eu(TFNB)3L] were estimated in detail. The synthesized octa coordinated complexes have different heteroaromatic ancillary ligand (L) i.e., 1,10-phenanthroline (Phen) derivatives. The synthesized heteroleptic europium complexes were...
Article
A series of luminous europium complexes were synthesized with general formula Eu(DAM)3L ; DAM symbolizes diacetylmethane and L refers to the substituted 1,10-phenathroline derivatives. Results of spectral analyses affirm the binding of Eu³⁺ ion with DAM and heteroaromatic auxiliary units via oxygen and nitrogen atoms respectively. From Tauc’s plot,...
Article
In the present study, ninety-five halogenated dioxins and related chemicals (dibenzo-p-dioxins, dibenzofurans, biphenyls, and naphthalene) with endpoint pEC50 were used to develop twelve quantitative structure toxicity relationship (QSTR) models using inbuilt Monte Carlo algorithm of CORAL software. The hybrid optimal descriptor of correlation weig...
Article
The goal of the present study was to use a quantitative structure-retention relationship (QSRR) for the retention indices of 1179 flavour and fragrance organic compounds using the Monte Carlo algorithm of CORAL software. All the organic compounds were represented by SMILES notation for computation of descriptor of correlation weight (DCW). The data...
Article
Full-text available
In the present era of the industrial revolution, we all are familiar with ever-increasing environmental pollution released from various chemical processes. Chemical production has had a severe impact on the environment and human health. For the betterment of our environment, the chemical community has turned their interest to developing green, harm...
Article
In present study, Meldrum’s acid modified magnetite nanoparticles (MA-Fe3O4) were synthesized for the removal of methylene blue by co-precipitation method. These coated nanoparticles were examined by TGA, FESEM, XRD, FTIR and UV-vis analysis. The FESEM results depicted that mean size of modified superparamagnetic iron oxide nanoparticles (SPIONs) w...
Article
In the present manuscript, 2-aryliminothiazolidin-4-ones (3 and 5) were utilized as dynamic chemical systems, whose different states are modulated in a reversible fashion through specific chemical stimuli. The in-depth NMR...
Article
The use of synthetic packaging materials and mulch films has retrogressive environmental effects. To replace these synthetic materials, high strength biodegradable polymer blends are synthesized using pectin, guar gum and polyvinyl pyrrolidone (PVP). The ternary blends are prepared with guar gum (10%-50%) and PVP (30%-50%), using the solvent castin...
Article
Green luminescent complexes of terbium based on derivatives of 1,10-phenanthroline auxiliary ligand and 1-phenyl-1,3-butanedione (PBD) with general formula [Tb(PBD)3L] were synthesized. The complexes were characterized by spectroscopic and thermal methods. Photoluminescence spectra demonstrated that on excitation under UV radiations, four emission...
Chapter
The present chapter highlights the recent advancement in the field of fused pyrrolotetrazoles in terms of new synthetic methodologies, structural features and newer application in the field of biology. A detailed discussion of the theoretical aspects of tautomerism has been included in this chapter. Novel Sugar fused pyrrolotetrazoles based analogs...
Article
Full-text available
The rising possibilities of quantum dots in biological fields have raised significant concerns about their toxicological influence, and there is a requirement of methods for prediction of toxic quantum dots. In the current research work, quantitative feature toxicity relationship models for HEK cells cytotoxicity of forty one CdSe/CdTe/CdZnS core q...
Article
Full-text available
Correction for ‘Ecotoxicological prediction of organic chemicals toward Pseudokirchneriella subcapitata by Monte Carlo approach’ by Shahram Lotfi et al. , RSC Adv. , 2022, 12 , 24988–24997, https://doi.org/10.1039/D2RA03936B.
Article
Liver toxicity of quantum dots varies with size, concentration, and other structural as well as experimental parameters. For modeling hepatotoxicity, the eclectic data associated with cadmium containing quantum dots have been used in the creation of quasiSMILES for their representation. The core diameter is normalized for wider applicability and th...
Article
Multifunctional iron oxide nanoparticles have a vast and emerging scope in the field of nanotechnology. Out of numerous techniques available to develop multifunctional magnetite nanoparticles, co-precipitation is considered as one of the most efficient and economical techniques. Bare magnetite nanoparticles could be functionalized to act as multifu...
Article
Global QSAR modelling was performed to predict the pIC50 values of 233 diverse heterocyclic compounds as BTK inhibitors with the Monte Carlo algorithm of CORAL software using the DCW hybrid descriptors extracted from SMILES notations of molecules. The dataset of 233 BTK inhibitors was randomly split into training, invisible training, calibration an...
