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Publications (169)
Objective: To evaluate the enzymatic activity of Adenosine Deaminase in type II diabetes mellitus (T2DM).
Methods: This study was conducted on 60 clinically diagnosed type II diabetes mellitus patients, with 60 healthy subjects as the control group. Subjects were enrolled in the study only after their written consent was obtained. The inclusion of...
Background: Metabolic syndrome is a set of metabolic disorders and is considered as a predictor of cardiovascular risks. The expression of several specific genes and the related protein products also show their significance in pathophysiology of Metabolic Syndrome. Secreted Frizzled Related Protein 4 is a product of expression of SFRP4 genes. SFRP4...
Since its sudden outbreak in December 2019 in Wuhan, A pandemic of SARS-CoV-2 has been announced. Vitamin C is a water-soluble vitamin with anti-oxidant and immunity-boosting properties. Vitamin C acts as a nutritional supplement profoundly impacting the immune response to the second or third wave of the coronavirus disease (COVID-19). Vitamin C ef...
Background: Improved prognosis and delay of clinical complications in Diabetes mellitus can be ensured by early screening and regular monitoring after diagnosis. This requires venipuncture at regular intervals of time causing anxiety and discomfort to the patient. Hence, development of a painless, non-invasive procedure is desirable for which saliv...
This study aimed to compare the effect of 4 different intracanal medicaments on the push-out bond strength of two sealers (AH Plus and MTA Fillapex). 100 single-rooted extracted premolar teeth were divided into 5 groups, with 20 samples in each group, one group being the control group. After cleaning and shaping procedures, the canals were filled w...
BACKGROUND Exclusive breastfeeding is recommended up to 6 months of age with all its beneficial effects on child survival. Several studies have shown that adequate intake of vitamin D cannot be met with human milk as the sole source of vitamin D, although risk factors for developing vitamin D deficiency may be low maternal levels of vitamin D, indo...
Background: The major causes of death both in developed and developing countries are diabetic mellitus, jaundice, cardiovascular disorders and hyperbilirubinemia. Higher concentration of cord blood glucose, urea, total protein and albumin in pre term neonates may increase their future risk of cardiovascular diseases. Early diagnosis and dietary mod...
Aims: This study was done to find out retrospective case-control with respect to myocardial infarction diagnosis on the basis of biochemical markers and lipid profile characteristics. Design and Setting: This study was conducted at the Department of Biochemistry and sample collection at LPS Institute of Cardiology & Cardiac Surgery Department, Kanp...
To assess C reactive protein (CRP) in detecting type-II diabetes mellitus with nephropathy. Patients with a history of diabetes type 2 with nephropathy and patients with diabetes type 2 without nephropathy were included in the study. A total of 30 cases, both male and female, were recruited and compared with30 normal healthy adults. Each participan...
Introduction: Recent studies suggest that saliva could be functionally equivalent to serum in reflecting the physiological state of the body. Studies are being conducted to develop saliva as a tool for the screening and monitoring of chronic systemic diseases like Diabetes mellitus. Dyslipidaemia is most commonly assessed by laboratory lipid profil...
The foremost causes of death in developed and developing countries both are cardiovascular disorders. Higher concentration of lipids in pre term neonates may increase their future risk of cardiovascular diseases. Early diagnosis and dietary modifications and proper management may rectify the risk factors and prevent future risk of cardiovascular di...
Coronavirus disease 19 is a global pandemic which infects over millions of people worldwide in a limited time and changes the lifestyle, clinical spectrum lies from asymptomatic infection to pneumonitis with cardiorespiratory failure and finally death. Higher mortality occurs in senior and who are suffering from co-morbidities like chronic kidney d...
Objective: In this study, the main objective was to evaluate the association of markers of obesity with the inflammatory markers in pre-diabetes and diabetes. Methods: This study recruited 300 participants (100 control group, 100 pre-diabetic group, and 100 diabetic group). The anthropometric variables such as body mass index (BMI), waist-hip ratio...
The complete microfloral debriment of the root canal is possible only through successful endodontic treatment. Due to complexicity constraints of root canal system complete microfloral removal by simply mechanical instruments is not sufficient. Therefore we aim to evaluate the antimicrobial efficacy of five different intracanal medicaments such as...
