Parikshit Juvekar

Parikshit Juvekar
Brigham and Women's Hospital | BWH · Department of Neurosurgery

MBBS

About

52
Publications
4,690
Reads
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317
Citations
Citations since 2017
39 Research Items
253 Citations
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2017201820192020202120222023020406080
2017201820192020202120222023020406080
Introduction
Prior to graduating medical school, Parikshit's research pursuits focused on Pharmacology and Natural Product Chemistry with a definitive shift toward Neurosurgery during his clinical years. His current research interests include projects pertaining to intra-operative brain shift, intra-operative fluorescence imaging, tractography using DTI, brain plasticity using fMRI and the development of tools to visualize the growth of meningiomas.
Additional affiliations
July 2018 - May 2022
Harvard Medical School
Position
  • PostDoc Position
Education
August 2009 - May 2016
K. J. Somaiya Medical College
Field of study
  • Bachelor of Medicine, Bachelor of Surgery

Publications

Publications (52)
Article
Full-text available
IntroductionNeuronavigation greatly improves the surgeon’s ability to approach, assess and operate on brain tumors, but tends to lose its accuracy as the surgery progresses and substantial brain shift and deformation occurs. Intraoperative MRI (iMRI) can partially address this problem but is resource intensive and workflow disruptive. Intraoperativ...
Article
Full-text available
Given the difficulty and importance of achieving maximal resection in chordomas and chondrosarcomas, all available tools offered by modern neurosurgery are to be deployed for planning and resection of these complex lesions. As demonstrated by the review of our series of skull base chordoma and chondrosarcoma resections in the Advanced Multimodality...
Article
Full-text available
Numerous traditional linguistic theories propose that semantic language pathways convert sounds to meaningful concepts, generating interpretations ranging from simple object descriptions to communicating complex, analytical thinking. Although the dual-stream model of Hickok and Poeppel is widely employed, proposing a dorsal stream, mapping speech s...
Article
Full-text available
Accurate brain meningioma segmentation and volumetric assessment are critical for serial patient follow-up, surgical planning and monitoring response to treatment. Current gold standard of manual labeling is a time-consuming process, subject to inter-user variability. Fully-automated algorithms for meningioma segmentation have the potential to brin...
Article
Full-text available
Background Presence of residual neurovascular activity within glioma lesions have been recently demonstrated via functional MRI (fMRI) along with active electrical synapses between glioma cells and healthy neurons that influence survival. In this study, we aimed to investigate whether gliomas demonstrate synchronized neurovascular activity with the...
Article
Full-text available
This work presents a novel tool-free neuronavigation method that can be used with a single RGB commodity camera. Compared with freehand craniotomy placement methods, the proposed system is more intuitive and less error prone. The proposed method also has several advantages over standard neuronavigation platforms. First, it has a much lower cost, si...
Article
Full-text available
Purpose: NousNav is a complete low-cost neuronavigation system that aims to democratize access to higher-quality healthcare in lower-resource settings. NousNav's goal is to provide a model for local actors to be able to reproduce, build and operate a fully functional neuronavigation system at an affordable cost. Methods: NousNav is entirely open...
Article
Full-text available
Introduction Patients with recurrent brain metastases who have exhausted external radiation options pose a treatment challenge in the setting of advances in systemic disease control which have improved quality of life and survival. Brachytherapy holds promise as salvage therapy given its ability to enforce surgical cytoreduction and minimize region...
Article
Full-text available
Purpose The safety and effectiveness of laser interstitial thermal therapy (LITT) relies critically on the ability to continuously monitor the ablation based on real-time temperature mapping using magnetic resonance thermometry (MRT). This technique uses gradient recalled echo (GRE) sequences that are especially sensitive to susceptibility effects...
Article
Full-text available
We propose in this paper an efficient method to segment cortical vessels in craniotomy images acquired by the surgical microscope. Our method uses a vesselness-enforced convolutional neural network to classify each pixel of a craniotomy image as a vessel or surrounding tissue. This permits training the network not only on appearance-based features...
Chapter
Full-text available
Digital Subtraction Angiography (DSA) provides high resolution image sequences of blood flow through arteries and veins and is considered the gold standard for visualizing cerebrovascular anatomy for neurovascular interventions. However, acquisition frame rates are typically limited to 1–3 fps to reduce radiation exposure, and thus DSA sequences of...
Article
Full-text available