Article
In present work, the synthesis of the humic acid functionalized iron oxide nanoparticles and their application in water treatment are reported. The bare and humic acid functionalized iron oxide nanoparticles were characterized using different techniques such as X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), thermograv...
Article
A new series of macrocyclic complexes have been synthesized by template condensation between 3,4- diaminotoluene and acetylacetone in the presence of trivalent metal ions to form macrocyclic complexes having four coordination sites. Different spectroscopic and physicochemical techniques were used to establish the geometry and structural framework o...
Article
The application of ion liquids (ILs) as green solvents has attracted the attention of the scientific community. However, ILs may play the role of toxins. Even though ionic liquids may assist to minimise air pollution, but their discharge into aquatic ecosystems might result in significant water pollution due to their potential toxicity and inaccess...
Article
In the present study, chitosan functionalized magnetite nanoparticles (CS@MNPs) were synthesized by a simple and economical coprecipitation technique for efficient magnetic removal of allura red dye (ARD) by adsorption technique from the aqueous solution. Size and surface properties of the bare and surface functionalized MNPs were determined with t...
Article
Full-text available
Ionic liquids (ILs) have captured intensive attention owing to their unique properties such as high thermal stability, negligible vapour pressure, high dissolution capacity and high ionic conductivity as well as their wide applications in various scientific fields including organic synthesis, catalysis, and industrial extraction processes. Many app...
Article
Simplified molecular-input line-entry system (SMILES) notation and inbuilt Monte Carlo algorithm of CORAL software were employed to construct generative and prediction QSPR models for the analysis of the power conversion efficiency (PCE) of 215 phenothiazine derivatives. The dataset was divided into four splits and each split was further divided in...
Article
In an effort to explore a class of novel antidiabetic agents, we have made an effort to synergize the α-amylase inhibitory potential of 1,3-benzothiazole and 1,3,4-oxadiazole scaffolds by combining the two into a single structure via an ether linkage. The structure of synthesized benzothiazole clubbed oxadiazole derivatives are established by diffe...
Article
The influenza virus threat continues to be a major global health issue. Although comprehensive studies concentrate on anti-influenza testing, however, the worldwide reports of fatalities caused by the influenza virus are still constant. The hemagglutinin viral protein (HA) is responsible for the first stage of the influenza virus, thus, it is consi...
Article
Full-text available
Benzothiazole and its derivatives have been manifested as an optimistic scaffold due to their immense biological importance. Several methodologies have been reported as modifications after the first report of 2‐substituted benzothiazole. Among them, many involve a shift from the conventional synthetic approach by utilizing different catalytic syste...
Article
The thermal hazard, has become one of the basic characteristics of different Ionic Liquids (ILs). The thermal decomposition of ionic liquids (ILs) is also an important aspect to evaluate the thermal hazard of ILs. So, in the present manuscript, we have paid our attention to predict the thermal decomposition temperature (Td) of ionic liquids (ILs)....
Article
Full-text available
The last few centuries are witness of a remarkable increase in the trend towards industrialization and this, in turn, has led to a historic rise in many environmental problems. One of the major problems is the discharge of wastewater from industries to various natural water sources including rivers. Generally, the industrial effluents possess heavy...
Article
Full-text available
A large amount of synthetic dyes is being produced worldwide and a significant amount of these dyes are consumed in various industries like textiles, leather, cosmetics, plastic, paper, printing, pharmaceutical, food industries and many more. The processed water streams containing dyes as major contaminants are discharged into water bodies leading...
Article
Full-text available
Based on the mechanism of action of PKC-θ, the inhibition of this enzyme is considered a potential target for the treatment of autoimmune diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and psoriasis. In the present study, 57 structurally diverse tricyclic triazinone analogues as potential PKC-θ inhibitors has been tak...
Article
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Cancer is a disease portrayed by the uncontrolled growth of irregular cells. Tankyrase, a member of poly(ADP-ribose)polymerase family, mediates Wnt signal transduction and has emerged as a new molecular target for the therapy of different kinds of cancer. Wnt/β-catenin signaling functions significantly in a wide scope of biological events, such as...
Article
Full-text available
The present manuscript describes the synthesis, a-amylase inhibition, in silico studies and in-depth quantitative structure–activity relationship (QSAR) of a library of aroyl hydrazones based on benzothiazole skeleton. All the compounds of the developed library are characterized by various spectral techniques. a-Amylase inhibitory potential of all...