Background: One of the leading causes of diabetic mortality is cardiovascular disease. Diabetes progression is preceded by pre-diabetic phase which is also at higher cardiovascular risk. Both hyperglycemia and atherosclerotic processes are inflammatory phenomenon. Keeping this in view, it was aimed to evaluate atherogenic indices and correlate them...
Background: Subclinical inflammation characterized by elevated inflammatory markers is found in diabetic patients. Inflammation, an important cardiovascular risk factor, is elevated in diabetics with poor glycemic control than those with good control. Aim: To study the effect between glycemic status on inflammatory markers in pre-diabetes and diabe...
Concurrent with the misbalance of oxidizing agents and antioxidants, high blood pressure is a major physical burden condition in the current scenario. Tumor necrosis factor-α (TNF-α) plays a vital role in the pathogenesis of hypertension. Tumor necrosis factor-α, inhibitor improves clinical symptoms however their outcome on high blood pressure has...
Almost 30 years have passed since the term 'tissue engineering' was created to represent a new concept that focuses on the regeneration of neotissues from cells with the support of biomaterials and growth factors. This interdisciplinary engineering has attracted much attention as a new therapeutic means that may overcome the drawbacks involved in t...
MAS, which is currently grouped under secondary or acquired haemophagocytic lymphohistiocytosis (sHLH), is a rare and fatal disorder that results from excess activation of T-cells and macrophages. Though the pathogenesis of MAS is poorly understood, various proinflammatory cytokines like interleukins (IL-1, IL-6), tumor necrosis factor α (tNF α), i...
Inborn errors of metabolism belong to heterogenous group of disorders which cause a number of morbidities and mortality in pediatric population and come under the class of genetic rare diseases. With the advent of newer molecular tools and techniques, so for several hundreds of disorders have been defined after the first description by Garrod in th...
Background: Concurrent with the imbalance of oxidizing agents and antioxidants, high blood pressure (BP) is a major physical condition burden in the current scenario. Tumor necrosis factor-alpha (TNF-α) plays a vital role in the pathogenesis of hypertension (HTN). TNF-α inhibitor improves clinical symptoms; however, their outcome on high BP has not...
Objective: Subclinical hypothyroidism (SCH) patients may present with abnormal lipid profile more specifically in patients having thyroid-stimulating hormone (TSH) >10 mIU/L. Since the contradiction still lies with patients having TSH <10 mIU/L, so the role of high-sensitive C-reactive protein (Hs- CRP) may be important with the prediction of infla...
In the present study, an effort was made to quantify the total endogenous ascorbic acid to reveal if it has any association with vase life of chrysanthemum (Chrysanthemum × morifolium Ramat) cultivars. Among 30 cultivars, maximum total ascorbic acid content (441.29 mg/100 g fresh weight) was recorded in cv. Red Gold followed by cv. Jaya (336.34 mg/...
The objective is to the study the Interactions between thyroid hormones and kidney functioning may coexist. The aim of this study was to investigate the renal function status in perimenopausal women with hypothyroidism. Total 60 perimenopausal women (30 cases and 30 controls) were recruited for the study. Thyroid hormones including thyroid stimulat...
Objectives: Adiponectin, a major cytokine from adipose tissue, and high sensitivity C-reactive protein (hs-CRP), well-established markers of inflammation are known to be associated with increased risk of cardiovascular disorders (CVD). Therefore the objective of our study was to evaluate the levels of these parameters and determine their correlatio...
Crossing the threshold in clinical activity, chimeric antigen receptor-modified T cells have emerged as a new effective therapeutic regimen against various types of cancer both in adults and pediatric oncology. Currently available CARs are designed in a manner so that that they are capable of recognizing MHC independent antigen and incorporate cost...
Introduction: Among the most advanced public health promotion and disease prevention programs, the newborn screening is of paramount importance, seeking timely detection, diagnosis and treatment of genetic disorders which may otherwise lead to serious consequences upon the health of newborn. Aim: To evaluate the prevalence of Inborn Error of Metabo...
Background: Subclinical hypothyroidism causes development of cardiovascular risk is not very well defined due to contradictory findings over the years. Role of inflammatory markers in Subclinical hypothyroidism is not very well studied in the past. Objective: The main objective of this study was to assessment of the role of interleukin-6 and C reac...
Natural Killer (NK) cells are potent cytotoxic effector cells for cancer therapy and also for keeping severe viral infections in check. Since, they represent only 10% of the lymphocytes and are often dysfunctional, there are technical challenges in obtaining sufficient numbers of functionally active NK cells from a patient’s blood. Recent advances...