Objective: A craniotomy is the removal of a part of the skull to allow surgeons to have access to the brain and treat tumors. When accessing the brain, a tissue deformation occurs and can negatively influence the surgical procedure outcome. In this work, we present a novel Augmented Reality neurosurgical system to superimpose pre-operative 3D mesh...
Preprint
Full-text available
Accurate brain meningioma detection, segmentation and volumetric assessment are critical for serial patient follow-up, surgical planning and monitoring response to treatment. Current gold standard of manual labeling is a time-consuming process, subject to inter-user variability. Fully-automated algorithms for meningioma detection and segmentation h...
Conference Paper
Identification and labelling of white matter tracts is a crucial but time-consuming step in neurosurgical planning requiring user expertise. This is pronounced in regions of edema where fiber-tracking tools, utilizing single-tensor DTI (Diffusion Tensor Imaging), on commercial neuronavigation platforms hinder clinical decision-making with inadequat...
Poster
INTRODUCTION: Previous literature reports freehand EVD misplacement occurs up to 41% of the time, requires 2 or more passes, with 39% of patients requiring multiple passes (mean of 4.1). Image-guidance (IG) offers near-perfect catheter placement but is often unamenable for bedside use for a multitude of reasons such as limited portability, extensiv...
Poster
Full-text available
Neuroimaging offers a non-invasive means to probe tumor tissue in order to inform decision making at all phases of brain tumor treatment. Diffusion MRI is particularly sensitive to tumor tissue microstructure, with greater heterogeneity being reflected as a larger diffusional kurtosis. Q-Space Trajectory Imaging (QTI) uses tensor-valued diffusion e...
Article
During a craniotomy, the skull is opened to allow surgeons to have access to the brain and perform the procedure. The position and size of this opening are chosen in a way to avoid critical structures, such as vessels, and facilitate the access to tumours. Planning the operation is done based on pre-operative images and does not account for intra-o...
Chapter
Intra-operative brain shift is a well-known phenomenon that describes non-rigid deformation of brain tissues due to gravity and loss of cerebrospinal fluid among other phenomena. This has a negative influence on surgical outcome that is often based on pre-operative planning where the brain shift is not considered. We present a novel brain-shift awa...
Conference Paper
Abstract #4779: Diffusion MRI is sensitive to the configuration of cell structures on the microscopic level, and may be a biomarker of tumor grade. High-grade gliomas are hypothesized to be more heterogeneous on a microscopic scale, when compared to low-grade; a feature that should be reflected in the diffusional kurtosis. To explore this premise,...
Conference Paper
Full-text available
Synopsis We present an open-source software suite, SlicerDMRI (dmri.slicer.org), that enables neurosurgical planning research using diffusion magnetic resonance imaging (dMRI). SlicerDMRI is built upon and deeply integrated with 3D Slicer, an NIH-supported open-source platform for medical image informatics, image processing, and three-dimensional v...
Preprint
Full-text available
With the increasing availability of new image registration approaches, an unbiased evaluation is becoming more needed so that clinicians can choose the most suitable approaches for their applications. Current evaluations typically use landmarks in manually annotated datasets. As a result, the quality of annotations is crucial for unbiased compariso...
Conference Paper
Brain shift is a non-rigid deformation of brain tissue that is affected by loss of cerebrospinal fluid, tissue manipulation and gravity among other phenomena. This deformation can negatively influence the outcome of a surgical procedure since surgical planning based on pre-operative image becomes less valid. We present a novel method to compensate...
Article
PURPOSE We present SlicerDMRI, an open-source software suite that enables research using diffusion magnetic resonance imaging (dMRI), the only modality that can map the white matter connections of the living human brain. SlicerDMRI enables analysis and visualization of dMRI data and is aimed at the needs of clinical research users. SlicerDMRI is bu...
Article
Full-text available
Differences between males and females in brain development and in the organization and hemispheric lateralization of brain functions have been described, including in language. Sex differences in language organization may have important implications for language mapping performed to assess, and minimize neurosurgical risk to, language function. Thi...
Article
Full-text available
Purpose To evaluate surgical resection with brachytherapy placement as a salvage treatment in patients with recurrent high-grade meningioma who exhausted prior external beam treatment options. Methods Single-center retrospective review of our institutional experience of brachytherapy implantation from 2012 to 2018. The primary outcome of the study...
Article
Differences between males and females in brain development, organization, and hemispheric lateralization have been described, including for language function. However, the implications of sex differences in language organization for presurgical language mapping are unknown. We carried out a retrospective analysis in 47 patients with MBT (22 females...
