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Introduction
Current institution
Publications
Publications (4)
The evolution of genetic diversity and population structure of Plasmodium vivax as malaria elimination approaches remains unclear. This study analyzed the genetic variation and molecular epidemiology of P. vivax from Yala Province in southern Thailand, an area in the pre-elimination phase. Seventy P. vivax isolates, collected between 2017 and 2020,...
Background
Recent reports from Thailand reveal a substantial surge in Plasmodium knowlesi cases over the past decades, with a more than eightfold increase in incidence by 2023 compared to 2018. This study investigates temporal changes in genetic polymorphism associated with the escalating transmission of P. knowlesi malaria in Thailand over time us...
The local diversity and population structure of malaria parasites vary across different regions of the world, reflecting variations in transmission intensity, host immunity, and vector species. This study aimed to use amplicon sequencing to investigate the genotypic patterns and population structure of P. vivax isolates from a highly endemic provin...
The liver is the first destination of malaria parasites in humans. After reaching the liver by the blood stream, Plasmodium sporozoites cross the liver sinusoid epithelium, enter and exit several hepatocytes, and eventually invade a final hepatocyte host cell. At present, the mechanism of hepatocyte invasion is only partially understood, presenting...
Questions
Questions (2)
After I have processed raw .fastq file to align with reference sequence in bowtie2. It generates .bam file to visualize the localization of my reads to the reference genome in IGV. I need the consensus sequence to perform population genetic analysis with other softwares which require fasta format. How can I get that one, may someone please suggest the pipeline.
I'm working on analysis of genetic diversity of P. vivax in Thailand by DNA sequencing using Illumina Miseq. Gene targets are polymorphic regions of PvMSP-1, PvAMA-1, PvCSP, and PvDBP (4 markers). The problem is how I can estimate the number of samples or isolates as a good representative of certain population. Are there any similar previous works I can look for? Thank you in advance.