Tight regulation of immunotolerance at fetomaternal interface facilitates the survival of allogeneic embryo. Natural Killer (NK) cells are immune cells capable of lysing the target cells via the release of cytolytic granules containing perforin, granzyme and granulysin. Besides the peripheral circulation, NK cells are also present in the uterine mu...
Objective: In view of marked accentuations in cardiometabolic diseases in developing countries such as India, we aimed to conduct a cross-sectional study analyzing the prevalence of cardiometabolic risk factors in local population of Ghaziabad.Methods: The study is descriptive, random sample survey, and cross-sectional study. The study was carried...
Background: Diabetic nephropathy (DN) is a common complication of diabetes mellitus that lead to end-stage of kidney disease (ESKD). Detection of early-stage can slow loss of kidney function and improve patient outcomes with use of diagnostic biomarker detection of DN. Aims and objectives of this study is to evaluate the possible association betwee...
Different genotypes of marigold (Tagetes sp) belonging to T. patula were investigated for essential oil content in leaves by hydro distillation and examined by gas chromatography (GC) and GC-mass spectrometry (GC-MS). Results indicated that there were wide variations in genotypes for essential oil yield and chemical composition. Essential oil conte...
One of the important components of the immune system, the major histocompatibility complex (MHC) molecules allow T-lymphocytes to detect cells, such as macrophages, B-lymphocytes, and dendritic cells that ingest infectious microorganisms or the self-cells infected with microorganism. On being engulfed a microorganism, macrophage partially digests i...
A broad range of health-care practices is required to exploit the beneficial effects of Ayurveda, which is the most ancient system of medicines. Being the essence of Ayurvedic medicines, Indian medicinal plants manifest miraculous effects in curing a vast range of diseases and disorders among humans and can be better called as “elixirs of life.” Cu...
The experiment was conducted with 22 hybrids and one check of Gladiolus hybridus at the research farm of the Division of Floriculture and Landscaping, Indian Agricultural Research Institute, New Delhi for three years from 2012-13 to 2014-15 to study their performance and genetic diversity under ecological conditions of Delhi for commercial traits....
Objective: Objective is to study the prevalence of microalbuminuria among patients suffering from essential hypertension and also to evaluate theresponse of microalbuminuria to angiotensin-converting enzyme (ACE) inhibitors therapy.Methods: The study conducted at Santosh Medical College and Hospital, Ghaziabad, on 300 patients with essential hypert...
The most potential application of the stem cells (SCs) in human beings lies in their ability to regenerate cells and tissues. They differentiate themselves into specific cell type, thereby availing remarkable source of replacement cells and tissues. They differentiate themselves into specific cell types, thereby availing renewable source of replace...
The present investigation was carried out at Division of Floriculture and Landscaping, Indian Agricultural Research Institute, Pusa, New Delhi. The experiment was laid out in randomized block design (RBD) with three replications and seven treatments consisting of six varieties (viz. Selection 1, Bargusto, Panama, Panam, Palma and Tifdwarf 419) and...
Objective: To assess the effect of 45 minute yogic kriya (Surya Namaskar and Kapalbhati) for 30 days on various physiological and biochemical parameters. Methods: About 20 Nursing College students of the Santosh Medical University, Ghaziabad, between the age group 17 and 21 years volunteered to participate in the study. They were divided into two G...
An IMC controller is designed for two input and two output (TITO) processes with dead time where the closed-loop time constant is varied depending on the process operating condition. For a TITO process, proper decoupling can minimize the loop interaction. Here, we develop an inverted decoupler so that the TITO process can be decoupled into two SISO...
Among the adipokines, adiponectin is the first one to be described just over a decade ago. It is produced exclusively by adipose tissue and circulatesin high concentration in human plasma accounting for 0.01% of proteins in plasma, almost thousand times higher than that of leptin. The normalcirculating level of adiponectin ranges from 2 to 30 µg/ml...
Central nervous system involvement in childhood microscopic polyangiitis (MPA) is a very rare entity. Here we report a 14 year Indian female child, diagnosed case of MPA, presented with seizure. Magnetic resonance imaging (MRI) of brain showed diffuse involvement of brain parenchyma. Repeat MRI brain after 6 months revealed complete resolution of t...