Article
The Monte Carlo algorithm was applied to formulate a robust quantitative structure–property relationship (QSPR) model to compute the reactions rate constants of hydrated electron values for a data set of 309 water contaminants containing 125 aliphatic and 184 phenylbased chemicals. The QSPR models were computed with the hybrid optimal descriptors w...
Article
Full-text available
Malaria, a nocuous disease, which has become a major challenge for the health resulting in deaths of millions of people around the globe. Malaria is a parasitic disease propagated by mosquitoes and infects the human beings. Several species of Plasmodium are responsible for this life-threatening disease and Plasmodium falciparum being the most virul...
Article
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Drug abuse is a worldwide wide problem affecting individual, society and the environment in general and it is nothing less than the attempted ecocide. Designer drugs are the chemical substances used for recreational purposes and have addictive properties. The production of designer drugs at disturbing pace is creating difficulties for the investiga...
Article
Azo dyes are a group of chemical moieties joined by azo (-N=N-) group with potential usefulness in different industrial applications. But these dyes are not devoid of hazardous consequence because of poor affinity for the fibre and discharge into the water stream. The chemical aspects of 72 azo dyes towards cellulose fibre in terms of their affinit...
Article
The assessment of cytotoxicity of quantum dots is very essential for environmental and health risk analysis. In the present work we have modelled HeLa cell cytotoxicity of sixty one CdSe quantum dots with ZnS shell as a function of its experimental conditions and molecular construction using quasiSMILES representations. The index of ideality of cor...
Article
Alzheimer’s disease is the most common neurodegenerative disorder and being a social burden Alzheimer’s has become an economic liability on developing countries. With limited understanding regarding the cause of disease, it is commonly identified by extracellular deposit of amyloid β (Aβ) peptides as senile plaques. Pyroglutamated Aβ is identified...
Article
Ionic liquids (ILs) have enticed the curiosity of chemists due to their vast applications in academic and industrial research. These have many advantages over other conventional solvents such as broad liquid temperature, negligible vapour pressure, non-volatility, etc. But, from an environmental point of view, these advantages can develop heterogen...
Article
An efficient, novel and transition metal-free protocol has been developed for the synthesis of polyfunctionalized aminothioalkenes via direct C-H sulfenylation of in situ generated enamines. The reaction was performed using a catalytic amount of inexpensive and non-toxic K2CO3 under mild reaction condition. All the reactions resulted in good to exc...
Article
In this study, different water-soluble derivatives of chitosan were synthesized by treating chitosan with monochloroacetic acid to yield O-carboxymethyl chitosan (O-CMC) and this O-CMC treated with vanillin to form Schiff base. Metal complexes of this Schiff base were prepared with different salt of metal ions like Cu(II), Ni(II), Fe(II) and Zn(II)...
Article
Human African trypanosomiasis (HAT) or sleeping sickness like infections remain a serious health concern around the globe due to unavailability of safe and potential drugs for their treatment. Moreover, developing safe, potential and highly specific target based treatments is still a challenge for present drug discovery programs. A series of pyrazo...
Article
Alzheimer’s disease is one of the leading causes of disability and death in the global scenario. Acetylcholinesterase inhibitors are symptomatically involved in the therapeutic management of Alzheimer’s disease. Due to the prophetic capability of SMILES-based QSAR studies, the current method explored its efficiency for designing novel inhibitors of...
Article
Fructose-1,6-bisphosphatase performs a significant function in regulating the blood glucose level in type 2 diabetes by controlling the process gluconeogenesis. In this research work optimal descriptor (graph) based quantitative structural activity relationship studies of a set of 203 fructose-1,6-bisphosphatase has been performed with the help of...
Article
Full-text available
Glucokinase is an enzyme which is responsible for the conversion of glucose to glucose-6-phosphate through ATP-dependent phosphorylation and has a significant role in glycogen synthesis and hepatic glucose production. Allosteric activators of glucokinase could be an attractive approach for the treatment of T2DM (type 2 diabetes mellitus). Recently,...
Article
Obesity has acquired notable attention due to its high occurrence and link with grievous health problems such as hypertension, diabetes and heart disease. It has been reported that the endocannabinoid system executes a pivotal part in the management of food absorption, fat augmentation, and energy balance. In the present manuscript, we report a det...
Article
Full-text available
The last few centuries are witness of a remarkable increase in the trend towards industrialization and this, in turn, has led to a historic rise in many environmental problems. One of the major problems is the discharge of wastewater from industries to various natural water sources including rivers. Generally, the industrial effluents possess heavy...