Article
Background/Objective: Pituitary adenomas, particularly functional adenomas, can cause drastic hormone fluctuations throughout the body. However, it is not known how endogenous hormone disorders shape the patient’s brain. This study used resting-state functional magnetic resonance imaging (rsfMRI) to investigate whole-brain networks in patients with...
Article
INTRODUCTION Numerous differences between males and females in brain organization have been described including in the development, performance, and lateralization of language function. However, there is very limited knowledge of whether language processing differs across sex in patients with brain lesions. In particular, malignant brain tumors (MB...
Preprint
Full-text available
Background and Objective Prolactinomas may cause drastic hormone fluctuations throughout the body. It is not fully understood how endogenous hormone disorders such as prolactinomas reshape the patient’s brain. By employing the resting-state functional magnetic resonance imaging technique, we aimed to investigate the whole-brain functional connectiv...
Article
Purpose Brain shift during tumor resection can progressively invalidate the accuracy of neuronavigation systems and affect neurosurgeons’ ability to achieve optimal resections. This paper compares two methods that have been presented in the literature to compensate for brain shift: a thin-plate spline deformation model and a finite element method (...
Article
INTRODUCTION Numerous differences between males and females in brain organization have been described including in the development, performance, and lateralization of language function. However, there is very limited knowledge of whether language processing differs across sex in patients with brain lesions. In particular, malignant brain tumors (MB...
Article
Full-text available
Fluorescence guided surgery (FGS) has fueled the development of novel technologies aimed at maximizing the utility of fluorescence imaging to help clinicians diagnose and in certain cases treat diseases across a breadth of disciplines such as dermatology, gynecology, oncology, ophthalmology, and neurosurgery. In neurosurgery, the goal of FGS techno...
Conference Paper
Full-text available
Brain shift compensation attempts to model the deformation of the brain which occurs during the surgical removal of brain tumors to enable mapping of presurgical image data into patient coordinates during surgery and thus improve the accuracy and utility of neuro-navigation. We present preliminary results from clinical tumor resections that compare...
Article
In present study, we investigated the in vitro antioxidant and free radical scavenging activities of crude methanolic and aqueous extract of Indigofera cordifolia (Fabaceae) seeds. The antioxidant and free radical-scavenging activities of Indigofera cordifolia seed extracts were evaluated using different tests involving inhibition of DPPH, ABTS, TB...
Article
This study was designed to evaluate the anti-inflammatory activity of aqueous and 70% methanolic extracts of pollen grains of Typha angustifolia. Female Sprague Dawley rats were used for the study. The acute anti-inflammatory activity of pollen grains of T. angustifolia was studied using the carrageenan as phlogistic agent, whereas its chronic anti...
Article
In the present study, aqueous extract of Avicennia officinalis was screened for lipid peroxidation inhibitory and anti-arthritic activities using standard in vitro procedures. It exhibited important free radical-scavenging activity towards the lipid peroxidation and DPPH radicals. A. officinalis also revealed moderate anti-arthritic activity. Folin...
Article
Anti-lipid peroxidation effect of aqueous extracts of Ocimum sanctum, Tinospora cordifolia and Withania somnifera was evaluated against Fe 2+-ascorbic acid-induced lipid peroxidation using rat liver mitochondria as model system, whereas, anti-arthritic activity was evaluated by proteinase inhibitory assay. O. sanctum showed potent anti-lipid peroxi...
Article
Full-text available
The aim of present in vitro study was to investigate antioxidant and anti-arthritic activities of Shilajit. The antioxidant activity of aqueous extract of Shilajit was determined by using 3 in vitro parameters, namely, DPPH radical-scavenging assay, lipid peroxidation inhibitory assay and reducing power assay, whereas, anti-arthritic activity was e...
Article
Full-text available
Introduction: Oxidative stress resulted from free radicals and reactive oxygen species are associated with many diseases. Several studies are going on worldwide directed towards finding natural antioxidants of plant origin. Plants containing phenolic compounds have been reported to possess strong antioxidant activity. The aim of the present study w...

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Projects

Projects (7)
Project
Research focusing on the neuro-oncological aspects of neurosurgical practice.
Project
To investigate non-invasive imaging biomarkers for evaluation of brain lesions and further research in the areas of structural and functional neuroimaging.
Project
To evaluate the pharmacokinetics and pharmacodynamics of phytochemical extracts in preclinical animal models.