Objective: Osteoporosis is a quite common in post-menopausal women due to estrogen deficiency. Uric acid (UA) concentration has found some
controversial association with bone mineral density (BMD). Hence, the role of UA may be beneficial to know due to the sign and symptoms presented
by osteoporosis patients.
Methods: A total of 79 post-menopausal...
Thyroid hormones evidently play a very important role in regulation of carbohydrate metabolism. The present study was done to understand the association between the Thyroid Disorders and Diabetes Mellitus, the two major endocrinological diaorders. 1000 patients with type -2 DM irrespective of the age and gender both, randomly selected for study. 33...
Diabetes is becoming fast growing disorder worldwide, accompanying dyslipidemia thereby causing cardiovascular complication. The study aimed to evaluate the relationship among glycated hemoglobin and lipid profile in diabetic subjects with and without complications. About 50 patients (30 cases of diabetes without complications. 20 cases of diabetes...
Inborn errors of metabolism (IEM) arise from inherited errors in enzyme in any of the metabolic pathways. Symptoms are developed due to the accumulation of biosynthetic precursors or product that baby cannot excrete. IEM screening is a field that is undergoing a revolutionary change in its all aspects. Technological advances are transforming the wa...
Objective: Weight gain is a characteristic feature of hypothyroidism. People with subclinical hypothyroidism (SCH) are also characterized by the same is still unclear. Methods: Height and weight were calculated of SCH women as well as normal healthy adult women. Body mass index (BMI) was calculated as per WHO guidelines. The thyroid stimulating hor...
The stability of the plane interface separating two Rivlin-Ericksen elastico-viscous superposed fluids of uniform densities when the whole system is immersed in a uniform horizontal magnetic field has been studied. The stability analysis has been carried out, for mathematical simplicity, for two highly viscous fluids of equal kinematic viscosities...
The thermal instability of a layer of Rivlin-Ericksen elastico-viscous fluid acted on by a uniform rotation is considered. For stationary convection, a Rivlin-Ericksen elastico-viscous fluid behaves like a Newtonian fluid. It is found that rotation has a stabilizing effect and introduces oscillatory modes in the system. The visco-elasticity also in...
The thermal instability of a layer of Rivlin-Ericksen elastico-viscous fluid acted on by a uniform vertical magnetic field is considered. For stationary convection, a Rivlin-Ericksen elastico-viscous fluid behaves like a Newtonian fluid. The magnetic field has a stabilizing effect. It is found that the presence of a magnetic field introduces oscill...
RNA interference (RNAi) represents a powerful, new tool for scientific investigation as well as a promising new form of targeted gene therapy, with applications currently in clinical trials. Bifunctional short hairpin RNA (shRNA) are synthetic RNAi molecules, engineered to utilize multiple endogenous RNAi pathways to specifically silence target gen...
Tuberculosis is one of the major causes of the mortality from single infectious agent worldwide. India has the highest number of TB cases in the world. It is the leading cause of death, because of its high mortality and morbidity because of the disease, is due to emergence of multidrug resistant TB strains, and the HIV infection which reactivates t...
The present study was carried out on 40 healthy volunteers, to analyze their SGPT (serum glutamate pyruvate transaminase) and uric acid level in the serum. The volunteers had the access to light meal containing a standard amount of carbohydrate, protein and lipid. Blood was taken for analysis of aforesaid parameters, before the meal and 1, 2, & 4 h...
Recent studies which were undertaken at CDRI to study the effect of N- acyl derivatives of various aminoacids, have culminated in the identification of an oxazolidine derivatives 4, 5 cis-5-styryl-2- oxo-oxazolidine-4-carboxylic acid(CDRI 85/92) having good proton pump inhibitory activity. This compound is as potent as omeprazole in in vitro inhibi...
Fisher Island and the Broknes Peninsula in the Larsemann Hills are part of a polar lowland periglacial environment between marine and glacial ecosystems. The landscape is characterized by gently rolling hills and broad valleys interspersed with lakes formed in glacially scoured basins. We analyzed the physicochemical parameters and the ionic consti...
PDX1 (pancreatic and duodenal homeobox 1) is overexpressed in pancreatic cancer, and its reduction results in tumor regression. Bi-functional pbi-shRNA PDX1 nanoparticle (OFHIRNA-PDX1) utilizes the endogenous micro-RNA biogenesis pathway to effect cleavage- and non-cleavage-dependent degradation of PDX1 mRNA. We have shown that OFHIRNA-PDX1 reduces...