Article
Acetylcholinesterase inhibitors are the most promising therapeutics for Alzheimer’s disease treatment as these prevent the loss of acetylcholine and slows the progression of disease. The drugs approved for management of Alzheimer’s disease by FDA are acetylcholinesterase inhibitors but are associated with side effects. Consistent and stringent effo...
Article
In search of potent α-amylase inhibitors, herein we report the synthesis, molecular docking and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) i.e., 1-((1-phenyl-3-aryl-1H-pyrazole-4-yl)methylene)-2-(4-arylthiazole-2-yl)hydrazine (4a-4r) as an α-amylase inhibitors. Among the different analogues, compounds 4g and 4h were found to be mos...
Article
Molecular hybrids based on thiazolidin‐4‐one and pyrazolyl pharmacophore (THZP) as new antidiabetic agents were synthesized. Two sets of signals came into view in 1H NMR of THZP8‐THZP14 exhibited the presence of a configurational isomeric mixture of 2E,5Z (38.24%‐41.58%) and 2Z,5Z isomers (58.42%‐61.76%), which was further endorsed by density funct...
Article
Full-text available
Research often leads to unprecedented results that open the gates for new methodologies. We report herein the oxidative aromatization and serendipitous regioselective nitration of 1,3,5‐trisubstituted‐4,5‐dihydro‐1H‐pyrazoles under mild reaction conditions using SiO2‐HNO3 as an oxidizing agent to afford 1,3,5‐trisubstituted pyrazoles with high regi...
Article
This study describes in silico designing of aptamers against the influenza virus using Monte Carlo method. Aptamers are short, single-stranded oligonucleotides and these bind to an ample range of biologically important proteins which are related to many disease conditions. The affinities and specificities of aptamers are comparable to antibodies. I...
Article
Diabetes, obesity and other diseases related to metabolism are worldwide health problems. These syndromes can be well treated when a particular enzyme-based therapy is developed. Diacylglycerol acyltransferase (DGAT; EC 2.3.1.20) is a microsomal enzyme which is responsible for the synthesis of triglycerides from 1,2-diacylglycerol by catalyzing the...
Article
Quantitative structure-activity relationship (QSAR) modelling of 55 focal adhesion kinase (FAK) (EC 2.7.10.2) inhibitors of triazinic nature was performed using the Monte Carlo method. The QSAR models were designed by CORAL software, and optimal descrip�tors were calculated with the simplified molecular input line entry system (SMILES). Four splits...
Article
Fructose-1,6-bisphosphatase (FBPase) is an enzyme important for regulation of gluconeogenesis, which is a major process in the liver responsible for glucose production. Inhibition of FBPase enzyme causing blockage of the gluconeogenesis process represents a newer scheme in the progress of anti-diabetic drugs. The current research describes the deve...
Article
Full-text available
Methods: A series of 1-{2-(prop-2-ynyloxy)aryl}-3-hydroxy-3-(4'-trifluoromethylphenyl) prop-2-en-1-ones obtained by photo-irradiation of 2-{2-(prop-2-ynyloxy)benzoyl}-3-(4- trifluorome-thyl-phenyl)oxiranes (that were characterized by spectral studies: FT-IR, 1H NMR, 13C NMR and Mass analysis) was screened for the anti-malarial activity by evaluati...
Article
An efficient and environmentally benign methodology for the oxidative aromatization of 1,4-dihydropyridines to their corresponding pyridine derivatives is developed. The oxidative aromatization of 1,4-dihydropyridines was explored using silica-supported ceric ammonium nitrate as catalyst in CH3CN with or without sonication at room temperature. This...
Article
Human farnesyl pyrophosphate synthase (hFPPS) is a well-settled therapeutic target and it is an enzyme of the mevalonate pathway which catalyzes the biosynthesis of the C-15 isoprenoid farnesyl pyrophosphate. QSAR studies by using Monte Carlo method for human farnesyl pyrophosphate synthase inhibitors has been carried out using balance of correlati...
Article
A simple, green and cost-effective protocol has been devised for the synthesis of 4-substituted-2,6-dimethyl-3,5-pyridinecarboxylates from Hantzsch-type 1,4-dihydropyridines via rapid oxidation in excellent yields using 1.5 equivalent of ceric ammonium nitrate within 15 minutes in solvent-free conditions. The method was able to furnish the products...
Article
The synthesis of Schiff bases of chitosan is performed by the reaction of chitosan with different heteroaryl aldehydes, i.e., furfuraldehyde, thiophene-2-carboxylaldehyde, pyrrole-2-carboxylaldehyde, pyridine-2-carboxylaldehyde, pyridine-3-carboxylaldehyde and pyridine-4-carboxylaldehyde. The structural characterizations of the biopolymeric Schiff...
Article
Full-text available
After publication of the original article [1], the following error was reported in the Results section of the Abstract: "antifungal activity against one yeast i.e. Aspergillus niger" should read: "antifungal activity against one fungus i.e. Aspergillus niger". The authors would like to confirm all antifungal activity has been screened against fungi...
Article
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Background Acyl hydrazones are an important class of heterocyclic compounds promising pharmacological characteristics. Malaria is a life-threatening mosquito-borne blood disease caused by a plasmodium parasite. In some places, malaria can be treated and controlled with early diagnosis. However, some countries lack the resources to do this effective...
Article
Monte Carlo method based QSAR studies for inhibitors of Mer kinase, a potential novel target for cancer treatment, has been carried out using balance of correlation technique. The data was divided into three random and dissimilar splits and hybrid optimal descriptors derived from SMILES and hydrogen filled graphs based notations were used for const...
Article
The present study describes a multicomponent synthesis of molecular hybrid containing pyrazole, thiazole moiety using hydrazone as a linker, which have been synthesized by condensation of 1-phenyl-3-(aryl)-1H-pyrazole-4-carbaldehydes 1a-b, thiosemicarbazide and α-bromoketones 2a-c.The target hybrid compounds, 1-((1-phenyl-3-aryl-1H-pyrazole-4-yl)me...
Article
The present communication demonstrates the development of urea nitrate as an effective and efficient catalyst for the synthesis of some 2-substituted benzothiazoles. Instant progress of reaction at room temperature under solvent-free condition, very high catalytic activity, inexpensive, clean reaction profile, operational simplicity, large-scale sy...
Article
Postprandial hyperglycemia can be controlled by delaying the absorption of glucose resulting from carbohydrate digestion. α-amylase is the initiator of the hydrolysis of polysaccharides, therefore developing α-amylase inhibitors can lead to development of new treatments for metabolic disorders like diabetes mellitus. In the present work, we set out...
Article
A series of some substituted diethyl 4-(2-chloroquinolin-3-yl)-2,6-dimethylpyridine-3,5-dicarboxylates has been synthesized from substituted diethyl4-(2-chloroquinolin-3-yl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates (1,4-DHPs) by treating the latter with SiO2–HNO3 which proved to be a better oxidant in terms of product yield, reaction tim...
Article
Photo-reorganization of 3-alkoxy-6-chloro-2-(benzo[b]thiophen-2-yl)-4H-chromen-4-ones in methanol with Pyrex filtered UV-light from a medium pressure 125 W Hg-vapor lamp led to the formation of angular pentacyclic compounds (dihydro and aromatic products) along with some rearranged chromenones where the product(s) distribution depended upon the str...
Article
In this work, we have synthesized thirteen (SB1-SB13) Schiff bases derived from condensation reaction of pyrrole-2-carboxaldehyde with different aniline derivatives. The structures of the synthesized products were confirmed by physicochemical and spectral (IR and 1H NMR) means. These compounds were screened for their antimicrobial activity against...
Article
Full-text available
The extracts of ginger and cardamom were chosen for studies on estrogen receptors and Alzheimer’s disease on the basis of various in silico studies of their constituents. Estrogenic effect was evaluated by uterine weight method while effect on learning and memory was studied using elevated plus maze method. Cardamom extract showed better estrogenic...
Article
Full-text available
In this article, an efficient, environmentally benign, solvent-free synthesis of diethyl-2,6-dimethyl-4-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylates and their simple oxidative aromatization in presence of selected hypervalent iodine (III) reagents under solvent-free condition at room temperature is demonstrated. All reac...
Article
The present work was undertaken to develop an economic method for the synthesis of 2-aryl/heteroaryl/styryl/alkylbenzothiazoles mediated by SiO2–HNO3. In this report, we have demonstrated the catalytic potential of SiO2–HNO3 for the oxidative condensation of 2-aminothiophenol and aldehydes. Instant reaction at room temperature under solvent-free co...
Article
The present work was undertaken to develop an economic method for the synthesis of 2-aryl/heteroaryl/styryl/alkylbenzothiazoles mediated by SiO2–HNO3. In this report, we have demonstrated the catalytic potential of SiO2–HNO3 for the oxidative condensation of 2-aminothiophenol and aldehydes. Instant reaction at room temperature under solvent-free co...